Pacers vs. Cavaliers
Prediction, Odds & Props
May 06 | NBA AI Picks

Updated: 2025-05-04T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The Indiana Pacers and Cleveland Cavaliers are set to clash in Game 2 of their Eastern Conference Semifinal series on Tuesday, May 6, 2025, at Rocket Mortgage FieldHouse in Cleveland. The Pacers currently lead the series 1-0 after a surprising 121-112 victory in Game 1, where they outshot the Cavaliers from beyond the arc and capitalized on Cleveland’s shooting woes.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: May 06, 2025

Start Time: 7:00 PM EST​

Venue: Rocket Arena​

Cavaliers Record: (64-18)

Pacers Record: (50-32)

OPENING ODDS

IND Moneyline: +345

CLE Moneyline: -446

IND Spread: +9.5

CLE Spread: -9.5

Over/Under: 229.5

IND
Betting Trends

  • The Indiana Pacers have a 50-26-2 record against the spread (ATS) this season, covering the spread in approximately 65.8% of their games.

CLE
Betting Trends

  • The Cleveland Cavaliers have a 56-28-2 ATS record this season, covering the spread in about 66.7% of their games.

MATCHUP TRENDS

  • In their last 10 games, the Pacers have covered the spread in 8 games, demonstrating strong performance against the spread leading into this series.

IND vs. CLE
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: D. Garland over 26.5 PTS+REB+AST.

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Indiana vs Cleveland Prediction & Odds:
Free NBA Betting Insights for 5/6/25

The Indiana Pacers and Cleveland Cavaliers are set to battle once again in Game 2 of the Eastern Conference Semifinals on Tuesday, May 6, 2025, after the Pacers shocked the top-seeded Cavaliers with a 121-112 road win in the opener that flipped the momentum and raised questions about Cleveland’s ability to adjust without one of their stars. Indiana, riding a wave of confidence from their offensive cohesion and consistent shooting, took full advantage of the Cavaliers’ cold perimeter shooting and defensive breakdowns, hitting 53% from beyond the arc compared to Cleveland’s 24%, a disparity that defined the outcome of Game 1. Andrew Nembhard stepped up with a team-high 23 points and near-perfect shooting from deep, while Tyrese Haliburton operated as the engine of the offense, dropping 22 points and 12 assists with surgical control, stretching the floor and manipulating Cleveland’s defensive rotations. Pascal Siakam and Myles Turner added valuable two-way contributions, combining to provide physicality in the paint and versatility on switches, while head coach Rick Carlisle’s game plan of constant ball movement, spacing, and disciplined off-ball cutting left Cleveland scrambling on closeouts. For the Cavaliers, the loss highlighted several concerning areas, most notably their reliance on Donovan Mitchell to carry the scoring load, as he poured in 33 points but struggled mightily from deep, hitting just 1 of 11 from three-point range. The absence of Darius Garland, out due to injury, was felt profoundly, as the Cavaliers lacked a secondary shot creator and offensive initiator capable of relieving pressure off Mitchell or punishing doubles when they came; the ball movement stagnated, and too many possessions devolved into isolation or forced attempts late in the shot clock. Evan Mobley was a bright spot, putting up 20 points and grabbing 10 rebounds, but Jarrett Allen was largely neutralized, and the supporting cast failed to make a meaningful impact.

Defensively, Cleveland’s signature toughness and communication were missing, as they were often late rotating to the perimeter and failed to contest Indiana’s rhythm shooters, a surprising development given the Cavaliers’ second-ranked defensive efficiency during the regular season. Looking ahead to Game 2, Cleveland must regroup and bring greater urgency to their defensive sets, potentially adjusting their coverages to limit Haliburton’s playmaking while closing out more aggressively on Indiana’s perimeter threats. A potential return from Garland could be the spark they need, rebalancing the offense and giving the Cavaliers more lineup flexibility to counter Indiana’s pace and movement. For the Pacers, the challenge will be sustaining their offensive execution while preparing for a much more desperate and likely more physical Cleveland team, but if they can continue to spread the floor, hit timely threes, and execute in transition, they have a real chance to head back to Indiana with a commanding 2-0 series lead. The strategic chess match between Carlisle and Kenny Atkinson now takes center stage, as both coaches look to exploit matchup weaknesses and adjust rotations, knowing that Game 2 could swing the trajectory of what has quickly become one of the most intriguing series of the postseason.

