Pacers vs Knicks Prediction — AI Finds CAN'T MISS NBA Lines & Props (May 21)

Updated: 2025-05-19T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The Indiana Pacers and New York Knicks will clash in Game 1 of the Eastern Conference Finals on Wednesday, May 21, 2025, at Madison Square Garden. This series marks a rematch of last year’s playoff encounter, where the Pacers triumphed in seven games, setting the stage for a highly anticipated showdown.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: May 21, 2025

Start Time: 8:00 PM EST​

Venue: Madison Square Garden​

Knicks Record: (51-31)

Pacers Record: (50-32)

OPENING ODDS

IND Moneyline: +155

NY Moneyline: -186

IND Spread: +4.5

NY Spread: -4.5

Over/Under: 223.5

IND
Betting Trends

  • The Indiana Pacers have a 40-42-2 record against the spread (ATS) this season, indicating a near-even performance in covering the spread.

NY
Betting Trends

  • The New York Knicks hold a 48-38-3 ATS record this season, reflecting a strong ability to surpass betting expectations.

MATCHUP TRENDS

  • Despite the Knicks being -145 favorites, 78% of the total money wagered is backing New York, suggesting strong public confidence in their victory.

IND vs. NY
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: P. Siakam over 28.5 PTS+REB+AST.

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Indiana vs New York Prediction & Odds:
Free NBA Betting Insights for 5/21/25

The 2025 Eastern Conference Finals between the Indiana Pacers and the New York Knicks marks the revival of a classic NBA rivalry and presents one of the most stylistically compelling matchups of the postseason. The Pacers, led by the electric Tyrese Haliburton, enter the series playing their most confident basketball of the year after dismantling the top-seeded Cleveland Cavaliers in just five games. Indiana’s offensive pace has been their trademark all season, ranking first in the league in transition points and fast-break efficiency. Haliburton’s ability to orchestrate the break, coupled with the depth of Rick Carlisle’s 10-man rotation, gives Indiana an edge in stamina and offensive variation. Players like Pascal Siakam, Bennedict Mathurin, and Andrew Nembhard have stepped up consistently in the postseason, and their ability to space the floor and make timely plays has kept defenses in constant flux. What’s more, Indiana’s defense has quietly improved, climbing to eighth overall in the playoffs, with an emphasis on perimeter pressure and active hands generating turnovers that fuel their tempo. On the other side, the Knicks arrive with a different but equally effective identity—gritty, methodical, and built around physical defense and half-court execution. Head coach Tom Thibodeau has leaned on a tight rotation that thrives in high-leverage situations, and the combination of Jalen Brunson’s calm decision-making and Karl-Anthony Towns’ offensive versatility makes the Knicks a challenging team to scheme against. Brunson has averaged over 28 points per game in the playoffs, consistently delivering in crunch time, while Towns’ inside-out game forces opposing bigs to defend all over the court.

Their path to the Conference Finals has not been easy—having taken down the Miami Heat and Boston Celtics—but they’ve emerged with the battle scars and belief of a contender. The Knicks rank fifth in playoff defensive efficiency, bolstered by elite rebounding and physical on-ball defenders like Josh Hart and OG Anunoby. They thrive on slowing the game down, executing in the half-court, and grinding opponents into submission. This series will be a study in contrasting philosophies: the Pacers aim to speed up the game, force turnovers, and attack in early offense, while the Knicks will look to control tempo, limit possessions, and make every trip down the floor a half-court slugfest. Key factors to watch include whether Indiana can maintain their pace against New York’s structured defense, how well the Knicks’ starters hold up over what could be a long series, and whether either team can gain an edge on the boards. The Pacers’ bench depth may tilt certain games in their favor, but the Knicks’ home-court advantage at Madison Square Garden—where they’ve been exceptional—can’t be underestimated. With both teams carrying legitimate momentum, passionate fan bases, and physical, playoff-hardened cores, this series is expected to be tightly contested, emotional, and potentially a seven-game thriller. Whoever wins will have earned their spot in the NBA Finals through resilience, poise, and timely execution under pressure.

