Celtics vs Knicks Prediction — AI Finds CAN'T MISS NBA Lines & Props (May 16)

Updated: 2025-05-14T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The Boston Celtics and New York Knicks are set to clash in Game 6 of their Eastern Conference Semifinal series on May 16, 2025, at Madison Square Garden. The Knicks lead the series 3-2 and aim to close it out at home, while the Celtics look to force a decisive Game 7.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: May 16, 2025

Start Time: 8:00 PM EST​

Venue: Madison Square Garden​

Knicks Record: (51-31)

Celtics Record: (61-21)

OPENING ODDS

BOS Moneyline: +116

NY Moneyline: -138

BOS Spread: +2.5

NY Spread: -2.5

Over/Under: 209.5

BOS
Betting Trends

  • The Boston Celtics have struggled against the spread (ATS) recently, with a 1-4 record in their last five games.

NY
Betting Trends

  • The New York Knicks have been solid ATS, boasting a 4-1 record in their last five games.

MATCHUP TRENDS

  • In the current playoff series, the Knicks have covered the spread in three of the five games, indicating their strong performance relative to expectations.

BOS vs. NY
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: K. Towns over 33.5 PTS+REB+AST.

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Boston vs New York Prediction & Odds:
Free NBA Betting Insights for 5/16/25

The Boston Celtics and New York Knicks are set to face off in a high-stakes Game 6 of their Eastern Conference Semifinal series on May 16, 2025, at Madison Square Garden, with the Knicks holding a 3-2 series lead and looking to punch their ticket to the Conference Finals for the first time in over two decades. The Celtics, who finished the regular season with the NBA’s best record at 61-21, now find themselves one loss away from elimination after dropping Game 5 at home in a hard-fought 104-98 contest that underscored their recent struggles with offensive execution and defensive adjustments. Despite boasting a dynamic duo in Jayson Tatum and Jaylen Brown, Boston has been unable to consistently solve the Knicks’ tenacious defense, and their dependence on perimeter shooting has led to cold stretches that New York has capitalized on to shift momentum. Jalen Brunson has been the difference-maker in the series, orchestrating the Knicks’ offense with poise and precision, getting into the paint at will, and exploiting mismatches, while Karl-Anthony Towns has stretched Boston’s defense by knocking down threes and punishing switches in the post. The Knicks have also received valuable contributions from OG Anunoby and Mikal Bridges, both of whom have played key roles in limiting Boston’s wing production and forcing turnovers with suffocating perimeter defense.

On the other end, the Celtics have struggled to slow New York’s interior scoring, with Mitchell Robinson and Isaiah Hartenstein crashing the glass and generating second-chance points that have swung multiple games in the series. Boston’s path to forcing a Game 7 hinges on their ability to clean up their offensive sets, limit turnovers, and get more efficient shot-making from Tatum, who has been forced into difficult looks due to New York’s defensive coverage. Joe Mazzulla’s offense, which thrived in the regular season by spreading the floor and launching threes, has sputtered under playoff pressure, particularly when their ball movement stalls and they settle for contested jumpers late in the shot clock. Defensively, the Celtics will need to contain Brunson’s dribble penetration and do a better job of rotating on pick-and-roll actions that have consistently pulled their bigs away from the rim. For the Knicks, playing at home in Game 6 presents a prime opportunity to close out a heavyweight series and avoid a return to Boston for a win-or-go-home Game 7. Thibodeau will continue to lean on his defensive foundation, trusting Brunson to control tempo, while Towns and the supporting cast provide scoring support in timely moments. The Garden crowd is sure to bring playoff energy, and if the Knicks can harness that intensity, maintain their defensive edge, and limit Boston’s second-chance opportunities, they’ll be in a strong position to end the series. This Game 6 represents a defining moment for both teams: for the Knicks, it’s a chance to validate their playoff toughness and advance as legitimate title contenders; for the Celtics, it’s an opportunity to remind the league why they were the top seed, but only if their stars rise to the occasion and their role players deliver in one of the league’s toughest environments.

