Mustangs vs. Cardinals
Prediction, Odds & Props
Oct 05 | CFB AI Picks
Updated: 2024-09-28T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The SMU Mustangs (4-1) will visit the Louisville Cardinals (3-1) on October 5, 2024, at L&N Federal Credit Union Stadium in Louisville, Kentucky. Both teams have high-powered offenses, with SMU averaging 42.2 points per game and Louisville averaging 41.5 points per game. This matchup will be a test of which defense can step up and make key stops in a game expected to be high-scoring.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

GAME INFO
Date: Oct 05, 2024
Start Time: 12:00 PM EST
Venue: L&N Federal Credit Union Stadium
Cardinals Record: (3-1)
Mustangs Record: (4-1)
OPENING ODDS
SMU Moneyline: +199
LVILLE Moneyline: -249
SMU Spread: +7
LVILLE Spread: -7.0
Over/Under: 57
SMU
Betting Trends
- The Mustangs are 3-2 against the spread this season. Despite their offensive firepower, they have struggled to cover in games where they were the underdog against strong defenses. Their solid rushing attack, averaging 205.6 rushing yards per game, has been key to their success.
LVILLE
Betting Trends
- The Cardinals are 2-2 against the spread this season. They have been reliable when playing at home, but their inconsistency in the red zone has made it difficult to cover large spreads. They rely heavily on quarterback Tyler Shough, who has thrown for over 1,100 yards and 11 touchdowns so far.
MATCHUP TRENDS
- The over/under for this game is set at 57 points, and both teams have regularly been involved in high-scoring matchups. SMU’s games have gone over the total in three of their last four, while Louisville has hit the over in two of their last three. This trend suggests that this could be another game with plenty of scoring.
SMU vs. LVILLE
Best Prop Bet
- Remi's searched hard and is crunching tons of data, but hasn't found a good Prop Bet yet for this game.
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SMU vs Louisville Prediction & Odds:
Free CFB Betting Insights for 10/5/24
Louisville’s offense is built around quarterback Tyler Shough, who has thrown for 1,114 yards and 11 touchdowns. His primary target, Ja’Corey Brooks, has been a consistent threat, with 368 receiving yards and six touchdowns. The Cardinals have a more balanced offensive attack, averaging 297.0 passing yards and 178.5 rushing yards per game, which ranks them among the top offenses in the ACC. Defensively, both teams have shown vulnerability. SMU’s defense allows 21.4 points per game, while Louisville’s defense is slightly better, giving up 16 points per game. The Mustangs have been strong against the run, allowing just 88.8 rushing yards per game, but their pass defense has been a weak spot, giving up 222.4 passing yards per game. The key to this game will be whether SMU can contain Shough and prevent big plays.
Headed up north.#PonyUpDallas pic.twitter.com/5Y7gFKAbTo
— SMU Football (@SMUFB) September 30, 2024
SMU Mustangs CFB Preview
The SMU Mustangs come into this game with a 4-1 record, looking to build on a strong start to their season. Quarterback Kevin Jennings has been effective, throwing for 733 yards and six touchdowns with only one interception. SMU’s balanced offensive approach has been key, as their ground game, led by Brashard Smith’s 509 rushing yards and eight touchdowns, has helped open up the passing game. The Mustangs have averaged 42.2 points per game, making them one of the highest-scoring teams in the ACC. Defensively, the Mustangs have been hit-or-miss. Their run defense has been stout, giving up only 88.8 rushing yards per game, but their pass defense has been vulnerable, allowing over 222 passing yards per contest. They have struggled against elite quarterbacks, which could be a problem against Shough and Louisville’s explosive offense. To compete, SMU will need to generate pressure and create turnovers to keep the Cardinals from scoring at will.

Credit: USA TODAY/IMAGN
Louisville Cardinals CFB Preview
The Louisville Cardinals are looking to solidify their position in the ACC with a statement win over SMU. Sitting at 3-1, Louisville has leaned heavily on quarterback Tyler Shough, who has been the engine of the offense, throwing for over 1,100 yards with 11 touchdowns and only one interception. His accuracy and poise have been key factors in the team’s offensive success. Ja’Corey Brooks has been Shough’s go-to target, averaging 92 yards per game and leading the team in receiving touchdowns. On the ground, Louisville has relied on a committee approach, with running backs Isaac Brown and Maurice Turner combining for over 400 yards. This balanced attack has allowed the Cardinals to keep defenses guessing, making it difficult for opponents to key in on any single playmaker. Defensively, Louisville has been solid, ranking 35th in the FBS by allowing only 289 total yards per game. Their ability to stifle opposing run games, holding teams to just 94.8 rushing yards per game, will be crucial in limiting SMU’s potent rushing attack.
