Bills vs Browns Prediction — AI Finds CAN'T MISS NFL Lines & Props (Dec 21)
Updated: 2025-12-14T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.
GAME INFO
Date: Dec 21, 2025
Start Time: 1:00 PM EST
Venue:
Browns Record:
Bills Record:
OPENING ODDS
BUF Moneyline:
CLE Moneyline:
BUF Spread: 0
CLE Spread:
Over/Under:
BUF
Betting Trends
CLE
Betting Trends
MATCHUP TRENDS
BUF vs. CLE
Best Prop Bet
LIVE NFL ODDS
NFL ODDS COMPARISON
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Buffalo vs Cleveland Prediction & Odds:
Free NFL Betting Insights for 12/21/25
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Buffalo Bills NFL Preview
Credit: USA TODAY/IMAGN
Cleveland Browns NFL Preview
Buffalo vs Cleveland Prop Picks (AI)
AI algorithm Remi is pouring through mountains of data on each team. In fact, anytime the Bills and Browns play there’s always several intriguing trends to key in on. Not to mention games played at in Dec seemingly never follow normal, predictable patterns.
Buffalo vs Cleveland Prediction (AI)
Remi, our AI sports algorithm, has been pouring over mountains of data from every past game between the Bills and Browns and using recursive machine learning and cutting-edge AI to examine the data to a single cover probability.
The Algorithm has been most watching on the trending emphasis human bettors regularly put on coaching factors between a Bills team going up against a possibly improved Browns team. Trends look to say the true game analytics might reflect a slight lean against one Vegas line specifically.
Unlock this in-depth AI prediction and all of our NFL AI picks for FREE now.
Below is our current AI Buffalo vs Cleveland picks, computer picks Bills vs Browns, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
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| NFL | 12/4 | DAL@DET | UNLOCK THIS PICK | 7 |
VAULT v4
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| NFL | 12/4 | DAL@DET | UNLOCK THIS PICK | 4 |
EXECUTIVE
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| NFL | 12/4 | DAL@DET | UNLOCK THIS PICK | 1 |
INTEL
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These picks update as information changes—injury reports, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full NFL schedule.
Buffalo Betting Trends
Cleveland Betting Trends
Bills vs. Browns Matchup Trends
Buffalo vs. Cleveland Game Info
Buffalo vs Cleveland starts on December 21, 2025 at 1:00 PM EST.
Venue: .
Spread: Cleveland
Moneyline: Buffalo , Cleveland
Over/Under:
Buffalo: | Cleveland:
. Prices move—always shop for the best number.
BUF trend:
CLE trend:
See our latest NFL picks and odds pages for 2025 to compare prices before you bet.
Buffalo vs. Cleveland Odds
AI algorithm Remi is pouring through mountains of stats on each team. In fact, anytime the Buffalo vs Cleveland trends are analyzed, there’s always several intriguing trends to key in on. Not to mention games played at extreme altitude rarely follow normal, predictable betting trends.
| BUF Moneyline | |
|---|---|
| CLE Moneyline | |
| BUF Spread | 0 |
| CLE Spread | |
| Over / Under |
Buffalo vs Cleveland Live Odds
| Games | PTS | ML | SPR | O/U | |
|---|---|---|---|---|---|
|
Dec 7, 2025 1:00PM EST
New Orleans Saints
Tampa Bay Buccaneers
12/7/25 1PM
Saints
Buccaneers
|
–
–
|
+350
-450