Boston Celtics NBA Preview

The Boston Celtics head into Game 6 of their Eastern Conference Semifinal series against the New York Knicks on May 16, 2025, with the season on the line and their championship ambitions hanging by a thread after falling behind 3-2 in a series that has exposed the inconsistencies and vulnerabilities that were masked during a dominant regular season. Despite finishing with a league-best 61-21 record, the Celtics now face a hostile Madison Square Garden crowd and a Knicks team that has found its defensive identity at the perfect time, holding Boston to under 100 points in two of the last three games. Jayson Tatum and Jaylen Brown, the core of Boston’s offensive attack, have delivered scoring in stretches, but their efficiency has dropped significantly under constant pressure from OG Anunoby and Mikal Bridges, whose physical defense and ability to force contested shots have disrupted Boston’s rhythm and forced them into hero-ball sequences late in the shot clock. Boston’s three-point shooting, which carried them through much of the regular season, has gone cold at the worst possible time, and the team’s overreliance on perimeter scoring has resulted in scoring droughts that have allowed New York to control the pace and momentum of the series. Defensively, the Celtics have not had an answer for Jalen Brunson, who has carved them up with pick-and-roll actions, mid-range jumpers, and timely drives that have either resulted in buckets or drawn help, creating open looks for Towns, Bridges, and New York’s bench.

Boston’s interior defense has also been shaky, with the absence of consistent rim protection allowing Mitchell Robinson and Isaiah Hartenstein to feast on second-chance opportunities and disrupt any rhythm the Celtics try to build on the defensive glass. While Derrick White and Jrue Holiday have made strong individual defensive efforts, the lack of cohesion in Boston’s help rotations and the inability to defend without fouling has been costly in close games. Head coach Joe Mazzulla has tried to make in-series adjustments—most notably switching coverages and staggering Tatum and Brown’s minutes more—but the Celtics have yet to find a sustained rhythm against New York’s physical, grinding style of play. In order to force a Game 7, Boston must not only shoot better from deep but also make a concerted effort to attack the rim, draw fouls, and reestablish a physical tone early in the game to prevent the Knicks from setting the pace and engaging the MSG crowd. For the Celtics, Game 6 is not just about extending their season—it’s a test of character for a team that has faced repeated playoff heartbreaks over the last several years. If Tatum and Brown can play with urgency and poise, if the bench can provide meaningful minutes, and if Boston can finally win the hustle categories that the Knicks have dominated, they still have the talent to turn this series around. But if they again fall into the same trap of rushed possessions, soft interior defense, and poor late-game execution, their 2025 playoff run will end short of expectations, and questions about this team’s ability to close in high-pressure moments will resurface louder than ever. Game 6 is the ultimate gut check for a Celtics team that came into the season with title-or-bust expectations—and now has to prove it in the toughest road environment in the NBA.

The Boston Celtics and New York Knicks are set to clash in Game 6 of their Eastern Conference Semifinal series on May 16, 2025, at Madison Square Garden. The Knicks lead the series 3-2 and aim to close it out at home, while the Celtics look to force a decisive Game 7. Boston vs New York AI Prediction: Free NBA Betting Insights for May 16. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

New York Knicks NBA Preview

The New York Knicks return to Madison Square Garden for Game 6 of their Eastern Conference Semifinal series on May 16, 2025, with a 3-2 lead over the Boston Celtics and a golden opportunity to close out one of the NBA’s top title contenders in front of a raucous home crowd. Under the steady leadership of Tom Thibodeau, the Knicks have methodically taken control of the series after falling behind 2-1, winning two straight games with a formula built on physical defense, half-court execution, and elite clutch play from Jalen Brunson, who has outdueled Boston’s All-Stars down the stretch in every one of New York’s victories. Brunson’s poise, ability to control the tempo, and shot creation in tight spaces have been the cornerstone of the Knicks’ offense, while Karl-Anthony Towns has provided versatility by scoring both inside and from the perimeter, forcing Boston’s bigs to defend away from the rim and creating crucial spacing for New York’s attack. OG Anunoby and Mikal Bridges have been instrumental in slowing down Jayson Tatum and Jaylen Brown, using length, anticipation, and relentless pressure to contest shots, force turnovers, and disrupt Boston’s rhythm offensively—an edge that has fueled New York’s momentum and turned defense into offense consistently throughout the series. The Knicks’ role players have risen to the moment as well, with key contributions from Isaiah Hartenstein, Donte DiVincenzo, and Josh Hart helping New York outplay Boston’s bench in terms of energy, rebounding, and hustle. Hartenstein’s rebounding and physicality have helped control the paint, while DiVincenzo’s timely shot-making and Hart’s all-around grit have allowed the Knicks to win the effort categories that make the difference in playoff basketball. Thibodeau has masterfully staggered rotations and kept fresh legs on the court without sacrificing defensive integrity, maintaining pressure on Boston throughout the game and denying the Celtics the rhythm they thrived on during the regular season. New York’s success at home has been no fluke—the team is feeding off the energy of the MSG crowd, who have transformed each home playoff game into an electric, playoff-hardened atmosphere that’s disrupted visiting stars and galvanized the Knicks’ physical style of play. With Boston reeling and struggling to generate offense outside of isolation sets and long-distance shooting, the Knicks are poised to seize control early in Game 6 and apply pressure throughout, forcing the Celtics to adapt to their game rather than dictate their own. If the Knicks continue to defend with the same intensity, execute offensively through Brunson and Towns, and dominate the intangibles—second-chance points, loose balls, and transition defense—they have every tool needed to close out this series without a return trip to Boston. The home crowd will be a factor from the opening tip, and New York’s ability to stay composed, respond to runs, and stick to their blueprint will be key to finishing the job. Game 6 offers the franchise a chance to make its first Conference Finals appearance in over two decades and signal a legitimate return to contention in the Eastern Conference—an outcome that now feels within reach, provided the Knicks play their game and capitalize on the opportunity in front of them.