Week 4 ✔️#GoCards x #ProCards pic.twitter.com/83FjJCoFI9
— Louisville Football (@LouisvilleFB) October 1, 2024
SMU vs. Louisville Prop Picks (AI)
SMU vs. Louisville Prediction (AI)

Remi, our AI sports wizard, has been pouring over exorbitant amounts of data from every simulation between the Mustangs and Cardinals and using recursive machine learning and industry leading AI to crunch the data to a single cover probability.
Remi has been most fixated on the growing factor human bettors regularly put on Louisville’s strength factors between a Mustangs team going up against a possibly healthy Cardinals team. In reality, the true game analytics appear to reflect a slight lean against one Vegas line in particular.
Unlock this in-depth AI prediction and all of our CFB AI picks for FREE now.
Below is our current AI SMU vs Louisville picks, computer picks Mustangs vs Cardinals, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
---|---|---|---|---|---|---|
CFB | 9/26 | TCU@ARIZST | UNLOCK THIS PICK | 3 |
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CFB | 9/26 | FSU@UVA | UNLOCK THIS PICK | 0 |
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full CFB schedule.
Mustangs Betting Trends
The Mustangs are 3-2 against the spread this season. Despite their offensive firepower, they have struggled to cover in games where they were the underdog against strong defenses. Their solid rushing attack, averaging 205.6 rushing yards per game, has been key to their success.
Cardinals Betting Trends
The Cardinals are 2-2 against the spread this season. They have been reliable when playing at home, but their inconsistency in the red zone has made it difficult to cover large spreads. They rely heavily on quarterback Tyler Shough, who has thrown for over 1,100 yards and 11 touchdowns so far.
Mustangs vs. Cardinals Matchup Trends
The over/under for this game is set at 57 points, and both teams have regularly been involved in high-scoring matchups. SMU’s games have gone over the total in three of their last four, while Louisville has hit the over in two of their last three. This trend suggests that this could be another game with plenty of scoring.
SMU vs. Louisville Game Info
What time does SMU vs Louisville start on October 05, 2024?
SMU vs Louisville starts on October 05, 2024 at 12:00 PM EST.
Where is SMU vs Louisville being played?
Venue: L&N Federal Credit Union Stadium.
What are the opening odds for SMU vs Louisville?
Spread: Louisville -7.0
Moneyline: SMU +199, Louisville -249
Over/Under: 57
What are the records for SMU vs Louisville?
SMU: (4-1) | Louisville: (3-1)
What is the AI best bet for SMU vs Louisville?
Remi's searched hard and is crunching tons of data, but hasn't found a good Prop Bet yet for this game.. Prices move—always shop for the best number.
What are SMU vs Louisville trending bets?
The over/under for this game is set at 57 points, and both teams have regularly been involved in high-scoring matchups. SMU’s games have gone over the total in three of their last four, while Louisville has hit the over in two of their last three. This trend suggests that this could be another game with plenty of scoring.
What are SMU trending bets?
SMU trend: The Mustangs are 3-2 against the spread this season. Despite their offensive firepower, they have struggled to cover in games where they were the underdog against strong defenses. Their solid rushing attack, averaging 205.6 rushing yards per game, has been key to their success.
What are Louisville trending bets?
LVILLE trend: The Cardinals are 2-2 against the spread this season. They have been reliable when playing at home, but their inconsistency in the red zone has made it difficult to cover large spreads. They rely heavily on quarterback Tyler Shough, who has thrown for over 1,100 yards and 11 touchdowns so far.
Where can I find AI Picks for SMU vs Louisville?
See our latest CFB picks and odds pages for 2024 to compare prices before you bet.
SMU vs. Louisville Odds
AI algorithm Remi is pouring through loads of data points on each team. In fact, anytime the SMU vs Louisville trends are analyzed, there’s always several intriguing trends to key in on. Not to mention games played at extreme hostile environments can often follow normal, predictable betting trends.
