Jaguars vs Cardinals Prediction — AI Finds CAN'T MISS NFL Lines & Props (Nov 23)
Updated: 2025-11-16T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The Jacksonville Jaguars travel to face the Arizona Cardinals on November 23, 2025 in a matchup of optimism versus reconstruction—Jacksonville arrives at 6–4, riding defensive confidence and increased tempo, while Arizona stands at 3–7, still seeking structural identity and clarity under a young roster in transition.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.
GAME INFO
Date: Nov 23, 2025
Start Time: 5:05 PM EST
Venue: State Farm Stadium
Cardinals Record: (3-7)
Jaguars Record: (6-4)
OPENING ODDS
JAX Moneyline: -148
ARI Moneyline: +124
JAX Spread: -2.5
ARI Spread: +2.5
Over/Under: 47.5
JAX
Betting Trends
- Jacksonville holds an ATS record of approximately 4-5 (44.4%), suggesting that while they’ve had success, they’ve not consistently covered as favorites.
ARI
Betting Trends
- Arizona carries an ATS mark of about 5-4 (55.6%), indicating slightly better cover performance than their win total would suggest.
MATCHUP TRENDS
- From an ATS perspective, this matchup presents subtle value: the under-dog Cardinals’ modest cover rate and the Jaguars’ near-50% road cover history suggest the spread may lean toward the visitor, yet Jacksonville’s rising momentum and Arizona’s back-foot posture complicate public perception—meaning tempo, turnovers, and hidden yardage will likely influence the spread more than outcomes alone.
JAX vs. ARI
Best Prop Bet
- Remi's searched hard and found the best prop for this matchup: B. Knight over 45.5 Rushing Yards.
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Jacksonville vs Arizona Prediction & Odds:
Free NFL Betting Insights for 11/23/25
The matchup between the Jacksonville Jaguars and the Arizona Cardinals on November 23, 2025 arrives as one of Week 12’s most intriguing contrasts, pairing a Jaguars team steadily crafting a late-season surge with an Arizona squad still wrestling with inconsistency, identity gaps, and personnel limitations, creating a game shaped heavily by tempo, situational execution, and each team’s ability to impose its preferred style over four quarters. Jacksonville enters with a 6–4 record rooted in defensive improvement, cleaner offensive rhythm, and a growing comfort in leveraging tempo and balance to control possessions, and their ability to generate pressure, win early downs, and create turnovers has shifted them from an opportunistic team into one capable of dictating game flow. Arizona, at 3–7, remains a team in transition, battling injuries in the backfield, relying on Jacoby Brissett to stabilize drives, and struggling to consistently protect the passer or sustain their run game long enough to keep defenses honest, which places a premium on quick-game passing, motion concepts, and avoiding third-and-long situations that have been a recurring problem this season. For Jacksonville, the blueprint is clear: maintain pace, protect the football, use defensive physicality to disrupt Arizona’s timing, and force Brissett into throws that invite turnover opportunities, while offensively using balance to set up explosive shots against an Arizona defense that has struggled to contain perimeter speed and maintain discipline on extended drives.
For Arizona, the task is equally clear but more complex: minimize negative plays, slow Jacksonville’s tempo with sustained possessions, win early-down efficiency, and depend on defensive opportunism to shorten the field, as allowing Jacksonville to control momentum would tilt the game quickly. Special teams and hidden yardage may become the quiet determining factors, as both teams experience fluctuations in penalty discipline and kickoff coverage, and games involving rebuilding teams often swing on field position more than box-score metrics would suggest. Emotionally, the teams arrive from different vantage points—Jacksonville playing like a group discovering its stride and trusting its structure, while Arizona, though struggling, still carries enough competitive fire at home to challenge opponents when early confidence builds and crowd energy translates to defensive urgency. The Jaguars hold advantages in continuity, efficiency, and late-game execution, but the Cardinals’ ability to disrupt rhythm and turn the contest into a grind cannot be dismissed, especially if they generate early turnovers. Ultimately, this matchup hinges on which team controls first- and second-down success, manages pressure situations with poise, and keeps the game within the script most favorable to its strengths, with Jacksonville seeking to impose structure and Arizona trying to break it, creating a compelling, layered contest defined by tempo, discipline, and resilience rather than headline star power alone.
