49ers vs Seahawks Prediction — AI Finds CAN'T MISS NFL Lines & Props (Sep 07)

Updated: 2025-08-31T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The Seattle Seahawks open their 2025 season at Lumen Field against the San Francisco 49ers on Sunday, September 7. Seattle is about a 1.5‑point home underdog, with the over/under set around 46 points.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Sep 07, 2025

Start Time: 4:05 PM EST​

Venue: Lumen Field​

Seahawks Record: (0-0)

49ers Record: (0-0)

OPENING ODDS

SF Moneyline: -123

SEA Moneyline: +104

SF Spread: -1.5

SEA Spread: +1.5

Over/Under: 45.5

SF
Betting Trends

  • San Francisco finished 5 – 12 ATS in 2024, covering just 29.4 % of their games.

SEA
Betting Trends

  • Seattle posted a modest 6 – 10 – 1 ATS last season, covering approximately 37.5 % of the time—even while going 7–1 on the road.

MATCHUP TRENDS

  • Seattle has gone 4–5–1 ATS as underdogs at home vs. San Francisco historically—suggesting this matchup hasn’t been kind to them at home even when the odds are in their favor.

SF vs. SEA
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: B. Aiyuk under 65.5 Receiving Yards.

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San Francisco vs Seattle Prediction & Odds:
Free NFL Betting Insights for 9/7/25

The 2025 NFL season brings an early divisional showdown in the NFC West as the San Francisco 49ers head to Seattle to face the Seahawks on Sunday, September 7, in what promises to be a tightly contested matchup between two franchises that know each other intimately. The 49ers are coming off a disappointing 6–11 campaign in 2024 marred by injuries to cornerstone players like Christian McCaffrey, Nick Bosa, and Trent Williams, but they are healthier entering this season and benefit from the return of former defensive coordinator Robert Saleh to stabilize a once-dominant unit. The Seahawks, meanwhile, narrowly missed the playoffs at 10–7 and struggled to find consistency at home, finishing 3–6 at Lumen Field and covering just 6 times in 17 games, including a 6–10–1 overall ATS record. Seattle underwent a dramatic offensive overhaul in the offseason by trading away quarterback Geno Smith and star wide receiver DK Metcalf, instead handing the offense over to Sam Darnold while acquiring veteran Cooper Kupp to guide a young receiving group that includes Jaxon Smith-Njigba. The 49ers retained Brock Purdy, who returns after an injury-plagued season that still saw him finish with over 3,800 yards passing, and the offense remains centered around McCaffrey’s versatility and the play-action passing game.

Defensively, San Francisco is banking on a resurgence under Saleh, with Bosa leading the pass rush and Fred Warner anchoring the linebacker corps, both crucial in keeping Darnold uncomfortable. Seattle’s new-look offense will have to find rhythm early, with an offensive line still sorting out roles and a backfield committee approach likely featuring Zach Charbonnet. The 49ers opened as slight favorites on the road, reflecting their higher ceiling and perceived bounce-back potential, while the total hovering near 46 indicates expectations of a balanced game—perhaps dictated more by field position and turnovers than offensive fireworks. Seattle will look to leverage their home-field advantage and the energy of the 12s to rattle Purdy and force early mistakes, but with a historically poor ATS record at home against the Niners, the psychological edge may lean toward San Francisco. If the 49ers’ offensive line holds up and Purdy avoids turnovers, they should be able to establish long drives and keep Darnold and Kupp off the field. For the Seahawks, success hinges on their ability to protect Darnold, scheme Kupp open in tight windows, and prevent San Francisco from gashing them on the ground. Both teams are entering this season with redemption on their minds—Seattle trying to prove that last year’s near-miss was no fluke, and San Francisco aiming to reclaim dominance in the division. With both defenses capable of making game-changing plays and each offense dealing with personnel adjustments, the margin for error will be razor-thin. Expect a physical, emotional clash between rivals, with San Francisco possessing the slight edge in cohesion and talent if they execute cleanly.

