Duke vs Tulane Prediction — AI Finds CAN'T MISS CFB Lines & Props (Sep 13)

Updated: 2025-09-06T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

Tulane hosts Duke at Yulman Stadium in Week 3 of the college football season, as both programs attempt to build early momentum—Tulane fresh off a dominant debut win and Duke seeking consistency with a high-profile transfer quarterback. Betting lines opened with Tulane favored by around 3 points, and the total was initially set near 50, indicating expectations of a tight, competitive showdown.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Sep 13, 2025

Start Time: 8:00 PM EST​

Venue: Benson Field at Yulman Stadium​

Green Wave Record: (2-0)

Blue Devils Record: (1-1)

OPENING ODDS

DUKE Moneyline: +134

TULANE Moneyline: -159

DUKE Spread: +3

TULANE Spread: -3.0

Over/Under: 52.5

DUKE
Betting Trends

  • Duke enters at 1–1 ATS, covering easily in their season opener against Elon, but failing to cover as small favorites in a Week 2 loss to Illinois.

TULANE
Betting Trends

  • Tulane is also 1–1 ATS, with a dominant cover over Northwestern in Week 1, followed by a solid performance in Week 2, though specific ATS data isn’t confirmed—still, preseason expectations and dominant displays suggest strong support.

MATCHUP TRENDS

  • With almost even ATS records and a slim line of about three points, the matchup hinges on whether Duke’s talented transfer QB—Darian Mensah—can connect early, and if Tulane’s opportunistic defense can force turnovers to flip field position. Low red-zone conversion and a timely big play could swing the betting margin.

DUKE vs. TULANE
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: A. Anthony over 35.5 Receiving Yards.

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Duke vs Tulane Prediction & Odds:
Free CFB Betting Insights for 9/13/25

The September 13, 2025 clash between Duke and Tulane at Yulman Stadium is a fascinating non-conference showdown between two programs charting ambitious courses, with Tulane aiming to prove their dominance as an AAC contender and Duke seeking to establish consistency under a new quarterback-led attack. The betting market opened Tulane as a slim three-point favorite with a total hovering around 50, signaling expectations of a competitive game where situational execution and turnover margin will likely decide the outcome rather than sheer talent disparity. Tulane enters with momentum after a 23–3 win over Northwestern where the Green Wave forced five turnovers, suffocated the Wildcats defensively, and showcased an offense with balance under quarterback Jake Retzlaff, who managed tempo while leaning on a physical ground game and efficient RPO structures. The defense has been the headline so far—athletic, opportunistic, and relentless in creating short fields—and if it can continue to generate pressure and capitalize on mistakes, Tulane can tilt possession and scoreboard control. Duke counters with the upside of transfer quarterback Darian Mensah, who shined in a Week 1 45–17 rout of Elon with multiple explosive touchdown passes and a command of the Blue Devils’ spread system, but the Week 2 31–24 stumble against Illinois revealed growing pains, including costly turnovers and inconsistency in protection that left too much on the quarterback’s shoulders.

The challenge for Duke is finding rhythm against a defense built to capitalize on exactly those issues, meaning the offensive line and run game must keep Tulane honest to give Mensah time to connect with his playmakers. Special teams and hidden yardage will matter significantly in this matchup—Tulane has shown discipline in coverage and returns, while Duke must avoid penalties and miscues that gift the Green Wave short fields in a game lined tightly enough that a single possession swing could determine who covers. The ATS angles suggest Tulane’s cover path relies on maintaining its opportunistic defense and finishing red-zone trips with touchdowns to stretch Duke out of their comfort zone, while Duke’s key to staying within the number or springing the upset is to protect the football, hit on at least two explosive plays over 20 yards, and keep Tulane’s early-down success rate below 50 percent. Both teams have played to a near even ATS record through the first two weeks, underscoring that neither has separated from preseason expectations, and that makes this contest a benchmark moment for both programs. The “middle eight” minutes around halftime could be the decisive stretch, as Tulane used that span to bury Northwestern, while Duke struggled to finish drives during that same window against Illinois. Ultimately, this matchup comes down to whether Tulane’s defense can continue forcing mistakes and controlling tempo, or whether Duke’s playmakers and Mensah’s talent can break through in a hostile road environment. Expect a back-and-forth contest with momentum swings, but the team that wins the turnover battle and executes in the red zone will almost certainly walk away with both the victory and the cover.