Indiana Pacers NBA Preview

The Indiana Pacers come into Game 2 of their Eastern Conference Semifinal series against the Cleveland Cavaliers with the momentum and confidence of a team that not only won on the road but did so with style and precision, executing a balanced offensive attack that overwhelmed the NBA’s top-seeded team in a 121-112 Game 1 victory. With a 50-26-2 record against the spread this season and covers in eight of their last ten games, the Pacers have become one of the most consistent and resilient teams in the league, and their Game 1 performance only reinforced their identity as a dangerous, well-coached group that thrives on offensive rhythm, ball movement, and smart shot selection. Tyrese Haliburton was once again the orchestrator, delivering 22 points and 12 assists with surgical efficiency, controlling the tempo and exploiting Cleveland’s slower defensive rotations with high-IQ pick-and-rolls and timely passes to shooters in space. Andrew Nembhard was the breakout star, pouring in 23 points on 5-of-6 shooting from deep, and his ability to stretch the floor, defend multiple positions, and provide secondary playmaking was pivotal in taking pressure off Haliburton and opening up the Cavaliers’ defense. Veterans Pascal Siakam and Myles Turner added physicality and versatility on both ends of the floor, with Siakam scoring in transition and in the midrange, while Turner held his own against Cleveland’s bigs by contesting shots at the rim and cleaning the glass.

Head coach Rick Carlisle’s offensive system, built on spacing, movement, and selflessness, allowed Indiana to pick apart Cleveland’s usually elite defense by forcing them into tough closeouts and exploiting lapses in communication, and that discipline will be crucial again in Game 2, especially with the Cavaliers likely to respond with greater intensity. On the defensive end, the Pacers were far from perfect but timely with their rotations and physical in their contests, especially on Cleveland’s shooters, and they consistently denied easy looks around the arc while protecting the paint just enough to frustrate Donovan Mitchell, who, despite scoring 33 points, went 1-for-11 from three. Indiana’s ability to take Cleveland out of their comfort zone, force isolation-heavy possessions, and capitalize on their own efficient shooting was the formula for Game 1 success—and maintaining that composure will be vital in Game 2 as the Cavaliers adjust and push back with urgency. The Pacers understand that this is a golden opportunity to take a commanding 2-0 lead back to Indiana, and with their offensive chemistry clicking, their role players stepping up, and Haliburton firmly in control of the tempo, they appear fully prepared to meet the moment. Whether they can replicate their sharp shooting and disciplined execution under heightened pressure will determine if their Game 1 win was an outlier or the beginning of a legitimate run toward the Eastern Conference Finals, but one thing is certain—this Indiana team is fearless, fluid, and fully capable of rewriting expectations with every possession.

The Indiana Pacers and Cleveland Cavaliers are set to clash in Game 2 of their Eastern Conference Semifinal series on Tuesday, May 6, 2025, at Rocket Mortgage FieldHouse in Cleveland. The Pacers currently lead the series 1-0 after a surprising 121-112 victory in Game 1, where they outshot the Cavaliers from beyond the arc and capitalized on Cleveland’s shooting woes. Indiana vs Cleveland AI Prediction: Free NBA Betting Insights for May 06. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Cleveland Cavaliers NBA Preview

The Cleveland Cavaliers return to Rocket Mortgage FieldHouse for Game 2 of the Eastern Conference Semifinals with urgency and determination after a disappointing 121-112 loss to the Indiana Pacers in Game 1, a game in which their strengths unraveled under pressure and their normally disciplined defense failed to contain one of the NBA’s most fluid offensive teams. Despite finishing the regular season with a league-best 64-18 record and boasting one of the top defenses in the league, Cleveland looked out of sync defensively, allowing Indiana to shoot a blistering 53% from three-point range and break them down with constant ball movement and off-ball activity. Donovan Mitchell led the Cavaliers offensively with 33 points, but his inefficiency from deep—just 1-for-11 from beyond the arc—highlighted how much pressure he was under without All-Star guard Darius Garland, who missed Game 1 due to injury and whose absence severely limited the team’s offensive flexibility. Evan Mobley played well with 20 points and 10 rebounds, showing touch in the mid-post and effort defensively, but Jarrett Allen was largely neutralized by Indiana’s spacing and Turner’s ability to pull him away from the basket, which opened up cutting lanes and offensive rebounding opportunities for the Pacers. Without Garland to help create and spread the floor, the Cavaliers’ offense leaned heavily on Mitchell’s isolation scoring and Mobley’s interior touch, both of which faltered against Indiana’s timely double teams and help defense.