Boston vs. New York Prop Picks (AI)

AI algorithm Remi is pouring through tons of datapoints on each team. In fact, anytime the Celtics and Knicks play there’s always several intriguing trends to key in on. Not to mention games played at Madison Square Garden in May can often follow normal, predictable betting trends.
Remi's searched hard and found the best prop for this matchup: K. Towns over 33.5 PTS+REB+AST.

Boston vs. New York Prediction (AI)

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Remi, our AI sports algorithm, has been pouring over mountains of data from every angle between the Celtics and Knicks and using recursive machine learning and impressive AI to examine the data to a single cover probability.

Interestingly enough, the data has been most keyed in on the growing weight emotional bettors often put on New York’s strength factors between a Celtics team going up against a possibly tired Knicks team. It appears the true game analytics might reflect a slight lean against one Vegas line specifically.

Unlock this in-depth AI prediction and all of our NBA AI picks for FREE now.

Below is our current AI Boston vs New York picks, computer picks Celtics vs Knicks, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full NBA schedule.

Celtics Betting Trends

The Boston Celtics have struggled against the spread (ATS) recently, with a 1-4 record in their last five games.

Knicks Betting Trends

The New York Knicks have been solid ATS, boasting a 4-1 record in their last five games.

Celtics vs. Knicks Matchup Trends

In the current playoff series, the Knicks have covered the spread in three of the five games, indicating their strong performance relative to expectations.

Boston vs. New York Game Info

Boston vs New York starts on May 16, 2025 at 8:00 PM EST.

Venue: Madison Square Garden.

Spread: New York -2.5
Moneyline: Boston +116, New York -138
Over/Under: 209.5

Boston: (61-21)  |  New York: (51-31)

Remi's searched hard and found the best prop for this matchup: K. Towns over 33.5 PTS+REB+AST.. Prices move—always shop for the best number.

In the current playoff series, the Knicks have covered the spread in three of the five games, indicating their strong performance relative to expectations.

BOS trend: The Boston Celtics have struggled against the spread (ATS) recently, with a 1-4 record in their last five games.

NY trend: The New York Knicks have been solid ATS, boasting a 4-1 record in their last five games.

See our latest NBA picks and odds pages for 2025 to compare prices before you bet.

Boston vs. New York Odds

AI algorithm Remi is pouring through mountains of data points on each player. In fact, anytime the Boston vs New York trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme travel distance almost always follow normal, predictable patterns.

Boston vs New York Opening Odds

BOS Moneyline: +116
NY Moneyline: -138
BOS Spread: +2.5
NY Spread: -2.5
Over/Under: 209.5