San Francisco 49ers NFL Preview

The San Francisco 49ers arrive in Seattle to begin their 2025 campaign with urgency and high expectations after a frustrating 6–11 season in 2024 that saw them miss the playoffs for the first time since 2020. Much of last year’s struggle came from a devastating rash of injuries to key players including Christian McCaffrey, Nick Bosa, Brandon Aiyuk, and Trent Williams—nearly all of whom are healthy and ready to go for Week 1. The return of Robert Saleh as defensive coordinator has energized the locker room and reinstalled the aggressive, swarming defensive identity that made the Niners a perennial NFC powerhouse in prior seasons. Brock Purdy is back under center after posting over 3,800 passing yards in a season that was efficient but often lacked rhythm due to the rotating door of injured starters. With McCaffrey expected to return to full speed, the 49ers can once again build their offense around his unique dual-threat capabilities, allowing Purdy to operate off play action and find targets like George Kittle and Aiyuk in space. On the outside, the receiving corps is healthy and dangerous, with Deebo Samuel expected to play a more prominent role alongside Aiyuk, giving Purdy a deep and versatile array of weapons. Up front, the offensive line remains anchored by future Hall-of-Famer Trent Williams, though there are still concerns about depth, especially against a Seattle front that loves to generate pressure through the interior.

Defensively, San Francisco enters the season determined to return to its dominant form, with Nick Bosa leading the edge rush and Fred Warner continuing to be the unit’s cerebral leader in the middle. The secondary features Charvarius Ward and emerging young safety Ji’Ayir Brown, giving Saleh plenty of flexibility in disguising coverages and confusing Sam Darnold, Seattle’s new quarterback. While the 49ers struggled against the spread last year at just 5–12, their familiarity with Seattle, especially under head coach Kyle Shanahan, has generally led to solid game plans and execution in this rivalry. San Francisco swept the Seahawks in both meetings in 2022 and 2023 before a slip in late 2024, and the coaching staff will be emphasizing discipline, field position, and mistake-free football to start 2025 the right way. On special teams, rookie kicker Will Reichard will make his debut in the thin margin environment of divisional play, and the team expects to lean on directional punting and coverage units to control the field. With McCaffrey as a bell cow, the defense at full strength, and Purdy operating with more continuity than a year ago, the 49ers are positioned to open the season with a calculated, physical effort. They know that division games carry extra weight in playoff tiebreakers, and a win in Seattle would immediately signal that the Niners are back to contending form. If they execute and avoid early miscues, the 49ers are capable of controlling time of possession, wearing down Seattle’s defense, and walking out of Lumen Field with a key road win and a strong statement.

The Seattle Seahawks open their 2025 season at Lumen Field against the San Francisco 49ers on Sunday, September 7. Seattle is about a 1.5‑point home underdog, with the over/under set around 46 points. San Francisco vs Seattle AI Prediction: Free NFL Betting Insights for Sep 07. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Seattle Seahawks NFL Preview

The Seattle Seahawks enter the 2025 NFL season at a crossroads, facing a challenging Week 1 test against divisional rival San Francisco 49ers at Lumen Field in a game that could reveal a great deal about the team’s new identity. With Mike Macdonald entering his second year as head coach and major changes across the roster, including at quarterback and wide receiver, the Seahawks are looking to reestablish themselves as a playoff-caliber squad after a 10–7 season that ended in an early postseason exit. Sam Darnold, now the starting quarterback, replaces Geno Smith and inherits a system built around quick decision-making, motion-heavy formations, and getting the ball out fast to mitigate pressure. Seattle’s biggest offseason splash came in the form of wide receiver Cooper Kupp, who joins Tyler Lockett and Jaxon Smith-Njigba to form an intriguing mix of experience, explosiveness, and reliability in the passing game. In the backfield, Kenneth Walker III returns as the lead rusher, with rookie Zach Charbonnet adding physicality and third-down utility. Seattle’s offensive line, while solid in 2024, must play at a high level to neutralize San Francisco’s defensive front that still includes Nick Bosa and Arik Armstead, who have repeatedly made life difficult for Seattle quarterbacks in recent seasons.