Defensively, the Cavaliers struggled to track shooters and failed to communicate effectively on switches, allowing Andrew Nembhard to explode for 23 points and Tyrese Haliburton to orchestrate clean looks with ease. Head coach Kenny Atkinson will need to tighten up the defensive rotations and potentially mix in more aggressive on-ball pressure or switch-heavy schemes to keep Indiana’s guards from getting comfortable early, while on offense, more ball movement, screen action, and transition scoring will be needed to relieve the stagnation that plagued them in Game 1. If Garland is able to return for Game 2, his playmaking and ability to collapse the defense will be a welcome addition that could completely shift the tone, but even without him, Cleveland’s deep roster, including Caris LeVert, Max Strus, and Georges Niang, must step up and hit perimeter shots to keep pace with Indiana’s spacing. Playing in front of their home crowd, the Cavaliers have an opportunity to reassert their identity as a physical, disciplined defensive team that dictates tempo and forces opponents to grind for every look, and they will need to do so with increased urgency and focus to avoid falling into a daunting 0-2 hole. For Cleveland, this game is about responding to adversity, restoring rhythm on both ends, and proving that their dominance all season wasn’t just statistical—it was real, and it’s ready to surface when the stakes are highest.

Indiana vs. Cleveland Prop Picks (AI)

Remi is pouring through mountains of stats on each player. In fact, anytime the Pacers and Cavaliers play there’s always several intriguing observations to key in on. Not to mention games played at Rocket Arena in May seemingly never follow normal, predictable patterns.
Remi's searched hard and found the best prop for this matchup: D. Garland over 26.5 PTS+REB+AST.

Indiana vs. Cleveland Prediction (AI)

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Remi, our AI sports wizard, has been pouring over exorbitant amounts of data from every simulation between the Pacers and Cavaliers and using recursive machine learning and kick-ass AI to boil down the data to a single cover probability.

Interestingly enough, the data has been most focused on the trending factor human bettors tend to put on player performance factors between a Pacers team going up against a possibly rested Cavaliers team. It appears the true game analytics appear to reflect a moderate lean against one Vegas line specifically.

Unlock this in-depth AI prediction and all of our NBA AI picks for FREE now.

Below is our current AI Indiana vs Cleveland picks, computer picks Pacers vs Cavaliers, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full NBA schedule.

Pacers Betting Trends

The Indiana Pacers have a 50-26-2 record against the spread (ATS) this season, covering the spread in approximately 65.8% of their games.

Cavaliers Betting Trends

The Cleveland Cavaliers have a 56-28-2 ATS record this season, covering the spread in about 66.7% of their games.

Pacers vs. Cavaliers Matchup Trends

In their last 10 games, the Pacers have covered the spread in 8 games, demonstrating strong performance against the spread leading into this series.

Indiana vs. Cleveland Game Info

Indiana vs Cleveland starts on May 06, 2025 at 7:00 PM EST.

Spread: Cleveland -9.5
Moneyline: Indiana +345, Cleveland -446
Over/Under: 229.5

Indiana: (50-32)  |  Cleveland: (64-18)

Remi's searched hard and found the best prop for this matchup: D. Garland over 26.5 PTS+REB+AST.. Prices move—always shop for the best number.

In their last 10 games, the Pacers have covered the spread in 8 games, demonstrating strong performance against the spread leading into this series.

IND trend: The Indiana Pacers have a 50-26-2 record against the spread (ATS) this season, covering the spread in approximately 65.8% of their games.

CLE trend: The Cleveland Cavaliers have a 56-28-2 ATS record this season, covering the spread in about 66.7% of their games.

See our latest NBA picks and odds pages for 2025 to compare prices before you bet.

Indiana vs. Cleveland Odds

Remi is pouring through tons of data points on each player. In fact, anytime the Indiana vs Cleveland trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme travel distance seemingly never follow normal, predictable patterns.