Indiana Pacers NBA Preview

The Indiana Pacers enter the Eastern Conference Finals as one of the most exhilarating and relentless teams of the 2025 NBA Playoffs, powered by a breakneck offense, deep bench, and the elite leadership of Tyrese Haliburton. Their unexpected but dominant run through the Eastern bracket has seen them outpace the Bucks and outclass the top-seeded Cavaliers in just five games, establishing them as a force that’s not merely hot but built for the postseason. Haliburton has been the central engine of this movement, averaging over 22 points and 9 assists per game in the playoffs while controlling tempo, distributing with flair, and making clutch buckets when needed. But what makes the Pacers so dangerous isn’t just their superstar—it’s the cohesion and depth of their roster. Pascal Siakam has slotted in seamlessly as both a versatile scorer and veteran presence, while Myles Turner’s rim protection and floor spacing have been crucial in neutralizing opposing bigs. Andrew Nembhard and Bennedict Mathurin have shined on both ends, providing spark, perimeter defense, and shot-making that make Indiana’s rotation one of the deepest left in the postseason. Coach Rick Carlisle has leveraged a 10-man rotation better than any other team this postseason, keeping legs fresh and the pace high into the fourth quarter. The Pacers average over 118 points per game in the playoffs, using fast-break opportunities, early clock threes, and quick rim attacks to overwhelm opponents before defenses can even set.

Defensively, they’ve made quiet but steady improvements, climbing to eighth in playoff defensive efficiency, a testament to their growing chemistry and effort on that end. Nembhard, in particular, has emerged as a capable perimeter stopper who will be tasked with slowing down Jalen Brunson throughout the series. The Pacers will need to continue creating turnovers and converting in transition to mitigate the Knicks’ half-court grind, especially considering New York’s physical style and the intimidating environment of Madison Square Garden. Another challenge will be rebounding—while Turner and Siakam are active on the boards, they’ll need all five players crashing the glass to avoid giving second-chance points to a rugged Knicks frontcourt. Yet Indiana’s ability to counterpunch quickly, knock down threes at volume, and exploit mismatches in transition gives them a blueprint for success, even on the road. Their 21-20 away record in the regular season is respectable, but they’ve shown in these playoffs that they’re unbothered by hostile crowds and tight finishes. If Haliburton continues to control pace, Siakam maintains his inside-out dominance, and the bench delivers its usual spark, the Pacers could very well steal Game 1 and flip the pressure squarely onto the Knicks. Indiana has become more than a feel-good story—they’re a team with elite talent, purpose, and belief, and they arrive in New York ready to run, gun, and take the next step toward an NBA Finals berth.

The Indiana Pacers and New York Knicks will clash in Game 1 of the Eastern Conference Finals on Wednesday, May 21, 2025, at Madison Square Garden. This series marks a rematch of last year’s playoff encounter, where the Pacers triumphed in seven games, setting the stage for a highly anticipated showdown. Indiana vs New York AI Prediction: Free NBA Betting Insights for May 21. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

New York Knicks NBA Preview

The New York Knicks return to the Eastern Conference Finals riding a wave of gritty, battle-tested momentum that has defined their 2025 postseason identity, shaped by the steely leadership of Jalen Brunson, the versatile presence of Karl-Anthony Towns, and the relentless culture instilled by head coach Tom Thibodeau. The Knicks fought through a physical six-game series against the Boston Celtics after eliminating the Miami Heat, demonstrating a signature brand of tough, defensive-minded basketball backed by timely scoring and elite execution in clutch moments. At the center of their run is Brunson, who has transformed into a full-fledged superstar and the emotional engine of the franchise. His poise in crunch time, efficient mid-range scoring, and uncanny ability to get to his spots have made him a nightmare for opposing guards, and his leadership has galvanized a roster that thrives in adversity. Alongside him, Towns has brought needed frontcourt versatility—stretching the floor with his shooting while also punishing mismatches in the post. RJ Barrett and Josh Hart have both stepped up as secondary scoring options, with Hart particularly embodying the Knicks’ rugged defensive identity through hustle plays, rebounding, and perimeter coverage. Defensively, New York has been elite, ranking fifth in playoff defensive efficiency, using aggressive closeouts, physical post defense, and sharp rotations to limit opponents’ clean looks. Mitchell Robinson and Isaiah Hartenstein have formed a formidable rim-protecting tandem, controlling the paint and giving the Knicks a rebounding edge nearly every night.

