Lions vs Bengals Prediction — AI Finds CAN'T MISS NFL Lines & Props (Oct 05)
Updated: 2025-09-28T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The Detroit Lions travel to face the Cincinnati Bengals on October 5, 2025 in what looms as a high-stakes AFC matchup between a potent Detroit offense and a Bengals team that must shore up gaps if it hopes to keep pace. With both clubs eager to make statements early in the season, this game could become a litmus test for divisional and conference ambitions.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

GAME INFO
Date: Oct 05, 2025
Start Time: 4:25 PM EST
Venue: Paycor Stadium
Bengals Record: (2-1)
Lions Record: (3-1)
OPENING ODDS
DET Moneyline: -444
CIN Moneyline: +342
DET Spread: -8.5
CIN Spread: +8.5
Over/Under: 48.5
DET
Betting Trends
- Detroit has been strong against the spread lately, posting an 8–2 mark over its last 10 games, demonstrating a consistent ability to cover even when results fluctuate.
CIN
Betting Trends
- Cincinnati’s recent performance ATS is more erratic; across the 2024–2025 stretch, the Bengals hold a cumulative 4–3 ATS record, reflecting their unpredictability under varied lines.
MATCHUP TRENDS
- Oddsmakers and matchup models suggest the spread for this game could be narrow, likely hovering in the range of 2 to 4 points, which sets the stage for sharp bettors to exploit situational edges. In past differentials when Detroit has faced AFC North teams on the road, the Lions have often outperformed expectations ATS, especially when their offense is firing.
DET vs. CIN
Best Prop Bet
- Remi's searched hard and found the best prop for this matchup, but hasn't found a good Prop Bet yet for this game.
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Detroit vs Cincinnati Prediction & Odds:
Free NFL Betting Insights for 10/5/25
The Bengals will also lean on Joe Mixon and the ground game to maintain balance, something critical if they want to slow Detroit’s pass rush and keep Burrow in favorable down-and-distance situations. Defensively, Cincinnati has struggled at times against balanced attacks like Detroit’s, and their ability to contain Gibbs and Montgomery while still limiting Goff’s timing throws will be a defining factor in this matchup. From a betting perspective, Detroit’s 8–2 ATS mark in their last ten games underscores how consistently they’ve played above market expectations, while Cincinnati’s 4–3 ATS record highlights their uneven nature and suggests bettors view them as a volatile team to trust. The game projects as a tight spread, likely between two and four points, meaning situational football—third downs, turnovers, red-zone efficiency, and special teams—will loom large in determining the final outcome. Ultimately, this game could evolve into a chess match of discipline and execution, with Detroit bringing momentum, confidence, and balance into a hostile road setting, while Cincinnati leans on home-field energy and their explosive playmakers to tilt momentum their way. If the Lions can control the trenches and avoid giving Burrow short fields, they hold the advantage in overall structure and balance, but the Bengals’ ability to strike quickly means this contest could come down to a handful of plays late in the fourth quarter, making it a must-watch clash with postseason implications already starting to take shape.
Defended the Den 🔒 pic.twitter.com/gJNxtJ1Gj0
— Detroit Lions (@Lions) September 29, 2025
Detroit Lions NFL Preview
The Detroit Lions enter their October 5, 2025 matchup against the Cincinnati Bengals with confidence and a clear sense of identity, bringing one of the most balanced rosters in the NFL into a challenging road environment where they will be tested on both sides of the ball. Offensively, Detroit has thrived behind one of the league’s premier offensive lines, a unit that has allowed Jared Goff to play with timing, confidence, and precision while also opening lanes for the dynamic rushing duo of Jahmyr Gibbs and David Montgomery, whose contrasting styles give the Lions flexibility in dictating tempo. The passing game has been efficient and dangerous, with Amon-Ra St. Brown continuing to emerge as one of the NFL’s most reliable receivers, Jameson Williams providing vertical explosiveness, and tight end Sam LaPorta blossoming into a versatile safety valve who can attack defenses in the middle of the field. This arsenal, combined with coordinator Ben Johnson’s creative play-calling that utilizes motion, play-action, and layered route concepts, makes Detroit a tough assignment for any defense, and Cincinnati’s secondary will have to remain disciplined to avoid getting picked apart.