Get live NFL odds and precise AI NFL picks, predictions, and cover probabilities.
Nothing to be shocked about#DUUUVAL pic.twitter.com/2ewCM9t8lt
— Jacksonville Jaguars (@Jaguars) November 17, 2025
Jacksonville Jaguars NFL Preview
The Jacksonville Jaguars enter this matchup against the Arizona Cardinals looking like a team gaining traction at the right time, building their identity around efficiency, physicality, and situational discipline, and their away performance has increasingly reflected a group comfortable imposing its style in hostile environments through balanced offense and opportunistic defense, making them a difficult opponent for any team struggling with consistency. Offensively, Jacksonville has leaned into a rhythmic approach that blends calculated early-down passing with a steady run presence designed to keep defenses honest and create manageable third-down situations, and this formula has traveled well because it minimizes volatility and reduces the likelihood of road-game momentum swings. Their quarterback play has stabilized, with improved decision-making under pressure and better recognition of disguised coverages, while the receiving corps has grown more reliable in spacing, route integrity, and yards-after-catch efficiency, enabling the Jaguars to sustain drives even without relying on explosive plays every series. On the ground, their committee approach has functioned effectively behind improved run-blocking angles and a commitment to inside-zone concepts that help them wear down fronts over time, which becomes especially valuable on the road where quieting a home crowd requires consistent, patient ball control. Defensively, Jacksonville’s growth has been even more pronounced, particularly in their ability to generate pressure without sacrificing coverage integrity, and their road performances have highlighted a defense that thrives on forcing opponents into predictable situations, capitalizing on mistakes, and limiting big-play vulnerabilities that once plagued them in prior seasons.
Their edge rushers have become tone-setters early in games, their linebackers have improved in coverage discipline, and the secondary has demonstrated better communication and leverage, all of which make them more resilient when facing offenses that rely heavily on quick timing throws or horizontal spacing to create rhythm. On special teams, the Jaguars have been more consistent than in previous seasons, reducing penalties, improving field-goal reliability, and managing field position effectively enough to influence the hidden-yardage battles that often determine road outcomes. Psychologically, Jacksonville carries the profile of a team growing in confidence away from home, trusting its game plan more fully, and demonstrating poise in fourth-quarter situations that previously derailed them, showing that their improved structure is traveling as well as their talent. While they are not immune to slow starts or occasional lapses in red-zone execution, their recent road form suggests a team capable of controlling tempo, dictating physicality, and exploiting opponents who struggle to maintain operational consistency for four quarters, making the Jaguars a formidable away presence as they continue their push in the AFC playoff hunt.
Credit: USA TODAY/IMAGN
Arizona Cardinals NFL Preview
The Arizona Cardinals return home for this matchup against the Jacksonville Jaguars looking to stabilize a season defined by flashes of promise mixed with stretches of uneven execution, and their ability to harness the energy of their home crowd has been central to their competitive peaks, making State Farm Stadium a venue where their speed, creativity, and defensive intensity often elevate noticeably. Offensively, Arizona’s identity continues to revolve around pace, spacing, and quarterback improvisation, with their attack showing its most dangerous form when they blend quick-game timing with vertical shots that challenge defensive structure and force opponents into coverage conflicts, particularly when their receivers are winning isolated matchups and their motion packages create leverage advantages. Their quarterback has shown improvement at home in both pre-snap recognition and post-snap decision-making, particularly against disguised pressure looks, and the added comfort of playing indoors—without weather variance—sharpens the precision of their route timing, ball velocity, and downfield accuracy, allowing them to sustain drives and maintain an aggressive tempo. Their run game, while inconsistent on the road, tends to find better rhythm at home thanks to cleaner blocking communication and the ability to exploit defensive fronts that fail to match their speed, giving them a more balanced play-calling profile that helps prevent defenses from overloading coverage and crashing passing lanes. Defensively, the Cardinals become significantly more assertive at home, often using crowd noise to disrupt opposing offensive timing while leaning into their strengths as a unit built on burst, range, and multiplicity, and their pass rush especially benefits from early-down energy as their edge defenders fire off with more explosiveness, creating pressure that forces hurried throws or compresses the pocket into high-traffic zones where turnovers become more likely.