Defensively, the Seahawks will depend on a young core of rising stars, including cornerback Devon Witherspoon and linebacker Boye Mafe, as well as free-agent acquisition Leonard Williams up front. Last season, Seattle posted just a 6–10–1 ATS record, struggling to meet betting expectations even in games they won, and they were particularly inconsistent at home, going 3–6 straight up at Lumen Field. That trend must reverse quickly if Seattle hopes to keep pace in the always-tight NFC West. Against San Francisco, the key lies in third-down efficiency and preventing explosive plays—two areas where Seattle’s defense lagged in 2024. Macdonald’s defensive background brings hope for a more organized and aggressive scheme, especially in disguising coverages and dialing up timely pressure packages. Special teams will also be a point of emphasis, with veteran kicker Jason Myers and returner Dee Eskridge capable of flipping momentum in tight games. Historically, the Seahawks have enjoyed home-field advantage in this rivalry, but recent years have seen the 49ers take control, winning five of the last six meetings. Still, if Darnold can play mistake-free football, get into rhythm with Kupp early, and avoid the kind of backbreaking sacks or turnovers that have plagued previous openers, Seattle stands a real chance to cover as slight underdogs—and perhaps even steal a vital divisional win that could reshape expectations for the season. While oddsmakers are leaning toward San Francisco, the Seahawks have quietly upgraded across the board and now face the opportunity to reintroduce themselves to the league with a strong performance against a familiar and formidable foe in their own building.

San Francisco vs. Seattle Prop Picks (AI)

Remi is pouring through loads of data on each line. In fact, anytime the 49ers and Seahawks play there’s always several intriguing angles to key in on. Not to mention games played at Lumen Field in Sep almost always follow normal, predictable patterns.
Remi's searched hard and found the best prop for this matchup: B. Aiyuk under 65.5 Receiving Yards.

San Francisco vs. Seattle Prediction (AI)

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Remi, our AI sports genius, has been pouring over exorbitant amounts of data from every simulation between the 49ers and Seahawks and using recursive machine learning and industry leading AI to examine the data to a single cover probability.

Interestingly enough, the data has been most fixated on the growing factor human bettors tend to put on player performance factors between a 49ers team going up against a possibly improved Seahawks team. In reality, the true game analytics appear to reflect a slight lean against one Vegas line specifically.

Unlock this in-depth AI prediction and all of our NFL AI picks for FREE now.

Below is our current AI San Francisco vs Seattle picks, computer picks 49ers vs Seahawks, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full NFL Schedule.

49ers Betting Trends

San Francisco finished 5 – 12 ATS in 2024, covering just 29.4 % of their games.

Seahawks Betting Trends

Seattle posted a modest 6 – 10 – 1 ATS last season, covering approximately 37.5 % of the time—even while going 7–1 on the road.

49ers vs. Seahawks Matchup Trends

Seattle has gone 4–5–1 ATS as underdogs at home vs. San Francisco historically—suggesting this matchup hasn’t been kind to them at home even when the odds are in their favor.

San Francisco vs. Seattle Game Info

San Francisco vs Seattle starts on September 07, 2025 at 4:05 PM EST.

Spread: Seattle +1.5
Moneyline: San Francisco -123, Seattle +104
Over/Under: 45.5

San Francisco: (0-0)  |  Seattle: (0-0)

Remi's searched hard and found the best prop for this matchup: B. Aiyuk under 65.5 Receiving Yards.. Prices move—always shop for the best number.

Seattle has gone 4–5–1 ATS as underdogs at home vs. San Francisco historically—suggesting this matchup hasn’t been kind to them at home even when the odds are in their favor.

SF trend: San Francisco finished 5 – 12 ATS in 2024, covering just 29.4 % of their games.

SEA trend: Seattle posted a modest 6 – 10 – 1 ATS last season, covering approximately 37.5 % of the time—even while going 7–1 on the road.

See our latest NFL picks and odds pages for 2025 to compare prices before you bet.

San Francisco vs. Seattle Odds

Remi is pouring through tons of data on each team. In fact, anytime the San Francisco vs Seattle trends are analyzed, there’s always several intriguing trends to key in on. Not to mention games played at extreme altitude almost always follow normal, predictable betting trends.