SMU vs Louisville Opening Odds
SMU Moneyline:
+199 LVILLE Moneyline: -249
SMU Spread: +7
LVILLE Spread: -7.0
Over/Under: 57
SMU vs Louisville Live Odds
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+143
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–
–
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-750
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-16.5 (-110)
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O 59 (-110)
U 59 (-110)
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Alabama Crimson Tide
Georgia Bulldogs
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–
–
|
+112
-141
|
+2.5 (-110)
-2.5 (-113)
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O 53.5 (-114)
U 53.5 (-109)
|
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MIZZOU
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–
–
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-44.5 (-110)
|
O 56.5 (-110)
U 56.5 (-110)
|
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San Jose State Spartans
Stanford Cardinal
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SJST
STNFRD
|
–
–
|
+129
-150
|
+3 (-110)
-3 (-110)
|
O 49.5 (-110)
U 49.5 (-110)
|
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Sep 27, 2025 7:30PM EDT
Washington State Cougars
Colorado State Rams
9/27/25 7:30PM
WASHST
COLOST
|
–
–
|
+175
-205
|
+5.5 (-110)
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O 49.5 (-110)
U 49.5 (-110)
|
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Kentucky Wildcats
South Carolina Gamecocks
9/27/25 7:45PM
UK
SC
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–
–
|
+180
-210
|
+5.5 (-110)
-5.5 (-110)
|
O 47.5 (-110)
U 47.5 (-110)
|
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Marshall Thundering Herd
Louisiana Ragin Cajuns
9/27/25 8PM
MARSH
UL
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–
–
|
-125
+105
|
-2 (-110)
+2 (-110)
|
O 48 (-115)
U 48 (-105)
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Sep 27, 2025 9:00PM EDT
Louisiana Tech Bulldogs
UTEP Miners
9/27/25 9PM
LATECH
UTEP
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–
–
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-175
+150
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-3.5 (-110)
+3.5 (-110)
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O 48 (-110)
U 48 (-110)
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BYU Cougars
Colorado Buffaloes
9/27/25 10:15PM
BYU
COLO
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–
–
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-235
+200
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-6.5 (-110)
+6.5 (-110)
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O 49.5 (-110)
U 49.5 (-110)
|
|
Oct 4, 2025 12:00PM EDT
Minnesota Golden Gophers
Ohio State Buckeyes
10/4/25 12PM
MINN
OHIOST
|
–
–
|
|
+21 (-110)
-21 (-110)
|
|
|
Oct 4, 2025 12:00PM EDT
Kentucky Wildcats
Georgia Bulldogs
10/4/25 12PM
UK
UGA
|
–
–
|
|
+20.5 (-110)
-20.5 (-110)
|
|
|
Oct 4, 2025 12:00PM EDT
Clemson Tigers
North Carolina Tar Heels
10/4/25 12PM
CLEM
UNC
|
–
–
|
-550
+400
|
-13.5 (-110)
+13.5 (-110)
|
O 48.5 (-110)
U 48.5 (-110)
|
|
Oct 4, 2025 12:00PM EDT
Wisconsin Badgers
Michigan Wolverines
10/4/25 12PM
WISC
MICH
|
–
–
|
+580
-880
|
+16.5 (-110)
-16.5 (-110)
|
O 41.5 (-105)
U 41.5 (-115)
|
|
Oct 4, 2025 1:00PM EDT
UTSA Roadrunners
Temple Owls
10/4/25 1PM
UTSA
TEMPLE
|
–
–
|
-210
+172
|
-5.5 (-115)
+5.5 (-105)
|
O 56.5 (-110)
U 56.5 (-110)
|
|
Oct 4, 2025 3:30PM EDT
Vanderbilt Commodores
Alabama Crimson Tide
10/4/25 3:30PM
VANDY
BAMA
|
–
–
|
+360
-480
|
+11.5 (-102)
-11.5 (-120)
|
O 51.5 (-110)
U 51.5 (-110)
|
|
Oct 4, 2025 3:30PM EDT
Washington Huskies
Maryland Terrapins
10/4/25 3:30PM
WASH
MD
|
–
–
|
|
-7 (-110)
+7 (-110)
|
|
|
Oct 4, 2025 3:30PM EDT
Boise State Broncos
Notre Dame Fighting Irish
10/4/25 3:30PM
BOISE
ND
|
–
–
|
+365
-490
|
+15.5 (-110)
-15.5 (-110)
|
O 61.5 (-110)
U 61.5 (-110)
|
|
Oct 4, 2025 3:30PM EDT
Texas Longhorns
Florida Gators
10/4/25 3:30PM
TEXAS
FLA
|
–
–
|
-300
+240
|
-7.5 (-110)
+7.5 (-110)
|
O 46.5 (-110)
U 46.5 (-110)
|
|
Oct 4, 2025 4:00PM EDT
Kent State Golden Flashes
Oklahoma Sooners
10/4/25 4PM
KENT
OKLA
|
–
–
|
|
+45.5 (-110)
-45.5 (-110)
|
O 52.5 (-115)
U 52.5 (-105)
|
|
Oct 4, 2025 4:00PM EDT
Michigan State Spartans
Nebraska Cornhuskers
10/4/25 4PM
MICHST
NEB
|
–
–
|
+360
-480
|
+12.5 (-105)
-12.5 (-115)
|
O 53.5 (-110)
U 53.5 (-110)
|
CFB Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers SMU Mustangs vs. Louisville Cardinals on October 05, 2024 at L&N Federal Credit Union Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our CFB odds pages, and compare prices before you place a bet.
