Vanderbilt vs South Carolina Prediction — AI Finds CAN'T MISS CFB Lines & Props (Sep 13)

Updated: 2025-09-06T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

Williams–Brice under the lights usually means volume and velocity, and No. 11 South Carolina’s SEC opener fits the bill as LaNorris Sellers leads a 2–0 start into a primetime tilt. Vanderbilt rides genuine momentum after hammering Virginia Tech on the road, setting up a sharper, more physical version of Clark Lea’s team to test the Gamecocks’ early top-15 form.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Sep 13, 2025

Start Time: 7:45 PM EST​

Venue: Williams-Brice Stadium​

Gamecocks Record: (2-0)

Commodores Record: (2-0)

OPENING ODDS

VANDY Moneyline: +170

SC Moneyline: -206

VANDY Spread: +5.5

SC Spread: -5.5

Over/Under: 47.5

VANDY
Betting Trends

  • The Commodores covered comfortably as road underdogs at Virginia Tech (44–20), erupting for 34 unanswered after halftime to move to 2–0 straight up and cash in Week 2.

SC
Betting Trends

  • South Carolina covered versus Virginia Tech in Week 1 (24–11 on a one-score spread) and then failed to land a massive number against South Carolina State, netting an early 1–1 ATS profile at 2–0 SU.

MATCHUP TRENDS

  • Books and previews list South Carolina as a double-digit home favorite with evening kickoff; the Gamecocks have a 16-game win streak over Vandy, but the Commodores’ upgraded QB play (Diego Pavia back for 2025) and one-sack OL through two games create classic “backdoor” ingredients in a high-energy SEC opener.

VANDY vs. SC
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: D. Pavia under 196.5 Passing Yards.

LIVE CFB ODDS

CFB ODDS COMPARISON

WANT MORE AI PICKS?

VAULT
VS. SPREAD
325-240
VAULT
NET UNITS
(INCL VIG)
+395.4
VAULT
NET PROFIT
(INCL VIG)
$100/UNIT
$39,540
EXECUTIVE
VS. SPREAD
1593-1364
EXECUTIVE
NET UNITS
(INCL VIG)
+371.9
EXECUTIVE
NET PROFIT
(INCL VIG)
$100/UNIT
$37,192

AI SPORTS PICK PRODUCTS

Create a Free Account

‘Create an Account’ to Get Remi’s Picks Today.

Remi Finds New Picks

Remi calculates the probability a team will cover the line.

Remi Works 24/7

Remi uses this probability to assign units to each pick.

Get Remi's AI Picks

Get Remi’s Top AI Sports Picks sent direct to your inbox.

Vanderbilt vs South Carolina Prediction & Odds:
Free CFB Betting Insights for 9/13/25

The September 13, 2025 SEC opener between South Carolina and Vanderbilt at Williams–Brice Stadium offers a fascinating clash of narratives and betting profiles, with the Gamecocks riding top-15 momentum and the Commodores suddenly carrying credibility after a commanding win in Blacksburg. South Carolina has started 2–0, including a measured neutral-site victory over Virginia Tech and a tune-up rout at home, but they sit 1–1 ATS after failing to cover a hefty Week 2 number, a reminder of how challenging it can be for big favorites to match market expectation. Their offense under Shane Beamer and coordinator Dowell Loggains has found a rhythm with quarterback LaNorris Sellers, who has blended poise in the pocket with athleticism on designed runs, and the unit has operated with balance, using inside-zone and duo runs to set up RPOs and vertical shots once defenses cheat down. Sellers has protected the football and distributed efficiently, and his receiving corps has the speed to stress Vanderbilt both horizontally and vertically. On defense, the Gamecocks are showing SEC-level talent across the front, with sophomore Dylan Stewart quickly becoming a disruptive edge presence who can win one-on-one and create havoc without heavy blitz reliance. That ability to pressure with four is key, as it allows South Carolina to keep two safeties high, limit Vanderbilt’s deep shots, and rally to short throws to force long drives. Vanderbilt, meanwhile, has shown tangible growth under Clark Lea, punctuated by their 44–20 blowout of Virginia Tech on the road, where they erupted for 34 unanswered points in the second half.

