Colts vs Jaguars Prediction — AI Finds CAN'T MISS NFL Lines & Props (Dec 07)
Updated: 2025-11-30T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The Indianapolis Colts travel to face the Jacksonville Jaguars on December 7, 2025 — a clash with first-place control of the AFC South on the line and playoff implications for both teams.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.
GAME INFO
Date: Dec 07, 2025
Start Time: 2:00 PM EST
Venue: EverBank Stadium
Jaguars Record: (8-4)
Colts Record: (8-4)
OPENING ODDS
IND Moneyline: -129
JAX Moneyline: +109
IND Spread: -1.5
JAX Spread: +1.5
Over/Under: 47.5
IND
Betting Trends
- The Colts arrive on a down-swing after recent setbacks, while the Jaguars are entering hot, riding a three-game win streak and buoyed by defensive dominance and offensive rhythm under pressure.
JAX
Betting Trends
- Indianapolis has struggled to cover in recent weeks, including a loss at home last week to Houston that underscored their difficulties protecting leads and covering late in games.
MATCHUP TRENDS
- The line is expected to be close — early reports show a spread in the range of Jaguars –3 to –4, with the over/under in the mid-40s. Given both defenses’ capacity to force turnovers and slow pace, the under becomes appealing, though either team’s offense has shown flashes that could push the total higher if rhythm develops.
IND vs. JAX
Best Prop Bet
- Remi's searched hard and found the best prop for this matchup: D. Jones under 236.5 Passing Yards.
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Indianapolis vs Jacksonville Prediction & Odds:
Free NFL Betting Insights for 12/7/25
This Week 14 matchup between the Indianapolis Colts and the Jacksonville Jaguars on December 7, 2025 stands as one of the most consequential AFC South showdowns of the season, with both teams locked atop the division and the winner gaining not only a critical tiebreaker edge but also psychological control as the playoff race accelerates into December. Jacksonville enters the contest at 8–4 riding a wave of confidence generated by a three-game winning streak in which their defense has reasserted itself as one of the division’s most disruptive units, overwhelming opponents with front-seven pressure, disciplined gap control, and a secondary capable of capitalizing on even minor quarterback hesitation, and their offense has complemented that with renewed rhythm built on a stable run game and efficient, layered passing. The Jaguars understand that their formula hinges on controlling the trenches early, forcing the Colts into predictable situations, and leveraging home-field energy to disrupt timing and generate field-position advantages. Indianapolis, meanwhile, arrives at 8–4 as well but trending in the opposite direction after a painful home loss to Houston that exposed issues in protection, late-game composure, and situational discipline, creating doubts about their ability to withstand pressure on the road against a team built to punish inconsistency. The Colts must reestablish identity through balanced offense — leaning on the run to stabilize tempo, protect their quarterback from Jacksonville’s surging pass rush, and set up high-percentage passing sequences that avoid the forced, turnover-prone moments that have haunted them in recent weeks.
Defensively, Indianapolis must commit to disciplined tackling, tighter coverage communication, and strategic pressure, because Jacksonville’s offense thrives when opponents overcommit their linebackers or blow assignments that open the door to chunk plays. The tactical heart of the matchup rests in third-down execution, red-zone discipline, and turnover margin: Jacksonville excels at converting defensive stops into short fields and early scores, while Indianapolis is most successful when they stretch drives, keep possessions long, and avoid handing momentum to the opponent through mistakes or penalties. Special teams — often overlooked — may quietly define the flow of the game, as field position in a divisional matchup with two physical defenses can have outsized influence. Emotionally, Jacksonville carries the advantage of home-field momentum and renewed belief, but with that comes the expectation of execution; Indianapolis enters with underdog urgency, a chance to reclaim stability, and an opportunity to silence doubt by matching Jacksonville’s physicality and proving their resilience still holds. Ultimately, the outcome will hinge on consistency: the Jaguars must maintain disciplined aggression without losing composure, and the Colts must rediscover poise under pressure, because in a game this tightly matched, the victor will be the team that dominates the line of scrimmage, wins the situational battles, and converts moments of opportunity into game-shifting sequences that define December football.
