Cardinals vs. Colts
Prediction, Odds & Props
Oct 12 | NFL AI Picks
Updated: 2025-10-05T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.
GAME INFO
Date: Oct 12, 2025
Start Time: 1:00 PM EST​
Venue: ​
Colts Record:
Cardinals Record:
OPENING ODDS
ARI Moneyline:
IND Moneyline:
ARI Spread: 0
IND Spread:
Over/Under:
ARI
Betting Trends
IND
Betting Trends
MATCHUP TRENDS
ARI vs. IND
Best Prop Bet
LIVE NFL ODDS
NFL ODDS COMPARISON
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Arizona vs Indianapolis Prediction & Odds:
Free NFL Betting Insights for 10/12/25
Arizona Cardinals NFL Preview
Credit: USA TODAY/IMAGN
Indianapolis Colts NFL Preview
Arizona vs. Indianapolis Prop Picks (AI)
Arizona vs. Indianapolis Prediction (AI)
Remi, our AI sports wizard, has been pouring over mountains of data from every facet between the Cardinals and Colts and using recursive machine learning and cutting-edge AI to crunch the data to a single cover probability.
Remi has been most keyed in on the trending factor emotional bettors regularly put on coaching factors between a Cardinals team going up against a possibly rested Colts team. We’ve found the true game analytics might reflect a strong lean against one Vegas line specifically.
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Below is our current AI Arizona vs Indianapolis picks, computer picks Cardinals vs Colts, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
|---|---|---|---|---|---|---|
| ACTIVE PICKS LOCKED - SEE NOW | ||||||
These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full NFL Schedule.
Cardinals Betting Trends
Colts Betting Trends
Cardinals vs. Colts Matchup Trends
Arizona vs. Indianapolis Game Info
What time does Arizona vs Indianapolis start on October 12, 2025?
Arizona vs Indianapolis starts on October 12, 2025 at 1:00 PM EST.
What are the opening odds for Arizona vs Indianapolis?
Spread: Indianapolis
Moneyline: Arizona , Indianapolis
Over/Under:
What are the records for Arizona vs Indianapolis?
Arizona: Â |Â Indianapolis:
What is the AI best bet for Arizona vs Indianapolis?
. Prices move—always shop for the best number.
What are Arizona trending bets?
ARI trend:
What are Indianapolis trending bets?
IND trend:
Where can I find AI Picks for Arizona vs Indianapolis?
See our latest NFL picks and odds pages for 2025 to compare prices before you bet.
Arizona vs. Indianapolis Odds
AI algorithm Remi is pouring through mountains of data points on each line. In fact, anytime the Arizona vs Indianapolis trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme travel distance almost always follow normal, predictable betting trends.
Arizona vs Indianapolis Opening Odds
ARI Moneyline:
IND Moneyline:
ARI Spread: 0
IND Spread:
Over/Under:
Arizona vs Indianapolis Live Odds
| Games | PTS | ML | SPR | O/U | |
|---|---|---|---|---|---|
|
Oct 2, 2025 8:16PM EDT
