Lions vs Packers Prediction — AI Finds CAN'T MISS NFL Lines & Props (Sep 07)

Updated: 2025-08-31T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The Detroit Lions open Week 1 of the 2025 season on the road at Lambeau Field against the Green Bay Packers as 1.5‑point underdogs, with the over/under set around 49.5 points. This NFC North opener pits the defending division champion Lions against a Packers squad looking to rise after a solid playoff run.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Sep 07, 2025

Start Time: 4:25 PM EST​

Venue: Lambeau Field​

Packers Record: (0-0)

Lions Record: (0-0)

OPENING ODDS

DET Moneyline: +105

GB Moneyline: -124

DET Spread: +1.5

GB Spread: -1.5

Over/Under: 49.5

DET
Betting Trends

  • Detroit posted an exceptional 12–6 ATS record in 2024, tied for the best in the NFL, reflecting consistent performance and strong value as both underdogs and favorites.

GB
Betting Trends

  • Green Bay finished an even 9–9 ATS in 2024, demonstrating middle‑of‑the-road results that left bettors unsure whether they could be trusted in divisional games.

MATCHUP TRENDS

  • Although the Packers host this game, early betting interest has skewed toward the Lions covering, continuing Detroit’s trend of overperforming expectations—even on the road.

DET vs. GB
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: J. Gibbs over 66.5 Rushing Yards.

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Detroit vs Green Bay Prediction & Odds:
Free NFL Betting Insights for 9/7/25

The 2025 NFL season kicks off with a pivotal NFC North showdown as the Detroit Lions travel to Lambeau Field to face the Green Bay Packers on Sunday, September 7. This Week 1 matchup has major implications not just for early momentum, but also for establishing divisional hierarchy in a competitive North where both teams made the playoffs in 2024. The Lions are coming off a breakout 15–2 season, arguably the most successful in franchise history, and look to maintain their dominance with a high-octane offense led by Jared Goff, who returns alongside star skill players Amon-Ra St. Brown, Sam LaPorta, Jahmyr Gibbs, and David Montgomery. The defense was among the most improved in football last year, boasting a relentless front seven and a secondary that matured significantly as the season wore on. Meanwhile, the Packers went 11–6 and made the postseason under the developing leadership of Jordan Love, who emerged as a dynamic dual-threat quarterback with a knack for clutch throws and second-half adjustments. Green Bay boasts a strong offensive line and one of the best running backs in Josh Jacobs, giving them the tools to control tempo if they execute cleanly.

Their defense, led by Rashan Gary and Quay Walker, remains capable of making impact plays but struggled at times last year against creative playcallers like Detroit’s Ben Johnson. Betting markets opened the game with Detroit as a slight 1.5-point underdog, but action has gradually moved toward the Lions thanks to their 12–6 ATS performance in 2024 and recent head-to-head success against Green Bay. The over/under total hovering around 49.5 points suggests an expectation for a moderately high-scoring contest, where each team’s red zone efficiency and ability to finish drives will be crucial. The chess match between Detroit’s evolving passing game and Green Bay’s physical secondary could be the fulcrum on which the outcome swings, especially if weather plays a factor in Lambeau’s early September conditions. Detroit’s offensive line, one of the best in the league, will be tasked with containing Green Bay’s pass rush and opening lanes for Gibbs and Montgomery, while the Packers need to ensure they don’t fall behind early—a vulnerability that cost them in both regular season meetings last year. On special teams, both units are solid, but any lapse could prove costly in a tight divisional opener. Coaching will also play a large role: Dan Campbell’s Lions have been one of the most disciplined and aggressive teams on fourth downs, while Matt LaFleur’s Packers tend to rely more on field position and structured drives. If the Lions strike first and dictate pace, they could silence Lambeau early and steal an important road win. Conversely, if Green Bay’s defense sets the tone and Jordan Love manages clean offensive possessions, the Packers can reassert themselves in the division hierarchy. It’s a game loaded with narrative and opportunity, and one that should set the tone for two franchises who believe they’re poised to contend well beyond the NFC North in 2025.

