USC vs Purdue Prediction — AI Finds CAN'T MISS CFB Lines & Props (Sep 13)

Updated: 2025-09-06T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

USC visits Purdue at Ross-Ade Stadium on Saturday, September 13, 2025 (3:30 p.m. ET), in a Big Ten crossover that doubles as the Trojans’ first true road test against a Boilermakers team seeking validation after a fast 2–0 start. Market screens list USC around a three-touchdown favorite with a total near the high-50s, signaling expectations of Trojans tempo and explosives versus Purdue’s bid to drag the game into a field-position fight.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Sep 13, 2025

Start Time: 3:30 PM EST​

Venue: Ross-Ade Stadium​

Boilermakers Record: (2-0)

Trojans Record: (2-0)

OPENING ODDS

USC Moneyline: -1724

PURDUE Moneyline: +940

USC Spread: -21.5

PURDUE Spread: +21.5

Over/Under: 58.5

USC
Betting Trends

  • USC opened 2025 at 1–0 ATS, covering comfortably in Week 1 as the offense hammered the gas and the defense limited explosives.

PURDUE
Betting Trends

  • Purdue began 2025 1–0 ATS, cashing in the opener and positioning itself as an early-season home cover threat before stepping way up in class here.

MATCHUP TRENDS

  • With USC laying ~21 and the total hovering around 58–59, the classic “big-spread/high-50s total” profile leaves backdoor room if Purdue sustains two late scoring drives or forces USC into red-zone threes; live odds boards reflect that volatility.

USC vs. PURDUE
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: R. Browne under 199.5 Passing Yards.

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USC vs Purdue Prediction & Odds:
Free CFB Betting Insights for 9/13/25

This matchup is framed by contrast: USC’s big-play machine under Lincoln Riley against a Purdue program trying to convert Week-1 sharpness into staying power when the talent gap widens. The Trojans arrive with clear early tells—fast starts, a downhill run game that keeps the RPO menu live, and a vertical shot package that punishes single-high looks. Their offensive identity, which has stabilized behind improved OL cohesion and a deep skill room, pairs tempo with efficiency; when USC is winning first down (four to six yards on inside zone, bubbles that function as handoffs), Riley can call the entire sheet, and the defense has to pick its poison between extra hats in the box or help over the top. Purdue’s counter is to disarm that rhythm at the line of scrimmage: dent doubles on standard downs, tackle through contact on the perimeter, and force second-and-long that brings simulated pressures and disguised coverage into play. The first quarter will tell on leverage; if USC hits its opening script and lands two scores before Purdue finds a handle on run fits, clock and crowd pressure shift immediately. If the Boilers trade an early stop for a points-bearing drive, the tempo compresses and backdoor equity grows with each long march. Purdue’s offense under Ryan Walters needs boredom-as-a-weapon: four-yard wins, pace changes to catch sub packages, and play-action on second-and-short to chase a single explosive that flips the field.

Purdue can’t live in obvious pass; USC’s front has improved enough year-over-year to win with games and late triggers if the down-and-distance tilts their way. The middle eight minutes (last four of the first half, first four of the second) are the fulcrum: USC’s depth often creates separation there, stacking possessions around halftime to build a two-score runway; Purdue must either steal a possession (onside, fake, fourth-and-short) or force a field-goal trade to keep the script within reach. Red-zone finishing is the cover hinge. USC’s pathway to matching the number depends on touchdowns inside the 10—fade/slot-fade and leak concepts that have been staples under Riley—while Purdue’s upset/cover math improves dramatically with two low-red stands and a turnover margin of +1 or better. Hidden yardage also looms: directional punting, return decisions, and penalty discipline swing four to seven points in spread environments like this. Statistically, the market’s stance—USC around −21.5 with ~58.5 total—telegraphs trust in the Trojans’ explosives and possession volume; it also implies the Boilers need long fields and clean operation to avoid avalanche stretches. The most probable shape is USC building a double-digit platform by halftime, leaning on run-rate in Q3 to bleed clock, and sprinkling timely shots to prevent a rally; Purdue’s backdoor path is live only if it strings sustained drives late and USC trades sevens for threes. Scoreboard aside, the game grades both programs on their 2025 intentions: USC’s bid to look like a Big Ten title contender on the road and Purdue’s push to convert early competence into resilience against blue-chip depth.

