Bills vs Browns Prediction — AI Finds CAN'T MISS NFL Lines & Props (Dec 21)
Updated: 2025-12-14T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.
GAME INFO
Date: Dec 21, 2025
Start Time: 1:00 PM EST
Venue:
Browns Record:
Bills Record:
OPENING ODDS
BUF Moneyline:
CLE Moneyline:
BUF Spread: 0
CLE Spread:
Over/Under:
BUF
Betting Trends
CLE
Betting Trends
MATCHUP TRENDS
BUF vs. CLE
Best Prop Bet
LIVE NFL ODDS
NFL ODDS COMPARISON
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Buffalo vs Cleveland Prediction & Odds:
Free NFL Betting Insights for 12/21/25
Buffalo Bills NFL Preview
Credit: USA TODAY/IMAGN
Cleveland Browns NFL Preview
Buffalo vs. Cleveland Prop Picks (AI)
Buffalo vs. Cleveland Prediction (AI)
Remi, our AI sports wizard, has been pouring over tons of data from every past game between the Bills and Browns and using recursive machine learning and cutting-edge AI to examine the data to a single cover probability.
Oddly enough, we’ve seen the AI has been most focused on the growing emphasis knucklehead sportsbettors tend to put on Buffalo’s strength factors between a Bills team going up against a possibly improved Browns team. Trends look to say the true game analytics appear to reflect a strong lean against one Vegas line specifically.
Unlock this in-depth AI prediction and all of our NFL AI picks for FREE now.
Below is our current AI Buffalo vs Cleveland picks, computer picks Bills vs Browns, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
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| NFL | 11/10 | PHI@GB | UNLOCK THIS PICK | 6 |
VAULT v3
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| NFL | 11/10 | PHI@GB | UNLOCK THIS PICK | 4 |
EXECUTIVE
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| NFL | 11/10 | PHI@GB | UNLOCK THIS PICK | 4 |
EXECUTIVE
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| NFL | 11/10 | PHI@GB | UNLOCK THIS PICK | 1 |
INTEL
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full NFL Schedule.
Bills Betting Trends
Browns Betting Trends
Bills vs. Browns Matchup Trends
Buffalo vs. Cleveland Game Info
What time does Buffalo vs Cleveland start on December 21, 2025?
Buffalo vs Cleveland starts on December 21, 2025 at 1:00 PM EST.
What are the opening odds for Buffalo vs Cleveland?
Spread: Cleveland
Moneyline: Buffalo , Cleveland
Over/Under:
What are the records for Buffalo vs Cleveland?
Buffalo: | Cleveland:
What is the AI best bet for Buffalo vs Cleveland?
. Prices move—always shop for the best number.
What are Buffalo trending bets?
BUF trend:
What are Cleveland trending bets?
CLE trend:
Where can I find AI Picks for Buffalo vs Cleveland?
See our latest NFL picks and odds pages for 2025 to compare prices before you bet.
Buffalo vs. Cleveland Odds
AI algorithm Remi is pouring through loads of data on each player. In fact, anytime the Buffalo vs Cleveland trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme temps can often follow normal, predictable betting trends.