Defensively, the Lions have developed a stronger identity behind Aidan Hutchinson, whose pass rush presence can disrupt quarterbacks and set the tone for a unit that has improved in coverage and tackling consistency, though they will face one of their toughest challenges in trying to slow Joe Burrow and his weapons, particularly Ja’Marr Chase and Tee Higgins. Detroit’s key defensively will be preventing explosive plays while forcing the Bengals into long, methodical drives where mistakes become more likely, and if they can win on early downs to create third-and-long situations, they may tilt the balance. The Lions’ 8–2 record against the spread in their last ten games reflects their ability to not only win but often outperform expectations, and that confidence will be crucial in a setting where crowd noise and Cincinnati’s urgency will make execution paramount. As a road team, Detroit must stay disciplined with penalties, remain sharp in situational football, and avoid slow starts that could energize the Bengals’ home crowd, as giving Burrow and his offense momentum early could prove costly. Still, the Lions carry a blend of offensive versatility, defensive grit, and coaching creativity that positions them as a legitimate contender, and if they can control the line of scrimmage and stay efficient in the red zone, they have every chance to not just cover but secure a statement win on the road against one of the AFC’s most dangerous teams.

Credit: USA TODAY/IMAGN
Cincinnati Bengals NFL Preview
The Cincinnati Bengals approach their October 5, 2025 matchup against the Detroit Lions with the advantage of playing at Paycor Stadium, where the energy of a passionate fan base and the urgency of defending home turf could help elevate a team still working to find consistent form. Offensively, Cincinnati’s fortunes ride on the health and rhythm of Joe Burrow, who when protected remains one of the NFL’s most dangerous quarterbacks, capable of dissecting defenses with precision and pushing the ball vertically to stars like Ja’Marr Chase and Tee Higgins, while also leaning on Joe Mixon to keep defenses honest with the run. The offensive line remains the critical factor, as when it holds up Burrow can operate comfortably and orchestrate drives, but when pressure collapses the pocket their offense sputters into inefficiency. Against a Detroit defense led by Aidan Hutchinson and a pass rush that thrives on disrupting timing, the Bengals must be prepared with quick reads, max protection schemes, and play designs that allow Burrow to get the ball out efficiently to avoid costly sacks or turnovers. On defense, Cincinnati has shown flashes of quality play but has also struggled to consistently slow down balanced attacks, and the challenge against Detroit’s versatile offense will be significant, as the Bengals will need to contain Jahmyr Gibbs and David Montgomery while also maintaining coverage integrity against Amon-Ra St. Brown and Jameson Williams.
The Bengals’ secondary will have to play disciplined football to prevent Detroit’s receivers from finding mismatches, and their linebackers must remain sharp in coverage against Sam LaPorta, who has been a reliable option in the Lions’ passing game. From a betting perspective, Cincinnati’s recent 4–3 ATS record underscores a degree of unpredictability, and to cover in this contest they will need to execute situational football better than they have in recent weeks by converting red-zone trips into touchdowns rather than field goals and avoiding drive-killing penalties. Special teams execution could also prove pivotal, as flipping field position against a disciplined Lions team could provide the incremental advantage necessary in what oddsmakers project to be a narrow contest. Ultimately, the Bengals must blend offensive explosiveness with defensive resilience, leaning on Burrow’s leadership and the big-play ability of his supporting cast while trusting their defense to make just enough stops to give them a chance. If they protect the football, take advantage of their scoring opportunities, and energize the home crowd early with momentum plays, the Bengals have the tools to not only defend home turf but also hand Detroit one of its toughest early-season challenges.
Primetime pending.#CINvsDEN | @Ticketmaster pic.twitter.com/R6Bfla9nuD
— Cincinnati Bengals (@Bengals) September 29, 2025
Detroit vs. Cincinnati Prop Picks (AI)
Detroit vs. Cincinnati Prediction (AI)

Remi, our AI sports wizard, has been pouring over mountains of data from every facet between the Lions and Bengals and using recursive machine learning and cutting-edge AI to analyze the data to a single cover probability.
Remi has been most focused on the linear correlation of factor knucklehead sportsbettors regularly put on coaching factors between a Lions team going up against a possibly rested Bengals team. It appears the true game analytics might reflect a moderate lean against one Vegas line in particular.
Unlock this in-depth AI prediction and all of our NFL AI picks for FREE now.