USC Trojans CFB Preview

USC’s road identity gets a stress test in West Lafayette, and the Trojans have the tools to make it look routine if they stay on schedule. The foundation is early-down efficiency: inside-zone and duo to set second-and-medium, perimeter access throws that double as run game, and tempo used as a scalpel, not a sledgehammer. That sequencing keeps play-action and RPOs live and allows Riley to pick matchups—slot receivers on safeties, boundary isolations versus off-coverage, wheel/post combinations when Purdue overplays glance. The offensive line’s year-over-year cohesion is the quiet driver; if it holds up against simulated pressures and interior games, the Trojans can spend the afternoon in favorable downs and distances. Defensively, USC’s charge is to choke standard downs and force Purdue’s quarterback into obvious pass. The Trojans’ front, deeper than a year ago, can win with four if it owns first down; on passing downs, expect late green-dog triggers and rotation that tries to rob the first read while the rush squeezes landmarks. The tackling piece is non-negotiable—Purdue will throw perimeter quicks to create second-and-five; USC has to turn those into second-and-seven by arriving with leverage and wrapping through contact. Special teams are a leverage engine for USC on the road: touchbacks to eliminate return variance, directional punts that pin, and automatic points if drives stall pre-goal-to-go.

From an odds perspective, the −21.5/58.5 scaffold puts outcome and margin in different buckets; to clear both, USC must finish drives with touchdowns (north of 60% red-zone TD rate) and avoid the low-probability turnover that gifts Purdue a short field. The Trojans’ ATS open at 1–0 mirrors what the tape suggests—clean operation and explosives layered onto a high floor. The coaching emphasis will be on the middle eight minutes and penalty discipline; big favorites become sweat-worthy only when they trade sevens for threes or give back hidden yards with false starts and holds. Personnel rotation is another subplot: if USC builds the expected runway, second-unit reps can arrive in Q4 without compromising tempo, but the staff will likely keep a starter spine in to close the door on backdoor chatter. The most USC-friendly script features a two-score lead by halftime built on balanced efficiency, a third-quarter tilt to the run game that bleeds clock while setting up one or two dagger shots, and a defense that forces four or more three-and-outs. If that shows up, the Trojans exit with a road cover and a tidy 3–0 mark. If not—if Purdue steals a possession and USC blinks in the low red—this becomes a fourth-quarter management exercise rather than a procession. Either way, the evening grades USC not just on fireworks but on habits: communication up front, tackling in space, and the ability to play low-variance, high-leverage football away from home—traits that separate playoff contenders from mere highlight machines.

USC visits Purdue at Ross-Ade Stadium on Saturday, September 13, 2025 (3:30 p.m. ET), in a Big Ten crossover that doubles as the Trojans’ first true road test against a Boilermakers team seeking validation after a fast 2–0 start. Market screens list USC around a three-touchdown favorite with a total near the high-50s, signaling expectations of Trojans tempo and explosives versus Purdue’s bid to drag the game into a field-position fight.  USC vs Purdue AI Prediction: Free CFB Betting Insights for Sep 13. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Purdue Boilermakers CFB Preview

For Purdue, the mandate is clarity and discipline. The Boilermakers’ opening win and early cover marked tangible progress after 2024’s struggles, but USC represents a dramatic step up in speed, depth, and in-game problem solving. Walters’ defense has to start by dismantling first down: wrong-arm and spill outside zone to help, squeeze the quick game with rally-and-wrap tackling, and challenge USC to live in second-and-eight where the Trojans’ RPO windows tighten. That invites creepers, mugged A-gaps, and late rotation on passing downs—tools that matter only if Purdue avoids giving away free yards on early snaps. The secondary’s job is less about eliminating catches than erasing yards after the catch; USC’s receivers win with leverage and acceleration, so Purdue’s corners and nickels must tackle on arrival and keep everything capped. Offensively, the plan is the same one underdogs have used forever in these spots—but it must be executed at a high level: a run game that generates manageable thirds; rhythm throws (outs, sticks, slants) that act as extended handoffs; and selective play-action shots once safeties crowd. The line has to stay out of penalty traps (first-and-15 is a possession tax) and ID pressures cleanly; USC’s front has gotten better at twisting the interior and triggering late, and hesitation is a drive killer.

