Lions vs. Packers
Prediction, Odds & Props
Sep 07 | NFL AI Picks
Updated: 2025-08-31T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The Detroit Lions open Week 1 of the 2025 season on the road at Lambeau Field against the Green Bay Packers as 1.5‑point underdogs, with the over/under set around 49.5 points. This NFC North opener pits the defending division champion Lions against a Packers squad looking to rise after a solid playoff run.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

GAME INFO
Date: Sep 07, 2025
Start Time: 4:25 PM EST
Venue: Lambeau Field
Packers Record: (0-0)
Lions Record: (0-0)
OPENING ODDS
DET Moneyline: +105
GB Moneyline: -124
DET Spread: +1.5
GB Spread: -1.5
Over/Under: 49.5
DET
Betting Trends
- Detroit posted an exceptional 12–6 ATS record in 2024, tied for the best in the NFL, reflecting consistent performance and strong value as both underdogs and favorites.
GB
Betting Trends
- Green Bay finished an even 9–9 ATS in 2024, demonstrating middle‑of‑the-road results that left bettors unsure whether they could be trusted in divisional games.
MATCHUP TRENDS
- Although the Packers host this game, early betting interest has skewed toward the Lions covering, continuing Detroit’s trend of overperforming expectations—even on the road.
DET vs. GB
Best Prop Bet
- Remi's searched hard and found the best prop for this matchup: J. Gibbs over 66.5 Rushing Yards.
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Detroit vs Green Bay Prediction & Odds:
Free NFL Betting Insights for 9/7/25
Their defense, led by Rashan Gary and Quay Walker, remains capable of making impact plays but struggled at times last year against creative playcallers like Detroit’s Ben Johnson. Betting markets opened the game with Detroit as a slight 1.5-point underdog, but action has gradually moved toward the Lions thanks to their 12–6 ATS performance in 2024 and recent head-to-head success against Green Bay. The over/under total hovering around 49.5 points suggests an expectation for a moderately high-scoring contest, where each team’s red zone efficiency and ability to finish drives will be crucial. The chess match between Detroit’s evolving passing game and Green Bay’s physical secondary could be the fulcrum on which the outcome swings, especially if weather plays a factor in Lambeau’s early September conditions. Detroit’s offensive line, one of the best in the league, will be tasked with containing Green Bay’s pass rush and opening lanes for Gibbs and Montgomery, while the Packers need to ensure they don’t fall behind early—a vulnerability that cost them in both regular season meetings last year. On special teams, both units are solid, but any lapse could prove costly in a tight divisional opener. Coaching will also play a large role: Dan Campbell’s Lions have been one of the most disciplined and aggressive teams on fourth downs, while Matt LaFleur’s Packers tend to rely more on field position and structured drives. If the Lions strike first and dictate pace, they could silence Lambeau early and steal an important road win. Conversely, if Green Bay’s defense sets the tone and Jordan Love manages clean offensive possessions, the Packers can reassert themselves in the division hierarchy. It’s a game loaded with narrative and opportunity, and one that should set the tone for two franchises who believe they’re poised to contend well beyond the NFC North in 2025.
Lions have released CB Stantley Thomas-Oliver. pic.twitter.com/I55W3LA90K
— Detroit Lions (@Lions) July 27, 2025
Detroit Lions NFL Preview
The Detroit Lions enter the 2025 season with soaring expectations and a target on their back as defending NFC North champions, traveling to Lambeau Field in Week 1 to face the rival Green Bay Packers in a game that could immediately reinforce their hold on the division. After finishing 15–2 last year with a league-best 12–6 ATS record, Detroit is widely considered one of the most complete teams in the NFL, featuring a deep, balanced offense and an aggressive, physical defense that punishes mistakes. Quarterback Jared Goff returns with full command of Ben Johnson’s offensive system and an elite supporting cast that includes All-Pro receiver Amon-Ra St. Brown, dynamic rookie-turned-star Jahmyr Gibbs, dependable power back David Montgomery, and breakout tight end Sam LaPorta. The offensive line, anchored by Penei Sewell and Frank Ragnow, is among the league’s best and key to both the run game’s success and Goff’s clean pocket operation. Defensively, the Lions expect to take another step forward after making major improvements in 2024, especially in their pass rush and coverage schemes. Aidan Hutchinson leads the defensive line while Alim McNeill and Jack Campbell provide stability in the front seven, and the return of Brian Branch in the secondary adds versatility and playmaking to a group that thrived late last season.