Duke Blue Devils CFB Preview

For Duke, the trip to Yulman Stadium on September 13 is a pivotal early-season test and a chance to prove they can rebound quickly after the sting of a 31–24 loss to Illinois in Week 2, a result that showed both the potential of their new-look offense and the vulnerabilities that come with transition. The centerpiece is quarterback Darian Mensah, a transfer whose arm talent and composure turned heads in a Week 1 blowout of Elon, where he threw multiple deep touchdowns and looked completely in command of the Blue Devils’ spread system. Mensah gives Duke the ability to stretch the field vertically and horizontally, something that has been missing from their attack in recent years, but his effectiveness is tied directly to the offensive line’s ability to keep him upright and the run game’s capacity to create balance. Against Tulane, who forced five turnovers and blanketed Northwestern in a 23–3 opening victory, the Blue Devils cannot afford to put everything on Mensah’s shoulders or allow protection breakdowns to snowball into sacks and giveaways. Offensive coordinator Kevin Johns will need to lean into quick-game concepts early—slants, hitches, and RPOs—to keep Tulane’s pass rush honest, while selectively dialing up play-action shots once the Green Wave safeties start creeping into the box. Duke’s run game, led by a committee of backs who can grind out tough yards, must aim for at least four yards per carry to keep the chains moving and to prevent Tulane’s defense from teeing off on obvious passing downs.

Defensively, Duke must bounce back from a shaky effort against Illinois by focusing on first-down success and gap integrity, because Tulane has shown an ability to pound the ball between the tackles and then use tempo to exploit defenses that are slow to reset. Linebacker discipline and tackling in space will be paramount, as Tulane’s offense thrives on converting manageable third downs and staying ahead of the sticks. On special teams, Duke has to be sharp, because hidden yardage is critical in games lined around three points, and a shanked punt or missed kick could spell disaster. From an ATS perspective, Duke’s cover path is clear: protect the ball at all costs, hit on at least two explosive passing plays to loosen Tulane’s secondary, and maintain composure in the “middle eight” minutes around halftime, a stretch where Tulane buried Northwestern but where Duke faltered against Illinois. The danger lies in a repeat of Week 2’s mistakes—turnovers, pre-snap penalties, and missed blocking assignments—that give Tulane short fields and force Duke into catch-up mode. But if Mensah finds rhythm, the offensive line holds firm, and the defense can generate one or two critical stops, Duke has every reason to believe they can not only hang inside the number but also leave New Orleans with a confidence-building win that would reshape the narrative of their season.

Tulane hosts Duke at Yulman Stadium in Week 3 of the college football season, as both programs attempt to build early momentum—Tulane fresh off a dominant debut win and Duke seeking consistency with a high-profile transfer quarterback. Betting lines opened with Tulane favored by around 3 points, and the total was initially set near 50, indicating expectations of a tight, competitive showdown.  Duke vs Tulane AI Prediction: Free CFB Betting Insights for Sep 13. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Tulane Green Wave CFB Preview

For Tulane, the September 13 home date with Duke is an opportunity to validate their standing as one of the AAC’s top-tier programs and to show that their defensive revival and offensive balance can hold up against a Power Five opponent with a quarterback capable of testing their structure. The Green Wave opened their season with a dominant 23–3 win over Northwestern in which they forced five turnovers, controlled tempo, and smothered the Wildcats’ attempts to establish rhythm, and that performance reaffirmed the identity head coach Jon Sumrall wants to build: a defense-first operation that complements an efficient, opportunistic offense. Quarterback Jake Retzlaff brings dual-threat capability to Tulane’s attack, extending plays with his legs and leveraging a system heavy on RPOs and quick reads to stay ahead of the chains, while the run game provides the balance necessary to prevent defenses from overloading coverage. Against Duke, the formula will be to keep the offense on schedule, aiming for early-down success rates above 50 percent and finishing red-zone trips with touchdowns rather than field goals, because the Blue Devils’ transfer quarterback Darian Mensah has the arm strength and explosiveness to punish even small lapses if the margin remains tight.

Defensively, Tulane’s secondary will be tested far more than it was against Northwestern, but the unit thrives on disguising coverages and baiting quarterbacks into mistakes, and the pass rush must collapse Duke’s pocket consistently to prevent Mensah from settling into a rhythm. Turnover margin will again be a swing factor; the Green Wave have already shown their knack for takeaways, and forcing just one or two critical errors could be enough to create separation at home. Special teams, often overlooked, may also tip the balance: clean punts, accurate field goals, and disciplined coverage can maximize hidden yardage, which matters enormously in a contest lined close to a field goal. From a betting standpoint, Tulane’s path to both victory and cover lies in maintaining the same opportunistic defense that throttled Northwestern, while also leveraging home-field advantage and crowd energy to disrupt Duke’s communication and tempo. The “middle eight” minutes around halftime could again prove decisive, as Tulane has demonstrated an ability to swing games in that window with back-to-back possessions, and if they can replicate that against Duke, they may break the game open. The risks are clear: if the offense stalls in the red zone, if Retzlaff struggles with decision-making under pressure, or if the defense cannot generate turnovers, then the Blue Devils’ explosiveness could make the game much tighter than expected. Still, Tulane’s combination of depth, discipline, and defensive opportunism gives them a well-defined edge at home, and if they execute their blueprint, they not only have a strong chance of winning outright but also of delivering a cover that would keep their early-season momentum rolling.

