Jacksonville returns from its bye as a 7.5-point favorite against a Colts team riding three straight losses. Trevor Lawrence has the stronger passing profile, but Jonathan Taylor gives Indianapolis a credible way to shorten this divisional matchup.
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| Sportsbook | Spread | Moneyline | Total |
|---|---|---|---|
| FanDuel | IND +7.5 JAC -7.5 | IND +330 JAC -420 | O 46.5 U 46.5 |
| DraftKings | IND +7.5 JAC -7.5 | IND +310 JAC -395 | O 46.5 U 46.5 |
| BetMGM | IND +7.5 JAC -7.5 | IND +310 JAC -400 | O 46.5 U 46.5 |
| BetRivers | IND +7.5 JAC -7.5 | IND +320 JAC -420 | O 46.5 U 46.5 |
| Fanatics | IND +8 JAC -8 | IND +310 JAC -400 | O 46.5 U 46.5 |
| Bovada | IND +8 JAC -8 | IND +305 JAC -410 | O 46.5 U 46.5 |
| BetOnline.ag | IND +8 JAC -8 | IND +310 JAC -390 | O 46.5 U 46.5 |
| LowVig.ag | IND +8 JAC -8 | IND +310 JAC -390 | O 46.5 U 46.5 |
| MyBookie.ag | IND +7.5 JAC -7.5 | IND +300 JAC -400 | O 46.5 U 46.5 |
| BetUS | IND +8 JAC -8 | IND +312 JAC -390 | O 46.5 U 46.5 |
| Caesars | IND +7.5 JAC -7.5 | IND +295 JAC -380 | O 46.5 U 46.5 |
Injury Report
Indianapolis ruled out cornerback Sauce Gardner with a calf injury, tight end Tyler Warren with a groin injury, linebacker CJ Allen with an ankle injury and receiver Anthony Gould with a concussion for its October 25 game. Their Week 8 status requires a new report. Jacksonville last listed cornerbacks Montaric Brown and Jaylon Jones with hamstring concerns, while tackle Anton Harrison was on injured reserve. Those secondary and protection situations matter more than speculative availability projections.
Key Players
Key Matchup Edge
Jacksonville owns the cleaner passing matchup: Lawrence averages roughly 247 passing yards per game with 14 touchdowns against four interceptions, while Daniel Jones has four passing touchdowns and seven picks in seven outings. The Colts need efficient Taylor runs to protect Jones and avoid obvious passing downs against a favored home defense.
3 Things to Watch
- Taylor carries against Jacksonville run fronts
- Lawrence efficiency against depleted Colts coverage
- Fourth-quarter margin around seven points
Betting Breakdown
Jacksonville is a 7.5-point home favorite with the total at 46.5 for its first 2026 meeting against Indianapolis. The Jaguars are 4-2 and fresh off a bye after a 34-31 loss to Houston in London. They have won both games played at EverBank Stadium this season, holding Cleveland and New England to 10 and six points. Trevor Lawrence has delivered 14 touchdown passes in six games, a sharp contrast with Daniel Jones, whose seven interceptions exceed his four passing touchdowns. Indianapolis fell to 2-5 after a 16-10 loss at Minnesota, its third consecutive defeat. The Colts generated just 108 gross passing yards that afternoon, even as Jonathan Taylor ran for 95 yards and a score. Taylor is the underdogs clearest path to control possession and limit Jacksonville possessions. Indianapolis has nonetheless posted a 4-3 ATS record, compared with Jacksonville at 3-3, which cautions against equating the win-loss gap with spread value. Jacksonville swept both 2025 meetings. The primary handicap is whether the Jaguars convert their passing advantage into a margin beyond one touchdown.