Quarterback Diego Pavia, whose eligibility return this offseason was critical, has transformed the Commodores’ offense into a more dynamic unit, combining structure with improvisation to extend plays and create chunk gains. The offensive line has been excellent through two games, allowing just one sack, and that protection clarity is the hinge on which their chances in Columbia rest, because if Pavia is kept clean, Vanderbilt’s RPOs and play-action shots can keep them on schedule. Defensively, Vanderbilt improved in space tackling and edge-setting in Week 2, and that bend-don’t-break profile is their best bet to hang close in an environment where big plays are almost inevitable; if they can force South Carolina to settle for field goals twice in the red zone, the cover math changes significantly. The fulcrums for this matchup are clear: early-down success rates, red-zone finishing, and hidden yardage. If South Carolina maintains 55 percent or better success on first and second downs, their offense will hum and put them in position to cover; if Vanderbilt holds them nearer 48 percent and prevents explosives, they can force longer third downs and hang around. Red-zone precision will be decisive—two Gamecock field goals instead of touchdowns can swing the ATS outcome by nearly a possession. Special teams could also tip the balance, as directional punts, touchbacks, or a single return lane can shift expected value in a game lined with South Carolina as a double-digit favorite. The middle eight minutes around halftime are another key battleground: South Carolina has used that window to separate, while Vanderbilt flipped its Virginia Tech game in that same stretch. The likeliest script sees South Carolina’s depth and pass rush asserting control by the fourth quarter, but whether they cover depends on Vanderbilt’s ability to keep Pavia upright, generate two explosives, and force the Gamecocks into at least one or two red-zone stalls that keep the margin inside the number.

Vanderbilt Commodores CFB Preview

For Vanderbilt, the September 13 trip to Williams–Brice is about bringing the proof of concept from Blacksburg into an SEC cauldron and showing that their Week 2 surge wasn’t a one-off but the new baseline under Clark Lea. The Commodores arrive 2–0 straight up and off one of the program’s most convincing road performances in years, a 44–20 win at Virginia Tech in which they ripped off 34 unanswered points after halftime and covered easily as underdogs. The heart of that explosion was quarterback Diego Pavia, whose offseason eligibility victory kept intact an identity that marries structure with improvisation: inside-zone runs paired with quick-game RPOs to win early downs, then Pavia’s escapability and deep-ball aggression to punish safeties once they creep downhill. The offensive line has been the unsung engine, allowing just one sack through two games and giving Pavia the platform to operate at his tempo, while the backs have provided steady four- to five-yard runs that keep the call sheet balanced. Against South Carolina, the key is sustaining that early-down success, because falling into third-and-long is a death sentence against Dylan Stewart and an SEC front that can win with four and sit in two-high shells.

Expect Vanderbilt to script quick throws to the boundary and motion-heavy formations to reveal coverages, aiming to slow Stewart’s get-off with hesitation and chip help, before testing deep on second-and-short when the odds favor aggression. Defensively, the Commodores know their best chance is a bend-don’t-break posture—concede the four-yard outs, rally-tackle bubbles, and compress space in the red zone where Sellers has less grass to stress them with dual-threat movement. The Virginia Tech tape showed improved tackling angles and more discipline on the edge, and those gains must hold in Columbia or South Carolina’s inside zone will wear them down. Special teams, another hidden edge in a game lined with USC as a two-touchdown favorite, need to deliver variance control: directional punts, touchbacks over risky kicks, and clean field-goal mechanics so momentum isn’t gifted away. From a betting standpoint, Vanderbilt’s ATS profile is trending up, and the cover path is clear: maintain turnover margin at +1 or better, generate two red-zone stands that force field goals, and craft at least two 10+ play scoring drives that bleed clock and silence the crowd. If they hit those benchmarks, they can stretch this game into a one-score affair late, putting pressure on South Carolina to execute cleanly rather than relying on sheer depth. The pitfalls, of course, are familiar to underdogs in the SEC: drive-killing pre-snap penalties, blown protections that lead to strip sacks, or a special-teams bust that flips field position in seconds. Still, this is not the same Commodores squad that entered SEC play hoping just to keep margins respectable; with Pavia’s confidence, trench stability, and a defense beginning to find its legs, Vanderbilt has the makeup to test South Carolina longer than history suggests, even if the final margin still tilts toward the home favorite.