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LEAN | %WIN | UNITS | RESULT |
---|---|---|---|---|
TULANE@OLEMISS | MISS -11.5 | 54.3% | 4 | WIN |
UNC@UCF | UCF -6.5 | 54.4% | 4 | WIN |
ARKST@KENSAW | KENSAW +4.5 | 54.5% | 4 | WIN |
ILL@IND | IND -6 | 53.2% | 3 | WIN |
SELOU@LSU | LSU -47.5 | 55.3% | 5 | LOSS |
TNMART@MIZZST | MIZZST -14.5 | 56.2% | 6 | WIN |
FRESNO@HAWAII | HAWAII +3 | 56.6% | 6 | WIN |
MRSHL@MTSU | MTSU +2.5 | 56.8% | 6 | LOSS |
MICH@NEB | NEB +1.5 | 57.3% | 7 | LOSS |
WASH@WASHST | DENZEL BOSTON UNDER 69.5 RECV YDS | 56.2% | 6 | LOSS |
IOWA@RUT | ANTWAN RAYMOND OVER 0.5 TOUCHDOWNS | 54.4% | 4 | WIN |
GEORGIA@TENN | UNDER 50.5 | 55.5% | 6 | LOSS |
ARK@OLEMISS | MISS -225 | 72.0% | 9 | WIN |
DUKE@TULANE | TULANE -120 | 56.5% | 4 | WIN |
ARK@OLEMISS | MISS -6.5 | 53.9% | 3 | LOSS |
AKRON@UAB | UAB -11 | 54.7% | 4 | LOSS |
UCONN@DEL | DEL +9.5 | 55.0% | 5 | WIN |
APLST@USM | USM +4 | 55.3% | 6 | WIN |
MERIMK@KENSAW | KENSAW -13.5 | 56.2% | 7 | WIN |
UMASS@IOWA | IOWA -34.5 | 56.4% | 7 | WIN |
UMASS@IOWA | JAZIUN PATTERSON UNDER 0.5 RUSH TDS | 54.8% | 4 | WIN |
NMEX@UCLA | NICO IAMALEAVA UNDER 31.5 PASS ATT | 53.4% | 3 | LOSS |
KSTATE@ARIZ | ARIZ +1.5 | 56.1% | 6 | WIN |
BC@MICHST | NICK MARSH OVER 47.5 RCV YDS | 53.6% | 3 | WIN |
ARIZST@MISSST | MISSST +7 | 54.2% | 4 | WIN |
TULSA@NMEXST | NMEXST +3.5 | 56.9% | 6 | WIN |
UCLA@UNLV | OVER 54.5 | 56.2% | 6 | LOSS |
FRESNO@OREGST | FRESNO +1.5 | 54.7% | 4 | WIN |
VANDY@VATECH | VANDY +2.5 | 55.8% | 5 | WIN |
JMAD@LVILLE | LVILLE -14.5 | 54.0% | 3 | LOSS |
TCU@UNC | JOSEPH MANJACK OVER 37.5 RECV YDS | 53.8% | 3 | LOSS |
ND@MIAMI | MIAMI +3 | 55.2% | 6 | WIN |
MISSST@USM | USM +14.5 | 56.0% | 6 | LOSS |
UTAH@UCLA | UCLA +5.5 | 56.2% | 6 | LOSS |
CAL@OREGST | OREGST +1.5 | 55.1% | 5 | LOSS |
FAU@MD | MD -13.5 | 55.2% | 5 | WIN |
GAS@FRESNO | FRESNO +2 | 55.2% | 5 | WIN |
TOLEDO@UK | UK -9.5 | 56.2% | 6 | LOSS |
AUSTPEAY@MTSU | PEAY +12.5 | 56.2% | 6 | WIN |
LSU@CLEM | GARRETT NUSSMEIER OVER 23.5 PASS COMP | 54.1% | 3 | WIN |
WMICH@MICHST | WMICH +21.5 | 56.2% | 6 | WIN |
ND@OHIOST | WILL HOWARD INTERCEPTIONS OVER 0.5 | 54.80% | 4 | LOSS |
OHIOST@TEXAS | WILL HOWARD PASS + RUSH YDS UNDER 262.5 | 54.70% | 4 | LOSS |
GEORGIA@TEXAS | TEXAS -144 | 54.40% | 4 | LOSS |
AUBURN@BAMA | PAYTON THORNE PASS TDS - UNDER 1.5 | 53.20% | 3 | WIN |
PURDUE@IND | IND -28.5 | 53.90% | 3 | WIN |
FRESNO@UCLA | T.J. HARDEN LONGEST RUSH OVER 17.5 YDS | 54.50% | 4 | LOSS |
TENN@VANDY | VANDY +10.5 | 54.90% | 4 | LOSS |
WVU@TXTECH | TXTECH -2.5 | 54.60% | 4 | WIN |
SC@CLEM | CLEM -130 | 58.70% | 4 | LOSS |
TCU@CINCY | TCU -3 | 54.20% | 4 | WIN |