Get live NFL odds and precise AI NFL picks, predictions, and cover probabilities.
AP being AP. #ProBowlVote X Alec Pierce pic.twitter.com/YyVE5pJQgE
— Indianapolis Colts (@Colts) December 1, 2025
Indianapolis Colts NFL Preview
The Indianapolis Colts enter this critical Week 14 matchup against the Jacksonville Jaguars carrying both the weight of recent setbacks and the urgency of a divisional race that leaves no room for hesitation, making this contest not just a test of talent but of composure, discipline, and the ability to respond to adversity in one of the loudest and most emotionally charged environments in the AFC South. Fresh off a disappointing home loss that exposed flaws in protection, late-game resilience, and overall consistency, the Colts must reestablish their offensive identity immediately, beginning with a commitment to a balanced approach that keeps Jacksonville’s aggressive front seven from dictating tempo. Their quarterback must deliver sharp, decisive throws and avoid the forced, turnover-prone plays that have derailed recent drives, while the offensive line must elevate its performance dramatically, sustaining blocks, anchoring against interior pressure, and providing cleaner pockets that allow the offense to function on schedule. The run game, which has been streaky at times, must serve as a stabilizer by generating consistent early-down gains that keep the Colts out of predictable passing situations, sustain drives, and limit opportunities for the Jaguars’ defense to unleash its pass-rush packages. Defensively, Indianapolis must play its most disciplined game of the season: their front must hold firm against Jacksonville’s improving run attack, their linebackers must avoid overcommitting to play-action, and their secondary must maintain tight communication to prevent the explosive plays that the Jaguars have increasingly produced when opponents lose eye discipline or spacing.
Pressure must be strategic and timely rather than reckless, seeking to disrupt rhythm without creating vulnerabilities that can be exploited for big gains. Special teams must also deliver with precision, as field position will hold outsized importance in a game where both offenses can be volatile and both defenses are capable of dictating phases if handed short fields or emotional momentum. Emotionally, the Colts must embrace the underdog mindset with controlled urgency—approaching the matchup with toughness and focus rather than anxiety, and refusing to let early setbacks trigger panic or sloppy execution. They must tune out crowd noise, maintain situational awareness, and lean into the fundamental football principles that have defined their best stretches of the season. If Indianapolis can protect the football, win the early-down battles, eliminate self-inflicted wounds, and maintain defensive discipline for a full four quarters, they possess a viable path to stealing a massive road victory. But if they repeat the same miscues that plagued them in their loss to Houston—missed assignments, protection breakdowns, penalties, and turnovers—the Jaguars have the momentum, the home-field advantage, and the defensive firepower to seize control quickly and make the climb back steep if not impossible.
Credit: USA TODAY/IMAGN
Jacksonville Jaguars NFL Preview
The Jacksonville Jaguars enter this pivotal Week 14 divisional matchup with confidence, momentum, and a sharpened identity as they look to seize sole control of the AFC South on their home field, carrying the energy of an 8–4 record and a three-game winning streak that has reestablished them as one of the conference’s most balanced and opportunistic teams. Their rise has been powered by a defense that has rediscovered its disruptive edge, overwhelming opponents with aggressive front-seven pressure, disciplined gap control, and a secondary that has tightened its coverage and shown the ability to capitalize instantly on hesitation, misreads, or off-target throws—something they will aim to exploit against an Indianapolis offense that has shown vulnerability under pressure. The Jaguars know that setting the tone begins in the trenches; their defensive line must control early downs, eliminate Indianapolis’ attempts to establish rhythm on the ground, and force the Colts into predictable passing scenarios where Jacksonville can unleash its pass rush and test protection breakdowns that appeared repeatedly in the Colts’ recent loss. Their offense must complement that defensive aggression by sustaining balance—establishing the run early to wear down Indianapolis’ front, maintaining disciplined blocking, and using play-action and intermediate passing concepts to get their quarterback into a comfortable rhythm that avoids unnecessary risk while still allowing for explosive plays when the coverage softens.