Duke vs. Tulane Prop Picks (AI)

Remi is pouring through mountains of datapoints on each line. In fact, anytime the Blue Devils and Green Wave play there’s always several intriguing trends to key in on. Not to mention games played at Benson Field at Yulman Stadium in Sep rarely follow normal, predictable betting trends.
Remi's searched hard and found the best prop for this matchup: A. Anthony over 35.5 Receiving Yards.

Duke vs. Tulane Prediction (AI)

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Remi, our AI sports genius, has been pouring over millions of data from every angle between the Blue Devils and Green Wave and using recursive machine learning and industry leading AI to crunch the data to a single cover probability.

Interestingly enough, the data has been most keyed in on the growing weight emotional bettors often put on player performance factors between a Blue Devils team going up against a possibly tired Green Wave team. Trends look to say the true game analytics appear to reflect a strong lean against one Vegas line in particular.

Unlock this in-depth AI prediction and all of our CFB AI picks for FREE now.

Below is our current AI Duke vs Tulane picks, computer picks Blue Devils vs Green Wave, best bets, model edges, confidence ratings.

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Blue Devils Betting Trends

Duke enters at 1–1 ATS, covering easily in their season opener against Elon, but failing to cover as small favorites in a Week 2 loss to Illinois.

Green Wave Betting Trends

Tulane is also 1–1 ATS, with a dominant cover over Northwestern in Week 1, followed by a solid performance in Week 2, though specific ATS data isn’t confirmed—still, preseason expectations and dominant displays suggest strong support.

Blue Devils vs. Green Wave Matchup Trends

With almost even ATS records and a slim line of about three points, the matchup hinges on whether Duke’s talented transfer QB—Darian Mensah—can connect early, and if Tulane’s opportunistic defense can force turnovers to flip field position. Low red-zone conversion and a timely big play could swing the betting margin.

Duke vs. Tulane Game Info

Duke vs Tulane starts on September 13, 2025 at 8:00 PM EST.

Venue: Benson Field at Yulman Stadium.

Spread: Tulane -3.0
Moneyline: Duke +134, Tulane -159
Over/Under: 52.5

Duke: (1-1)  |  Tulane: (2-0)

Remi's searched hard and found the best prop for this matchup: A. Anthony over 35.5 Receiving Yards.. Prices move—always shop for the best number.

With almost even ATS records and a slim line of about three points, the matchup hinges on whether Duke’s talented transfer QB—Darian Mensah—can connect early, and if Tulane’s opportunistic defense can force turnovers to flip field position. Low red-zone conversion and a timely big play could swing the betting margin.

DUKE trend: Duke enters at 1–1 ATS, covering easily in their season opener against Elon, but failing to cover as small favorites in a Week 2 loss to Illinois.

TULANE trend: Tulane is also 1–1 ATS, with a dominant cover over Northwestern in Week 1, followed by a solid performance in Week 2, though specific ATS data isn’t confirmed—still, preseason expectations and dominant displays suggest strong support.

See our latest CFB picks and odds pages for 2025 to compare prices before you bet.

Duke vs. Tulane Odds

Remi is pouring through tons of stats on each team. In fact, anytime the Duke vs Tulane trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme temps rarely follow normal, predictable patterns.

Duke vs Tulane Opening Odds

DUKE Moneyline: +134
TULANE Moneyline: -159
DUKE Spread: +3
TULANE Spread: -3.0
Over/Under: 52.5