The sideline levers matter, too: tempo to freeze personnel after chunk gains; a fourth-and-short go that steals a possession; a deliberate double-dip around halftime to compress variance. Special teams are Purdue’s equalizer—directional punts to the boundary, returns that net +10 hidden yards, and field-goal operation that cashes if drives stall inside the 25. On the betting axis, Purdue opened 1–0 ATS and returns home with a number that dares them to trade explosives for body blows; two 10-12 play scoring drives plus one red-zone stand bring the backdoor firmly into view. Practically, the Boilers’ benchmarks look like this: sub-50% success allowed on USC standard downs, two low-red stops, zero special-teams gaffes, and a turnover split no worse than even. If those stack, the fourth quarter becomes about a single leverage snap—third-and-five at midfield, a contested shot in the end zone—rather than a chase against the clock. However the score lands, Purdue is grading process as much as result; if the defense tackles cleanly and the offense manufactures enough on-schedule snaps to keep USC’s possession count down, the performance travels into the Big Ten slate with real confidence.

USC vs. Purdue Prop Picks (AI)

AI algorithm Remi is pouring through loads of stats on each player. In fact, anytime the Trojans and Boilermakers play there’s always several intriguing angles to key in on. Not to mention games played at Ross-Ade Stadium in Sep seemingly never follow normal, predictable patterns.
Remi's searched hard and found the best prop for this matchup: R. Browne under 199.5 Passing Yards.

USC vs. Purdue Prediction (AI)

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Remi, our AI sports genius, has been pouring over mountains of data from every facet between the Trojans and Boilermakers and using recursive machine learning and impressive AI to crunch the data to a single cover probability.

Interestingly enough, the data has been most keyed in on the unproportionally assigned emphasis emotional bettors regularly put on Purdue’s strength factors between a Trojans team going up against a possibly improved Boilermakers team. We’ve found the true game analytics might reflect a slight lean against one Vegas line specifically.

Unlock this in-depth AI prediction and all of our CFB AI picks for FREE now.

Below is our current AI USC vs Purdue picks, computer picks Trojans vs Boilermakers, best bets, model edges, confidence ratings.

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Trojans Betting Trends

USC opened 2025 at 1–0 ATS, covering comfortably in Week 1 as the offense hammered the gas and the defense limited explosives.

Boilermakers Betting Trends

Purdue began 2025 1–0 ATS, cashing in the opener and positioning itself as an early-season home cover threat before stepping way up in class here.

Trojans vs. Boilermakers Matchup Trends

With USC laying ~21 and the total hovering around 58–59, the classic “big-spread/high-50s total” profile leaves backdoor room if Purdue sustains two late scoring drives or forces USC into red-zone threes; live odds boards reflect that volatility.

USC vs. Purdue Game Info

USC vs Purdue starts on September 13, 2025 at 3:30 PM EST.

Venue: Ross-Ade Stadium.

Spread: Purdue +21.5
Moneyline: USC -1724, Purdue +940
Over/Under: 58.5

USC: (2-0)  |  Purdue: (2-0)

Remi's searched hard and found the best prop for this matchup: R. Browne under 199.5 Passing Yards.. Prices move—always shop for the best number.

With USC laying ~21 and the total hovering around 58–59, the classic “big-spread/high-50s total” profile leaves backdoor room if Purdue sustains two late scoring drives or forces USC into red-zone threes; live odds boards reflect that volatility.