San Francisco vs Seattle Opening Odds

SF Moneyline: -123
SEA Moneyline: +104
SF Spread: -1.5
SEA Spread: +1.5
Over/Under: 45.5

San Francisco vs Seattle Live Odds

Games PTS ML SPR O/U
Oct 30, 2025 8:15PM EDT
Baltimore Ravens
Miami Dolphins
10/30/25 8:15PM
Ravens
Dolphins
-440
+344
-7.5 (-110)
+7.5 (-110)
O 51 (-105)
U 51 (-115)
Nov 2, 2025 1:00PM EST
Chicago Bears
Cincinnati Bengals
11/2/25 1PM
Bears
Bengals
-160
+140
-2.5 (-125)
+2.5 (+105)
O 51.5 (-104)
U 51.5 (-116)
Nov 2, 2025 1:00PM EST
Indianapolis Colts
Pittsburgh Steelers
11/2/25 1PM
Colts
Steelers
-171
+150
-3 (-117)
+3 (-103)
O 50.5 (-110)
U 50.5 (-110)
Nov 2, 2025 1:00PM EST
Carolina Panthers
Green Bay Packers
11/2/25 1PM
Panthers
Packers
+613
-900
+13 (-105)
-13 (-115)
O 44 (-110)
U 44 (-110)
Nov 2, 2025 1:00PM EST
Atlanta Falcons
New England Patriots
11/2/25 1PM
Falcons
Patriots
+207
-250
+5 (-105)
-5 (-115)
O 45 (-110)
U 45 (-110)
Nov 2, 2025 1:00PM EST
Denver Broncos
Houston Texans
11/2/25 1PM
Broncos
Texans
+105
-125
+1 (+100)
-1 (-120)
O 40 (-110)
U 40 (-110)
Nov 2, 2025 1:00PM EST
San Francisco 49ers
New York Giants
11/2/25 1PM
49ers
Giants
-147
+127
-2.5 (-115)
+2.5 (-105)
O 49 (-103)
U 49 (-117)
Nov 2, 2025 1:00PM EST
Los Angeles Chargers
Tennessee Titans
11/2/25 1PM
Chargers
Titans
-500
+383
-9.5 (-105)
+9.5 (-115)
O 43.5 (-108)
U 43.5 (-112)
Nov 2, 2025 1:00PM EST
Minnesota Vikings
Detroit Lions
11/2/25 1PM
Vikings
Lions
+374
-485
+9 (-110)
-9 (-110)
O 47.5 (-117)
U 47.5 (-103)
Nov 2, 2025 4:05PM EST
New Orleans Saints
Los Angeles Rams
11/2/25 4:05PM
Saints
Rams
+754
-1200
+13.5 (+100)
-13.5 (-120)
O 44 (-107)
U 44 (-113)
Nov 2, 2025 4:05PM EST
Jacksonville Jaguars
Las Vegas Raiders
11/2/25 4:05PM
Jaguars
Raiders
-150
+130
-3 (+100)
+3 (-120)
O 44.5 (-110)
U 44.5 (-110)
Nov 2, 2025 4:25PM EST
Kansas City Chiefs
Buffalo Bills
11/2/25 4:25PM
Chiefs
Bills
-130
+110
-2 (-110)
+2 (-110)
O 52.5 (-110)
U 52.5 (-110)
Nov 2, 2025 8:20PM EST
Seattle Seahawks
Washington Commanders
11/2/25 8:20PM
Seahawks
Commanders
-163
+143
-3 (-113)
+3 (-107)
O 48 (-110)
U 48 (-110)
Nov 3, 2025 8:15PM EST
Arizona Cardinals
Dallas Cowboys
11/3/25 8:15PM
Cardinals
Cowboys
+130
-150
+2.5 (-105)
-2.5 (-115)
O 53.5 (-105)
U 53.5 (-115)
Nov 6, 2025 8:15PM EST
Las Vegas Raiders
Denver Broncos
11/6/25 8:15PM
Raiders
Broncos
+370
-480
+9.5 (-106)
-9.5 (-114)
O 42.5 (-110)
U 42.5 (-110)
Nov 9, 2025 9:30AM EST
Atlanta Falcons
Indianapolis Colts
11/9/25 9:30AM
Falcons
Colts
+290
-360
+7 (-106)
-7 (-114)
O 48.5 (-110)
U 48.5 (-110)