Their secondary thrives when the front seven generates disruption, and at home they have shown better communication in combo coverages, improved tackling angles, and tighter spacing in the intermediate zones, making them a much more competitive defensive group than their road splits typically indicate. The Cardinals’ special teams also trend upward at home, with more consistent return production and stronger punt coverage that often flips field position in their favor, providing their offense shorter fields and reducing the strain on their defense in extended drives. Intangibly, Arizona plays with greater urgency and confidence at home, drawing energy from the crowd and showing sharper execution in red-zone opportunities where noise becomes a factor for opponents and where their play designs—rich in misdirection, motion, and option elements—tend to flourish. While they still face challenges in maintaining four-quarter consistency and avoiding the costly turnovers or defensive lapses that have occasionally undermined winnable games, the Cardinals’ home form underscores a team capable of competing with playoff-caliber opponents when their rhythm aligns, and their matchup with Jacksonville provides another proving ground for a squad eager to demonstrate that its progress is real, repeatable, and building toward a stronger long-term foundation.
Jacoby finds his way into the record book ✍️ pic.twitter.com/ABOj8b6iDK
— Arizona Cardinals (@AZCardinals) November 17, 2025
Jacksonville vs Arizona Prop Picks (AI)
AI algorithm Remi is pouring through tons of data on each line. In fact, anytime the Jaguars and Cardinals play there’s always several intriguing trends to key in on. Not to mention games played at State Farm Stadium in Nov can often follow normal, predictable betting trends.
Jacksonville vs Arizona Prediction (AI)
Remi, our AI sports algorithm, has been pouring over mountains of data from every facet between the Jaguars and Cardinals and using recursive machine learning and kick-ass AI to boil down the data to a single cover probability.
Remi has been most fixated on the linear correlation of emphasis human bettors tend to put on player performance factors between a Jaguars team going up against a possibly rested Cardinals team. In reality, the true game analytics might reflect a strong lean against one Vegas line specifically.
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Below is our current AI Jacksonville vs Arizona picks, computer picks Jaguars vs Cardinals, best bets, model edges, confidence ratings.
| DATE | GAME | LEAN | %WIN | UNITS | LEVEL | |
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| NFL | 12/4 | DAL@DET | UNLOCK THIS PICK | 7 |
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| NFL | 12/4 | DAL@DET | UNLOCK THIS PICK | 4 |
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| NFL | 12/4 | DAL@DET | UNLOCK THIS PICK | 1 |
INTEL
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These picks update as information changes—injury reports, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full NFL schedule.
Jacksonville Betting Trends
Jacksonville holds an ATS record of approximately 4-5 (44.4%), suggesting that while they’ve had success, they’ve not consistently covered as favorites.
Arizona Betting Trends
Arizona carries an ATS mark of about 5-4 (55.6%), indicating slightly better cover performance than their win total would suggest.
Jaguars vs. Cardinals Matchup Trends
From an ATS perspective, this matchup presents subtle value: the under-dog Cardinals’ modest cover rate and the Jaguars’ near-50% road cover history suggest the spread may lean toward the visitor, yet Jacksonville’s rising momentum and Arizona’s back-foot posture complicate public perception—meaning tempo, turnovers, and hidden yardage will likely influence the spread more than outcomes alone.