Indiana vs Cleveland Opening Odds

IND Moneyline: +345
CLE Moneyline: -446
IND Spread: +9.5
CLE Spread: -9.5
Over/Under: 229.5

Indiana vs Cleveland Live Odds

Games PTS ML SPR O/U
Oct 21, 2025 7:30PM EDT
Houston Rockets
Oklahoma City Thunder
10/21/25 7:30PM
Rockets
Thunder
+230
-305
+7.5 (-114)
-7.5 (-112)
O 225.5 (-114)
U 225.5 (-112)
Oct 21, 2025 10:00PM EDT
Golden State Warriors
Los Angeles Lakers
10/21/25 10PM
Warriors
Lakers
+135
-167
+3.5 (-112)
-3.5 (-114)
O 224.5 (-112)
U 224.5 (-114)
Oct 22, 2025 7:10PM EDT
Brooklyn Nets
Charlotte Hornets
10/22/25 7:10PM
Nets
Hornets
+145
-182
+4 (-115)
-4 (-110)
O 221 (-113)
U 221 (-113)
Oct 22, 2025 7:10PM EDT
Cleveland Cavaliers
New York Knicks
10/22/25 7:10PM
Cavaliers
Knicks
+145
-182
+4 (-114)
-4 (-112)
O 227.5 (-112)
U 227.5 (-114)
Oct 22, 2025 7:10PM EDT
Miami Heat
Orlando Magic
10/22/25 7:10PM
Heat
Magic
+240
-315
+7.5 (-113)
-7.5 (-113)
O 207 (-113)
U 207 (-112)
Oct 22, 2025 7:40PM EDT
Philadelphia 76ers
Boston Celtics
10/22/25 7:40PM
76ers
Celtics
+107
-132
+2 (-110)
-2 (-115)
O 221.5 (-115)
U 221.5 (-110)
Oct 22, 2025 7:40PM EDT
Toronto Raptors
Atlanta Hawks
10/22/25 7:40PM
Raptors
Hawks
+190
-245
+6 (-113)
-6 (-112)
O 236.5 (-114)
U 236.5 (-112)
Oct 22, 2025 8:10PM EDT
Washington Wizards
Milwaukee Bucks
10/22/25 8:10PM
Wizards
Bucks
+285
-385
+8.5 (-115)
-8.5 (-109)
O 225 (-110)
U 225 (-115)
Oct 22, 2025 8:10PM EDT
Detroit Pistons
Chicago Bulls
10/22/25 8:10PM
Pistons
Bulls
-132
+106
-2 (-114)
+2 (-112)
O 236.5 (-114)
U 236.5 (-112)
Oct 22, 2025 8:10PM EDT
New Orleans Pelicans
Memphis Grizzlies
10/22/25 8:10PM
Pelicans
Grizzlies
+150
-190
+4.5 (-112)
-4.5 (-113)
O 238.5 (-113)
U 238.5 (-113)
Oct 22, 2025 9:10PM EDT
Los Angeles Clippers
Utah Jazz
10/22/25 9:10PM
Clippers
Jazz
-345
+260
-8 (-113)
+8 (-112)
O 227.5 (-112)
U 227.5 (-114)
Oct 22, 2025 9:40PM EDT
San Antonio Spurs
Dallas Mavericks
10/22/25 9:40PM
Spurs
Mavericks
-113
-110
-1 (-109)
+1 (-117)
O 226.5 (-112)
U 226.5 (-113)
Oct 22, 2025 10:10PM EDT
Sacramento Kings
Phoenix Suns
10/22/25 10:10PM
Kings
Suns
-103
-121
+1.5 (-114)
-1.5 (-110)
O 229.5 (-112)
U 229.5 (-114)
Oct 22, 2025 10:10PM EDT
Minnesota Timberwolves
Portland Trail Blazers
10/22/25 10:10PM
Timberwolves
Trail Blazers
-143
+115
-2.5 (-114)
+2.5 (-112)
O 216 (-114)
U 216 (-112)
Oct 23, 2025 7:40PM EDT
Oklahoma City Thunder
Indiana Pacers
10/23/25 7:40PM
Thunder
Pacers
-323
+240
-7.5 (-110)
+7.5 (-110)
O 226.5 (-110)
U 226.5 (-110)
Oct 23, 2025 10:10PM EDT
Denver Nuggets
Golden State Warriors
10/23/25 10:10PM
Nuggets
Warriors
-109
-116
+1 (-110)
-1 (-110)
O 232.5 (-110)
U 232.5 (-110)