On the road at Lambeau, Detroit’s focus will be on dictating pace early, avoiding turnovers, and exploiting mismatches in the Packers’ secondary, particularly against younger or untested corners. Goff’s chemistry with St. Brown and LaPorta gives Detroit short-to-intermediate reliability, while Jameson Williams adds a vertical threat that can punish single-high looks. Against a Green Bay team that finished 9–9 ATS last season and has historically defended home turf well, Detroit’s edge lies in its continuity and offensive efficiency—an area where the Lions often gain early leads and force opponents into uncomfortable game scripts. Special teams also offer a quiet advantage for the Lions, who return kicker Michael Badgley and possess a disciplined coverage unit that rarely allows field-flipping returns. Dan Campbell’s aggressive fourth-down mindset and willingness to trust analytics have also made the Lions one of the most difficult teams to predict and prepare for, especially in divisional games. Detroit has won three of the last four meetings with Green Bay, including a statement win at Lambeau last season that helped clinch the division, and they arrive confident, rested, and relatively healthy. If the Lions can continue their trend of sharp execution, ball control, and red zone dominance, they should be in strong position to not only cover the spread but also start 1–0 and send a message that they remain the team to beat in the NFC North. Lambeau is never an easy place to win, but this version of the Lions is built to travel, handle adversity, and convert opportunities into early-season momentum.

Credit: USA TODAY/IMAGN
Green Bay Packers NFL Preview
The Green Bay Packers begin their 2025 season at home in iconic Lambeau Field with a critical NFC North clash against the defending division champion Detroit Lions, aiming to make an early statement against a team that bested them in both meetings last year. Under head coach Matt LaFleur, the Packers enter a pivotal year of development with quarterback Jordan Love, who showed real growth in 2024 by passing for over 3,600 yards and leading Green Bay to an 11–6 finish and a playoff berth. Love’s command of the offense continues to improve, and he now has additional tools at his disposal including veteran running back Josh Jacobs, a rebuilt receiving corps headlined by Christian Watson and Romeo Doubs, and one of the league’s most stable offensive lines, anchored by Elgton Jenkins and Zach Tom. That unit will be key in neutralizing Detroit’s relentless defensive front and giving Love the time to operate in both play-action and intermediate zone reads. Green Bay’s defense remains built around speed and disruption, with Rashan Gary and Kenny Clark leading the charge up front, while De’Vondre Campbell, Quay Walker, and safety Xavier McKinney add athleticism and experience at the second and third levels. Last season, the Packers finished an even 9–9 against the spread, and their home results were inconsistent—an issue that LaFleur and his staff have stressed throughout training camp. To reverse those trends, Green Bay needs to start fast, generate early pressure on Jared Goff, and keep the Lions’ offense from dictating tempo with their elite offensive line and versatile playmakers.
On offense, Green Bay will look to establish a physical identity by feeding Josh Jacobs early and using misdirection to freeze Detroit’s linebackers and safeties. Love’s ability to extend plays with his legs adds a crucial element, especially if the Lions focus heavily on collapsing the pocket. The Packers’ receiving group lacks a true No. 1 star but makes up for it with solid depth, and tight ends Luke Musgrave and Tucker Kraft are poised for bigger roles as safety valves and red zone targets. Special teams could play a vital role as well—Green Bay will lean on kicker Anders Carlson and dynamic returner Keisean Nixon to generate favorable field position and possibly swing momentum in a close contest. More importantly, Lambeau Field will be loud, cold, and hostile—ideal conditions for a young team trying to prove its mettle against a rising powerhouse. If Green Bay can win the turnover battle, capitalize in the red zone, and avoid the kind of mental mistakes that have haunted them in recent divisional games, they have a strong chance to not only cover the narrow spread but walk away with a confidence-building win. The coaching staff has emphasized execution and discipline throughout the offseason, and a clean, efficient game from Jordan Love could set the tone for a season where Green Bay believes it can compete for the division crown. The Lions may be favored by oddsmakers, but the Packers relish the underdog role, especially in front of their home fans to start a new chapter.
Getting back to ball@emplifybellin pic.twitter.com/lvToDpT7Rk
— Green Bay Packers (@packers) July 27, 2025
Detroit vs. Green Bay Prop Picks (AI)
Detroit vs. Green Bay Prediction (AI)

Remi, our AI sports algorithm, has been pouring over millions of data from every past game between the Lions and Packers and using recursive machine learning and kick-ass AI to analyze the data to a single cover probability.
The Algorithm has been most focused on the trending factor emotional bettors regularly put on Green Bay’s strength factors between a Lions team going up against a possibly unhealthy Packers team. We’ve found the true game analytics might reflect a strong lean against one Vegas line in particular.