Jacksonville vs. Arizona Game Info
Jacksonville vs Arizona starts on November 23, 2025 at 5:05 PM EST.
Venue: State Farm Stadium.
Spread: Arizona +2.5
Moneyline: Jacksonville -148, Arizona +124
Over/Under: 47.5
Jacksonville: (6-4) | Arizona: (3-7)
Remi's searched hard and found the best prop for this matchup: B. Knight over 45.5 Rushing Yards.. Prices move—always shop for the best number.
From an ATS perspective, this matchup presents subtle value: the under-dog Cardinals’ modest cover rate and the Jaguars’ near-50% road cover history suggest the spread may lean toward the visitor, yet Jacksonville’s rising momentum and Arizona’s back-foot posture complicate public perception—meaning tempo, turnovers, and hidden yardage will likely influence the spread more than outcomes alone.
JAX trend: Jacksonville holds an ATS record of approximately 4-5 (44.4%), suggesting that while they’ve had success, they’ve not consistently covered as favorites.
ARI trend: Arizona carries an ATS mark of about 5-4 (55.6%), indicating slightly better cover performance than their win total would suggest.
See our latest NFL picks and odds pages for 2025 to compare prices before you bet.
Jacksonville vs. Arizona Odds
AI algorithm Remi is pouring through tons of data points on each player. In fact, anytime the Jacksonville vs Arizona trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme travel distance rarely follow normal, predictable patterns.
| JAX Moneyline | -148 |
|---|---|
| ARI Moneyline | +124 |
| JAX Spread | -2.5 |
| ARI Spread | +2.5 |
| Over / Under | 47.5 |
Jacksonville vs Arizona Live Odds
| Games | PTS | ML | SPR | O/U | |
|---|---|---|---|---|---|
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–
–
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+330
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U 41.5 (-110)
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Indianapolis Colts
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-130
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O 47.5 (-115)
U 47.5 (-105)
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Pittsburgh Steelers
Baltimore Ravens
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–
–
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+210
-258
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O 42.5 (-112)
U 42.5 (-108)
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Dec 7, 2025 1:00PM EST
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–
–
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-105
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O 42.5 (-112)
U 42.5 (-108)
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Dec 7, 2025 1:00PM EST
Cincinnati Bengals
Buffalo Bills
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Bengals
Bills
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–
–
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+220
-270
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+5.5 (+100)
-5.5 (-120)
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O 53.5 (-112)
U 53.5 (-108)
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Dec 7, 2025 1:00PM EST
Miami Dolphins
New York Jets
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Jets
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–
–
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-155
+130
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-2.5 (-120)
+2.5 (+100)
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O 41.5 (-110)
U 41.5 (-110)
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Dec 7, 2025 1:00PM EST
Seattle Seahawks
Atlanta Falcons
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Seahawks
Falcons
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–
–
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-355
+280
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-7 (-105)
+7 (-115)
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O 44.5 (-112)
U 44.5 (-108)
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Dec 7, 2025 1:00PM EST
Tennessee Titans
Cleveland Browns
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Titans
Browns
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–
–
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+180
-218
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+4.5 (-115)
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O 33.5 (-115)
U 33.5 (-105)
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Dec 7, 2025 4:05PM EST
Denver Broncos
Las Vegas Raiders
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Broncos
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–
–
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-410
+320