Boston vs New York Live Odds

Games PTS ML SPR O/U
Oct 21, 2025 7:35PM EDT
Houston Rockets
Oklahoma City Thunder
10/21/25 7:35PM
Rockets
Thunder
+245
-300
+7.5 (-110)
-7.5 (-110)
O 226.5 (-115)
U 226.5 (-105)
Oct 21, 2025 10:00PM EDT
Golden State Warriors
Los Angeles Lakers
10/21/25 10PM
Warriors
Lakers
-130
+110
-2 (-110)
+2 (-110)
O 224.5 (-110)
U 224.5 (-110)
Oct 22, 2025 7:10PM EDT
Brooklyn Nets
Charlotte Hornets
10/22/25 7:10PM
Nets
Hornets
+150
-180
+4.5 (-110)
-4.5 (-110)
O 225.5 (-110)
U 225.5 (-110)
Oct 22, 2025 7:10PM EDT
Cleveland Cavaliers
New York Knicks
10/22/25 7:10PM
Cavaliers
Knicks
+140
-170
+3.5 (-105)
-3.5 (-115)
O 229.5 (-110)
U 229.5 (-110)
Oct 22, 2025 7:10PM EDT
Miami Heat
Orlando Magic
10/22/25 7:10PM
Heat
Magic
+280
-350
+8 (-110)
-8 (-110)
O 215.5 (-110)
U 215.5 (-110)
Oct 22, 2025 7:40PM EDT
Philadelphia 76ers
Boston Celtics
10/22/25 7:40PM
76ers
Celtics
+115
-140
+2.5 (-110)
-2.5 (-110)
O 225.5 (-110)
U 225.5 (-110)
Oct 22, 2025 7:40PM EDT
Toronto Raptors
Atlanta Hawks
10/22/25 7:40PM
Raptors
Hawks
+190
-240
+6 (-110)
-6 (-110)
O 235.5 (-110)
U 235.5 (-110)
Oct 22, 2025 8:10PM EDT
Washington Wizards
Milwaukee Bucks
10/22/25 8:10PM
Wizards
Bucks
+300
-375
+9 (-110)
-9 (-110)
O 228.5 (-110)
U 228.5 (-110)
Oct 22, 2025 8:10PM EDT
Detroit Pistons
Chicago Bulls
10/22/25 8:10PM
Pistons
Bulls
-140
+115
-2 (-110)
+2 (-110)
O 235 (-110)
U 235 (-110)
Oct 22, 2025 8:10PM EDT
New Orleans Pelicans
Memphis Grizzlies
10/22/25 8:10PM
Pelicans
Grizzlies
+130
-160
+3.5 (-110)
-3.5 (-110)
O 237 (-110)
U 237 (-110)
Oct 22, 2025 9:10PM EDT
Los Angeles Clippers
Utah Jazz
10/22/25 9:10PM
Clippers
Jazz
-375
+300
-9 (-110)
+9 (-110)
O 227 (-110)
U 227 (-110)
Oct 22, 2025 9:40PM EDT
San Antonio Spurs
Dallas Mavericks
10/22/25 9:40PM
Spurs
Mavericks
+120
-145
+3 (-115)
-3 (-105)
O 226.5 (+100)
U 226.5 (-120)
Oct 22, 2025 10:10PM EDT
Sacramento Kings
Phoenix Suns
10/22/25 10:10PM
Kings
Suns
+140
-170
+3.5 (-110)
-3.5 (-110)
O 227.5 (-110)
U 227.5 (-110)
Oct 22, 2025 10:10PM EDT
Minnesota Timberwolves
Portland Trail Blazers
10/22/25 10:10PM
Timberwolves
Trail Blazers
-170
+140
-3.5 (-110)
+3.5 (-110)
O 219.5 (-110)
U 219.5 (-110)
Oct 23, 2025 7:40PM EDT
Oklahoma City Thunder
Indiana Pacers
10/23/25 7:40PM
Thunder
Pacers
-325
+250
-7.5 (-110)
+7.5 (-110)
O 227 (-110)
U 227 (-110)
Oct 23, 2025 10:10PM EDT
Denver Nuggets
Golden State Warriors
10/23/25 10:10PM
Nuggets
Warriors
-115
-105
+1 (-115)
-1 (-105)
O 233.5 (-110)
U 233.5 (-110)

