The Week 11 clash between the Los Angeles Chargers and the Jacksonville Jaguars on November 16, 2025, at EverBank Stadium is set to be one of the most intriguing AFC matchups of the season, pitting two playoff hopefuls with very different styles of play against one another. The Chargers enter the contest with a 7-3 record, surging behind a balanced offensive attack and a defense that has finally found rhythm under head coach Jim Harbaugh, while the Jaguars, at 5-4, return home looking to reclaim consistency after a string of uneven performances. This game carries added significance not only for playoff seeding but also as a rematch of past postseason meetings that have built a quiet but growing rivalry between these two organizations. Los Angeles has looked sharper in recent weeks thanks to an improved offensive line and a recommitment to the run game, which has allowed quarterback Justin Herbert to play more freely and effectively from clean pockets. Herbert remains one of the league’s most efficient passers under pressure, and with his chemistry restored with wideouts Keenan Allen and rookie standout Ladd McConkey, the Chargers’ aerial attack has regained its explosive edge. Running back Gus Edwards has provided a reliable downhill element that complements Harbaugh’s physical offensive philosophy, keeping defenses honest and giving the Chargers balance they often lacked in prior seasons. Defensively, Los Angeles has made significant strides, particularly in third-down and red-zone efficiency. Edge rushers Joey Bosa and Khalil Mack remain the tone-setters, but the emergence of Tuli Tuipulotu has given the defensive front greater depth and rotational versatility. The secondary, led by Derwin James, has tightened up communication issues that plagued them early in the year, and the unit’s ability to generate timely takeaways has been key to closing out tight contests.

However, Los Angeles’ biggest challenge remains consistency — they have been known to play down to opponents at times, and their 4-6 ATS record reflects a tendency to win close rather than dominate. For Jacksonville, this home game arrives at a pivotal point in their season. Trevor Lawrence has been solid but not spectacular, showing flashes of brilliance offset by stretches of conservative play. The Jaguars’ offensive success depends heavily on their ability to protect Lawrence and establish rhythm through running back Travis Etienne, whose explosive playmaking as both a rusher and receiver gives the offense its unpredictability. The offensive line’s performance will be critical against a ferocious Chargers pass rush, as Lawrence has struggled under heavy pressure this season. On defense, Jacksonville remains stout against the run but has shown vulnerability against precise passing attacks, particularly when opposing quarterbacks are given time to throw. Josh Allen and Travon Walker headline a front seven capable of generating havoc, and they’ll need to deliver consistent pressure on Herbert to disrupt Los Angeles’ timing. The Jaguars’ secondary, anchored by Tyson Campbell and Andre Cisco, has been opportunistic but inconsistent in coverage, which could spell trouble if the Chargers’ receivers find separation early. From a betting perspective, this matchup is finely balanced: the Chargers’ superior overall efficiency makes them the rightful favorite, but their uneven ATS track record suggests that Jacksonville could hang around longer than expected, especially at home. Expect a strategic, physical contest defined by trench play and third-down execution. If Herbert gets into rhythm early and the Chargers’ defense limits Etienne’s impact, Los Angeles should emerge victorious. But if Jacksonville can control possession, pressure Herbert into hurried throws, and finish drives in the red zone, they have the tools to spring the upset. In a matchup filled with playoff undertones and contrasting philosophies, this battle between Harbaugh’s disciplined Chargers and Doug Pederson’s versatile Jaguars could come down to which team better handles situational football in the game’s final minutes.