Williams–Brice under the lights usually means volume and velocity, and No. 11 South Carolina’s SEC opener fits the bill as LaNorris Sellers leads a 2–0 start into a primetime tilt. Vanderbilt rides genuine momentum after hammering Virginia Tech on the road, setting up a sharper, more physical version of Clark Lea’s team to test the Gamecocks’ early top-15 form.  Vanderbilt vs South Carolina AI Prediction: Free CFB Betting Insights for Sep 13. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

South Carolina Gamecocks CFB Preview

For South Carolina, the September 13 SEC opener against Vanderbilt at Williams–Brice Stadium is less about simply extending a 16-game win streak in the series and more about proving that their top-15 billing is grounded in consistency, discipline, and the ability to handle business as a heavy favorite. The Gamecocks are 2–0 straight up but 1–1 ATS, having covered against Virginia Tech in Week 1 before failing to match a massive spread in their Week 2 tune-up, and that profile underscores the importance of finishing drives and avoiding the kind of late-game stalls that keep underdogs within the number. Offensively, Shane Beamer’s team has been paced by quarterback LaNorris Sellers, who has shown poise beyond his years with on-time throws, dual-threat mobility, and command of a system that builds balance through inside zone, duo, and quick RPOs before layering in vertical shots when safeties get nosy. Sellers’ ability to protect the football and distribute to a talented receiver group has allowed the Gamecocks to stay on schedule, and the offensive line’s improvement in communication has been quietly critical in keeping the offense balanced. Against Vanderbilt, expect an approach that uses early runs to force the Commodores’ linebackers into tighter fits, then exploits the vacated space with glance routes, slot fades, and play-action shots downfield. Defensively, South Carolina leans on a front that looks every bit the SEC part, with Dylan Stewart emerging as a havoc-wreaking edge presence who can collapse pockets without heavy blitz support, giving coordinator flexibility to keep two safeties high and erase explosives.

The task against Vanderbilt is to compress Diego Pavia’s improvisational magic, rally to his scrambles, and make him repeatedly convert long drives rather than generate chunk scores. Special teams, a Beamer hallmark, must play to control rather than chaos in this setting: directional punts, touchbacks that erase return variance, and clean field-goal operations that convert red-zone trips into sevens more often than threes. From a betting perspective, the path to covering as a double-digit home favorite is simple but unforgiving: maintain early-down success rates north of 55 percent, keep turnover margin at least even, and finish at least 60 percent of red-zone trips with touchdowns. Hit those benchmarks, and the Gamecocks’ superior depth should produce a separation window in the “middle eight” minutes around halftime, where they have consistently been able to stack points and flip one-score games into two- or three-score cushions. The risks lie in self-inflicted wounds: pre-snap penalties that kill rhythm, red-zone inefficiency that trades sevens for threes, or a blown coverage that gifts Vanderbilt an explosive play. Yet the home environment, the defensive front’s ability to dictate, and Sellers’ steady command of the offense give South Carolina a clear blueprint to not only win outright but also assert the kind of control expected from a team with SEC title ambitions. If they execute cleanly, the Gamecocks should reaffirm their place among the conference’s contenders while sending Vanderbilt home with the familiar reminder of just how high the bar is in Columbia.

Vanderbilt vs. South Carolina Prop Picks (AI)

AI algorithm Remi is pouring through loads of datapoints on each line. In fact, anytime the Commodores and Gamecocks play there’s always several intriguing trends to key in on. Not to mention games played at Williams-Brice Stadium in Sep rarely follow normal, predictable betting trends.
Remi's searched hard and found the best prop for this matchup: D. Pavia under 196.5 Passing Yards.

Vanderbilt vs. South Carolina Prediction (AI)

Remi Robot Icon

Remi, our AI sports genius, has been pouring over mountains of data from every simulation between the Commodores and Gamecocks and using recursive machine learning and kick-ass AI to boil down the data to a single cover probability.

Interestingly enough, the data has been most watching on the unproportionally assigned factor human bettors tend to put on coaching factors between a Commodores team going up against a possibly improved Gamecocks team. Trends look to say the true game analytics appear to reflect a moderate lean against one Vegas line specifically.

Unlock this in-depth AI prediction and all of our CFB AI picks for FREE now.

Below is our current AI Vanderbilt vs South Carolina picks, computer picks Commodores vs Gamecocks, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
CFB 10/21 KENSAW@FIU UNLOCK THIS PICK 3 EXECUTIVE Locked EXECUTIVE
CFB 10/21 WKY@LATECH UNLOCK THIS PICK 2 INTEL Locked INTEL

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full CFB schedule

Commodores Betting Trends

The Commodores covered comfortably as road underdogs at Virginia Tech (44–20), erupting for 34 unanswered after halftime to move to 2–0 straight up and cash in Week 2.

Gamecocks Betting Trends

South Carolina covered versus Virginia Tech in Week 1 (24–11 on a one-score spread) and then failed to land a massive number against South Carolina State, netting an early 1–1 ATS profile at 2–0 SU.