Unlock this in-depth AI prediction and all of our NFL AI picks for FREE now.
Below is our current AI Detroit vs Green Bay picks, computer picks Lions vs Packers, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
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NFL | 9/18 | MIA@BUF | UNLOCK THIS PICK | 6 |
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NFL | 9/18 | MIA@BUF | UNLOCK THIS PICK | 1 |
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NFL | 9/18 | MIA@BUF | GET FREE PICK NOW | 1 | – |
These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number.
Lions Betting Trends
Detroit posted an exceptional 12–6 ATS record in 2024, tied for the best in the NFL, reflecting consistent performance and strong value as both underdogs and favorites.
Packers Betting Trends
Green Bay finished an even 9–9 ATS in 2024, demonstrating middle‑of‑the-road results that left bettors unsure whether they could be trusted in divisional games.
Lions vs. Packers Matchup Trends
Although the Packers host this game, early betting interest has skewed toward the Lions covering, continuing Detroit’s trend of overperforming expectations—even on the road.
Detroit vs. Green Bay Game Info
What time does Detroit vs Green Bay start on September 07, 2025?
Detroit vs Green Bay starts on September 07, 2025 at 4:25 PM EST.
Where is Detroit vs Green Bay being played?
Venue: Lambeau Field.
What are the opening odds for Detroit vs Green Bay?
Spread: Green Bay -1.5
Moneyline: Detroit +105, Green Bay -124
Over/Under: 49.5
What are the records for Detroit vs Green Bay?
Detroit: (0-0) | Green Bay: (0-0)
What is the AI best bet for Detroit vs Green Bay?
Remi's searched hard and found the best prop for this matchup: J. Gibbs over 66.5 Rushing Yards.. Prices move—always shop for the best number.
What are Detroit vs Green Bay trending bets?
Although the Packers host this game, early betting interest has skewed toward the Lions covering, continuing Detroit’s trend of overperforming expectations—even on the road.
What are Detroit trending bets?
DET trend: Detroit posted an exceptional 12–6 ATS record in 2024, tied for the best in the NFL, reflecting consistent performance and strong value as both underdogs and favorites.
What are Green Bay trending bets?
GB trend: Green Bay finished an even 9–9 ATS in 2024, demonstrating middle‑of‑the-road results that left bettors unsure whether they could be trusted in divisional games.
Where can I find AI Picks for Detroit vs Green Bay?
See our latest NFL picks and odds pages for 2025 to compare prices before you bet.
Detroit vs. Green Bay Odds
Remi is pouring through loads of stats on each line. In fact, anytime the Detroit vs Green Bay trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme temps seemingly never follow normal, predictable patterns.
Detroit vs Green Bay Opening Odds
DET Moneyline:
+105 GB Moneyline: -124
DET Spread: +1.5
GB Spread: -1.5
Over/Under: 49.5
Detroit vs Green Bay Live Odds
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---|---|---|---|---|---|
Sep 21, 2025 1:00PM EDT
New York Jets
Tampa Bay Buccaneers
9/21/25 1PM
Jets
Buccaneers
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–
–
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+255
-345
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+6.5 (-110)
-6.5 (-115)
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O 43.5 (-113)
U 43.5 (-113)
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Sep 21, 2025 1:00PM EDT
Las Vegas Raiders