Jacksonville’s receivers must be sharp in their timing and separation to avoid allowing Indianapolis’ defense to sit on routes or overplay short concepts, and the offensive line must anchor against a Colts front that remains powerful enough to collapse pockets when given opportunities. Special teams, often decisive in close divisional battles, must be crisp and reliable; field position, clean coverage lanes, and steady kicking can tilt momentum quietly but significantly, especially in a game where both defenses are capable of dictating stretches of play. Emotionally, the Jaguars must channel the home-field energy into focused urgency rather than overexcitement, avoiding early penalties or forced plays that could derail drives or ignite Indianapolis’ confidence. They must play with poise, trust the structure that has guided their recent success, and maintain a mindset of sustained pressure rather than assuming momentum will come automatically. If Jacksonville continues its disciplined defensive execution, maintains offensive balance, protects the football, and leverages the psychological advantage of playing in front of a home crowd eager to see the division tilt in their favor, they have a clear opportunity not only to secure a crucial win but also to send a message to the conference that their late-season surge is rooted in substance—physicality, resilience, and the ability to adapt under pressure—making them a dangerous opponent as the playoff race intensifies.
A big one on Sunday.@Nemours | #DUUUVAL https://t.co/yxstqRP8qZ
— Jacksonville Jaguars (@Jaguars) December 1, 2025
Indianapolis vs Jacksonville Prop Picks (AI)
Remi is pouring through tons of datapoints on each player. In fact, anytime the Colts and Jaguars play there’s always several intriguing angles to key in on. Not to mention games played at EverBank Stadium in Dec almost always follow normal, predictable patterns.
Indianapolis vs Jacksonville Prediction (AI)
Remi, our AI sports algorithm, has been pouring over exorbitant amounts of data from every past game between the Colts and Jaguars and using recursive machine learning and impressive AI to boil down the data to a single cover probability.
Oddly enough, we’ve seen the AI has been most keyed in on the growing weight human bettors often put on coaching factors between a Colts team going up against a possibly rested Jaguars team. In reality, the true game analytics appear to reflect a moderate lean against one Vegas line in particular.
Unlock this in-depth AI prediction and all of our NFL AI picks for FREE now.
Below is our current AI Indianapolis vs Jacksonville picks, computer picks Colts vs Jaguars, best bets, model edges, confidence ratings.
| DATE | GAME | LEAN | %WIN | UNITS | LEVEL | |
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| NFL | 12/4 | DAL@DET | UNLOCK THIS PICK | 7 |
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| NFL | 12/4 | DAL@DET | UNLOCK THIS PICK | 4 |
EXECUTIVE
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| NFL | 12/4 | DAL@DET | UNLOCK THIS PICK | 1 |
INTEL
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These picks update as information changes—injury reports, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full NFL schedule.
Indianapolis Betting Trends
The Colts arrive on a down-swing after recent setbacks, while the Jaguars are entering hot, riding a three-game win streak and buoyed by defensive dominance and offensive rhythm under pressure.
Jacksonville Betting Trends
Indianapolis has struggled to cover in recent weeks, including a loss at home last week to Houston that underscored their difficulties protecting leads and covering late in games.
Colts vs. Jaguars Matchup Trends
The line is expected to be close — early reports show a spread in the range of Jaguars –3 to –4, with the over/under in the mid-40s. Given both defenses’ capacity to force turnovers and slow pace, the under becomes appealing, though either team’s offense has shown flashes that could push the total higher if rhythm develops.
Indianapolis vs. Jacksonville Game Info
Indianapolis vs Jacksonville starts on December 07, 2025 at 2:00 PM EST.
Venue: EverBank Stadium.
Spread: Jacksonville +1.5
Moneyline: Indianapolis -129, Jacksonville +109
Over/Under: 47.5
Indianapolis: (8-4) | Jacksonville: (8-4)
Remi's searched hard and found the best prop for this matchup: D. Jones under 236.5 Passing Yards.. Prices move—always shop for the best number.
The line is expected to be close — early reports show a spread in the range of Jaguars –3 to –4, with the over/under in the mid-40s. Given both defenses’ capacity to force turnovers and slow pace, the under becomes appealing, though either team’s offense has shown flashes that could push the total higher if rhythm develops.