|
+9 (-110)
-9 (+100)
|
O 41.5 (-109)
U 41.5 (-105)
|
|
|
Dec 7, 2025 1:00PM EST
Indianapolis Colts
Jacksonville Jaguars
12/7/25 1PM
Colts
Jaguars
|
–
–
|
-130
+110
|
-1.5 (-109)
+1.5 (-101)
|
O 46.5 (-107)
U 46.5 (-107)
|
|
|
Dec 7, 2025 1:00PM EST
Pittsburgh Steelers
Baltimore Ravens
12/7/25 1PM
Steelers
Ravens
|
–
–
|
+215
-260
|
+5.5 (-110)
-5.5 (+100)
|
O 42.5 (-110)
U 42.5 (-104)
|
|
|
Dec 7, 2025 1:00PM EST
Washington Commanders
Minnesota Vikings
12/7/25 1PM
Commanders
Vikings
|
–
–
|
+103
-123
|
+2 (-110)
-2 (+100)
|
O 42.5 (-112)
U 42.5 (-103)
|
|
|
Dec 7, 2025 1:00PM EST
Cincinnati Bengals
Buffalo Bills
12/7/25 1PM
Bengals
Bills
|
–
–
|
+219
-265
|
+5.5 (-103)
-5.5 (-107)
|
O 53.5 (-113)
U 53.5 (-102)
|
|
|
Dec 7, 2025 1:00PM EST
Miami Dolphins
New York Jets
12/7/25 1PM
Dolphins
Jets
|
–
–
|
-148
+128
|
-3 (+105)
+3 (-116)
|
O 41.5 (-104)
U 41.5 (-110)
|
|
|
Dec 7, 2025 1:00PM EST
Seattle Seahawks
Atlanta Falcons
12/7/25 1PM
Seahawks
Falcons
|
–
–
|
-345
+278
|
-7 (+101)
+7 (-112)
|
O 44.5 (-107)
U 44.5 (-107)
|
|
|
Dec 7, 2025 1:00PM EST
Tennessee Titans
Cleveland Browns
12/7/25 1PM
Titans
Browns
|
–
–
|
+177
-205
|
+4 (-110)
-4 (+100)
|
O 34 (-107)
U 34 (-107)
|
|
|
Dec 7, 2025 4:05PM EST
Denver Broncos
Las Vegas Raiders
12/7/25 4:05PM
Broncos
Raiders
|
–
–
|
-400
+316
|
-7.5 (+102)
+7.5 (-113)
|
O 40.5 (-104)
U 40.5 (-110)
|
|
|
Dec 7, 2025 4:25PM EST
Los Angeles Rams
Arizona Cardinals
12/7/25 4:25PM
Rams
Cardinals
|
–
–
|
-410
+324
|
-8 (-108)
+8 (-102)
|
O 47.5 (-107)
U 47.5 (-107)
|
|
|
Dec 7, 2025 4:25PM EST
Chicago Bears
Green Bay Packers
12/7/25 4:25PM
Bears
Packers
|
–
–
|
+245
-300
|
+6.5 (+101)
-6.5 (-112)
|
O 44.5 (-107)
U 44.5 (-107)
|
|
|
Dec 7, 2025 8:20PM EST
Houston Texans
Kansas City Chiefs
12/7/25 8:20PM
Texans
Chiefs
|
–
–
|
+157
-180
|
+3 (+105)
-3 (-116)
|
O 41.5 (-107)
U 41.5 (-107)
|
|
|
Dec 8, 2025 8:15PM EST
Philadelphia Eagles
Los Angeles Chargers
12/8/25 8:15PM
Eagles
Chargers
|
–
–
|
-146
+126
|
-2.5 (-108)
+2.5 (-102)
|
O 40.5 (-113)
U 40.5 (-102)
|
|
|
Dec 11, 2025 8:15PM EST
Atlanta Falcons
Tampa Bay Buccaneers
12/11/25 8:15PM
Falcons
Buccaneers
|
–
–
|
+235
-290
|
+6 (-105)
-6 (-105)
|
O 44.5 (-107)
U 44.5 (-107)
|
|
|
Dec 14, 2025 1:00PM EST
New York Jets
Jacksonville Jaguars
12/14/25 1PM
Jets
Jaguars
|
–
–
|
+420
-560
|
+9.5 (-105)
-9.5 (-105)
|
O 43 (-107)
U 43 (-107)
|
|
|
Dec 14, 2025 1:00PM EST
Baltimore Ravens
Cincinnati Bengals
12/14/25 1PM
Ravens
Bengals
|
–
–
|
-148
+126
|
-2.5 (-110)
+2.5 (+100)
|
O 51.5 (-107)
U 51.5 (-107)
|
|
|
Dec 14, 2025 1:00PM EST
Washington Commanders
New York Giants
12/14/25 1PM
Commanders
Giants
|
–
–
|
-126
+108
|
-1.5 (-105)
+1.5 (-105)
|
O 47.5 (-107)
U 47.5 (-107)
|
|
|
Dec 14, 2025 1:00PM EST
Las Vegas Raiders
Philadelphia Eagles
12/14/25 1PM
Raiders
Eagles
|
–
–
|
+730
-1150
|
+12.5 (-105)
-12.5 (-105)
|
O 40 (-107)
U 40 (-107)
|
|
|
Dec 14, 2025 1:00PM EST
Cleveland Browns
Chicago Bears
12/14/25 1PM
Browns
Bears
|
–
–
|
+370
-480
|
+7.5 (-105)
-7.5 (-115)
|
O 39.5 (-115)
U 39.5 (-105)
|
|
|
Dec 14, 2025 1:00PM EST
Arizona Cardinals
Houston Texans
12/14/25 1PM
Cardinals
Texans
|
–
–
|
+260
-320
|
+7 (-110)
-7 (+100)
|
O 42.5 (-107)
U 42.5 (-107)
|
NFL Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers Buffalo Bills vs. Cleveland Browns on December 21, 2025 at .