While the Knicks deploy a tighter rotation than most playoff teams—usually leaning on 7–8 players—Thibodeau’s emphasis on conditioning and accountability ensures his core group is prepared to play heavy minutes at a high level. This structure works especially well at Madison Square Garden, where the Knicks are 27-14 this season and feed off one of the NBA’s most passionate crowds. Against the Pacers, New York’s focus will be on controlling tempo, slowing down Indiana’s league-best transition offense, and forcing them into difficult half-court sets. Brunson will likely be defended by Andrew Nembhard, a strong on-ball guard, but the Knicks will run multiple pick-and-roll variations and off-ball sets to get Brunson clean looks and create switches they can exploit. Limiting Tyrese Haliburton’s playmaking and stopping Indiana’s bench from changing the game’s pace will be priorities on defense. While the Pacers’ depth and speed are dangerous, the Knicks hold the edge in physicality, rebounding, and half-court execution—areas that tend to define playoff series as they progress. New York also benefits from the experience of last year’s seven-game battle with Indiana, a series they lost but learned from, and the core group returns this time smarter, stronger, and with a deeper hunger to break through. If Brunson continues his All-NBA form and Towns remains aggressive on both ends, the Knicks are positioned not only to protect home court but to seize control of this series from the outset, inching one step closer to their first NBA Finals appearance since 1999.

Indiana vs. New York Prop Picks (AI)

AI algorithm Remi is pouring through mountains of datapoints on each player. In fact, anytime the Pacers and Knicks play there’s always several intriguing angles to key in on. Not to mention games played at Madison Square Garden in May almost always follow normal, predictable betting trends.
Remi's searched hard and found the best prop for this matchup: P. Siakam over 28.5 PTS+REB+AST.

Indiana vs. New York Prediction (AI)

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Remi, our AI sports wizard, has been pouring over millions of data from every facet between the Pacers and Knicks and using recursive machine learning and industry leading AI to analyze the data to a single cover probability.

Remi has been most keyed in on the linear correlation of weight emotional bettors often put on New York’s strength factors between a Pacers team going up against a possibly deflated Knicks team. We’ve found the true game analytics appear to reflect a moderate lean against one Vegas line specifically.

Unlock this in-depth AI prediction and all of our NBA AI picks for FREE now.

Below is our current AI Indiana vs New York picks, computer picks Pacers vs Knicks, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full NBA schedule.

Pacers Betting Trends

The Indiana Pacers have a 40-42-2 record against the spread (ATS) this season, indicating a near-even performance in covering the spread.

Knicks Betting Trends

The New York Knicks hold a 48-38-3 ATS record this season, reflecting a strong ability to surpass betting expectations.

Pacers vs. Knicks Matchup Trends

Despite the Knicks being -145 favorites, 78% of the total money wagered is backing New York, suggesting strong public confidence in their victory.

Indiana vs. New York Game Info

Indiana vs New York starts on May 21, 2025 at 8:00 PM EST.

Venue: Madison Square Garden.

Spread: New York -4.5
Moneyline: Indiana +155, New York -186
Over/Under: 223.5

Indiana: (50-32)  |  New York: (51-31)

Remi's searched hard and found the best prop for this matchup: P. Siakam over 28.5 PTS+REB+AST.. Prices move—always shop for the best number.

Despite the Knicks being -145 favorites, 78% of the total money wagered is backing New York, suggesting strong public confidence in their victory.

IND trend: The Indiana Pacers have a 40-42-2 record against the spread (ATS) this season, indicating a near-even performance in covering the spread.

NY trend: The New York Knicks hold a 48-38-3 ATS record this season, reflecting a strong ability to surpass betting expectations.

See our latest NBA picks and odds pages for 2025 to compare prices before you bet.

Indiana vs. New York Odds

Remi is pouring through tons of stats on each team. In fact, anytime the Indiana vs New York trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme altitude seemingly never follow normal, predictable patterns.

Indiana vs New York Opening Odds

IND Moneyline: +155
NY Moneyline: -186
IND Spread: +4.5
NY Spread: -4.5
Over/Under: 223.5