USC trend: USC opened 2025 at 1–0 ATS, covering comfortably in Week 1 as the offense hammered the gas and the defense limited explosives.

PURDUE trend: Purdue began 2025 1–0 ATS, cashing in the opener and positioning itself as an early-season home cover threat before stepping way up in class here.

See our latest CFB picks and odds pages for 2025 to compare prices before you bet.

USC vs. Purdue Odds

AI algorithm Remi is pouring through loads of stats on each player. In fact, anytime the USC vs Purdue trends are analyzed, there’s always several intriguing trends to key in on. Not to mention games played at extreme hostile environments almost always follow normal, predictable patterns.

USC vs Purdue Opening Odds

USC Moneyline: -1724
PURDUE Moneyline: +940
USC Spread: -21.5
PURDUE Spread: +21.5
Over/Under: 58.5

USC vs Purdue Live Odds

Games PTS ML SPR O/U
Oct 21, 2025 7:00PM EDT
Kennesaw State Owls
FIU Panthers
10/21/25 7PM
KENSAW
FIU
-145
 
-3 (-110)
 
O 49.5 (-105)
U 49.5 (-115)
Oct 21, 2025 7:30PM EDT
Western Kentucky Hilltoppers
Louisiana Tech Bulldogs
10/21/25 7:30PM
WKY
LATECH
+145
-170
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O 50 (-110)
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Oct 22, 2025 7:30PM EDT
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Delaware Blue Hens
10/22/25 7:30PM
MTSU
DEL
 
-360
 
-9 (-110)
O 54.5 (-110)
U 54.5 (-110)
Oct 22, 2025 9:00PM EDT
Missouri State Bears
New Mexico State Aggies
10/22/25 9PM
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+100
-1.5 (-110)
+1.5 (-110)
O 50.5 (-110)
U 50.5 (-110)
Oct 23, 2025 7:30PM EDT
South Alabama Jaguars
Georgia State Panthers
10/23/25 7:30PM
SBAMA
GAST
-230
+190
-6.5 (-110)
+6.5 (-110)
O 56 (-110)
U 56 (-110)
Oct 24, 2025 7:00PM EDT
North Texas Mean Green
Charlotte 49ers
10/24/25 7PM
NOTEX
CHARLO
-6500
+1300
-27 (-110)
+27 (-110)
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U 61.5 (-110)
Oct 24, 2025 7:30PM EDT
California Golden Bears
Virginia Tech Hokies
10/24/25 7:30PM
CAL
VATECH
+170
-200
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-4.5 (-110)
O 50 (-110)
U 50 (-110)
Oct 24, 2025 10:00PM EDT
Boise State Broncos
Nevada Wolf Pack
10/24/25 10PM
BOISE
NEVADA
-1800
+850
-21 (-110)
+21 (-110)
O 50.5 (-105)
U 50.5 (-115)
Oct 25, 2025 12:00PM EDT
Virginia Cavaliers
North Carolina Tar Heels
10/25/25 12PM
UVA
UNC
-410
+305
-10.5 (-105)
+10.5 (-115)
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U 52 (-115)
Oct 25, 2025 12:00PM EDT
Bowling Green Falcons
Kent State Golden Flashes
10/25/25 12PM
BGREEN
KENT
-290
+240
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+7 (-105)
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U 48.5 (-110)
Oct 25, 2025 12:00PM EDT
Rutgers Scarlet Knights
Purdue Boilermakers
10/25/25 12PM
RUT
PURDUE
-130
+110
-2.5 (-115)
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U 58.5 (-110)
Oct 25, 2025 12:00PM EDT
South Florida Bulls
Memphis Tigers
10/25/25 12PM
SFLA
MEMP
-200
+170
-4.5 (-110)
+4.5 (-110)
O 63.5 (-110)
U 63.5 (-110)
Oct 25, 2025 12:00PM EDT
UCLA Bruins
Indiana Hoosiers
10/25/25 12PM
UCLA
IND
+1100
-3500
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U 55.5 (-110)
Oct 25, 2025 12:00PM EDT
Northwestern Wildcats
Nebraska Cornhuskers
10/25/25 12PM
NWEST
NEB
+235
-285
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O 43.5 (-110)
U 43.5 (-110)
Oct 25, 2025 12:00PM EDT
Ohio Bobcats
Eastern Michigan Eagles
10/25/25 12PM
OHIO
EMICH
-480
+350
-12.5 (-110)
+12.5 (-110)
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U 59.5 (-105)
Oct 25, 2025 12:00PM EDT
SMU Mustangs
Wake Forest Demon Deacons
10/25/25 12PM
SMU
WAKE
-175
+150
-3.5 (-105)
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O 54 (-110)
U 54 (-110)
Oct 25, 2025 12:00PM EDT
Syracuse Orange
Georgia Tech Yellow Jackets
10/25/25 12PM
CUSE
GATECH
+600
-950
+17.5 (-110)
-17.5 (-110)
O 53.5 (-105)
U 53.5 (-115)
Oct 25, 2025 12:00PM EDT
App State Mountaineers
Old Dominion Monarchs
10/25/25 12PM
APPST
OLDDOM
 