San Francisco 49ers
Los Angeles Rams
10/2/25 8:16PM
49ers
Rams
|
–
–
|
+274
-340
|
+7 (-106)
-7 (-104)
|
O 46.5 (-107)
U 46.5 (-107)
|
|
|
Oct 5, 2025 9:31AM EDT
Minnesota Vikings
Cleveland Browns
10/5/25 9:31AM
Vikings
Browns
|
–
–
|
-195
+170
|
-3.5 (-102)
+3.5 (-118)
|
O 36 (-110)
U 36 (-110)
|
|
|
Oct 5, 2025 1:01PM EDT
Las Vegas Raiders
Indianapolis Colts
10/5/25 1:01PM
Raiders
Colts
|
–
–
|
+249
-305
|
+6.5 (+107)
-6.5 (-118)
|
O 48 (-107)
U 48 (-107)
|
|
|
Oct 5, 2025 1:01PM EDT
New York Giants
New Orleans Saints
10/5/25 1:01PM
Giants
Saints
|
–
–
|
+112
-132
|
+2 (-104)
-2 (-106)
|
O 42 (-110)
U 42 (-104)
|
|
|
Oct 5, 2025 1:01PM EDT
Houston Texans
Baltimore Ravens
10/5/25 1:01PM
Texans
Ravens
|
–
–
|
-120
+100
|
-1 (-110)
+1 (+100)
|
O 40 (-107)
U 40 (-107)
|
|
|
Oct 5, 2025 1:01PM EDT
Denver Broncos
Philadelphia Eagles
10/5/25 1:01PM
Broncos
Eagles
|
–
–
|
+177
-205
|
+3.5 (-105)
-3.5 (-105)
|
O 43.5 (-113)
U 43.5 (-102)
|
|
|
Oct 5, 2025 1:01PM EDT
Dallas Cowboys
New York Jets
10/5/25 1:01PM
Cowboys
Jets
|
–
–
|
-140
+120
|
-2.5 (-104)
+2.5 (-106)
|
O 47 (-113)
U 47 (-102)
|
|
|
Oct 5, 2025 1:01PM EDT
Miami Dolphins
Carolina Panthers
10/5/25 1:01PM
Dolphins
Panthers
|
–
–
|
-118
-102
|
-1 (-113)
+1 (-107)
|
O 44.5 (-105)
U 44.5 (-115)
|
|
|
Oct 5, 2025 4:06PM EDT
Tampa Bay Buccaneers
Seattle Seahawks
10/5/25 4:06PM
Buccaneers
Seahawks
|
–
–
|
+157
-180
|
+3.5 (-108)
-3.5 (-102)
|
O 44.5 (-107)
U 44.5 (-107)
|
|
|
Oct 5, 2025 4:06PM EDT
Tennessee Titans
Arizona Cardinals
10/5/25 4:06PM
Titans
Cardinals
|
–
–
|
+327
-415
|
+7.5 (-113)
-7.5 (-107)
|
O 41.5 (-110)
U 41.5 (-110)
|
|
|
Oct 5, 2025 4:26PM EDT
Washington Commanders
Los Angeles Chargers
10/5/25 4:26PM
Commanders
Chargers
|
–
–
|
+125
-145
|
+2.5 (+104)
-2.5 (-115)
|
O 48 (-107)
U 48 (-107)
|
|
|
Oct 5, 2025 4:26PM EDT
Detroit Lions
Cincinnati Bengals
10/5/25 4:26PM
Lions
Bengals
|
–
–
|
-525
+400
|
-10 (-105)
+10 (-105)
|
O 49.5 (-107)
U 49.5 (-107)
|
|
|
Oct 5, 2025 8:21PM EDT
New England Patriots
Buffalo Bills
10/5/25 8:21PM
Patriots
Bills
|
–
–
|
+316
-400
|
+7.5 (-112)
-7.5 (+101)
|
O 49.5 (-102)
U 49.5 (-113)
|
|
|
Oct 6, 2025 8:16PM EDT
Kansas City Chiefs
Jacksonville Jaguars
10/6/25 8:16PM
Chiefs
Jaguars
|
–
–
|
-185
+161
|
-3.5 (+102)
+3.5 (-113)
|
O 46.5 (-110)
U 46.5 (-104)
|
|
|
Oct 9, 2025 8:16PM EDT
Philadelphia Eagles
New York Giants
10/9/25 8:16PM
Eagles
Giants
|
–
–
|
-395
+310
|
-7.5 (-105)
+7.5 (-105)
|
O 42.5 (-107)
U 42.5 (-107)
|
|
|
Oct 12, 2025 8:31AM EDT
Denver Broncos
New York Jets
10/12/25 8:31AM
Broncos
Jets
|
–
–
|
-298
+240
|
-6.5 (+100)
+6.5 (-120)
|
O 43 (-110)
U 43 (-110)
|
NFL Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers Arizona Cardinals vs. Indianapolis Colts on October 12, 2025 at .
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our NFL odds pages, and compare prices before you place a bet.