IND trend: The Colts arrive on a down-swing after recent setbacks, while the Jaguars are entering hot, riding a three-game win streak and buoyed by defensive dominance and offensive rhythm under pressure.
JAX trend: Indianapolis has struggled to cover in recent weeks, including a loss at home last week to Houston that underscored their difficulties protecting leads and covering late in games.
See our latest NFL picks and odds pages for 2025 to compare prices before you bet.
Indianapolis vs. Jacksonville Odds
Remi is pouring through tons of stats on each line. In fact, anytime the Indianapolis vs Jacksonville trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme travel distance can often follow normal, predictable betting trends.
| IND Moneyline | -129 |
|---|---|
| JAX Moneyline | +109 |
| IND Spread | -1.5 |
| JAX Spread | +1.5 |
| Over / Under | 47.5 |
Indianapolis vs Jacksonville Live Odds
| Games | PTS | ML | SPR | O/U | |
|---|---|---|---|---|---|
|
Dec 7, 2025 1:00PM EST
New Orleans Saints
Tampa Bay Buccaneers
12/7/25 1PM
Saints
Buccaneers
|
–
–
|
+330
-425
|
+8.5 (-112)
-8.5 (-108)
|
O 41.5 (-110)
U 41.5 (-110)
|
|
|
Dec 7, 2025 1:00PM EST
Indianapolis Colts
Jacksonville Jaguars
12/7/25 1PM
Colts
Jaguars
|
–
–
|
-130
+110
|
-1.5 (-112)
+1.5 (-108)
|
O 47.5 (-115)
U 47.5 (-105)
|
|
|
Dec 7, 2025 1:00PM EST
Pittsburgh Steelers
Baltimore Ravens
12/7/25 1PM
Steelers
Ravens
|
–
–
|
+210
-258
|
+5.5 (-105)
-5.5 (-115)
|
O 42.5 (-112)
U 42.5 (-108)
|
|
|
Dec 7, 2025 1:00PM EST
Washington Commanders
Minnesota Vikings
12/7/25 1PM
Commanders
Vikings
|
–
–
|
-105
-115
|
+1.5 (-118)
-1.5 (-102)
|
O 42.5 (-112)
U 42.5 (-108)
|
|
|
Dec 7, 2025 1:00PM EST
Cincinnati Bengals
Buffalo Bills
12/7/25 1PM
Bengals
Bills
|
–
–
|
+220
-270
|
+5.5 (+100)
-5.5 (-120)
|
O 53.5 (-112)
U 53.5 (-108)
|
|
|
Dec 7, 2025 1:00PM EST
Miami Dolphins
New York Jets
12/7/25 1PM
Dolphins
Jets
|
–
–
|
-155
+130
|
-2.5 (-120)
+2.5 (+100)
|
O 41.5 (-110)
U 41.5 (-110)
|
|
|
Dec 7, 2025 1:00PM EST
Seattle Seahawks
Atlanta Falcons
12/7/25 1PM
Seahawks
Falcons
|
–
–
|
-355
+280
|
-7 (-105)
+7 (-115)
|
O 44.5 (-112)
U 44.5 (-108)
|
|
|
Dec 7, 2025 1:00PM EST
Tennessee Titans
Cleveland Browns
12/7/25 1PM
Titans
Browns
|
–
–
|
+180
-218
|
+4.5 (-115)
-4.5 (-105)
|
O 33.5 (-115)