Indianapolis Betting Outlook
Indianapolis enters at 2-5 following losses to Pittsburgh, Tennessee and Minnesota. Its 4-3 ATS mark is more competitive than its win-loss record, but the offense has recently struggled to sustain explosive passing production. Daniel Jones completed 13 of 22 passes for 108 yards with an interception against Minnesota, absorbing four sacks. Jonathan Taylor supplied 95 rushing yards and the lone Colts touchdown, extending a season that includes 587 yards and eight rushing scores. Taylor and the ground game must keep Indianapolis ahead of schedule against a Jacksonville defense that has been sturdy in its two true home dates. Watch the status of tight end Tyler Warren and cornerback Sauce Gardner after their Week 7 absences.
Jacksonville Betting Outlook
Jacksonville sits atop the division at 4-2 and comes off its Week 7 bye, giving the Jaguars preparation time after two straight London games. Trevor Lawrence leads the passing game with 1,480 yards, 14 touchdowns and four interceptions; Parker Washington has 416 receiving yards and four scores. Bhayshul Tuten leads the ground attack with 388 rushing yards. Jacksonville has defeated Cleveland 34-10 and New England 35-6 in its two games at EverBank Stadium, but the 3-3 ATS record underlines that not every Jaguars victory has cleared market expectations. The defense will look to pressure Daniel Jones and force Indianapolis away from a Taylor-centered plan. Monitor the Jaguars secondary health before laying a full touchdown plus the hook.
Latest Team Buzz
Takedowns by Tomi https://t.co/JBBcc9WiYc
— Indianapolis Colts (@Colts) October 25, 2026
See you tomorrow night as Chris Rodriguez Jr. joins us for All Access at Strings Sports Brewery! Live every Monday at 7pm on FOX30. @FieldsAuto | #DUUUVAL https://t.co/PfVkUnOylq
— Jacksonville Jaguars (@Jaguars) October 26, 2026
Indianapolis Colts vs Jacksonville Jaguars FAQ
What is the current spread for Indianapolis Colts vs Jacksonville Jaguars?
The current home spread is JAC -7.5, while the away spread is IND +7.5.
How far has the spread moved for Indianapolis Colts vs Jacksonville Jaguars?
The spread opened at JAC -4.5 and is now JAC -7.5.
What is the current moneyline for Indianapolis Colts vs Jacksonville Jaguars?
The current moneyline is IND +310 / JAC -395.
How far has the moneyline moved for Indianapolis Colts vs Jacksonville Jaguars?
The moneyline opened at IND +180 / JAC -218 and is now IND +310 / JAC -395.
What is the current total for Indianapolis Colts vs Jacksonville Jaguars?
The current total is 46.5.
How far has the total moved for Indianapolis Colts vs Jacksonville Jaguars?
The total opened at 49.5 and is now 46.5.
Is the market taking the underdog in Indianapolis Colts vs Jacksonville Jaguars?
Current market signal: Market Widening.
Is the market taking the favorite in Indianapolis Colts vs Jacksonville Jaguars?
Current market signal: Favorite Taking Support.
Is the total dropping for Indianapolis Colts vs Jacksonville Jaguars?
Current totals signal: Total Dropping.
Is the total rising for Indianapolis Colts vs Jacksonville Jaguars?
Current totals signal: Total Dropping.
Where to watch Indianapolis Colts vs Jacksonville Jaguars?
You can watch this game on CBS. For the latest broadcast details, see Where to Watch.
Where to stream Indianapolis Colts vs Jacksonville Jaguars?
You can stream this game on Paramount+.
What is the best free prop bet for Indianapolis Colts vs Jacksonville Jaguars?
Brenton Strange Over 38.5 Receiving Yards
What is the biggest matchup edge for Indianapolis Colts vs Jacksonville Jaguars?
Jacksonville owns the cleaner passing matchup: Lawrence averages roughly 247 passing yards per game with 14 touchdowns against four interceptions, while Daniel Jones has four passing touchdowns and seven picks in seven outings. The Colts need efficient Taylor runs to protect Jones and avoid obvious passing downs against a favored home defense.
NFL Past Picks
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