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-7.5 (-108)
+7.5 (-112)
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O 40.5 (+102)
U 40.5 (-122)
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Dec 7, 2025 4:25PM EST
Los Angeles Rams
Arizona Cardinals
12/7/25 4:25PM
Rams
Cardinals
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–
–
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-455
+350
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-8.5 (-105)
+8.5 (-115)
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O 47.5 (-110)
U 47.5 (-110)
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Dec 7, 2025 4:25PM EST
Chicago Bears
Green Bay Packers
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Bears
Packers
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–
–
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+270
-340
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+6.5 (-105)
-6.5 (-115)
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O 44.5 (-110)
U 44.5 (-110)
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Dec 7, 2025 8:20PM EST
Houston Texans
Kansas City Chiefs
12/7/25 8:20PM
Texans
Chiefs
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–
–
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+150
-180
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+3.5 (-115)
-3.5 (-105)
|
O 41.5 (-115)
U 41.5 (-105)
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Dec 8, 2025 8:15PM EST
Philadelphia Eagles
Los Angeles Chargers
12/8/25 8:15PM
Eagles
Chargers
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–
–
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-148
+124
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-2.5 (-115)
+2.5 (-105)
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O 41.5 (-108)
U 41.5 (-112)
|
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Dec 11, 2025 8:15PM EST
Atlanta Falcons
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12/11/25 8:15PM
Falcons
Buccaneers
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–
–
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+205
-250
|
+6 (-112)
-6 (-108)
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O 44.5 (-110)
U 44.5 (-110)
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Dec 14, 2025 1:00PM EST
New York Jets
Jacksonville Jaguars
12/14/25 1PM
Jets
Jaguars
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–
–
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+340
-440
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+9.5 (-112)
-9.5 (-108)
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O 43.5 (-110)
U 43.5 (-110)
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Dec 14, 2025 1:00PM EST
Baltimore Ravens
Cincinnati Bengals
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Ravens
Bengals
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–
–
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-155
+130
|
-2.5 (-120)
+2.5 (+100)
|
O 51.5 (-110)
U 51.5 (-110)
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Dec 14, 2025 1:00PM EST
Washington Commanders
New York Giants
12/14/25 1PM
Commanders
Giants
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–
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-130
+110
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-1.5 (-115)
+1.5 (-105)
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O 47.5 (-110)
U 47.5 (-110)
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Dec 14, 2025 1:00PM EST
Las Vegas Raiders
Philadelphia Eagles
12/14/25 1PM
Raiders
Eagles
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–
–
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+625
-950
|
+12.5 (-110)
-12.5 (-110)
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O 40.5 (-110)
U 40.5 (-110)
|
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Dec 14, 2025 1:00PM EST
Cleveland Browns
Chicago Bears
12/14/25 1PM
Browns
Bears
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–
–
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+340
-440
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+7.5 (-115)
-7.5 (-105)
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O 39.5 (-112)
U 39.5 (-108)
|
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Dec 14, 2025 1:00PM EST
Arizona Cardinals
Houston Texans
12/14/25 1PM
Cardinals
Texans
|
–
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+280
-355
|
+7 (-105)
-7 (-115)
|
O 42.5 (-110)
U 42.5 (-110)
|
NFL Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers Jacksonville Jaguars vs. Arizona Cardinals on November 23, 2025 at State Farm Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our NFL odds pages, and compare prices before you place a bet.