Washington Commanders
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Raiders
Commanders
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–
–
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+143
-186
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+3.5 (-115)
-3.5 (-110)
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O 44 (-115)
U 44 (-110)
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Sep 21, 2025 1:00PM EDT
Atlanta Falcons
Carolina Panthers
9/21/25 1PM
Falcons
Panthers
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–
–
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-250
+195
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-5.5 (-114)
+5.5 (-112)
|
O 43.5 (-112)
U 43.5 (-113)
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Sep 21, 2025 1:00PM EDT
Green Bay Packers
Cleveland Browns
9/21/25 1PM
Packers
Browns
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–
–
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-480
+330
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-8 (-110)
+8 (-115)
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O 41.5 (-113)
U 41.5 (-113)
|
|
Sep 21, 2025 1:00PM EDT
Houston Texans
Jacksonville Jaguars
9/21/25 1PM
Texans
Jaguars
|
–
–
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+100
-125
|
+1.5 (-113)
-1.5 (-113)
|
O 44 (-112)
U 44 (-114)
|
|
Sep 21, 2025 1:00PM EDT
Pittsburgh Steelers
New England Patriots
9/21/25 1PM
Steelers
Patriots
|
–
–
|
-125
+100
|
-1.5 (-113)
+1.5 (-113)
|
O 44.5 (-112)
U 44.5 (-114)
|
|
Sep 21, 2025 1:00PM EDT
Cincinnati Bengals
Minnesota Vikings
9/21/25 1PM
Bengals
Vikings
|
–
–
|
+120
-152
|
+3 (-117)
-3 (-108)
|
O 42 (-114)
U 42 (-112)
|
|
Sep 21, 2025 1:01PM EDT
Los Angeles Rams
Philadelphia Eagles
9/21/25 1:01PM
Rams
Eagles
|
–
–
|
+155
-195
|
+3.5 (-120)
-3.5 (-107)
|
O 44.5 (-113)
U 44.5 (-113)
|
|
Sep 21, 2025 1:01PM EDT
Indianapolis Colts
Tennessee Titans
9/21/25 1:01PM
Colts
Titans
|
–
–
|
-215
+165
|
-4 (-113)
+4 (-113)
|
O 43.5 (-114)
U 43.5 (-112)
|
|
Sep 21, 2025 4:05PM EDT
Denver Broncos
Los Angeles Chargers
9/21/25 4:05PM
Broncos
Chargers
|
–
–
|
+120
-150
|
+2.5 (-109)
-2.5 (-115)
|
O 45.5 (-112)
U 45.5 (-114)
|
|
Sep 21, 2025 4:05PM EDT
New Orleans Saints
Seattle Seahawks
9/21/25 4:05PM
Saints
Seahawks
|
–
–
|
+295
-420
|
+7.5 (-117)
-7.5 (-109)
|
O 41.5 (-114)
U 41.5 (-112)
|
|
Sep 21, 2025 4:25PM EDT
Dallas Cowboys
Chicago Bears
9/21/25 4:25PM
Cowboys
Bears
|
–
–
|
-114
-110
|
pk
pk
|
O 50.5 (-112)
U 50.5 (-114)
|
|
Sep 21, 2025 4:26PM EDT
Arizona Cardinals
San Francisco 49ers
9/21/25 4:26PM
Cardinals
49ers
|
–
–
|
+123
-159
|
+2.5 (-113)
-2.5 (-113)
|
O 45.5 (-115)
U 45.5 (-110)
|
|
Sep 21, 2025 8:21PM EDT
Kansas City Chiefs
New York Giants
9/21/25 8:21PM
Chiefs
Giants
|
–
–
|
-315
+235
|
-6 (-112)
+6 (-114)
|
O 44.5 (-115)
U 44.5 (-110)
|
|
Sep 22, 2025 8:15PM EDT
Detroit Lions
Baltimore Ravens
9/22/25 8:15PM
Lions
Ravens
|
–
–
|
+190
-250
|
+5 (-115)
-5 (-110)
|
O 52.5 (-112)
U 52.5 (-113)
|
|
Sep 25, 2025 8:16PM EDT
Seattle Seahawks
Arizona Cardinals
9/25/25 8:16PM
Seahawks
Cardinals
|
–
–
|
+108
-137
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+2.5 (-113)
-2.5 (-113)
|
O 43.5 (-113)
U 43.5 (-112)
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NFL Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers Detroit Lions vs. Green Bay Packers on September 07, 2025 at Lambeau Field.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our NFL odds pages, and compare prices before you place a bet.