U 33.5 (-105)
|
|
|
Dec 7, 2025 4:05PM EST
Denver Broncos
Las Vegas Raiders
12/7/25 4:05PM
Broncos
Raiders
|
–
–
|
-410
+320
|
-7.5 (-108)
+7.5 (-112)
|
O 40.5 (+102)
U 40.5 (-122)
|
|
|
Dec 7, 2025 4:25PM EST
Los Angeles Rams
Arizona Cardinals
12/7/25 4:25PM
Rams
Cardinals
|
–
–
|
-455
+350
|
-8.5 (-105)
+8.5 (-115)
|
O 47.5 (-110)
U 47.5 (-110)
|
|
|
Dec 7, 2025 4:25PM EST
Chicago Bears
Green Bay Packers
12/7/25 4:25PM
Bears
Packers
|
–
–
|
+270
-340
|
+6.5 (-105)
-6.5 (-115)
|
O 44.5 (-110)
U 44.5 (-110)
|
|
|
Dec 7, 2025 8:20PM EST
Houston Texans
Kansas City Chiefs
12/7/25 8:20PM
Texans
Chiefs
|
–
–
|
+150
-180
|
+3.5 (-115)
-3.5 (-105)
|
O 41.5 (-115)
U 41.5 (-105)
|
|
|
Dec 8, 2025 8:15PM EST
Philadelphia Eagles
Los Angeles Chargers
12/8/25 8:15PM
Eagles
Chargers
|
–
–
|
-148
+124
|
-2.5 (-115)
+2.5 (-105)
|
O 41.5 (-108)
U 41.5 (-112)
|
|
|
Dec 11, 2025 8:15PM EST
Atlanta Falcons
Tampa Bay Buccaneers
12/11/25 8:15PM
Falcons
Buccaneers
|
–
–
|
+205
-250
|
+6 (-112)
-6 (-108)
|
O 44.5 (-110)
U 44.5 (-110)
|
|
|
Dec 14, 2025 1:00PM EST
New York Jets
Jacksonville Jaguars
12/14/25 1PM
Jets
Jaguars
|
–
–
|
+340
-440
|
+9.5 (-112)
-9.5 (-108)
|
O 43.5 (-110)
U 43.5 (-110)
|
|
|
Dec 14, 2025 1:00PM EST
Baltimore Ravens
Cincinnati Bengals
12/14/25 1PM
Ravens
Bengals
|
–
–
|
-155
+130
|
-2.5 (-120)
+2.5 (+100)
|
O 51.5 (-110)
U 51.5 (-110)
|
|
|
Dec 14, 2025 1:00PM EST
Washington Commanders
New York Giants
12/14/25 1PM
Commanders
Giants
|
–
–
|
-130
+110
|
-1.5 (-115)
+1.5 (-105)
|
O 47.5 (-110)
U 47.5 (-110)
|
|
|
Dec 14, 2025 1:00PM EST
Las Vegas Raiders
Philadelphia Eagles
12/14/25 1PM
Raiders
Eagles
|
–
–
|
+625
-950
|
+12.5 (-110)
-12.5 (-110)
|
O 40.5 (-110)
U 40.5 (-110)
|
|
|
Dec 14, 2025 1:00PM EST
Cleveland Browns
Chicago Bears
12/14/25 1PM
Browns
Bears
|
–
–
|
+340
-440
|
+7.5 (-115)
-7.5 (-105)
|
O 39.5 (-112)
U 39.5 (-108)
|
|
|
Dec 14, 2025 1:00PM EST
Arizona Cardinals
Houston Texans
12/14/25 1PM
Cardinals
Texans
|
–
–
|
+280
-355
|
+7 (-105)
-7 (-115)
|
O 42.5 (-110)
U 42.5 (-110)
|
NFL Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers Indianapolis Colts vs. Jacksonville Jaguars on December 07, 2025 at EverBank Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our NFL odds pages, and compare prices before you place a bet.