Below is our current AI Detroit vs Cincinnati picks, computer picks Lions vs Bengals, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
---|---|---|---|---|---|---|
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full NFL Schedule.
Lions Betting Trends
Detroit has been strong against the spread lately, posting an 8–2 mark over its last 10 games, demonstrating a consistent ability to cover even when results fluctuate.
Bengals Betting Trends
Cincinnati’s recent performance ATS is more erratic; across the 2024–2025 stretch, the Bengals hold a cumulative 4–3 ATS record, reflecting their unpredictability under varied lines.
Lions vs. Bengals Matchup Trends
Oddsmakers and matchup models suggest the spread for this game could be narrow, likely hovering in the range of 2 to 4 points, which sets the stage for sharp bettors to exploit situational edges. In past differentials when Detroit has faced AFC North teams on the road, the Lions have often outperformed expectations ATS, especially when their offense is firing.
Detroit vs. Cincinnati Game Info
What time does Detroit vs Cincinnati start on October 05, 2025?
Detroit vs Cincinnati starts on October 05, 2025 at 4:25 PM EST.
Where is Detroit vs Cincinnati being played?
Venue: Paycor Stadium.
What are the opening odds for Detroit vs Cincinnati?
Spread: Cincinnati +8.5
Moneyline: Detroit -444, Cincinnati +342
Over/Under: 48.5
What are the records for Detroit vs Cincinnati?
Detroit: (3-1) | Cincinnati: (2-1)
What is the AI best bet for Detroit vs Cincinnati?
Remi's searched hard and found the best prop for this matchup, but hasn't found a good Prop Bet yet for this game.. Prices move—always shop for the best number.
What are Detroit vs Cincinnati trending bets?
Oddsmakers and matchup models suggest the spread for this game could be narrow, likely hovering in the range of 2 to 4 points, which sets the stage for sharp bettors to exploit situational edges. In past differentials when Detroit has faced AFC North teams on the road, the Lions have often outperformed expectations ATS, especially when their offense is firing.
What are Detroit trending bets?
DET trend: Detroit has been strong against the spread lately, posting an 8–2 mark over its last 10 games, demonstrating a consistent ability to cover even when results fluctuate.
What are Cincinnati trending bets?
CIN trend: Cincinnati’s recent performance ATS is more erratic; across the 2024–2025 stretch, the Bengals hold a cumulative 4–3 ATS record, reflecting their unpredictability under varied lines.
Where can I find AI Picks for Detroit vs Cincinnati?
See our latest NFL picks and odds pages for 2025 to compare prices before you bet.
Detroit vs. Cincinnati Odds
Remi is pouring through mountains of data on each line. In fact, anytime the Detroit vs Cincinnati trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme travel distance seemingly never follow normal, predictable patterns.
Detroit vs Cincinnati Opening Odds
DET Moneyline:
-444 CIN Moneyline: +342
DET Spread: -8.5