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LEAN | %WIN | UNITS | RESULT |
---|---|---|---|---|
LAC@LV | LAC -3 | 54.9% | 4 | WIN |
TB@HOU | BAKER MAYFIELD OVER 1.5 PASS TDS | 54.4% | 4 | WIN |
CHI@DET | DET -6.5 | 54.3% | 4 | WIN |
DEN@IND | DEN -118 | 60.1% | 10 | LOSS |
PHI@KC | PHI -115 | 56.7% | 6 | WIN |
SF@NO | SF -3 | 58.8% | 8 | WIN |
SEA@PIT | OVER 40 | 54.9% | 4 | WIN |
CAR@ARI | BRYCE YOUNG INTERCEPTIONS UNDER 0.5 | 56.4% | 6 | LOSS |
DEN@IND | JOSH DOWNS RECEPTIONS OVER 3.5 | 54.7% | 4 | WIN |
ATL@MIN | BIJAN ROBINSON RUSH + REC YDS OVER 94.5 | 53.4% | 3 | WIN |
WAS@GB | WAS +3.5 | 56.5% | 6 | LOSS |
WAS@GB | JORDAN LOVE OVER 5.5 RUSH YDS | 54.7% | 4 | WIN |
MIN@CHI | CALEB WILLIAMS OVER 219.5 PASS YDS | 53.4% | 3 | LOSS |
TEN@DEN | DEN -8.5 | 55.3% | 5 | LOSS |
SF@SEA | SF -115 | 54.6% | 4 | WIN |
SF@SEA | KENNETH WALKER III UNDER 79.5 RUSH+REC YDS | 54.6% | 4 | WIN |
CAR@JAC | TANK BIGSBY OVER 10.5 RUSH ATT | 56.1% | 6 | LOSS |
KC@LAC | JUSTIN HERBERT UNDER 0.5 INT | 54.1% | 3 | WIN |
DAL@PHI | GEORGE PICKENS LONGEST RECEPTION OVER 22.5 YDS | 54.1% | 4 | LOSS |
KC@PHI | JUJU SMITH-SCHUSTER UNDER 16.5 RECV YDS | 53.90% | 5 | WIN |
KC@PHI | DEVONTA SMITH LONGEST RECEPTION OVER 20.5 YDS | 54.40% | 6 | WIN |
KC@PHI | PATRICK MAHOMES UNDER 68.3% PASS COMP | 55.00% | 8 | WIN |
KC@PHI | JALEN HURTS LONGEST RUSH OVER 12.5 YDS | 55.60% | 8 | WIN |
BUF@KC | DALTON KINCAID OVER 29.5 RECV YDS | 55.10% | 8 | LOSS |
WAS@PHI | DEVONTA SMITH OVER 3.5 RECEPTIONS | 55.80% | 8 | WIN |
BUF@KC | JAMES COOK ANYTIME TD | 53.00% | 5 | WIN |
LAR@PHI | SAQUON BARKLEY UNDER 128 RUSH + REC YDS | 53.20% | 5 | LOSS |
BAL@BUF | LAMAR JACKSON OVER 54.5 RUSH YDS | 54.50% | 6 | LOSS |
HOU@KC | C.J. STROUD RUSH YDS UNDER 14.5 | 53.10% | 5 | LOSS |
WAS@DET | JAMESON WILLIAMS RUSH YDS OVER 1.5 | 53.30% | 5 | WIN |
WAS@DET | JARED GOFF PASS COMP % UNDER 72.3 | 54.30% | 6 | WIN |
MIN@LAR | COOPER KUPP ANYTIME TOUCHDOWN | 52.60% | 3 | LOSS |
MIN@LAR | MATTHEW STAFFORD OVER 21.5 PASS COMP | 54.10% | 6 | LOSS |
WAS@TB | BRIAN ROBINSON JR OVER 1.5 REC TARGETS | 53.50% | 5 | WIN |
WAS@TB | BAKER MAYFIELD UNDER 33.5 PASS ATT | 54.90% | 6 | WIN |
GB@PHI | JALEN HURTS OVER 67.1 PASS COMP PERCENTAGE | 54.60% | 6 | LOSS |
LAC@HOU | J.K. DOBBINS ANYTIME TD | 52.80% | 3 | LOSS |
LAC@HOU | LAC -2.5 | 53.40% | 3 | LOSS |
LAC@HOU | JUSTIN HERBERT OVER 19.5 RUSH YDS | 53.40% | 5 | LOSS |
PIT@BAL | JUSTICE HILL OVER 2.5 RECEPTIONS | 55.30% | 8 | WIN |
MIN@DET | DET -3 | 53.90% | 3 | WIN |
KC@DEN | DEN -11.5 | 53.80% | 3 | WIN |
MIN@DET | T.J. HOCKENSON RECV YDS OVER 46.5 | 55.00% | 6 | LOSS |
SEA@LAR | ZACH CHARBONNET RECV YDS OVER 18.5 | 53.90% | 8 | WIN |
TB@NO | BAKER MAYFIELD PASS ATT OVER 31.5 | 53.80% | 8 | WIN |
CIN@PIT | CIN -130 | 56.20% | 3 | WIN |
CIN@PIT | RUSSELL WILSON PASS ATT OVER 31.5 | 54.60% | 6 | LOSS |
CLE@BAL | ELIJAH MOORE RECV TARGETS OVER 5.5 | 54.30% | 6 | LOSS |
CIN@PIT | PAT FREIERMUTH ANYTIME TD (UNITS ADJ FOR +400 ODDS) | 52.50% | 9 | WIN |
DET@SF | DET -3.5 | 54.10% | 4 | WIN |
DET@SF | JAHMYR GIBBS LONGEST RUSH OVER 16.5 YDS | 53.60% | 5 | WIN |