Commodores vs. Gamecocks Matchup Trends

Books and previews list South Carolina as a double-digit home favorite with evening kickoff; the Gamecocks have a 16-game win streak over Vandy, but the Commodores’ upgraded QB play (Diego Pavia back for 2025) and one-sack OL through two games create classic “backdoor” ingredients in a high-energy SEC opener.

Vanderbilt vs. South Carolina Game Info

Vanderbilt vs South Carolina starts on September 13, 2025 at 7:45 PM EST.

Spread: South Carolina -5.5
Moneyline: Vanderbilt +170, South Carolina -206
Over/Under: 47.5

Vanderbilt: (2-0)  |  South Carolina: (2-0)

Remi's searched hard and found the best prop for this matchup: D. Pavia under 196.5 Passing Yards.. Prices move—always shop for the best number.

Books and previews list South Carolina as a double-digit home favorite with evening kickoff; the Gamecocks have a 16-game win streak over Vandy, but the Commodores’ upgraded QB play (Diego Pavia back for 2025) and one-sack OL through two games create classic “backdoor” ingredients in a high-energy SEC opener.

VANDY trend: The Commodores covered comfortably as road underdogs at Virginia Tech (44–20), erupting for 34 unanswered after halftime to move to 2–0 straight up and cash in Week 2.

SC trend: South Carolina covered versus Virginia Tech in Week 1 (24–11 on a one-score spread) and then failed to land a massive number against South Carolina State, netting an early 1–1 ATS profile at 2–0 SU.

See our latest CFB picks and odds pages for 2025 to compare prices before you bet.

Vanderbilt vs. South Carolina Odds

AI algorithm Remi is pouring through tons of data points on each player. In fact, anytime the Vanderbilt vs South Carolina trends are analyzed, there’s always several intriguing trends to key in on. Not to mention games played at extreme travel distance almost always follow normal, predictable betting trends.

Vanderbilt vs South Carolina Opening Odds

VANDY Moneyline: +170
SC Moneyline: -206
VANDY Spread: +5.5
SC Spread: -5.5
Over/Under: 47.5

Vanderbilt vs South Carolina Live Odds

Games PTS ML SPR O/U
In Progress
Kennesaw State Owls
FIU Panthers
In Progress
KENSAW
FIU
24
14
-670
 
-10.5 (+104)
 
O 64.5 (-128)
U 64.5 (-104)
In Progress
Western Kentucky Hilltoppers
Louisiana Tech Bulldogs
In Progress
WKY
LATECH
20
7
-250
+190
-5.5 (-114)
+5.5 (-114)
O 56.5 (-104)
U 56.5 (-128)
Oct 22, 2025 7:30PM EDT
MTSU Blue Raiders
Delaware Blue Hens
10/22/25 7:30PM
MTSU
DEL
 