Buffalo vs Cleveland Opening Odds
BUF Moneyline:
CLE Moneyline:
BUF Spread: 0
CLE Spread:
Over/Under:
Buffalo vs Cleveland Live Odds
| Games | PTS | ML | SPR | O/U | |
|---|---|---|---|---|---|
|
Nov 13, 2025 8:15PM EST
New York Jets
New England Patriots
11/13/25 8:15PM
Jets
Patriots
|
–
–
|
+520
-800
|
+12.5 (-110)
-12.5 (-110)
|
O 43 (-110)
U 43 (-110)
|
|
|
Nov 16, 2025 9:30AM EST
Washington Commanders
Miami Dolphins
11/16/25 9:30AM
Commanders
Dolphins
|
–
–
|
+119
-153
|
+2.5 (+100)
-2.5 (-120)
|
O 47.5 (-110)
U 47.5 (-110)
|
|
|
Nov 16, 2025 1:00PM EST
Carolina Panthers
Atlanta Falcons
11/16/25 1PM
Panthers
Falcons
|
–
–
|
+155
-200
|
+3.5 (-110)
-3.5 (-110)
|
O 42.5 (-110)
U 42.5 (-110)
|
|
|
Nov 16, 2025 1:00PM EST
Chicago Bears
Minnesota Vikings
11/16/25 1PM
Bears
Vikings
|
–
–
|
+131
-169
|
+3 (-110)
-3 (-110)
|
O 48.5 (-110)
U 48.5 (-110)
|
|
|
Nov 16, 2025 1:00PM EST
Los Angeles Chargers
Jacksonville Jaguars
11/16/25 1PM
Chargers
Jaguars
|
–
–
|
-164
+129
|
-3 (-110)
+3 (-110)
|
O 44 (-110)
U 44 (-110)
|
|
|
Nov 16, 2025 1:00PM EST
Green Bay Packers
New York Giants
11/16/25 1PM
Packers
Giants
|
–
–
|
-420
+300
|
-8 (-110)
+8 (-110)
|
O 44 (-110)
U 44 (-110)
|
|
|
Nov 16, 2025 1:00PM EST
Cincinnati Bengals
Pittsburgh Steelers
11/16/25 1PM
Bengals
Steelers
|
–
–
|
+180
-236
|
+5.5 (-110)
-5.5 (-110)
|
O 49 (-110)
U 49 (-110)
|
|
|
Nov 16, 2025 1:00PM EST
Tampa Bay Buccaneers
Buffalo Bills
11/16/25 1PM
Buccaneers
Bills
|
–
–
|
+187
-248
|
+5.5 (-110)
-5.5 (-110)
|
O 49 (-110)
U 49 (-110)
|
|
|
Nov 16, 2025 1:00PM EST
Houston Texans
Tennessee Titans
11/16/25 1PM
Texans
Titans
|
–
–
|
-420
+295
|
-7 (-110)
+7 (-110)
|
O 39.5 (-110)
U 39.5 (-110)
|
|
|
Nov 16, 2025 4:05PM EST
San Francisco 49ers
Arizona Cardinals
11/16/25 4:05PM
49ers
Cardinals
|
–
–
|
-142
+111
|
-2.5 (-110)
+2.5 (-110)
|
O 49 (-110)
U 49 (-110)
|
|
|
Nov 16, 2025 4:05PM EST
Seattle Seahawks
Los Angeles Rams
11/16/25 4:05PM
Seahawks
Rams
|
–
–
|
+129
-166
|
+3 (-120)
-3 (+100)
|
O 48.5 (-110)
U 48.5 (-110)
|
|
|
Nov 16, 2025 4:25PM EST
Kansas City Chiefs
Denver Broncos
11/16/25 4:25PM
Chiefs
Broncos
|
–
–
|
-208
+160
|
-4 (-110)
+4 (-110)
|
O 44.5 (-110)
U 44.5 (-110)
|
|
|
Nov 16, 2025 4:25PM EST
Baltimore Ravens
Cleveland Browns
11/16/25 4:25PM
Ravens
Browns
|
–
–
|
-429
+300
|
-8 (-110)
+8 (-110)
|
O 41.5 (-110)
U 41.5 (-110)
|
|
|
Nov 16, 2025 8:20PM EST
Detroit Lions
Philadelphia Eagles
11/16/25 8:20PM
Lions
Eagles
|
–
–
|
-106
-120
|
+1 (-110)
-1 (-110)
|
O 49 (-110)
U 49 (-110)
|
|
|
Nov 17, 2025 8:15PM EST
Dallas Cowboys
Las Vegas Raiders
11/17/25 8:15PM
Cowboys
Raiders
|
–
–
|
-194
+150
|
-3.5 (-110)
+3.5 (-110)
|
O 50 (-110)
U 50 (-110)
|
NFL Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers Buffalo Bills vs. Cleveland Browns on December 21, 2025 at .
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our NFL odds pages, and compare prices before you place a bet.