CIN Spread: +8.5
Over/Under: 48.5
Detroit vs Cincinnati Live Odds
Games | PTS | ML | SPR | O/U | |
---|---|---|---|---|---|
Oct 23, 2025 8:15PM EDT
Minnesota Vikings
Los Angeles Chargers
10/23/25 8:15PM
Vikings
Chargers
|
–
–
|
+152
-180
|
+3 (-102)
-3 (-120)
|
O 44.5 (-112)
U 44.5 (-108)
|
|
Oct 26, 2025 1:00PM EDT
Cleveland Browns
New England Patriots
10/26/25 1PM
Browns
Patriots
|
–
–
|
+290
-360
|
+7 (-114)
-7 (-106)
|
O 40.5 (-105)
U 40.5 (-115)
|
|
Oct 26, 2025 1:00PM EDT
Buffalo Bills
Carolina Panthers
10/26/25 1PM
Bills
Panthers
|
–
–
|
-390
+310
|
-7.5 (-102)
+7.5 (-120)
|
O 46.5 (-105)
U 46.5 (-115)
|
|
Oct 26, 2025 1:00PM EDT
New York Jets
Cincinnati Bengals
10/26/25 1PM
Jets
Bengals
|
–
–
|
+245
-300
|
+6.5 (-110)
-6.5 (-110)
|
O 43.5 (-115)
U 43.5 (-105)
|
|
Oct 26, 2025 1:00PM EDT
Chicago Bears
Baltimore Ravens
10/26/25 1PM
Bears
Ravens
|
–
–
|
+265
-330
|
+6.5 (-106)
-6.5 (-114)
|
O 50.5 (-105)
U 50.5 (-115)
|
|
Oct 26, 2025 1:00PM EDT
New York Giants
Philadelphia Eagles
10/26/25 1PM
Giants
Eagles
|
–
–
|
+285
-355
|
+7 (-108)
-7 (-112)
|
O 43.5 (-105)
U 43.5 (-115)
|
|
Oct 26, 2025 1:00PM EDT
San Francisco 49ers
Houston Texans
10/26/25 1PM
49ers
Texans
|
–
–
|
-102
-118
|
+1.5 (-115)
-1.5 (-105)
|
O 41.5 (-110)
U 41.5 (-110)
|
|
Oct 26, 2025 1:00PM EDT
Miami Dolphins
Atlanta Falcons
10/26/25 1PM
Dolphins
Falcons
|
–
–
|
+300
-375
|
+7.5 (-122)
-7.5 (+100)
|
O 44.5 (-114)
U 44.5 (-106)
|
|
Oct 26, 2025 4:05PM EDT
Tampa Bay Buccaneers
New Orleans Saints
10/26/25 4:05PM
Buccaneers
Saints
|
–
–
|
-225
+188
|
-4.5 (-106)
+4.5 (-114)
|
O 46.5 (-114)
U 46.5 (-106)
|
|
Oct 26, 2025 4:25PM EDT
Dallas Cowboys
Denver Broncos
10/26/25 4:25PM
Cowboys
Broncos
|
–
–
|
+146
-174
|
+3.5 (-118)
-3.5 (-104)
|
O 50.5 (-110)
U 50.5 (-110)
|
|
Oct 26, 2025 4:25PM EDT
Tennessee Titans
Indianapolis Colts
10/26/25 4:25PM
Titans
Colts
|
–
–
|
+750
-1200
|
+14.5 (-118)
-14.5 (-104)
|
O 46.5 (-114)
U 46.5 (-106)
|
|
Oct 26, 2025 8:20PM EDT
Green Bay Packers
Pittsburgh Steelers
10/26/25 8:20PM
Packers
Steelers
|
–
–
|
-176
+148
|
-3.5 (-104)
+3.5 (-118)
|
O 44.5 (-115)
U 44.5 (-105)
|
|
Oct 27, 2025 8:15PM EDT
Washington Commanders
Kansas City Chiefs
10/27/25 8:15PM
Commanders
Chiefs
|
–
–
|
+430
-590
|
+10.5 (-110)
-10.5 (-110)
|
O 47.5 (-110)
U 47.5 (-110)
|
|
Oct 30, 2025 8:15PM EDT
Baltimore Ravens
Miami Dolphins
10/30/25 8:15PM
Ravens
Dolphins
|
–
–
|
-430
+340
|
-8.5 (-105)
+8.5 (-115)
|
O 47.5 (-105)
U 47.5 (-115)
|
|
Nov 2, 2025 1:00PM EST
Chicago Bears
Cincinnati Bengals
11/2/25 1PM
Bears
Bengals
|
–
–
|
-120
+102
|
-1.5 (-110)
+1.5 (-110)
|
O 47.5 (-105)
U 47.5 (-115)
|
|
Nov 2, 2025 1:00PM EST
Indianapolis Colts
Pittsburgh Steelers
11/2/25 1PM
Colts
Steelers
|
–
–
|
-136
+116
|
-2.5 (-110)
+2.5 (-110)
|
O 47.5 (-110)
U 47.5 (-110)
|
NFL Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers Detroit Lions vs. Cincinnati Bengals on October 05, 2025 at Paycor Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our NFL odds pages, and compare prices before you place a bet.