-320
 
-9.5 (-106)
O 55.5 (-110)
U 55.5 (-110)
Oct 22, 2025 9:00PM EDT
Missouri State Bears
New Mexico State Aggies
10/22/25 9PM
MIZZST
NMEXST
-108
-108
-1.5 (-105)
+1.5 (-115)
O 51.5 (-110)
U 51.5 (-110)
Oct 23, 2025 7:30PM EDT
South Alabama Jaguars
Georgia State Panthers
10/23/25 7:30PM
SBAMA
GAST
-220
+184
-6.5 (-110)
+6.5 (-110)
O 55.5 (-110)
U 55.5 (-110)
Oct 24, 2025 7:00PM EDT
North Texas Mean Green
Charlotte 49ers
10/24/25 7PM
NOTEX
CHARLO
-4000
+1500
-27.5 (-102)
+27.5 (-120)
O 60.5 (-115)
U 60.5 (-105)
Oct 24, 2025 7:30PM EDT
California Golden Bears
Virginia Tech Hokies
10/24/25 7:30PM
CAL
VATECH
+160
-190
+4.5 (-110)
-4.5 (-110)
O 50.5 (-105)
U 50.5 (-115)
Oct 24, 2025 10:00PM EDT
Boise State Broncos
Nevada Wolf Pack
10/24/25 10PM
BOISE
NEVADA
-2000
+980
-21.5 (-105)
+21.5 (-115)
O 50.5 (-110)
U 50.5 (-110)
Oct 25, 2025 12:00PM EDT
Virginia Cavaliers
North Carolina Tar Heels
10/25/25 12PM
UVA
UNC
-430
+330
-10.5 (-110)
+10.5 (-110)
O 51.5 (-110)
U 51.5 (-110)
Oct 25, 2025 12:00PM EDT
Bowling Green Falcons
Kent State Golden Flashes
10/25/25 12PM
BGREEN
KENT
-285
+230
-7.5 (-105)
+7.5 (-115)
O 48.5 (-110)
U 48.5 (-110)
Oct 25, 2025 12:00PM EDT
Rutgers Scarlet Knights
Purdue Boilermakers
10/25/25 12PM
RUT
PURDUE
-140
+115
-2.5 (-115)
+2.5 (-105)
O 58.5 (-110)
U 58.5 (-110)
Oct 25, 2025 12:00PM EDT
South Florida Bulls
Memphis Tigers
10/25/25 12PM
SFLA
MEMP
-205
+168
-5.5 (-110)
+5.5 (-110)
O 63.5 (-106)
U 63.5 (-114)
Oct 25, 2025 12:00PM EDT
UCLA Bruins
Indiana Hoosiers
10/25/25 12PM
UCLA
IND
+1600
-4500
+25.5 (-110)
-25.5 (-110)
O 54.5 (-115)
U 54.5 (-105)
Oct 25, 2025 12:00PM EDT
Northwestern Wildcats
Nebraska Cornhuskers
10/25/25 12PM
NWEST
NEB
+235
-295
+7.5 (-118)
-7.5 (-104)
O 42.5 (-115)
U 42.5 (-105)
Oct 25, 2025 12:00PM EDT
Ohio Bobcats
Eastern Michigan Eagles
10/25/25 12PM
OHIO
EMICH
-450
+340
-12.5 (-110)
+12.5 (-110)
O 59.5 (-110)
U 59.5 (-110)
Oct 25, 2025 12:00PM EDT
SMU Mustangs
Wake Forest Demon Deacons
10/25/25 12PM
SMU
WAKE
-170
+140
-3.5 (-108)
+3.5 (-112)
O 54.5 (-110)
U 54.5 (-110)
Oct 25, 2025 12:00PM EDT
Syracuse Orange
Georgia Tech Yellow Jackets
10/25/25 12PM
CUSE
GATECH
+610
-950
+17.5 (-115)
-17.5 (-105)
O 53.5 (-110)
U 53.5 (-110)
Oct 25, 2025 12:00PM EDT
App State Mountaineers
Old Dominion Monarchs
10/25/25 12PM
APPST
OLDDOM
 
-550
 
-14.5 (+100)
O 62.5 (-115)
U 62.5 (-105)
Oct 25, 2025 12:00PM EDT
Ole Miss Rebels
Oklahoma Sooners
10/25/25 12PM
OLEMISS
OKLA
+158
-192
+4.5 (-105)
-4.5 (-115)
O 54.5 (-105)
U 54.5 (-115)
Oct 25, 2025 12:00PM EDT
Kansas State Wildcats
Kansas Jayhawks
10/25/25 12PM
KSTATE
KANSAS
+122
-146
+2.5 (+100)
-2.5 (-122)
O 56.5 (-110)
U 56.5 (-110)
Oct 25, 2025 12:45PM EDT
Auburn Tigers
Arkansas Razorbacks
10/25/25 12:45PM
AUBURN
ARK
-110
-110
+1.5 (-115)
-1.5 (-105)
O 57.5 (-105)
U 57.5 (-115)
Oct 25, 2025 1:00PM EDT
Akron Zips
Buffalo Bulls
10/25/25 1PM
AKRON
BUFF
+290
-375
+9.5 (-102)
-9.5 (-120)
O 47.5 (-110)
U 47.5 (-110)
Oct 25, 2025 3:00PM EDT
UConn Huskies
Rice Owls
10/25/25 3PM
UCONN
RICE
-400
+310
-10.5 (-110)
+10.5 (-110)
O 48.5 (-110)
U 48.5 (-110)
Oct 25, 2025 3:00PM EDT
Utah State Aggies
New Mexico Lobos
10/25/25 3PM
UTAHST
NMEX
+122
-146
+2.5 (-102)
-2.5 (-120)
O 61.5 (-110)
U 61.5 (-110)
Oct 25, 2025 3:30PM EDT
Minnesota Golden Gophers
Iowa Hawkeyes
10/25/25 3:30PM
MINN
IOWA
+275
-350
+8.5 (-110)
-8.5 (-110)
O 38.5 (-115)
U 38.5 (-105)
Oct 25, 2025 3:30PM EDT
Alabama Crimson Tide
South Carolina Gamecocks
10/25/25 3:30PM
BAMA
SC
-520
+385
-11.5 (-118)
+11.5 (-104)
O 47.5 (-105)
U 47.5 (-115)
Oct 25, 2025 3:30PM EDT
BYU Cougars
Iowa State Cyclones
10/25/25 3:30PM
BYU
IOWAST
+122
-146
+2.5 (+100)
-2.5 (-122)
O 48.5 (-115)
U 48.5 (-105)
Oct 25, 2025 3:30PM EDT
Temple Owls
Tulsa Golden Hurricane
10/25/25 3:30PM
TEMPLE
TULSA
-225
+188
-5.5 (-120)
+5.5 (-102)
O 54.5 (-110)
U 54.5 (-110)
Oct 25, 2025 3:30PM EDT
Ball State Cardinals
Northern Illinois Huskies
10/25/25 3:30PM
BALLST
NILL
+176
-215
+5.5 (-110)
-5.5 (-110)
O 41.5 (-105)
U 41.5 (-115)
Oct 25, 2025 3:30PM EDT
Toledo Rockets
Washington State Cougars
10/25/25 3:30PM
TOLEDO
WASHST
+104
-125
+1.5 (-105)
-1.5 (-115)
O 46.5 (-114)
U 46.5 (-106)
Oct 25, 2025 3:30PM EDT
Florida Atlantic Owls
Navy Midshipmen
10/25/25 3:30PM
FAU
NAVY
+480
-670
+15.5 (-110)
-15.5 (-110)
O 62.5 (-115)
U 62.5 (-105)
Oct 25, 2025 3:30PM EDT
Illinois Fighting Illini
Washington Huskies
10/25/25 3:30PM
ILL
WASH
+146
-176
+4.5 (-115)
-4.5 (-105)
O 54.5 (-110)
U 54.5 (-110)
Oct 25, 2025 3:30PM EDT
Umass Minutemen
Central Michigan Chippewas
10/25/25 3:30PM
UMASS
CMICH
 