NBA Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Boston Celtics vs. New York Knicks on May 16, 2025 at Madison Square Garden.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our NBA odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
IND@OKC PASCAL SIAKAM OVER 2.5 PERSONAL FOULS 54.20% 4 WIN
IND@OKC IND +10 54.00% 3 WIN
IND@OKC BENNEDICT MATHURIN OVER 2.5 FREE THROW ATT 54.90% 4 WIN
NY@IND MYLES TURNER OVER 6 REBOUNDS + ASSTS 54.40% 4 LOSS
IND@NY IND +5 55.60% 5 LOSS
NY@IND JALEN BRUNSON UNDER 22 FIELD GOAL ATT 54.70% 4 WIN
OKC@MIN RUDY GOBERT OVER 1.5 FREE THROWS MADE 54.00% 4 WIN
OKC@MIN OKC -2.5 56.70% 6 LOSS
NY@IND KARL ANTHONY TOWNS OVER 32.5 POINTS + REBOUNDS 54.00% 4 WIN
OKC@MIN NAZ REID OVER 9.0 FIELD GOAL ATT 54.60% 4 LOSS
IND@NY MYLES TURNER OVER 5 MADE FIELD GOALS 53.60% 3 WIN
IND@NY NY -5.5 55.00% 4 LOSS
MIN@OKC ISAIAH HARTENSTEIN UNDER 7.5 REBOUNDS 53.00% 3 LOSS
MIN@OKC MIN +7.5 54.70% 4 LOSS
IND@NY TYRESE HALIBURTON ASSTS - UNDER 8.5 54.10% 4 LOSS
IND@NY IND +4.5 54.80% 4 WIN
MIN@OKC ALEX CARUSO UNDER 2.5 ASSTS 54.10% 4 WIN
DEN@OKC MICHAEL PORTER UNDER 7.5 REBS + AST 54.80% 4 WIN
BOS@NY NY -2.5 55.60% 5 WIN
GS@MIN DONTE DIVINCENZO OVER 1.5 TURNOVERS 54.80% 4 LOSS
GS@MIN GS +10.5 54.70% 4 LOSS
DEN@OKC NIKOLA JOKIC UNDER 22.5 REBOUNDS + ASSTS 54.00% 4 WIN
MIN@GS JIMMY BUTLER UNDER 33.5 POINTS + REBOUNDS 54.50% 4 WIN
BOS@NY BOS -5.5 54.70% 4 WIN
OKC@DEN OKC -5 55.70% 5 LOSS
DEN@OKC SHAI GILGEOUS-ALEXANDER UNDER 12.5 REBOUNDS + ASSTS 54.20% 4 WIN
IND@CLE IND +8 54.00% 3 WIN
GS@MIN ANTHONY EDWARDS UNDER 40.5 PTS+REB+AST 54.00% 4 WIN
GS@MIN MIN -6.5 54.40% 4 LOSS
DEN@OKC NIKOLA JOKIC UNDER 36.5 POINTS + ASSTS 53.20% 3 LOSS
IND@CLE IND +8.5 55.70% 5 WIN
HOU@GS GS -5 53.70% 3 LOSS
HOU@GS BRANDIN PODZIEMSKI UNDER 5.5 REBOUNDS 54.10% 4 LOSS
DEN@LAC MICHAEL PORTER UNDER 7.5 REBS + AST 53.20% 3 WIN
DEN@LAC UNDER 212.5 54.00% 3 LOSS
MIN@LAL MIN +6 53.80% 3 WIN
MIN@LAL NAZ REID OVER 1.5 ASSTS 54.80% 4 WIN
LAC@DEN IVICA ZUBAC OVER 1.5 TURNOVERS 53.50% 3 LOSS
DET@NY DET +5.5 53.90% 3 WIN
CLE@MIA EVAN MOBLEY UNDER 29.5 PTS+REB+AST 53.90% 3 WIN
BOS@ORL KRISTAPS PORZINGIS UNDER 8.5 REBOUNDS + ASSTS 53.10% 3 WIN
HOU@GS GS -3 53.70% 3 WIN
HOU@GS JALEN GREEN OVER 2.5 TURNOVERS 54.40% 4 LOSS
LAL@MIN LEBRON JAMES UNDER 31.5 POINTS + REBOUNDS 54.50% 4 LOSS
BOS@ORL BOS -3.5 54.70% 4 LOSS
DEN@LAC BOGDAN BOGDANOVIC OVER 2.5 THREE POINTERS ATTEMPTED 53.60% 3 LOSS
GS@HOU JALEN GREEN UNDER 3.5 FREE THROWS MADE 54.40% 4 LOSS
ORL@BOS ORL +10.5 54.70% 4 WIN
MEM@OKC ISAIAH HARTENSTEIN OVER 19.5 PTS + REB 53.80% 3 LOSS
MEM@OKC OKC -14.5 54.80% 4 WIN
LAC@DEN IVICA ZUBAC OVER 3.5 OFFENSIVE REBOUNDS 53.30% 3 LOSS