NFL Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers San Francisco 49ers vs. Seattle Seahawks on September 07, 2025 at Lumen Field.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our NFL odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
TB@NO TB -3.5 52.3% 1 WIN
GB@PIT GB -2.5 52.3% 1 WIN
SF@HOU SF +2.5 56.0% 6 LOSS
NYG@PHI NYG +7.5 53.9% 3 LOSS
BUF@CAR CAR +7.5 54.2% 3 LOSS
DAL@DEN DAL +3.5 55.0% 4 LOSS
MIA@ATL MIA +7 54.3% 4 WIN
CLE@NE CLE +7 56.8% 6 LOSS
TB@NO BAKER MAYFIELD OVER 15.5 RUSH YDS 56.6% 6 LOSS
MIN@LAC JUSTIN HERBERT PASS ATT UNDER 35.5 55.5% 5 WIN
TB@DET TB +6.5 54.4% 4 LOSS
TB@DET RACHAAD WHITE UNDER 14.5 RUSH ATT 54.4% 4 WIN
NE@TEN NE -6.5 55.2% 5 WIN
CAR@NYJ CAR -110 57.4 4 WIN
PHI@MIN PHI -130 58.0% 6 WIN
GB@ARI ARI +7 54.8% 5 WIN
NO@CHI NO +4.5 57.4% 7 LOSS
WAS@DAL JAYDEN DANIELS 1H RUSH YDS OVER 22.5 56.1% 5 WIN
GB@ARI JORDAN LOVE 1Q PASS YDS OVER 54.5 56.6% 6 WIN
PIT@CIN JONNU SMITH RECEPTIONS OVER 3.5 55.3% 5 LOSS
BUF@ATL BUF -3.5 54.7% 4 LOSS
CHI@WAS JAYDEN DANIELS OVER 1.5 PASS TDS 56.6% 6 WIN
TEN@LV UNDER 42 54.8% 3 WIN
DET@KC DET +2.5 55.7% 7 LOSS
SEA@JAC SEA -112 55.7% 5 WIN
LAC@MIA LAC -3.5 54.0% 3 LOSS
ARI@IND IND -8.5 55.6% 5 LOSS
TEN@LV TEN +4.5 56.7% 6 LOSS
LAR@BAL LAR -7 56.2% 6 WIN
SF@TB SF +3.5 57.2% 7 LOSS
CLE@PIT JAYLEN WARREN UNDER 46.5 RUSH YDS 54.4% 4 LOSS
DEN@NYJ BREECE HALL OVER 26.5 RECV YDS 55.0% 4 LOSS
KC@JAC UNDER 45.5 54.9% 3 LOSS
KC@JAC PATRICK MAHOMES UNDER 23.5 PASS COMP 56.6% 6 LOSS
HOU@BAL HOU -125 58.5% 7 WIN
DET@CIN DET -10 55.6% 5 WIN
DAL@NYJ NYJ +1.5 53.7% 3 LOSS
TB@SEA TB +3.5 54.9% 4 WIN
TEN@ARI ARI -7 (BUY 0.5) 54.9% 4 LOSS
DEN@PHI DEN +4.5 57.5% 7 WIN
MIA@CAR TETAIROA MCMILLAN OVER 58.5 RECV YDS 54.5% 4 WIN
LV@IND ASHTON JEANTY UNDER 67.5 RUSH YDS 54.4% 4 WIN
SF@LAR DEMARCUS ROBINSON OVER 29.5 RECV YDS 55.7% 5 WIN
NYJ@MIA NYJ +3 53.8 3 LOSS
CIN@DEN DEN -7.5 54.8 4 WIN
NYJ@MIA OVER 44 52.9% 2 WIN
CIN@DEN UNDER 44.5 53.7% 3 WIN
NYJ@MIA GARRETT WILSON UNDER 9 TARGETS 53.7% 3 WIN
CIN@DEN TEE HIGGINS OVER 6.5 RECV TARGETS 55.5% 5 LOSS
WAS@ATL ATL -2.5 54.3 4 WIN
BAL@KC BAL -2.5 56.3% 6 LOSS