-720
 
-15.5 (-115)
O 46.5 (-110)
U 46.5 (-110)
Oct 25, 2025 3:30PM EDT
San Diego State Aztecs
Fresno State Bulldogs
10/25/25 3:30PM
SDGST
FRESNO
-146
+122
-2.5 (-122)
+2.5 (+100)
O 48.5 (-110)
U 48.5 (-110)
Oct 25, 2025 3:30PM EDT
Missouri Tigers
Vanderbilt Commodores
10/25/25 3:30PM
MIZZOU
VANDY
+115
-138
+2.5 (-106)
-2.5 (-114)
O 52.5 (-110)
U 52.5 (-110)
Oct 25, 2025 3:30PM EDT
NC State Wolfpack
Pittsburgh Panthers
10/25/25 3:30PM
NCST
PITT
+195
-240
+6.5 (-110)
-6.5 (-110)
O 56.5 (-110)
U 56.5 (-110)
Oct 25, 2025 3:30PM EDT
Western Michigan Broncos
Miami Ohio Redhawks
10/25/25 3:30PM
WMICH
MIAOH
+114
 
+2.5 (-110)
 
O 41.5 (-110)
U 41.5 (-110)
Oct 25, 2025 3:30PM EDT
UL Monroe Warhawks
USM Golden Eagles
10/25/25 3:30PM
MONROE
USM
+310
 
+11.5 (-115)
 
O 50.5 (-110)
U 50.5 (-110)
Oct 25, 2025 4:00PM EDT
Oklahoma State Cowboys
Texas Tech Red Raiders
10/25/25 4PM
OKLAST
TXTECH
+2800
-10000
+37.5 (-108)
-37.5 (-112)
O 56.5 (-105)
U 56.5 (-115)
Oct 25, 2025 4:00PM EDT
Baylor Bears
Cincinnati Bearcats
10/25/25 4PM
BAYLOR
CINCY
+152
-184
+4.5 (-115)
-4.5 (-105)
O 67.5 (-105)
U 67.5 (-115)
Oct 25, 2025 4:15PM EDT
Texas Longhorns
Mississippi State Bulldogs
10/25/25 4:15PM
TEXAS
MISSST
-285
+230
-7.5 (-102)
+7.5 (-120)
O 44.5 (-120)
U 44.5 (-102)
Oct 25, 2025 6:00PM EDT
TCU Horned Frogs
West Virginia Mountaineers
10/25/25 6PM
TCU
WVU
-670
+470
-15.5 (-112)
+15.5 (-108)
O 55.5 (-105)
U 55.5 (-115)
Oct 25, 2025 7:00PM EDT
Wisconsin Badgers
Oregon Ducks
10/25/25 7PM
WISC
OREG
 