NBA Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Indiana Pacers vs. Cleveland Cavaliers on May 06, 2025 at Rocket Arena.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our NBA odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
IND@OKC PASCAL SIAKAM OVER 2.5 PERSONAL FOULS 54.20% 4 WIN
IND@OKC IND +10 54.00% 3 WIN
IND@OKC BENNEDICT MATHURIN OVER 2.5 FREE THROW ATT 54.90% 4 WIN
NY@IND MYLES TURNER OVER 6 REBOUNDS + ASSTS 54.40% 4 LOSS
IND@NY IND +5 55.60% 5 LOSS
NY@IND JALEN BRUNSON UNDER 22 FIELD GOAL ATT 54.70% 4 WIN
OKC@MIN RUDY GOBERT OVER 1.5 FREE THROWS MADE 54.00% 4 WIN
OKC@MIN OKC -2.5 56.70% 6 LOSS
NY@IND KARL ANTHONY TOWNS OVER 32.5 POINTS + REBOUNDS 54.00% 4 WIN
OKC@MIN NAZ REID OVER 9.0 FIELD GOAL ATT 54.60% 4 LOSS
IND@NY MYLES TURNER OVER 5 MADE FIELD GOALS 53.60% 3 WIN
IND@NY NY -5.5 55.00% 4 LOSS
MIN@OKC ISAIAH HARTENSTEIN UNDER 7.5 REBOUNDS 53.00% 3 LOSS
MIN@OKC MIN +7.5 54.70% 4 LOSS
IND@NY TYRESE HALIBURTON ASSTS - UNDER 8.5 54.10% 4 LOSS
IND@NY IND +4.5 54.80% 4 WIN
MIN@OKC ALEX CARUSO UNDER 2.5 ASSTS 54.10% 4 WIN
DEN@OKC MICHAEL PORTER UNDER 7.5 REBS + AST 54.80% 4 WIN
BOS@NY NY -2.5 55.60% 5 WIN
GS@MIN DONTE DIVINCENZO OVER 1.5 TURNOVERS 54.80% 4 LOSS
GS@MIN GS +10.5 54.70% 4 LOSS
DEN@OKC NIKOLA JOKIC UNDER 22.5 REBOUNDS + ASSTS 54.00% 4 WIN
MIN@GS JIMMY BUTLER UNDER 33.5 POINTS + REBOUNDS 54.50% 4 WIN
BOS@NY BOS -5.5 54.70% 4 WIN
OKC@DEN OKC -5 55.70% 5 LOSS
DEN@OKC SHAI GILGEOUS-ALEXANDER UNDER 12.5 REBOUNDS + ASSTS 54.20% 4 WIN
IND@CLE IND +8 54.00% 3 WIN
GS@MIN ANTHONY EDWARDS UNDER 40.5 PTS+REB+AST 54.00% 4 WIN
GS@MIN MIN -6.5 54.40% 4 LOSS
DEN@OKC NIKOLA JOKIC UNDER 36.5 POINTS + ASSTS 53.20% 3 LOSS
IND@CLE IND +8.5 55.70% 5 WIN
HOU@GS GS -5 53.70% 3 LOSS
HOU@GS BRANDIN PODZIEMSKI UNDER 5.5 REBOUNDS 54.10% 4 LOSS
DEN@LAC MICHAEL PORTER UNDER 7.5 REBS + AST 53.20% 3 WIN
DEN@LAC UNDER 212.5 54.00% 3 LOSS
MIN@LAL MIN +6 53.80% 3 WIN
MIN@LAL NAZ REID OVER 1.5 ASSTS 54.80% 4 WIN
LAC@DEN IVICA ZUBAC OVER 1.5 TURNOVERS 53.50% 3 LOSS
DET@NY DET +5.5 53.90% 3 WIN
CLE@MIA EVAN MOBLEY UNDER 29.5 PTS+REB+AST 53.90% 3 WIN
BOS@ORL KRISTAPS PORZINGIS UNDER 8.5 REBOUNDS + ASSTS 53.10% 3 WIN
HOU@GS GS -3 53.70% 3 WIN
HOU@GS JALEN GREEN OVER 2.5 TURNOVERS 54.40% 4 LOSS
LAL@MIN LEBRON JAMES UNDER 31.5 POINTS + REBOUNDS 54.50% 4 LOSS
BOS@ORL BOS -3.5 54.70% 4 LOSS
DEN@LAC BOGDAN BOGDANOVIC OVER 2.5 THREE POINTERS ATTEMPTED 53.60% 3 LOSS
GS@HOU JALEN GREEN UNDER 3.5 FREE THROWS MADE 54.40% 4 LOSS
ORL@BOS ORL +10.5 54.70% 4 WIN
MEM@OKC ISAIAH HARTENSTEIN OVER 19.5 PTS + REB 53.80% 3 LOSS
MEM@OKC OKC -14.5 54.80% 4 WIN
LAC@DEN IVICA ZUBAC OVER 3.5 OFFENSIVE REBOUNDS 53.30% 3 LOSS