Detroit Lions NFL Preview

The Detroit Lions enter the 2025 season with soaring expectations and a target on their back as defending NFC North champions, traveling to Lambeau Field in Week 1 to face the rival Green Bay Packers in a game that could immediately reinforce their hold on the division. After finishing 15–2 last year with a league-best 12–6 ATS record, Detroit is widely considered one of the most complete teams in the NFL, featuring a deep, balanced offense and an aggressive, physical defense that punishes mistakes. Quarterback Jared Goff returns with full command of Ben Johnson’s offensive system and an elite supporting cast that includes All-Pro receiver Amon-Ra St. Brown, dynamic rookie-turned-star Jahmyr Gibbs, dependable power back David Montgomery, and breakout tight end Sam LaPorta. The offensive line, anchored by Penei Sewell and Frank Ragnow, is among the league’s best and key to both the run game’s success and Goff’s clean pocket operation. Defensively, the Lions expect to take another step forward after making major improvements in 2024, especially in their pass rush and coverage schemes. Aidan Hutchinson leads the defensive line while Alim McNeill and Jack Campbell provide stability in the front seven, and the return of Brian Branch in the secondary adds versatility and playmaking to a group that thrived late last season.

On the road at Lambeau, Detroit’s focus will be on dictating pace early, avoiding turnovers, and exploiting mismatches in the Packers’ secondary, particularly against younger or untested corners. Goff’s chemistry with St. Brown and LaPorta gives Detroit short-to-intermediate reliability, while Jameson Williams adds a vertical threat that can punish single-high looks. Against a Green Bay team that finished 9–9 ATS last season and has historically defended home turf well, Detroit’s edge lies in its continuity and offensive efficiency—an area where the Lions often gain early leads and force opponents into uncomfortable game scripts. Special teams also offer a quiet advantage for the Lions, who return kicker Michael Badgley and possess a disciplined coverage unit that rarely allows field-flipping returns. Dan Campbell’s aggressive fourth-down mindset and willingness to trust analytics have also made the Lions one of the most difficult teams to predict and prepare for, especially in divisional games. Detroit has won three of the last four meetings with Green Bay, including a statement win at Lambeau last season that helped clinch the division, and they arrive confident, rested, and relatively healthy. If the Lions can continue their trend of sharp execution, ball control, and red zone dominance, they should be in strong position to not only cover the spread but also start 1–0 and send a message that they remain the team to beat in the NFC North. Lambeau is never an easy place to win, but this version of the Lions is built to travel, handle adversity, and convert opportunities into early-season momentum.

The Detroit Lions open Week 1 of the 2025 season on the road at Lambeau Field against the Green Bay Packers as 1.5‑point underdogs, with the over/under set around 49.5 points. This NFC North opener pits the defending division champion Lions against a Packers squad looking to rise after a solid playoff run. Detroit vs Green Bay AI Prediction: Free NFL Betting Insights for Sep 07. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Green Bay Packers NFL Preview

The Green Bay Packers begin their 2025 season at home in iconic Lambeau Field with a critical NFC North clash against the defending division champion Detroit Lions, aiming to make an early statement against a team that bested them in both meetings last year. Under head coach Matt LaFleur, the Packers enter a pivotal year of development with quarterback Jordan Love, who showed real growth in 2024 by passing for over 3,600 yards and leading Green Bay to an 11–6 finish and a playoff berth. Love’s command of the offense continues to improve, and he now has additional tools at his disposal including veteran running back Josh Jacobs, a rebuilt receiving corps headlined by Christian Watson and Romeo Doubs, and one of the league’s most stable offensive lines, anchored by Elgton Jenkins and Zach Tom. That unit will be key in neutralizing Detroit’s relentless defensive front and giving Love the time to operate in both play-action and intermediate zone reads. Green Bay’s defense remains built around speed and disruption, with Rashan Gary and Kenny Clark leading the charge up front, while De’Vondre Campbell, Quay Walker, and safety Xavier McKinney add athleticism and experience at the second and third levels. Last season, the Packers finished an even 9–9 against the spread, and their home results were inconsistent—an issue that LaFleur and his staff have stressed throughout training camp. To reverse those trends, Green Bay needs to start fast, generate early pressure on Jared Goff, and keep the Lions’ offense from dictating tempo with their elite offensive line and versatile playmakers.