| LEAN | %WIN | UNITS | RESULT | |
|---|---|---|---|---|
| ATL@NYJ | NYJ +3 | 56.9% | 6 | WIN |
| MIN@SEA | SEA -11.5 | 54.5% | 4 | WIN |
| BUF@PIT | PIT +3.5 | 56.9% | 6 | LOSS |
| HOU@IND | IND -3 | 57.9% | 7 | LOSS |
| LAR@CAR | OVER 44.5 | 54.4% | 4 | WIN |
| CHI@PHI | CALEB WILLIAMS OVER 18.5 PASS COMP | 55.7% | 5 | LOSS |
| KC@DAL | DAL +3.5 | 56.3% | 6 | WIN |
| GB@DET | JORDAN LOVE OVER 1.5 PASS TDS | 55.6% | 5 | WIN |
| CIN@BAL | LAMAR JACKSON OVER 24.5 RUSH YDS | 56.7% | 6 | WIN |
| CAR@SF | UNDER 49.5 | 53.0% | 1 | WIN |
| CAR@SF | SF -7 | 54.0% | 3 | WIN |
| CAR@SF | BRYCE YOUNG OVER 61.7 PASS COMP PCT | 55.7% | 5 | WIN |
| NYJ@BAL | DERRICK HENRY OVER 17.5 CARRIES | 53.7% | 3 | WIN |
| JAC@ARI | ARI +2.5 | 55.2% | 5 | LOSS |
| PHI@DAL | DAL +3 | 53.3% | 2 | WIN |
| SEA@TEN | SEA -12 | 57.1% | 7 | LOSS |
| MIN@GB | GB -6 | 54.1% | 3 | WIN |
| IND@KC | IND +3.5 | 54.6% | 4 | WIN |
| TB@LAR | UNDER 49.5 | 52.4% | 1 | WIN |
| IND@KC | UNDER 50.5 | 53.1% | 2 | WIN |
| NYJ@BAL | BREECE HALL OVER 18.5 RECV YDS | 56.7% | 6 | WIN |
| PHI@DAL | JAKE ELLIOT OVER 2.5 EXTRA POINTS MADE | 55.2% | 5 | WIN |
| BUF@HOU | JAMES COOK UNDER 17.5 RUSH ATT | 54.4% | 4 | WIN |
| BUF@HOU | JOSH ALLEN UNDER 63.3 PASS COMP PCT | 56.8% | 6 | LOSS |
| DAL@LV | UNDER 49.5 | 54.3% | 3 | WIN |
| DAL@LV | BROCK BOWERS OVER 6.5 RECEPTIONS | 57.6% | 7 | WIN |
| CAR@ATL | BRYCE YOUNG UNDER 0.5 INT | 56.1% | 6 | WIN |
| KC@DEN | PATRICK MAHOMES UNDER 266.5 PASS YDS | 55.3% | 5 | LOSS |
| SF@ARI | SF -3 | 56.4% | 6 | WIN |
| GB@NYG | GB -7 | 54.3% | 4 | PUSH |
| LAC@JAC | LAC -3 | 53.2% | 3 | LOSS |
| SEA@LAR | SEA +3.5 | 57.2% | 7 | WIN |
| CHI@MIN | MIN -2.5 | 53.4% | 2 | LOSS |
| DET@PHI | DET +3 | 55.8% | 5 | LOSS |
| KC@DEN | DEN +4.5 | 53.0% | 2 | WIN |
| DET@PHI | UNDER 47 | 53.4% | 2 | WIN |
| SEA@LAR | OVER 48.5 | 54.6% | 4 | LOSS |
| NYJ@NE | UNDER 43.5 | 53.4% | 3 | WIN |
| NYJ@NE | JAMIEN SHERWOOD OVER 4.5 TACKLES | 56.8% | 6 | LOSS |
| PHI@GB | PHI +1.5 | 54.8% | 4 | WIN |
| PHI@GB | UNDER 45.5 | 52.4% | 2 | WIN |
| PHI@GB | SAQUON BARKLEY OVER 17.5 RUSH ATT | 56.6% | 6 | WIN |
| PHI@GB | JOSH JACOBS UNDER 42.5 1ST HALF RUSH + REC YDS | 54.4% | 4 | LOSS |
| NO@CAR | CAR -5 | 55.4% | 5 | LOSS |
| BAL@MIN | BAL -3.5 | 57.6% | 7 | WIN |
| CLE@NYJ | CLE -130 | 65.4% | 7 | LOSS |
| NYG@CHI | CHI -4.5 | 55.2% | 5 | LOSS |
| NE@TB | TB -2 | 56.1% | 6 | LOSS |
| LAR@SF | LAR -5.5 | 53.3% | 2 | WIN |
| JAC@HOU | UNDER 38 | 54.8% | 5 | LOSS |
| ARI@SEA | TREY MCBRIDE OVER 9 RECV TARGETS | 55.8% | 5 | WIN |