| LEAN | %WIN | UNITS | RESULT | |
|---|---|---|---|---|
| ATL@NYJ | NYJ +3 | 56.9% | 6 | WIN |
| MIN@SEA | SEA -11.5 | 54.5% | 4 | WIN |
| BUF@PIT | PIT +3.5 | 56.9% | 6 | LOSS |
| HOU@IND | IND -3 | 57.9% | 7 | LOSS |
| LAR@CAR | OVER 44.5 | 54.4% | 4 | WIN |
| CHI@PHI | CALEB WILLIAMS OVER 18.5 PASS COMP | 55.7% | 5 | LOSS |
| KC@DAL | DAL +3.5 | 56.3% | 6 | WIN |
| GB@DET | JORDAN LOVE OVER 1.5 PASS TDS | 55.6% | 5 | WIN |
| CIN@BAL | LAMAR JACKSON OVER 24.5 RUSH YDS | 56.7% | 6 | WIN |
| CAR@SF | UNDER 49.5 | 53.0% | 1 | WIN |
| CAR@SF | SF -7 | 54.0% | 3 | WIN |
| CAR@SF | BRYCE YOUNG OVER 61.7 PASS COMP PCT | 55.7% | 5 | WIN |
| NYJ@BAL | DERRICK HENRY OVER 17.5 CARRIES | 53.7% | 3 | WIN |
| JAC@ARI | ARI +2.5 | 55.2% | 5 | LOSS |
| PHI@DAL | DAL +3 | 53.3% | 2 | WIN |
| SEA@TEN | SEA -12 | 57.1% | 7 | LOSS |
| MIN@GB | GB -6 | 54.1% | 3 | WIN |
| IND@KC | IND +3.5 | 54.6% | 4 | WIN |
| TB@LAR | UNDER 49.5 | 52.4% | 1 | WIN |
| IND@KC | UNDER 50.5 | 53.1% | 2 | WIN |
| NYJ@BAL | BREECE HALL OVER 18.5 RECV YDS | 56.7% | 6 | WIN |
| PHI@DAL | JAKE ELLIOT OVER 2.5 EXTRA POINTS MADE | 55.2% | 5 | WIN |
| BUF@HOU | JAMES COOK UNDER 17.5 RUSH ATT | 54.4% | 4 | WIN |
| BUF@HOU | JOSH ALLEN UNDER 63.3 PASS COMP PCT | 56.8% | 6 | LOSS |
| DAL@LV | UNDER 49.5 | 54.3% | 3 | WIN |
| DAL@LV | BROCK BOWERS OVER 6.5 RECEPTIONS | 57.6% | 7 | WIN |
| CAR@ATL | BRYCE YOUNG UNDER 0.5 INT | 56.1% | 6 | WIN |
| KC@DEN | PATRICK MAHOMES UNDER 266.5 PASS YDS | 55.3% | 5 | LOSS |
| SF@ARI | SF -3 | 56.4% | 6 | WIN |
| GB@NYG | GB -7 | 54.3% | 4 | PUSH |
| LAC@JAC | LAC -3 | 53.2% | 3 | LOSS |
| SEA@LAR | SEA +3.5 | 57.2% | 7 | WIN |
| CHI@MIN | MIN -2.5 | 53.4% | 2 | LOSS |
| DET@PHI | DET +3 | 55.8% | 5 | LOSS |
| KC@DEN | DEN +4.5 | 53.0% | 2 | WIN |
| DET@PHI | UNDER 47 | 53.4% | 2 | WIN |
| SEA@LAR | OVER 48.5 | 54.6% | 4 | LOSS |
| NYJ@NE | UNDER 43.5 | 53.4% | 3 | WIN |
| NYJ@NE | JAMIEN SHERWOOD OVER 4.5 TACKLES | 56.8% | 6 | LOSS |
| PHI@GB | PHI +1.5 | 54.8% | 4 | WIN |
| PHI@GB | UNDER 45.5 | 52.4% | 2 | WIN |
| PHI@GB | SAQUON BARKLEY OVER 17.5 RUSH ATT | 56.6% | 6 | WIN |
| PHI@GB | JOSH JACOBS UNDER 42.5 1ST HALF RUSH + REC YDS | 54.4% | 4 | LOSS |
| NO@CAR | CAR -5 | 55.4% | 5 | LOSS |
| BAL@MIN | BAL -3.5 | 57.6% | 7 | WIN |
| CLE@NYJ | CLE -130 | 65.4% | 7 | LOSS |
| NYG@CHI | CHI -4.5 | 55.2% | 5 | LOSS |
| NE@TB | TB -2 | 56.1% | 6 | LOSS |
| LAR@SF | LAR -5.5 | 53.3% | 2 | WIN |
| JAC@HOU | UNDER 38 | 54.8% | 5 | LOSS |
| ARI@SEA | TREY MCBRIDE OVER 9 RECV TARGETS | 55.8% | 5 | WIN |