On offense, Green Bay will look to establish a physical identity by feeding Josh Jacobs early and using misdirection to freeze Detroit’s linebackers and safeties. Love’s ability to extend plays with his legs adds a crucial element, especially if the Lions focus heavily on collapsing the pocket. The Packers’ receiving group lacks a true No. 1 star but makes up for it with solid depth, and tight ends Luke Musgrave and Tucker Kraft are poised for bigger roles as safety valves and red zone targets. Special teams could play a vital role as well—Green Bay will lean on kicker Anders Carlson and dynamic returner Keisean Nixon to generate favorable field position and possibly swing momentum in a close contest. More importantly, Lambeau Field will be loud, cold, and hostile—ideal conditions for a young team trying to prove its mettle against a rising powerhouse. If Green Bay can win the turnover battle, capitalize in the red zone, and avoid the kind of mental mistakes that have haunted them in recent divisional games, they have a strong chance to not only cover the narrow spread but walk away with a confidence-building win. The coaching staff has emphasized execution and discipline throughout the offseason, and a clean, efficient game from Jordan Love could set the tone for a season where Green Bay believes it can compete for the division crown. The Lions may be favored by oddsmakers, but the Packers relish the underdog role, especially in front of their home fans to start a new chapter.

Detroit vs. Green Bay Prop Picks (AI)

AI algorithm Remi is pouring through loads of data on each team. In fact, anytime the Lions and Packers play there’s always several intriguing angles to key in on. Not to mention games played at Lambeau Field in Sep rarely follow normal, predictable betting trends.
Remi's searched hard and found the best prop for this matchup: J. Gibbs over 66.5 Rushing Yards.

Detroit vs. Green Bay Prediction (AI)

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Remi, our AI sports wizard, has been pouring over tons of data from every past game between the Lions and Packers and using recursive machine learning and impressive AI to crunch the data to a single cover probability.

The Algorithm has been most fixated on the unproportionally assigned weight knucklehead sportsbettors regularly put on coaching factors between a Lions team going up against a possibly healthy Packers team. We’ve found the true game analytics might reflect a strong lean against one Vegas line in particular.

Unlock this in-depth AI prediction and all of our NFL AI picks for FREE now.

Below is our current AI Detroit vs Green Bay picks, computer picks Lions vs Packers, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
NFL 10/9 PHI@NYG UNLOCK THIS PICK 0 INTEL Locked INTEL

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full NFL Schedule.

Lions Betting Trends

Detroit posted an exceptional 12–6 ATS record in 2024, tied for the best in the NFL, reflecting consistent performance and strong value as both underdogs and favorites.

Packers Betting Trends

Green Bay finished an even 9–9 ATS in 2024, demonstrating middle‑of‑the-road results that left bettors unsure whether they could be trusted in divisional games.

Lions vs. Packers Matchup Trends

Although the Packers host this game, early betting interest has skewed toward the Lions covering, continuing Detroit’s trend of overperforming expectations—even on the road.

Detroit vs. Green Bay Game Info

Detroit vs Green Bay starts on September 07, 2025 at 4:25 PM EST.

Spread: Green Bay -1.5
Moneyline: Detroit +105, Green Bay -124
Over/Under: 49.5

Detroit: (0-0)  |  Green Bay: (0-0)

Remi's searched hard and found the best prop for this matchup: J. Gibbs over 66.5 Rushing Yards.. Prices move—always shop for the best number.

Although the Packers host this game, early betting interest has skewed toward the Lions covering, continuing Detroit’s trend of overperforming expectations—even on the road.

DET trend: Detroit posted an exceptional 12–6 ATS record in 2024, tied for the best in the NFL, reflecting consistent performance and strong value as both underdogs and favorites.

GB trend: Green Bay finished an even 9–9 ATS in 2024, demonstrating middle‑of‑the-road results that left bettors unsure whether they could be trusted in divisional games.

See our latest NFL picks and odds pages for 2025 to compare prices before you bet.

Detroit vs. Green Bay Odds

Remi is pouring through mountains of data points on each player. In fact, anytime the Detroit vs Green Bay trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme hostile environments can often follow normal, predictable patterns.