Indiana vs New York Live Odds

Games PTS ML SPR O/U
Oct 21, 2025 7:35PM EDT
Houston Rockets
Oklahoma City Thunder
10/21/25 7:35PM
Rockets
Thunder
+245
-300
+7.5 (-110)
-7.5 (-110)
O 226.5 (-115)
U 226.5 (-105)
Oct 21, 2025 10:00PM EDT
Golden State Warriors
Los Angeles Lakers
10/21/25 10PM
Warriors
Lakers
-130
+110
-2 (-110)
+2 (-110)
O 224.5 (-110)
U 224.5 (-110)
Oct 22, 2025 7:10PM EDT
Brooklyn Nets
Charlotte Hornets
10/22/25 7:10PM
Nets
Hornets
+150
-180
+4.5 (-110)
-4.5 (-110)
O 225.5 (-110)
U 225.5 (-110)
Oct 22, 2025 7:10PM EDT
Cleveland Cavaliers
New York Knicks
10/22/25 7:10PM
Cavaliers
Knicks
+140
-170
+3.5 (-105)
-3.5 (-115)
O 229.5 (-110)
U 229.5 (-110)
Oct 22, 2025 7:10PM EDT
Miami Heat
Orlando Magic
10/22/25 7:10PM
Heat
Magic
+280
-350
+8 (-110)
-8 (-110)
O 215.5 (-110)
U 215.5 (-110)
Oct 22, 2025 7:40PM EDT
Philadelphia 76ers
Boston Celtics
10/22/25 7:40PM
76ers
Celtics
+115
-140
+2.5 (-110)
-2.5 (-110)
O 225.5 (-110)
U 225.5 (-110)
Oct 22, 2025 7:40PM EDT
Toronto Raptors
Atlanta Hawks
10/22/25 7:40PM
Raptors
Hawks
+190
-240
+6 (-110)
-6 (-110)
O 235.5 (-110)
U 235.5 (-110)
Oct 22, 2025 8:10PM EDT
Washington Wizards
Milwaukee Bucks
10/22/25 8:10PM
Wizards
Bucks
+300
-375
+9 (-110)
-9 (-110)
O 228.5 (-110)
U 228.5 (-110)
Oct 22, 2025 8:10PM EDT
Detroit Pistons
Chicago Bulls
10/22/25 8:10PM
Pistons
Bulls
-140
+115
-2 (-110)
+2 (-110)
O 235 (-110)
U 235 (-110)
Oct 22, 2025 8:10PM EDT
New Orleans Pelicans
Memphis Grizzlies
10/22/25 8:10PM
Pelicans
Grizzlies
+130
-160
+3.5 (-110)
-3.5 (-110)
O 237 (-110)
U 237 (-110)
Oct 22, 2025 9:10PM EDT
Los Angeles Clippers
Utah Jazz
10/22/25 9:10PM
Clippers
Jazz
-375
+300
-9 (-110)
+9 (-110)
O 227 (-110)
U 227 (-110)
Oct 22, 2025 9:40PM EDT
San Antonio Spurs
Dallas Mavericks
10/22/25 9:40PM
Spurs
Mavericks
+120
-145
+3 (-115)
-3 (-105)
O 226.5 (+100)
U 226.5 (-120)
Oct 22, 2025 10:10PM EDT
Sacramento Kings
Phoenix Suns
10/22/25 10:10PM
Kings
Suns
+140
-170
+3.5 (-110)
-3.5 (-110)
O 227.5 (-110)
U 227.5 (-110)
Oct 22, 2025 10:10PM EDT
Minnesota Timberwolves
Portland Trail Blazers
10/22/25 10:10PM
Timberwolves
Trail Blazers
-170
+140
-3.5 (-110)
+3.5 (-110)
O 219.5 (-110)
U 219.5 (-110)
Oct 23, 2025 7:40PM EDT
Oklahoma City Thunder
Indiana Pacers
10/23/25 7:40PM
Thunder
Pacers
-325
+250
-7.5 (-110)
+7.5 (-110)
O 227 (-110)
U 227 (-110)
Oct 23, 2025 10:10PM EDT
Denver Nuggets
Golden State Warriors
10/23/25 10:10PM
Nuggets
Warriors
-115
-105
+1 (-115)
-1 (-105)
O 233.5 (-110)
U 233.5 (-110)

