The October 12, 2025 matchup between the Seattle Seahawks and the Jacksonville Jaguars at EverBank Stadium presents a fascinating contrast between a Seattle team still searching for offensive rhythm and a Jacksonville squad that looks every bit like an AFC contender. The Jaguars enter this game riding high after a dramatic 31–28 comeback win over the Kansas City Chiefs, a victory that showcased both Trevor Lawrence’s composure and head coach Doug Pederson’s mastery of situational football. At 4–1, Jacksonville has found its balance between offensive explosiveness and defensive discipline, with Lawrence looking poised and polished in his fourth season. He’s completing passes with efficiency and taking command of a playbook that allows him to dissect defenses through both quick timing throws and deep shots. The addition of Brian Thomas Jr. as a vertical weapon has given the Jaguars another dimension, while Christian Kirk and Evan Engram continue to serve as reliable safety valves. Travis Etienne Jr. remains the heartbeat of this offense, capable of changing a game with one burst through the second level, and his ability to impact the passing game gives Jacksonville multiple ways to attack. Against Seattle’s defense, which has been stout against the run but inconsistent in coverage, the Jaguars will look to mix tempo and motion to exploit mismatches. Defensively, Jacksonville has turned a corner.

Defensive coordinator Ryan Nielsen has his front seven playing fast and physical, with Josh Allen and Travon Walker creating havoc off the edge and linebacker Devin Lloyd emerging as a leader in the middle. The secondary, anchored by Tyson Campbell and Andre Cisco, has been opportunistic, forcing turnovers at key moments. For Seattle, this game is an opportunity to steady the ship after a rollercoaster start. The Seahawks sit at 3–2, showing flashes of elite potential but struggling with offensive consistency. Quarterback Sam Darnold has been serviceable but erratic, and offensive coordinator Ryan Grubb is still working to tailor the offense to his strengths. The return of DK Metcalf and the emergence of Jaxon Smith-Njigba have provided firepower on the perimeter, while Kenneth Walker III continues to deliver as one of the NFL’s most dynamic young backs. However, Seattle’s offensive line has been a sore spot, allowing pressure at an unsustainable rate and often forcing Darnold into hurried decisions. Defensively, the Seahawks have been better, ranking near the top of the league in pressure rate thanks to Leonard Williams, Uchenna Nwosu, and Boye Mafe. But they’ve struggled to close games, often surrendering big plays late in drives. Against Jacksonville, Seattle must find ways to disrupt Lawrence’s rhythm and win on early downs to prevent sustained drives. This game ultimately comes down to execution and poise. Jacksonville has the advantage in quarterback play, offensive line cohesion, and defensive efficiency, while Seattle’s path to an upset relies on turnovers, explosive plays, and special teams execution. If the Jaguars play to their strengths, controlling pace and leveraging their balanced attack, they have the tools to extend their winning streak. But if Seattle can rediscover its offensive identity and tighten its coverage, this matchup has the potential to be one of Week 6’s most entertaining cross-conference battles.