-625
 
-14.5 (-105)
O 63 (-110)
U 63 (-110)
Oct 25, 2025 12:00PM EDT
Ole Miss Rebels
Oklahoma Sooners
10/25/25 12PM
OLEMISS
OKLA
+175
-210
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-5 (-110)
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U 53.5 (-110)
Oct 25, 2025 12:00PM EDT
Kansas State Wildcats
Kansas Jayhawks
10/25/25 12PM
KSTATE
KANSAS
+125
-145
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-3 (-105)
O 56.5 (-110)
U 56.5 (-110)
Oct 25, 2025 12:45PM EDT
Auburn Tigers
Arkansas Razorbacks
10/25/25 12:45PM
AUBURN
ARK
-105
-115
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-1 (-110)
O 57 (-105)
U 57 (-115)
Oct 25, 2025 1:00PM EDT
Akron Zips
Buffalo Bulls
10/25/25 1PM
AKRON
BUFF
+280
-360
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O 47 (-110)
U 47 (-110)
Oct 25, 2025 3:00PM EDT
UConn Huskies
Rice Owls
10/25/25 3PM
UCONN
RICE
-410
+305
-10.5 (-110)
+10.5 (-110)
O 49 (-110)
U 49 (-110)
Oct 25, 2025 3:00PM EDT
Utah State Aggies
New Mexico Lobos
10/25/25 3PM
UTAHST
NMEX
+130
-150
+3 (-110)
-3 (-110)
O 61.5 (-110)
U 61.5 (-110)
Oct 25, 2025 3:30PM EDT
Minnesota Golden Gophers
Iowa Hawkeyes
10/25/25 3:30PM
MINN
IOWA
+270
-340
+9.5 (-110)
-9.5 (-110)
O 39 (-110)
U 39 (-110)
Oct 25, 2025 3:30PM EDT
Alabama Crimson Tide
South Carolina Gamecocks
10/25/25 3:30PM
BAMA
SC
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+370
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+12.5 (-110)
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U 47.5 (-110)
Oct 25, 2025 3:30PM EDT
BYU Cougars
Iowa State Cyclones
10/25/25 3:30PM
BYU
IOWAST
+125
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O 48.5 (-110)
U 48.5 (-110)
Oct 25, 2025 3:30PM EDT
Temple Owls
Tulsa Golden Hurricane
10/25/25 3:30PM
TEMPLE
TULSA
-230
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U 53.5 (-110)
Oct 25, 2025 3:30PM EDT
Ball State Cardinals
Northern Illinois Huskies
10/25/25 3:30PM
BALLST
NILL
+180
-220
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-5.5 (-110)
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U 40.5 (-115)
Oct 25, 2025 3:30PM EDT
Toledo Rockets
Washington State Cougars
10/25/25 3:30PM
TOLEDO
WASHST
-105
-115
+1 (-110)
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O 46.5 (-110)
U 46.5 (-110)
Oct 25, 2025 3:30PM EDT
Florida Atlantic Owls
Navy Midshipmen
10/25/25 3:30PM
FAU
NAVY
+460
-675
+15 (-110)
-15 (-110)
O 62.5 (-110)
U 62.5 (-110)
Oct 25, 2025 3:30PM EDT
Illinois Fighting Illini
Washington Huskies
10/25/25 3:30PM
ILL
WASH
+165
-195
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-4.5 (-110)
O 54 (-105)
U 54 (-115)
Oct 25, 2025 3:30PM EDT
Umass Minutemen
Central Michigan Chippewas
10/25/25 3:30PM
UMASS
CMICH
 