 
+33.5 (-106)
-33.5 (-114)
O 44.5 (-108)
U 44.5 (-112)
Oct 25, 2025 7:00PM EDT
Louisiana Ragin Cajuns
Troy Trojans
10/25/25 7PM
UL
TROY
+270
-345
+9.5 (-110)
-9.5 (-110)
O 47.5 (-112)
U 47.5 (-108)
Oct 25, 2025 7:00PM EDT
Stanford Cardinal
Miami Hurricanes
10/25/25 7PM
STNFRD
MIAMI
+4000
-20000
+30.5 (-115)
-30.5 (-105)
O 45.5 (-104)
U 45.5 (-118)
Oct 25, 2025 7:00PM EDT
Georgia Southern Eagles
Arkansas State Red Wolves
10/25/25 7PM
GASO
ARKST
+106
-128
+1.5 (-105)
-1.5 (-115)
O 63.5 (-105)
U 63.5 (-115)
Oct 25, 2025 7:30PM EDT
Michigan Wolverines
Michigan State Spartans
10/25/25 7:30PM
MICH
MICHST
-630
+450
-14.5 (-105)
+14.5 (-115)
O 48.5 (-105)
U 48.5 (-115)
Oct 25, 2025 7:30PM EDT
Texas A&M Aggies
LSU Tigers
10/25/25 7:30PM
TEXAM
LSU
-144
+120
-2.5 (-120)
+2.5 (-102)
O 47.5 (-110)
U 47.5 (-110)
Oct 25, 2025 7:30PM EDT
Boston College Eagles
Louisville Cardinals
10/25/25 7:30PM
BC
LVILLE
+1600
-4500
+25.5 (-110)
-25.5 (-110)
O 55.5 (-104)
U 55.5 (-118)
Oct 25, 2025 7:30PM EDT
Colorado State Rams
Wyoming Cowboys
10/25/25 7:30PM
COLOST
WYO
+184
-225
+5.5 (-104)
-5.5 (-118)
O 46.5 (-110)
U 46.5 (-110)
Oct 25, 2025 7:45PM EDT
Tennessee Volunteers
Kentucky Wildcats
10/25/25 7:45PM
TENN
UK
-345
+270
-9.5 (-110)
+9.5 (-110)
O 53.5 (-118)
U 53.5 (-104)
Oct 25, 2025 8:00PM EDT
Houston Cougars
Arizona State Sun Devils
10/25/25 8PM
HOU
ARIZST
+220
-275
+7.5 (-120)
-7.5 (-102)
O 46.5 (-115)
U 46.5 (-105)
Oct 25, 2025 10:15PM EDT
Colorado Buffaloes
Utah Utes
10/25/25 10:15PM
COLO
UTAH
+375
-500
+13.5 (-110)
-13.5 (-110)
O 49.5 (-115)
U 49.5 (-105)
Oct 28, 2025 8:00PM EDT
James Madison Dukes
Texas State Bobcats
10/28/25 8PM
JMAD
TEXST
-275
+220
-7.5 (-104)
+7.5 (-118)
O 60.5 (-112)
U 60.5 (-108)
Oct 30, 2025 7:30PM EDT
Tulane Green Wave
UTSA Roadrunners
10/30/25 7:30PM
TULANE
UTSA
-200
+164
-5.5 (-110)
+5.5 (-110)
O 52.5 (-112)
U 52.5 (-108)
Nov 1, 2025 12:00PM EDT
Penn State Nittany Lions
Ohio State Buckeyes
11/1/25 12PM
PSU
OHIOST
+660
-1050
+17.5 (-115)
-17.5 (-105)
O 47.5 (-110)
U 47.5 (-110)
Nov 1, 2025 12:00PM EDT
Miami Hurricanes
SMU Mustangs
11/1/25 12PM
MIAMI
SMU
-430
+330
-10.5 (-110)
+10.5 (-110)
O 51.5 (-110)
U 51.5 (-110)
Nov 1, 2025 12:00PM EDT
Oklahoma Sooners
Tennessee Volunteers
11/1/25 12PM
OKLA
TENN
-105
-114
+1.5 (-114)
-1.5 (-106)
O 53.5 (-112)
U 53.5 (-108)
Nov 1, 2025 12:00PM EDT
Vanderbilt Commodores
Texas Longhorns
11/1/25 12PM
VANDY
TEXAS
+150
-182
+3.5 (-106)
-3.5 (-114)
O 45.5 (-110)
U 45.5 (-110)
Nov 1, 2025 3:30PM EDT
Georgia Bulldogs
Florida Gators
11/1/25 3:30PM
UGA
FLA
-280
+225
-7.5 (+100)
+7.5 (-122)
O 50.5 (-112)
U 50.5 (-108)