Detroit vs Green Bay Opening Odds

DET Moneyline: +105
GB Moneyline: -124
DET Spread: +1.5
GB Spread: -1.5
Over/Under: 49.5

Detroit vs Green Bay Live Odds

Games PTS ML SPR O/U
Oct 12, 2025 9:30AM EDT
Denver Broncos
New York Jets
10/12/25 9:30AM
Broncos
Jets
-380
+290
-7 (-110)
+7 (-110)
O 43.5 (-110)
U 43.5 (-110)
Oct 12, 2025 1:00PM EDT
Seattle Seahawks
Jacksonville Jaguars
10/12/25 1PM
Seahawks
Jaguars
-110
-110
-1 (-105)
+1 (-115)
O 47 (-115)
U 47 (-105)
Oct 12, 2025 1:00PM EDT
New England Patriots
New Orleans Saints
10/12/25 1PM
Patriots
Saints
-185
+160
-3.5 (+100)
+3.5 (-120)
O 45.5 (-115)
U 45.5 (-105)
Oct 12, 2025 1:01PM EDT
Cleveland Browns
Pittsburgh Steelers
10/12/25 1:01PM
Browns
Steelers
+225
-275
+6 (-105)
-6 (-115)
O 38.5 (-105)
U 38.5 (-115)
Oct 12, 2025 1:01PM EDT
Los Angeles Chargers
Miami Dolphins
10/12/25 1:01PM
Chargers
Dolphins
-200
+170
-3.5 (-110)
+3.5 (-110)
O 43.5 (-110)
U 43.5 (-110)
Oct 12, 2025 1:01PM EDT
Los Angeles Rams
Baltimore Ravens
10/12/25 1:01PM
Rams
Ravens
-415
+310
-7.5 (-110)
+7.5 (-110)
O 44.5 (-115)
U 44.5 (-105)
Oct 12, 2025 1:01PM EDT
Dallas Cowboys
Carolina Panthers
10/12/25 1:01PM
Cowboys
Panthers
-165
+140
-3 (-105)
+3 (-115)
O 49.5 (-110)
U 49.5 (-110)
Oct 12, 2025 1:01PM EDT
Arizona Cardinals
Indianapolis Colts
10/12/25 1:01PM
Cardinals
Colts
+285
-370
+7.5 (-110)
-7.5 (-110)
O 47 (-105)
U 47 (-115)
Oct 12, 2025 4:06PM EDT
Tennessee Titans
Las Vegas Raiders
10/12/25 4:06PM
Titans
Raiders
+190
-230
+3.5 (-110)
-3.5 (-110)
O 41.5 (-110)
U 41.5 (-110)
Oct 12, 2025 4:26PM EDT
Cincinnati Bengals
Green Bay Packers
10/12/25 4:26PM
Bengals
Packers
+725
-1300
+14 (-105)
-14 (-115)
O 45 (-105)
U 45 (-115)
Oct 12, 2025 4:26PM EDT
San Francisco 49ers
Tampa Bay Buccaneers
10/12/25 4:26PM
49ers
Buccaneers
+140
-165
+3 (-110)
-3 (-110)
O 47.5 (-105)
U 47.5 (-115)
Oct 12, 2025 8:20PM EDT
Detroit Lions
Kansas City Chiefs
10/12/25 8:20PM
Lions
Chiefs
+115
-135
+2 (-110)
-2 (-110)
O 52.5 (-115)
U 52.5 (-105)
Oct 13, 2025 7:15PM EDT
Buffalo Bills
Atlanta Falcons
10/13/25 7:15PM
Bills
Falcons
-225
+185
-4.5 (-110)
+4.5 (-110)
O 50 (-110)
U 50 (-110)
Oct 13, 2025 8:16PM EDT
Chicago Bears
Washington Commanders
10/13/25 8:16PM
Bears
Commanders
+190
-230
+4.5 (-110)
-4.5 (-110)
O 50 (-110)
U 50 (-110)
Oct 16, 2025 8:16PM EDT
Pittsburgh Steelers
Cincinnati Bengals
10/16/25 8:16PM
Steelers
Bengals
-210
+175
-4 (-110)
+4 (-110)
O 42.5 (-110)
U 42.5 (-110)
Oct 19, 2025 8:31AM EDT
Los Angeles Rams
Jacksonville Jaguars
10/19/25 8:31AM
Rams
Jaguars
-185
+154
-3 (-110)
+3 (-110)
O 47 (-110)
U 47 (-110)