Duke vs Tulane Live Odds

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Oct 25, 2025 12:00PM EDT
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10/25/25 12PM
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Oct 25, 2025 12:00PM EDT
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Oct 25, 2025 12:00PM EDT
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10/25/25 12PM
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Indiana Hoosiers
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App State Mountaineers
Old Dominion Monarchs
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Kansas Jayhawks
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U 56.5 (-110)
Oct 25, 2025 12:45PM EDT
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Arkansas Razorbacks
10/25/25 12:45PM
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Oct 25, 2025 1:00PM EDT
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Buffalo Bulls
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New Mexico Lobos
10/25/25 3PM
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Iowa Hawkeyes
10/25/25 3:30PM
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Alabama Crimson Tide
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10/25/25 3:30PM
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SC
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BYU Cougars
Iowa State Cyclones
10/25/25 3:30PM
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Temple Owls
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Oct 25, 2025 3:30PM EDT
Ball State Cardinals
Northern Illinois Huskies
10/25/25 3:30PM
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Toledo Rockets
Washington State Cougars
10/25/25 3:30PM
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Oct 25, 2025 3:30PM EDT
Florida Atlantic Owls
Navy Midshipmen
10/25/25 3:30PM
FAU
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Illinois Fighting Illini
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10/25/25 3:30PM
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Umass Minutemen
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CMICH
 
-750
 
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San Diego State Aztecs
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10/25/25 3:30PM
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Missouri Tigers
Vanderbilt Commodores
10/25/25 3:30PM
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U 52 (-110)
Oct 25, 2025 3:30PM EDT
NC State Wolfpack
Pittsburgh Panthers
10/25/25 3:30PM
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U 57 (-110)
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+335
 
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Texas Longhorns
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10/25/25 4:15PM
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TCU Horned Frogs
West Virginia Mountaineers
10/25/25 6PM
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WVU
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Wisconsin Badgers
Oregon Ducks
10/25/25 7PM
WISC
OREG
 
 
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Louisiana Ragin Cajuns
Troy Trojans
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UL
TROY
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Stanford Cardinal
Miami Hurricanes
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STNFRD
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Georgia Southern Eagles
Arkansas State Red Wolves
10/25/25 7PM
GASO
ARKST
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U 62.5 (-110)
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Michigan Wolverines
Michigan State Spartans
10/25/25 7:30PM
MICH
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Oct 25, 2025 7:30PM EDT
Texas A&M Aggies
LSU Tigers
10/25/25 7:30PM
TEXAM
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-135
+115
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O 47.5 (-110)
U 47.5 (-110)
Oct 25, 2025 7:30PM EDT
Boston College Eagles
Louisville Cardinals
10/25/25 7:30PM
BC
LVILLE
+1100
-3300
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-25 (-110)
O 55.5 (-105)
U 55.5 (-115)
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Colorado State Rams
Wyoming Cowboys
10/25/25 7:30PM
COLOST
WYO
+180
-220
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O 46.5 (-110)
U 46.5 (-110)
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Tennessee Volunteers
Kentucky Wildcats
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TENN
UK
-350
+275
-9.5 (-110)
+9.5 (-110)
O 54 (-115)
U 54 (-105)
Oct 25, 2025 8:00PM EDT
Houston Cougars
Arizona State Sun Devils
10/25/25 8PM
HOU
ARIZST
+250
-300
+7.5 (-110)
-7.5 (-110)
O 47 (-110)
U 47 (-110)
Oct 25, 2025 10:15PM EDT
Colorado Buffaloes
Utah Utes
10/25/25 10:15PM
COLO
UTAH
+425
-600
+14 (-115)
-14 (-105)
O 50 (-110)
U 50 (-110)
Oct 28, 2025 8:00PM EDT
James Madison Dukes
Texas State Bobcats
10/28/25 8PM
JMAD
TEXST
-320
+255
-8.5 (-110)
+8.5 (-110)
O 60.5 (-112)
U 60.5 (-108)
Oct 30, 2025 7:30PM EDT
Tulane Green Wave
UTSA Roadrunners
10/30/25 7:30PM
TULANE
UTSA
-200
+164
-5.5 (-110)
+5.5 (-110)
O 52.5 (-112)
U 52.5 (-108)
Nov 1, 2025 12:00PM EDT
Penn State Nittany Lions
Ohio State Buckeyes
11/1/25 12PM
PSU
OHIOST
+660
-1050
+17.5 (-115)
-17.5 (-105)
O 47.5 (-110)
U 47.5 (-110)
Nov 1, 2025 12:00PM EDT
Miami Hurricanes
SMU Mustangs
11/1/25 12PM
MIAMI
SMU
-430
+330
-10.5 (-110)
+10.5 (-110)
O 51.5 (-110)
U 51.5 (-110)
Nov 1, 2025 12:00PM EDT
Oklahoma Sooners
Tennessee Volunteers
11/1/25 12PM
OKLA
TENN
-105
-114
+1.5 (-114)
-1.5 (-106)
O 53.5 (-112)
U 53.5 (-108)
Nov 1, 2025 12:00PM EDT
Vanderbilt Commodores
Texas Longhorns
11/1/25 12PM
VANDY
TEXAS
+150
-182
+3.5 (-106)
-3.5 (-114)
O 45.5 (-110)
U 45.5 (-110)
Nov 1, 2025 3:30PM EDT
Georgia Bulldogs
Florida Gators
11/1/25 3:30PM
UGA
FLA
-280
+225
-7.5 (+100)
+7.5 (-122)
O 50.5 (-112)
U 50.5 (-108)