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LEAN | %WIN | UNITS | RESULT |
---|---|---|---|---|
TB@DET | RACHAAD WHITE UNDER 14.5 RUSH ATT | 54.4% | 4 | WIN |
NE@TEN | NE -6.5 | 55.2% | 5 | WIN |
CAR@NYJ | CAR -110 | 57.4 | 4 | WIN |
PHI@MIN | PHI -130 | 58.0% | 6 | WIN |
GB@ARI | ARI +7 | 54.8% | 5 | WIN |
NO@CHI | NO +4.5 | 57.4% | 7 | LOSS |
WAS@DAL | JAYDEN DANIELS 1H RUSH YDS OVER 22.5 | 56.1% | 5 | WIN |
GB@ARI | JORDAN LOVE 1Q PASS YDS OVER 54.5 | 56.6% | 6 | WIN |
PIT@CIN | JONNU SMITH RECEPTIONS OVER 3.5 | 55.3% | 5 | LOSS |
BUF@ATL | BUF -3.5 | 54.7% | 4 | LOSS |
CHI@WAS | JAYDEN DANIELS OVER 1.5 PASS TDS | 56.6% | 6 | WIN |
TEN@LV | UNDER 42 | 54.8% | 3 | WIN |
DET@KC | DET +2.5 | 55.7% | 7 | LOSS |
SEA@JAC | SEA -112 | 55.7% | 5 | WIN |
LAC@MIA | LAC -3.5 | 54.0% | 3 | LOSS |
ARI@IND | IND -8.5 | 55.6% | 5 | LOSS |
TEN@LV | TEN +4.5 | 56.7% | 6 | LOSS |
LAR@BAL | LAR -7 | 56.2% | 6 | WIN |
SF@TB | SF +3.5 | 57.2% | 7 | LOSS |
CLE@PIT | JAYLEN WARREN UNDER 46.5 RUSH YDS | 54.4% | 4 | LOSS |
DEN@NYJ | BREECE HALL OVER 26.5 RECV YDS | 55.0% | 4 | LOSS |
KC@JAC | UNDER 45.5 | 54.9% | 3 | LOSS |
KC@JAC | PATRICK MAHOMES UNDER 23.5 PASS COMP | 56.6% | 6 | LOSS |
HOU@BAL | HOU -125 | 58.5% | 7 | WIN |
DET@CIN | DET -10 | 55.6% | 5 | WIN |
DAL@NYJ | NYJ +1.5 | 53.7% | 3 | LOSS |
TB@SEA | TB +3.5 | 54.9% | 4 | WIN |
TEN@ARI | ARI -7 (BUY 0.5) | 54.9% | 4 | LOSS |
DEN@PHI | DEN +4.5 | 57.5% | 7 | WIN |
MIA@CAR | TETAIROA MCMILLAN OVER 58.5 RECV YDS | 54.5% | 4 | WIN |
LV@IND | ASHTON JEANTY UNDER 67.5 RUSH YDS | 54.4% | 4 | WIN |
SF@LAR | DEMARCUS ROBINSON OVER 29.5 RECV YDS | 55.7% | 5 | WIN |
NYJ@MIA | NYJ +3 | 53.8 | 3 | LOSS |
CIN@DEN | DEN -7.5 | 54.8 | 4 | WIN |
NYJ@MIA | OVER 44 | 52.9% | 2 | WIN |
CIN@DEN | UNDER 44.5 | 53.7% | 3 | WIN |
NYJ@MIA | GARRETT WILSON UNDER 9 TARGETS | 53.7% | 3 | WIN |
CIN@DEN | TEE HIGGINS OVER 6.5 RECV TARGETS | 55.5% | 5 | LOSS |
WAS@ATL | ATL -2.5 | 54.3 | 4 | WIN |
BAL@KC | BAL -2.5 | 56.3% | 6 | LOSS |
TEN@HOU | TEN +7.5 | 57.9% | 7 | LOSS |
LAC@NYG | LAC -6 | 57.3% | 7 | LOSS |
NO@BUF | UNDER 48.5 | 55.1% | 3 | LOSS |
GB@DAL | JAVONTE WILLIAMS UNDER 72.5 RUSH + REC YDS | 55.5% | 5 | LOSS |
CAR@NE | DRAKE MAYE TO THROW AN INT | 56.6% | 6 | LOSS |
SEA@ARI | SEA -125 | 57.7% | 6 | WIN |
SEA@ARI | KYLER MURRAY TO THROW AN INT | 56.6% | 6 | WIN |
DET@BAL | JAHMYR GIBBS OVER 0.5 RUSH TDS | 55.8% | 5 | WIN |
DAL@CHI | DAL -120 | 58.7% | 6 | LOSS |
PIT@NE | PIT -116 | 60.1% | 6 | WIN |
ATL@CAR | ATL -4.5 | 55.4% | 5 | LOSS |