NFL Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Detroit Lions vs. Green Bay Packers on September 07, 2025 at Lambeau Field.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our NFL odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
HOU@BAL HOU -125 58.5% 7 WIN
DET@CIN DET -10 55.6% 5 WIN
DAL@NYJ NYJ +1.5 53.7% 3 LOSS
TB@SEA TB +3.5 54.9% 4 WIN
TEN@ARI ARI -7 (BUY 0.5) 54.9% 4 LOSS
DEN@PHI DEN +4.5 57.5% 7 WIN
MIA@CAR TETAIROA MCMILLAN OVER 58.5 RECV YDS 54.5% 4 WIN
LV@IND ASHTON JEANTY UNDER 67.5 RUSH YDS 54.4% 4 WIN
SF@LAR DEMARCUS ROBINSON OVER 29.5 RECV YDS 55.7% 5 WIN
NYJ@MIA NYJ +3 53.8 3 LOSS
CIN@DEN DEN -7.5 54.8 4 WIN
NYJ@MIA OVER 44 52.9% 2 WIN
CIN@DEN UNDER 44.5 53.7% 3 WIN
NYJ@MIA GARRETT WILSON UNDER 9 TARGETS 53.7% 3 WIN
CIN@DEN TEE HIGGINS OVER 6.5 RECV TARGETS 55.5% 5 LOSS
WAS@ATL ATL -2.5 54.3 4 WIN
BAL@KC BAL -2.5 56.3% 6 LOSS
TEN@HOU TEN +7.5 57.9% 7 LOSS
LAC@NYG LAC -6 57.3% 7 LOSS
NO@BUF UNDER 48.5 55.1% 3 LOSS
GB@DAL JAVONTE WILLIAMS UNDER 72.5 RUSH + REC YDS 55.5% 5 LOSS
CAR@NE DRAKE MAYE TO THROW AN INT 56.6% 6 LOSS
SEA@ARI SEA -125 57.7% 6 WIN
SEA@ARI KYLER MURRAY TO THROW AN INT 56.6% 6 WIN
DET@BAL JAHMYR GIBBS OVER 0.5 RUSH TDS 55.8% 5 WIN
DAL@CHI DAL -120 58.7% 6 LOSS
PIT@NE PIT -116 60.1% 6 WIN
ATL@CAR ATL -4.5 55.4% 5 LOSS
LV@WAS LV +3 54.3% 4 LOSS
GB@CLE GB -7 54.3% 4 LOSS
ARI@SF ARI +3 57.7% 6 WIN
KC@NYG PATRICK MAHOMES OVER 230.5 PASS YDS 54.7% 4 WIN
GB@CLE JOE FLACCO OVER 37.5 PASS ATT 56.6% 6 LOSS
MIA@BUF TYREEK HILL OVER 5.5 TOTAL RECEPTIONS 56.8% 6 LOSS
LAC@LV LAC -3 54.9% 4 WIN
TB@HOU BAKER MAYFIELD OVER 1.5 PASS TDS 54.4% 4 WIN
CHI@DET DET -6.5 54.3% 4 WIN
DEN@IND DEN -118 60.1% 10 LOSS
PHI@KC PHI -115 56.7% 6 WIN
SF@NO SF -3 58.8% 8 WIN
SEA@PIT OVER 40 54.9% 4 WIN
CAR@ARI BRYCE YOUNG INTERCEPTIONS UNDER 0.5 56.4% 6 LOSS
DEN@IND JOSH DOWNS RECEPTIONS OVER 3.5 54.7% 4 WIN
ATL@MIN BIJAN ROBINSON RUSH + REC YDS OVER 94.5 53.4% 3 WIN
WAS@GB WAS +3.5 56.5% 6 LOSS
WAS@GB JORDAN LOVE OVER 5.5 RUSH YDS 54.7% 4 WIN
MIN@CHI CALEB WILLIAMS OVER 219.5 PASS YDS 53.4% 3 LOSS
TEN@DEN DEN -8.5 55.3% 5 LOSS
SF@SEA SF -115 54.6% 4 WIN
SF@SEA KENNETH WALKER III UNDER 79.5 RUSH+REC YDS 54.6% 4 WIN
CAR@JAC TANK BIGSBY OVER 10.5 RUSH ATT 56.1% 6 LOSS