-750
 
-16 (-110)
O 47 (-110)
U 47 (-110)
Oct 25, 2025 3:30PM EDT
San Diego State Aztecs
Fresno State Bulldogs
10/25/25 3:30PM
SDGST
FRESNO
-160
+135
-3 (-110)
+3 (-110)
O 48 (-110)
U 48 (-110)
Oct 25, 2025 3:30PM EDT
Missouri Tigers
Vanderbilt Commodores
10/25/25 3:30PM
MIZZOU
VANDY
+115
-135
+2.5 (-105)
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O 52 (-110)
U 52 (-110)
Oct 25, 2025 3:30PM EDT
NC State Wolfpack
Pittsburgh Panthers
10/25/25 3:30PM
NCST
PITT
+210
-250
+6.5 (-110)
-6.5 (-110)
O 57 (-110)
U 57 (-110)
Oct 25, 2025 3:30PM EDT
Western Michigan Broncos
Miami Ohio Redhawks
10/25/25 3:30PM
WMICH
MIAOH
+100
 
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O 41 (-115)
U 41 (-105)
Oct 25, 2025 3:30PM EDT
UL Monroe Warhawks
USM Golden Eagles
10/25/25 3:30PM
MONROE
USM
+335
 
+11 (-110)
 
O 50.5 (-110)
U 50.5 (-110)
Oct 25, 2025 4:00PM EDT
Oklahoma State Cowboys
Texas Tech Red Raiders
10/25/25 4PM
OKLAST
TXTECH
+3500
-10000
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-38.5 (-105)
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U 56.5 (-110)
Oct 25, 2025 4:00PM EDT
Baylor Bears
Cincinnati Bearcats
10/25/25 4PM
BAYLOR
CINCY
+160
-185
+4 (-110)
-4 (-110)
O 67 (-110)
U 67 (-110)
Oct 25, 2025 4:15PM EDT
Texas Longhorns
Mississippi State Bulldogs
10/25/25 4:15PM
TEXAS
MISSST
-260
+215
-7 (-105)
+7 (-115)
O 45 (-110)
U 45 (-110)
Oct 25, 2025 6:00PM EDT
TCU Horned Frogs
West Virginia Mountaineers
10/25/25 6PM
TCU
WVU
-750
+500
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+16 (-110)
O 55 (-110)
U 55 (-110)
Oct 25, 2025 7:00PM EDT
Wisconsin Badgers
Oregon Ducks
10/25/25 7PM
WISC
OREG
 