| NFL |
LEAN | %WIN | UNITS | RESULT |
|---|---|---|---|---|
| LV@DEN | RILEY MOSS OVER 4.5 TACKLE + ASST | 54.8% | 4 | WIN |
| LV@DEN | UNDER 43 | 53.4% | 2 | WIN |
| ARI@DAL | BUDDA BAKER OVER 7.5 TACKLES + ASSTS | 54.4% | 4 | WIN |
| ARI@DAL | GEORGE PICKENS OVER 4.5 RECEPTIONS | 56.6% | 6 | WIN |
| DEN@HOU | WIL LUTZ OVER 1.5 MADE FIELD GOALS | 54.2% | 3 | LOSS |
| SEA@WAS | SEA -3 | 56.7% | 6 | WIN |
| IND@PIT | IND -3 | 56.8% | 6 | LOSS |
| LAC@TEN | LAC -9.5 | 56.2% | 6 | LOSS |
| CHI@CIN | CHI -2.5 | 52.6% | 2 | WIN |
| SEA@WAS | OVER 48 | 52.9% | 2 | WIN |
| SEA@WAS | JAYDEN DANIELS OVER 20.5 PASS COMP | 56.7% | 6 | LOSS |
| JAC@LV | JAC -140 | 64.2% | 7 | WIN |
| NO@LAR | LAR -14 | 55.0% | 4 | WIN |
| DEN@HOU | HOU -1.5 | 54.2% | 3 | LOSS |
| CAR@GB | GB -12.5 | 55.4% | 5 | LOSS |
| SF@NYG | NYG +2.5 | 56.1% | 5 | LOSS |
| BAL@MIA | TUA TAGOVAILOA UNDER 0.5 INT | 55.3% | 5 | LOSS |
| TB@NO | TB -3.5 | 52.3% | 1 | WIN |
| GB@PIT | GB -2.5 | 52.3% | 1 | WIN |
| SF@HOU | SF +2.5 | 56.0% | 6 | LOSS |
| NYG@PHI | NYG +7.5 | 53.9% | 3 | LOSS |
| BUF@CAR | CAR +7.5 | 54.2% | 3 | LOSS |
| DAL@DEN | DAL +3.5 | 55.0% | 4 | LOSS |
| MIA@ATL | MIA +7 | 54.3% | 4 | WIN |
| CLE@NE | CLE +7 | 56.8% | 6 | LOSS |
| TB@NO | BAKER MAYFIELD OVER 15.5 RUSH YDS | 56.6% | 6 | LOSS |
| MIN@LAC | JUSTIN HERBERT PASS ATT UNDER 35.5 | 55.5% | 5 | WIN |
| TB@DET | TB +6.5 | 54.4% | 4 | LOSS |
| TB@DET | RACHAAD WHITE UNDER 14.5 RUSH ATT | 54.4% | 4 | WIN |
| NE@TEN | NE -6.5 | 55.2% | 5 | WIN |
| CAR@NYJ | CAR -110 | 57.4 | 4 | WIN |
| PHI@MIN | PHI -130 | 58.0% | 6 | WIN |
| GB@ARI | ARI +7 | 54.8% | 5 | WIN |
| NO@CHI | NO +4.5 | 57.4% | 7 | LOSS |
| WAS@DAL | JAYDEN DANIELS 1H RUSH YDS OVER 22.5 | 56.1% | 5 | WIN |
| GB@ARI | JORDAN LOVE 1Q PASS YDS OVER 54.5 | 56.6% | 6 | WIN |
| PIT@CIN | JONNU SMITH RECEPTIONS OVER 3.5 | 55.3% | 5 | LOSS |
| BUF@ATL | BUF -3.5 | 54.7% | 4 | LOSS |
| CHI@WAS | JAYDEN DANIELS OVER 1.5 PASS TDS | 56.6% | 6 | WIN |
| TEN@LV | UNDER 42 | 54.8% | 3 | WIN |
| DET@KC | DET +2.5 | 55.7% | 7 | LOSS |
| SEA@JAC | SEA -112 | 55.7% | 5 | WIN |
| LAC@MIA | LAC -3.5 | 54.0% | 3 | LOSS |
| ARI@IND | IND -8.5 | 55.6% | 5 | LOSS |
| TEN@LV | TEN +4.5 | 56.7% | 6 | LOSS |
| LAR@BAL | LAR -7 | 56.2% | 6 | WIN |
| SF@TB | SF +3.5 | 57.2% | 7 | LOSS |
| CLE@PIT | JAYLEN WARREN UNDER 46.5 RUSH YDS | 54.4% | 4 | LOSS |
| DEN@NYJ | BREECE HALL OVER 26.5 RECV YDS | 55.0% | 4 | LOSS |
| KC@JAC | UNDER 45.5 | 54.9% | 3 | LOSS |
| KC@JAC | PATRICK MAHOMES UNDER 23.5 PASS COMP | 56.6% | 6 | LOSS |