NBA Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Indiana Pacers vs. New York Knicks on May 21, 2025 at Madison Square Garden.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our NBA odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
IND@OKC PASCAL SIAKAM OVER 2.5 PERSONAL FOULS 54.20% 4 WIN
IND@OKC IND +10 54.00% 3 WIN
IND@OKC BENNEDICT MATHURIN OVER 2.5 FREE THROW ATT 54.90% 4 WIN
NY@IND MYLES TURNER OVER 6 REBOUNDS + ASSTS 54.40% 4 LOSS
IND@NY IND +5 55.60% 5 LOSS
NY@IND JALEN BRUNSON UNDER 22 FIELD GOAL ATT 54.70% 4 WIN
OKC@MIN RUDY GOBERT OVER 1.5 FREE THROWS MADE 54.00% 4 WIN
OKC@MIN OKC -2.5 56.70% 6 LOSS
NY@IND KARL ANTHONY TOWNS OVER 32.5 POINTS + REBOUNDS 54.00% 4 WIN
OKC@MIN NAZ REID OVER 9.0 FIELD GOAL ATT 54.60% 4 LOSS
IND@NY MYLES TURNER OVER 5 MADE FIELD GOALS 53.60% 3 WIN
IND@NY NY -5.5 55.00% 4 LOSS
MIN@OKC ISAIAH HARTENSTEIN UNDER 7.5 REBOUNDS 53.00% 3 LOSS
MIN@OKC MIN +7.5 54.70% 4 LOSS
IND@NY TYRESE HALIBURTON ASSTS - UNDER 8.5 54.10% 4 LOSS
IND@NY IND +4.5 54.80% 4 WIN
MIN@OKC ALEX CARUSO UNDER 2.5 ASSTS 54.10% 4 WIN
DEN@OKC MICHAEL PORTER UNDER 7.5 REBS + AST 54.80% 4 WIN
BOS@NY NY -2.5 55.60% 5 WIN
GS@MIN DONTE DIVINCENZO OVER 1.5 TURNOVERS 54.80% 4 LOSS
GS@MIN GS +10.5 54.70% 4 LOSS
DEN@OKC NIKOLA JOKIC UNDER 22.5 REBOUNDS + ASSTS 54.00% 4 WIN
MIN@GS JIMMY BUTLER UNDER 33.5 POINTS + REBOUNDS 54.50% 4 WIN
BOS@NY BOS -5.5 54.70% 4 WIN
OKC@DEN OKC -5 55.70% 5 LOSS
DEN@OKC SHAI GILGEOUS-ALEXANDER UNDER 12.5 REBOUNDS + ASSTS 54.20% 4 WIN
IND@CLE IND +8 54.00% 3 WIN
GS@MIN ANTHONY EDWARDS UNDER 40.5 PTS+REB+AST 54.00% 4 WIN
GS@MIN MIN -6.5 54.40% 4 LOSS
DEN@OKC NIKOLA JOKIC UNDER 36.5 POINTS + ASSTS 53.20% 3 LOSS
IND@CLE IND +8.5 55.70% 5 WIN
HOU@GS GS -5 53.70% 3 LOSS
HOU@GS BRANDIN PODZIEMSKI UNDER 5.5 REBOUNDS 54.10% 4 LOSS
DEN@LAC MICHAEL PORTER UNDER 7.5 REBS + AST 53.20% 3 WIN
DEN@LAC UNDER 212.5 54.00% 3 LOSS
MIN@LAL MIN +6 53.80% 3 WIN
MIN@LAL NAZ REID OVER 1.5 ASSTS 54.80% 4 WIN
LAC@DEN IVICA ZUBAC OVER 1.5 TURNOVERS 53.50% 3 LOSS
DET@NY DET +5.5 53.90% 3 WIN
CLE@MIA EVAN MOBLEY UNDER 29.5 PTS+REB+AST 53.90% 3 WIN
BOS@ORL KRISTAPS PORZINGIS UNDER 8.5 REBOUNDS + ASSTS 53.10% 3 WIN
HOU@GS GS -3 53.70% 3 WIN
HOU@GS JALEN GREEN OVER 2.5 TURNOVERS 54.40% 4 LOSS
LAL@MIN LEBRON JAMES UNDER 31.5 POINTS + REBOUNDS 54.50% 4 LOSS
BOS@ORL BOS -3.5 54.70% 4 LOSS
DEN@LAC BOGDAN BOGDANOVIC OVER 2.5 THREE POINTERS ATTEMPTED 53.60% 3 LOSS
GS@HOU JALEN GREEN UNDER 3.5 FREE THROWS MADE 54.40% 4 LOSS
ORL@BOS ORL +10.5 54.70% 4 WIN
MEM@OKC ISAIAH HARTENSTEIN OVER 19.5 PTS + REB 53.80% 3 LOSS
MEM@OKC OKC -14.5 54.80% 4 WIN
LAC@DEN IVICA ZUBAC OVER 3.5 OFFENSIVE REBOUNDS 53.30% 3 LOSS