CFB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Vanderbilt Commodores vs. South Carolina Gamecocks on September 13, 2025 at Williams-Brice Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our CFB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
FSU@STNFRD STNFRD +18 56.6% 6 WIN
WASHST@UVA WASHST +17.5 58.8% 8 WIN
NEVADA@NMEX NEVADA +13.5 57.8% 7 WIN
TEXAS@UK ARCH MANNING UNDER 1.5 PASS TD 56.1% 6 WIN
ARMY@TULANE ARMY +10 55.3% 5 WIN
SJST@UTAHST SJST +4 54.4% 4 LOSS
LVILLE@MIAMI LVILLE +12.5 56.5% 6 WIN
LVILLE@MIAMI CJ DANIELS UNDER 4.5 RECEPTIONS 54.4 4 LOSS
DEL@JAXST DEL -2.5 57.6% 6 LOSS
UTEP@SAMST UTEP -2.5 53.9% 3 WIN
FIU@WKY FIU +10.5 54.6% 4 WIN
ARKST@SALA ARKST +7.5 54.5% 4 WIN
ARKST@SALA JAYLEN RAYNOR UNDER 40.5 LONGEST PASS COMP 53.3% 3 WIN
SJST@WYO SJST -120 59.8% 7 LOSS
UMASS@KENTST KENTST -135 60.2% 6 WIN
NOILL@EMICH EMICH +2.5 53.9% 3 WIN
BYU@ARIZ ARIZ +2.5 54.2% 3 LOSS
OKLA@TEXAS OKLA +2.5 54.7% 4 LOSS
NMEX@BOISE NMEX +16.5 56.4% 6 WIN
WAKE@OREGST WAKE -2.5 56.7% 6 WIN
ULMON@COASTAL ULMON -2.5 56.8% 6 LOSS
IOWA@WISC WISC +4 54.8% 4 LOSS
TOLEDO@BGREEN TOLEDO -10 56.3% 6 LOSS
SFLA@NOTEX SFLA +2.5 54.3% 4 WIN
FRESNO@COLOST RICHIE ANDERSON III LONGEST RECEPTION UNDER 16.5 54.4% 4 LOSS
JAXST@SAMST SAMST +7.5 55.3% 5 WIN
USM@GAS GAS +3.5 57.4% 7 WIN
LIB@UTEP UTEP +2 54.5% 4 LOSS
SALA@TROY SALA -118 55.2% 4 LOSS
TULSA@MEMP MEMP -20.5 53.8% 3 WIN
JMAD@GAST GAST +20.5 54.6% 4 WIN
WAKE@VATECH VATECH -5.5 56.6% 6 LOSS
UNLV@WYO WYO +4.5 55.5% 5 LOSS
PSU@UCLA PSU -24.5 56.3% 6 LOSS
TXSTSM@ARKST TXSTSM -13 56.7% 6 LOSS
UVA@LVILLE ISAAC BROWN OVER 70.5 RUSH YDS 56.6% 6 LOSS
WVU@BYU WVU +20.5 54.7% 4 WIN
SAMST@NMEXST SAMST -1.5 54.1% 3 LOSS
EMICH@CMICH CMICH -148 62.8% 7 WIN
SDGST@NOILL SDGST -118 55.7% 3 WIN
BAMA@GEORGIA GEORGIA -125 58.7% 7 LOSS
TENN@MISSST MISSST +7.5 54.3% 4 WIN
UK@SC SC -5.5 54.8% 4 WIN
WKY@MIZZST MIZZST +4.5 55.6% 6 LOSS
JAXST@USM USM -3.5 56.0% 5 WIN
NMEXST@NMEX NMEX -14.5 56.9% 6 WIN
ARIZ@IOWAST ROCCO BECHT UNDER 1.5 PASS TDS 55.5% 5 WIN
TCU@ARIZST JOSH HOOVER PASS YDS UNDER 287.5 53.4% 3 WIN
ARIZST@BAYLOR BAYLOR -130 58.4% 6 LOSS
WYO@COLO WYO +13.5 54.1% 3 LOSS
TULANE@OLEMISS MISS -11.5 54.3% 4 WIN