 
+33.5 (-110)
-33.5 (-110)
O 44.5 (-110)
U 44.5 (-110)
Oct 25, 2025 7:00PM EDT
Louisiana Ragin Cajuns
Troy Trojans
10/25/25 7PM
UL
TROY
+260
-320
+8 (-110)
-8 (-110)
O 47.5 (-110)
U 47.5 (-110)
Oct 25, 2025 7:00PM EDT
Stanford Cardinal
Miami Hurricanes
10/25/25 7PM
STNFRD
MIAMI
+4000
-20000
+30 (-115)
-30 (-105)
O 45.5 (-110)
U 45.5 (-110)
Oct 25, 2025 7:00PM EDT
Georgia Southern Eagles
Arkansas State Red Wolves
10/25/25 7PM
GASO
ARKST
+100
-120
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-1.5 (-110)
O 62.5 (-110)
U 62.5 (-110)
Oct 25, 2025 7:30PM EDT
Michigan Wolverines
Michigan State Spartans
10/25/25 7:30PM
MICH
MICHST
-625
+430
-14.5 (-105)
+14.5 (-115)
O 47.5 (-110)
U 47.5 (-110)
Oct 25, 2025 7:30PM EDT
Texas A&M Aggies
LSU Tigers
10/25/25 7:30PM
TEXAM
LSU
-135
+115
-2.5 (-115)
+2.5 (-105)
O 47.5 (-110)
U 47.5 (-110)
Oct 25, 2025 7:30PM EDT
Boston College Eagles
Louisville Cardinals
10/25/25 7:30PM
BC
LVILLE
+1100
-3300
+25 (-110)
-25 (-110)
O 55.5 (-105)
U 55.5 (-115)
Oct 25, 2025 7:30PM EDT
Colorado State Rams
Wyoming Cowboys
10/25/25 7:30PM
COLOST
WYO
+180
-220
+5.5 (-105)
-5.5 (-115)
O 46.5 (-110)
U 46.5 (-110)
Oct 25, 2025 7:45PM EDT
Tennessee Volunteers
Kentucky Wildcats
10/25/25 7:45PM
TENN
UK
-350
+275
-9.5 (-110)
+9.5 (-110)
O 54 (-115)
U 54 (-105)
Oct 25, 2025 8:00PM EDT
Houston Cougars
Arizona State Sun Devils
10/25/25 8PM
HOU
ARIZST
+250
-300
+7.5 (-110)
-7.5 (-110)
O 47 (-110)
U 47 (-110)
Oct 25, 2025 10:15PM EDT
Colorado Buffaloes
Utah Utes
10/25/25 10:15PM
COLO
UTAH
+425
-600
+14 (-115)
-14 (-105)
O 50 (-110)
U 50 (-110)
Oct 28, 2025 8:00PM EDT
James Madison Dukes
Texas State Bobcats
10/28/25 8PM
JMAD
TEXST
-320
+255
-8.5 (-110)
+8.5 (-110)
O 60.5 (-112)
U 60.5 (-108)
Oct 30, 2025 7:30PM EDT
Tulane Green Wave
UTSA Roadrunners
10/30/25 7:30PM
TULANE
UTSA
-200
+164
-5.5 (-110)
+5.5 (-110)
O 52.5 (-112)
U 52.5 (-108)
Nov 1, 2025 12:00PM EDT
Penn State Nittany Lions
Ohio State Buckeyes
11/1/25 12PM
PSU
OHIOST
+660
-1050
+17.5 (-115)
-17.5 (-105)
O 47.5 (-110)
U 47.5 (-110)
Nov 1, 2025 12:00PM EDT
Miami Hurricanes
SMU Mustangs
11/1/25 12PM
MIAMI
SMU
-430
+330
-10.5 (-110)
+10.5 (-110)
O 51.5 (-110)
U 51.5 (-110)
Nov 1, 2025 12:00PM EDT
Oklahoma Sooners
Tennessee Volunteers
11/1/25 12PM
OKLA
TENN
-105
-114
+1.5 (-114)
-1.5 (-106)
O 53.5 (-112)
U 53.5 (-108)
Nov 1, 2025 12:00PM EDT
Vanderbilt Commodores
Texas Longhorns
11/1/25 12PM
VANDY
TEXAS
+150
-182
+3.5 (-106)
-3.5 (-114)
O 45.5 (-110)
U 45.5 (-110)
Nov 1, 2025 3:30PM EDT
Georgia Bulldogs
Florida Gators
11/1/25 3:30PM
UGA
FLA
-280
+225
-7.5 (+100)
+7.5 (-122)
O 50.5 (-112)
U 50.5 (-108)

