The September 13, 2025 clash between Duke and Tulane at Yulman Stadium is a fascinating non-conference showdown between two programs charting ambitious courses, with Tulane aiming to prove their dominance as an AAC contender and Duke seeking to establish consistency under a new quarterback-led attack. The betting market opened Tulane as a slim three-point favorite with a total hovering around 50, signaling expectations of a competitive game where situational execution and turnover margin will likely decide the outcome rather than sheer talent disparity. Tulane enters with momentum after a 23–3 win over Northwestern where the Green Wave forced five turnovers, suffocated the Wildcats defensively, and showcased an offense with balance under quarterback Jake Retzlaff, who managed tempo while leaning on a physical ground game and efficient RPO structures. The defense has been the headline so far—athletic, opportunistic, and relentless in creating short fields—and if it can continue to generate pressure and capitalize on mistakes, Tulane can tilt possession and scoreboard control. Duke counters with the upside of transfer quarterback Darian Mensah, who shined in a Week 1 45–17 rout of Elon with multiple explosive touchdown passes and a command of the Blue Devils’ spread system, but the Week 2 31–24 stumble against Illinois revealed growing pains, including costly turnovers and inconsistency in protection that left too much on the quarterback’s shoulders.

The challenge for Duke is finding rhythm against a defense built to capitalize on exactly those issues, meaning the offensive line and run game must keep Tulane honest to give Mensah time to connect with his playmakers. Special teams and hidden yardage will matter significantly in this matchup—Tulane has shown discipline in coverage and returns, while Duke must avoid penalties and miscues that gift the Green Wave short fields in a game lined tightly enough that a single possession swing could determine who covers. The ATS angles suggest Tulane’s cover path relies on maintaining its opportunistic defense and finishing red-zone trips with touchdowns to stretch Duke out of their comfort zone, while Duke’s key to staying within the number or springing the upset is to protect the football, hit on at least two explosive plays over 20 yards, and keep Tulane’s early-down success rate below 50 percent. Both teams have played to a near even ATS record through the first two weeks, underscoring that neither has separated from preseason expectations, and that makes this contest a benchmark moment for both programs. The “middle eight” minutes around halftime could be the decisive stretch, as Tulane used that span to bury Northwestern, while Duke struggled to finish drives during that same window against Illinois. Ultimately, this matchup comes down to whether Tulane’s defense can continue forcing mistakes and controlling tempo, or whether Duke’s playmakers and Mensah’s talent can break through in a hostile road environment. Expect a back-and-forth contest with momentum swings, but the team that wins the turnover battle and executes in the red zone will almost certainly walk away with both the victory and the cover.