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our NFL odds pages, and compare prices before you place a bet.
|
NFL |
LEAN | %WIN | UNITS | RESULT |
|---|---|---|---|---|
| ATL@NYJ | NYJ +3 | 56.9% | 6 | WIN |
| MIN@SEA | SEA -11.5 | 54.5% | 4 | WIN |
| BUF@PIT | PIT +3.5 | 56.9% | 6 | LOSS |
| HOU@IND | IND -3 | 57.9% | 7 | LOSS |
| LAR@CAR | OVER 44.5 | 54.4% | 4 | WIN |
| CHI@PHI | CALEB WILLIAMS OVER 18.5 PASS COMP | 55.7% | 5 | LOSS |
| KC@DAL | DAL +3.5 | 56.3% | 6 | WIN |
| GB@DET | JORDAN LOVE OVER 1.5 PASS TDS | 55.6% | 5 | WIN |
| CIN@BAL | LAMAR JACKSON OVER 24.5 RUSH YDS | 56.7% | 6 | WIN |
| CAR@SF | UNDER 49.5 | 53.0% | 1 | WIN |
| CAR@SF | SF -7 | 54.0% | 3 | WIN |
| CAR@SF | BRYCE YOUNG OVER 61.7 PASS COMP PCT | 55.7% | 5 | WIN |
| NYJ@BAL | DERRICK HENRY OVER 17.5 CARRIES | 53.7% | 3 | WIN |
| JAC@ARI | ARI +2.5 | 55.2% | 5 | LOSS |
| PHI@DAL | DAL +3 | 53.3% | 2 | WIN |
| SEA@TEN | SEA -12 | 57.1% | 7 | LOSS |
| MIN@GB | GB -6 | 54.1% | 3 | WIN |
| IND@KC | IND +3.5 | 54.6% | 4 | WIN |
| TB@LAR | UNDER 49.5 | 52.4% | 1 | WIN |
| IND@KC | UNDER 50.5 | 53.1% | 2 | WIN |
| NYJ@BAL | BREECE HALL OVER 18.5 RECV YDS | 56.7% | 6 | WIN |
| PHI@DAL | JAKE ELLIOT OVER 2.5 EXTRA POINTS MADE | 55.2% | 5 | WIN |
| BUF@HOU | JAMES COOK UNDER 17.5 RUSH ATT | 54.4% | 4 | WIN |
| BUF@HOU | JOSH ALLEN UNDER 63.3 PASS COMP PCT | 56.8% | 6 | LOSS |
| DAL@LV | UNDER 49.5 | 54.3% | 3 | WIN |
| DAL@LV | BROCK BOWERS OVER 6.5 RECEPTIONS | 57.6% | 7 | WIN |
| CAR@ATL | BRYCE YOUNG UNDER 0.5 INT | 56.1% | 6 | WIN |
| KC@DEN | PATRICK MAHOMES UNDER 266.5 PASS YDS | 55.3% | 5 | LOSS |
| SF@ARI | SF -3 | 56.4% | 6 | WIN |
| GB@NYG | GB -7 | 54.3% | 4 | PUSH |
| LAC@JAC | LAC -3 | 53.2% | 3 | LOSS |
| SEA@LAR | SEA +3.5 | 57.2% | 7 | WIN |
| CHI@MIN | MIN -2.5 | 53.4% | 2 | LOSS |
| DET@PHI | DET +3 | 55.8% | 5 | LOSS |
| KC@DEN | DEN +4.5 | 53.0% | 2 | WIN |
| DET@PHI | UNDER 47 | 53.4% | 2 | WIN |
| SEA@LAR | OVER 48.5 | 54.6% | 4 | LOSS |
| NYJ@NE | UNDER 43.5 | 53.4% | 3 | WIN |
| NYJ@NE | JAMIEN SHERWOOD OVER 4.5 TACKLES | 56.8% | 6 | LOSS |
| PHI@GB | PHI +1.5 | 54.8% | 4 | WIN |
| PHI@GB | UNDER 45.5 | 52.4% | 2 | WIN |
| PHI@GB | SAQUON BARKLEY OVER 17.5 RUSH ATT | 56.6% | 6 | WIN |
| PHI@GB | JOSH JACOBS UNDER 42.5 1ST HALF RUSH + REC YDS | 54.4% | 4 | LOSS |
| NO@CAR | CAR -5 | 55.4% | 5 | LOSS |
| BAL@MIN | BAL -3.5 | 57.6% | 7 | WIN |
| CLE@NYJ | CLE -130 | 65.4% | 7 | LOSS |
| NYG@CHI | CHI -4.5 | 55.2% | 5 | LOSS |
| NE@TB | TB -2 | 56.1% | 6 | LOSS |
| LAR@SF | LAR -5.5 | 53.3% | 2 | WIN |
| JAC@HOU | UNDER 38 | 54.8% | 5 | LOSS |
| ARI@SEA | TREY MCBRIDE OVER 9 RECV TARGETS | 55.8% | 5 | WIN |