CFB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers USC Trojans vs. Purdue Boilermakers on September 13, 2025 at Ross-Ade Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our CFB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
FSU@STNFRD STNFRD +18 56.6% 6 WIN
WASHST@UVA WASHST +17.5 58.8% 8 WIN
NEVADA@NMEX NEVADA +13.5 57.8% 7 WIN
TEXAS@UK ARCH MANNING UNDER 1.5 PASS TD 56.1% 6 WIN
ARMY@TULANE ARMY +10 55.3% 5 WIN
SJST@UTAHST SJST +4 54.4% 4 LOSS
LVILLE@MIAMI LVILLE +12.5 56.5% 6 WIN
LVILLE@MIAMI CJ DANIELS UNDER 4.5 RECEPTIONS 54.4 4 LOSS
DEL@JAXST DEL -2.5 57.6% 6 LOSS
UTEP@SAMST UTEP -2.5 53.9% 3 WIN
FIU@WKY FIU +10.5 54.6% 4 WIN
ARKST@SALA ARKST +7.5 54.5% 4 WIN
ARKST@SALA JAYLEN RAYNOR UNDER 40.5 LONGEST PASS COMP 53.3% 3 WIN
SJST@WYO SJST -120 59.8% 7 LOSS
UMASS@KENTST KENTST -135 60.2% 6 WIN
NOILL@EMICH EMICH +2.5 53.9% 3 WIN
BYU@ARIZ ARIZ +2.5 54.2% 3 LOSS
OKLA@TEXAS OKLA +2.5 54.7% 4 LOSS
NMEX@BOISE NMEX +16.5 56.4% 6 WIN
WAKE@OREGST WAKE -2.5 56.7% 6 WIN
ULMON@COASTAL ULMON -2.5 56.8% 6 LOSS
IOWA@WISC WISC +4 54.8% 4 LOSS
TOLEDO@BGREEN TOLEDO -10 56.3% 6 LOSS
SFLA@NOTEX SFLA +2.5 54.3% 4 WIN
FRESNO@COLOST RICHIE ANDERSON III LONGEST RECEPTION UNDER 16.5 54.4% 4 LOSS
JAXST@SAMST SAMST +7.5 55.3% 5 WIN
USM@GAS GAS +3.5 57.4% 7 WIN
LIB@UTEP UTEP +2 54.5% 4 LOSS
SALA@TROY SALA -118 55.2% 4 LOSS
TULSA@MEMP MEMP -20.5 53.8% 3 WIN
JMAD@GAST GAST +20.5 54.6% 4 WIN
WAKE@VATECH VATECH -5.5 56.6% 6 LOSS
UNLV@WYO WYO +4.5 55.5% 5 LOSS
PSU@UCLA PSU -24.5 56.3% 6 LOSS
TXSTSM@ARKST TXSTSM -13 56.7% 6 LOSS
UVA@LVILLE ISAAC BROWN OVER 70.5 RUSH YDS 56.6% 6 LOSS
WVU@BYU WVU +20.5 54.7% 4 WIN
SAMST@NMEXST SAMST -1.5 54.1% 3 LOSS
EMICH@CMICH CMICH -148 62.8% 7 WIN
SDGST@NOILL SDGST -118 55.7% 3 WIN
BAMA@GEORGIA GEORGIA -125 58.7% 7 LOSS
TENN@MISSST MISSST +7.5 54.3% 4 WIN
UK@SC SC -5.5 54.8% 4 WIN
WKY@MIZZST MIZZST +4.5 55.6% 6 LOSS
JAXST@USM USM -3.5 56.0% 5 WIN
NMEXST@NMEX NMEX -14.5 56.9% 6 WIN
ARIZ@IOWAST ROCCO BECHT UNDER 1.5 PASS TDS 55.5% 5 WIN
TCU@ARIZST JOSH HOOVER PASS YDS UNDER 287.5 53.4% 3 WIN
ARIZST@BAYLOR BAYLOR -130 58.4% 6 LOSS
WYO@COLO WYO +13.5 54.1% 3 LOSS
TULANE@OLEMISS MISS -11.5 54.3% 4 WIN