CFB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Duke Blue Devils vs. Tulane Green Wave on September 13, 2025 at Benson Field at Yulman Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our CFB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
FSU@STNFRD STNFRD +18 56.6% 6 WIN
WASHST@UVA WASHST +17.5 58.8% 8 WIN
NEVADA@NMEX NEVADA +13.5 57.8% 7 WIN
TEXAS@UK ARCH MANNING UNDER 1.5 PASS TD 56.1% 6 WIN
ARMY@TULANE ARMY +10 55.3% 5 WIN
SJST@UTAHST SJST +4 54.4% 4 LOSS
LVILLE@MIAMI LVILLE +12.5 56.5% 6 WIN
LVILLE@MIAMI CJ DANIELS UNDER 4.5 RECEPTIONS 54.4 4 LOSS
DEL@JAXST DEL -2.5 57.6% 6 LOSS
UTEP@SAMST UTEP -2.5 53.9% 3 WIN
FIU@WKY FIU +10.5 54.6% 4 WIN
ARKST@SALA ARKST +7.5 54.5% 4 WIN
ARKST@SALA JAYLEN RAYNOR UNDER 40.5 LONGEST PASS COMP 53.3% 3 WIN
SJST@WYO SJST -120 59.8% 7 LOSS
UMASS@KENTST KENTST -135 60.2% 6 WIN
NOILL@EMICH EMICH +2.5 53.9% 3 WIN
BYU@ARIZ ARIZ +2.5 54.2% 3 LOSS
OKLA@TEXAS OKLA +2.5 54.7% 4 LOSS
NMEX@BOISE NMEX +16.5 56.4% 6 WIN
WAKE@OREGST WAKE -2.5 56.7% 6 WIN
ULMON@COASTAL ULMON -2.5 56.8% 6 LOSS
IOWA@WISC WISC +4 54.8% 4 LOSS
TOLEDO@BGREEN TOLEDO -10 56.3% 6 LOSS
SFLA@NOTEX SFLA +2.5 54.3% 4 WIN
FRESNO@COLOST RICHIE ANDERSON III LONGEST RECEPTION UNDER 16.5 54.4% 4 LOSS
JAXST@SAMST SAMST +7.5 55.3% 5 WIN
USM@GAS GAS +3.5 57.4% 7 WIN
LIB@UTEP UTEP +2 54.5% 4 LOSS
SALA@TROY SALA -118 55.2% 4 LOSS
TULSA@MEMP MEMP -20.5 53.8% 3 WIN
JMAD@GAST GAST +20.5 54.6% 4 WIN
WAKE@VATECH VATECH -5.5 56.6% 6 LOSS
UNLV@WYO WYO +4.5 55.5% 5 LOSS
PSU@UCLA PSU -24.5 56.3% 6 LOSS
TXSTSM@ARKST TXSTSM -13 56.7% 6 LOSS
UVA@LVILLE ISAAC BROWN OVER 70.5 RUSH YDS 56.6% 6 LOSS
WVU@BYU WVU +20.5 54.7% 4 WIN
SAMST@NMEXST SAMST -1.5 54.1% 3 LOSS
EMICH@CMICH CMICH -148 62.8% 7 WIN
SDGST@NOILL SDGST -118 55.7% 3 WIN
BAMA@GEORGIA GEORGIA -125 58.7% 7 LOSS
TENN@MISSST MISSST +7.5 54.3% 4 WIN
UK@SC SC -5.5 54.8% 4 WIN
WKY@MIZZST MIZZST +4.5 55.6% 6 LOSS
JAXST@USM USM -3.5 56.0% 5 WIN
NMEXST@NMEX NMEX -14.5 56.9% 6 WIN
ARIZ@IOWAST ROCCO BECHT UNDER 1.5 PASS TDS 55.5% 5 WIN
TCU@ARIZST JOSH HOOVER PASS YDS UNDER 287.5 53.4% 3 WIN
ARIZST@BAYLOR BAYLOR -130 58.4% 6 LOSS
WYO@COLO WYO +13.5 54.1% 3 LOSS
TULANE@OLEMISS MISS -11.5 54.3% 4 WIN