| NFL |
   LEAN |    %WIN |    UNITS | RESULT |
|---|---|---|---|---|
| CIN@DEN | DEN -7.5 | 54.8 | 4 | WIN |
| NYJ@MIA | OVER 44 | 52.9% | 2 | WIN |
| CIN@DEN | UNDER 44.5 | 53.7% | 3 | WIN |
| NYJ@MIA | GARRETT WILSON UNDER 9 TARGETS | 53.7% | 3 | WIN |
| CIN@DEN | TEE HIGGINS OVER 6.5 RECV TARGETS | 55.5% | 5 | LOSS |
| WAS@ATL | ATL -2.5 | 54.3 | 4 | WIN |
| BAL@KC | BAL -2.5 | 56.3% | 6 | LOSS |
| TEN@HOU | TEN +7.5 | 57.9% | 7 | LOSS |
| LAC@NYG | LAC -6 | 57.3% | 7 | LOSS |
| NO@BUF | UNDER 48.5 | 55.1% | 3 | LOSS |
| GB@DAL | JAVONTE WILLIAMS UNDER 72.5 RUSH + REC YDS | 55.5% | 5 | LOSS |
| CAR@NE | DRAKE MAYE TO THROW AN INT | 56.6% | 6 | LOSS |
| SEA@ARI | SEA -125 | 57.7% | 6 | WIN |
| SEA@ARI | KYLER MURRAY TO THROW AN INT | 56.6% | 6 | WIN |
| DET@BAL | JAHMYR GIBBS OVER 0.5 RUSH TDS | 55.8% | 5 | WIN |
| DAL@CHI | DAL -120 | 58.7% | 6 | LOSS |
| PIT@NE | PIT -116 | 60.1% | 6 | WIN |
| ATL@CAR | ATL -4.5 | 55.4% | 5 | LOSS |
| LV@WAS | LV +3 | 54.3% | 4 | LOSS |
| GB@CLE | GB -7 | 54.3% | 4 | LOSS |
| ARI@SF | ARI +3 | 57.7% | 6 | WIN |
| KC@NYG | PATRICK MAHOMES OVER 230.5 PASS YDS | 54.7% | 4 | WIN |
| GB@CLE | JOE FLACCO OVER 37.5 PASS ATT | 56.6% | 6 | LOSS |
| MIA@BUF | TYREEK HILL OVER 5.5 TOTAL RECEPTIONS | 56.8% | 6 | LOSS |
| LAC@LV | LAC -3 | 54.9% | 4 | WIN |
| TB@HOU | BAKER MAYFIELD OVER 1.5 PASS TDS | 54.4% | 4 | WIN |
| CHI@DET | DET -6.5 | 54.3% | 4 | WIN |
| DEN@IND | DEN -118 | 60.1% | 10 | LOSS |
| PHI@KC | PHI -115 | 56.7% | 6 | WIN |
| SF@NO | SF -3 | 58.8% | 8 | WIN |
| SEA@PIT | OVER 40 | 54.9% | 4 | WIN |
| CAR@ARI | BRYCE YOUNG INTERCEPTIONS UNDER 0.5 | 56.4% | 6 | LOSS |
| DEN@IND | JOSH DOWNS RECEPTIONS OVER 3.5 | 54.7% | 4 | WIN |
| ATL@MIN | BIJAN ROBINSON RUSH + REC YDS OVER 94.5 | 53.4% | 3 | WIN |
| WAS@GB | WAS +3.5 | 56.5% | 6 | LOSS |
| WAS@GB | JORDAN LOVE OVER 5.5 RUSH YDS | 54.7% | 4 | WIN |
| MIN@CHI | CALEB WILLIAMS OVER 219.5 PASS YDS | 53.4% | 3 | LOSS |
| TEN@DEN | DEN -8.5 | 55.3% | 5 | LOSS |
| SF@SEA | SF -115 | 54.6% | 4 | WIN |
| SF@SEA | KENNETH WALKER III UNDER 79.5 RUSH+REC YDS | 54.6% | 4 | WIN |
| CAR@JAC | TANK BIGSBY OVER 10.5 RUSH ATT | 56.1% | 6 | LOSS |
| KC@LAC | JUSTIN HERBERT UNDER 0.5 INT | 54.1% | 3 | WIN |
| DAL@PHI | GEORGE PICKENS LONGEST RECEPTION OVER 22.5 YDS | 54.1% | 4 | LOSS |
| KC@PHI | JUJU SMITH-SCHUSTER UNDER 16.5 RECV YDS | 53.90% | 5 | WIN |
| KC@PHI | DEVONTA SMITH LONGEST RECEPTION OVER 20.5 YDS | 54.40% | 6 | WIN |
| KC@PHI | PATRICK MAHOMES UNDER 68.3% PASS COMP | 55.00% | 8 | WIN |
| KC@PHI | JALEN HURTS LONGEST RUSH OVER 12.5 YDS | 55.60% | 8 | WIN |
| BUF@KC | DALTON KINCAID OVER 29.5 RECV YDS | 55.10% | 8 | LOSS |
| WAS@PHI | DEVONTA SMITH OVER 3.5 RECEPTIONS | 55.80% | 8 | WIN |
| BUF@KC | JAMES COOK ANYTIME TD | 53.00% | 5 | WIN |
| LAR@PHI | SAQUON BARKLEY UNDER 128 RUSH + REC YDS | 53.20% | 5 | LOSS |