Pistons vs Knicks Prediction — AI Finds CAN'T MISS NBA Lines & Props (Apr 21)

Updated: 2025-04-19T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The New York Knicks host the Detroit Pistons at Madison Square Garden for Game 2 of their Eastern Conference first-round playoff series. The Knicks lead the series 1–0 after a strong fourth-quarter performance in Game 1, overcoming a late deficit to secure a 113–105 victory.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Apr 21, 2025

Start Time: 7:30 PM EST​

Venue: Madison Square Garden​

Knicks Record: (51-31)

Pistons Record: (44-38)

OPENING ODDS

DET Moneyline: +213

NY Moneyline: -263

DET Spread: +6.5

NY Spread: -6.5

Over/Under: 220.5

DET
Betting Trends

  • The Pistons have covered the spread in 53.9% of their games this season, with a 42–36–3 ATS record, indicating consistent performance against the spread.

NY
Betting Trends

  • The Knicks have covered the spread in 48.8% of their games this season, holding a 39–41–1 ATS record, reflecting some inconsistency in meeting betting expectations at home.

MATCHUP TRENDS

  • In their last five head-to-head matchups, the Pistons have covered the spread in three games against the Knicks, suggesting a competitive trend in recent meetings.

DET vs. NY
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: J. Duren over 23.5 PTS+REB+AST.

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Detroit vs New York Prediction & Odds:
Free NBA Betting Insights for 4/21/25

The New York Knicks and Detroit Pistons will square off once again on April 21, 2025, in Game 2 of their Eastern Conference first-round playoff series at Madison Square Garden. After falling behind in the second half of Game 1, the Knicks rallied with a dominant fourth-quarter performance to pull out a 113–105 victory, showcasing the grit and composure that has defined their late-season surge. The win was anchored by Jalen Brunson’s leadership and shot-making under pressure, while Karl-Anthony Towns provided a strong interior presence that helped tilt the rebounding battle in New York’s favor. The Pistons, meanwhile, showed tremendous poise for a young team making its return to postseason action, led by Cade Cunningham, who posted 27 points and seven assists in a near-flawless three quarters before late turnovers and offensive stagnation allowed the Knicks to swing momentum. Detroit’s strategy of using its youthful speed and spacing to attack mismatches worked well for much of the game, but their late-game execution exposed some inexperience that New York exploited with veteran savvy and defensive discipline. As both teams prepare for Game 2, the adjustments will center on execution in the final minutes—whether Detroit can hold onto leads, and whether New York can maintain defensive intensity without waiting for desperation time. The Pistons outpaced the Knicks in transition early in Game 1, with Jaden Ivey and Ausar Thompson applying constant pressure off turnovers and defensive rebounds. Their ability to push the pace caught New York’s defense off guard, and for stretches, the Pistons appeared to control the rhythm of the game.

However, that early burst gave way to rushed possessions and contested perimeter shots as the Knicks tightened up defensively in the final 12 minutes. Coach Tom Thibodeau adjusted his rotations late in the game, opting for a smaller, switch-heavy defensive lineup that stifled Detroit’s half-court sets and turned stagnant possessions into fast-break opportunities for New York. Bench contributions also played a pivotal role, with Miles McBride and Donte DiVincenzo making key hustle plays and connecting on timely jumpers that kept the Knicks within striking distance before they pulled ahead. Rebounding also played a key role in swinging momentum, with Towns and Isaiah Hartenstein combining for 22 boards and limiting Detroit’s second-chance opportunities in the closing stages. For the Pistons, reasserting their early-game ball movement, limiting turnovers, and maintaining composure when the game slows down in the half-court will be essential adjustments for Game 2. Heading into Monday night’s contest, both teams will be fully aware that Game 2 could set the trajectory for the rest of the series—especially if the Knicks are able to head to Detroit with a 2–0 lead. For New York, the blueprint is simple: stay aggressive defensively, move the ball with pace, and continue leveraging Brunson’s ability to create separation late in games. For Detroit, a bounce-back will hinge on executing their game plan for a full 48 minutes, maintaining defensive discipline, and avoiding the late-game lapses that cost them in Game 1. Given the competitiveness of the opener, Game 2 has all the makings of another tightly contested battle, and the winner will hold more than just a statistical edge—it’ll claim crucial momentum in a series that’s proving to be more even than the seeding might suggest. With rising stars on one side and seasoned playoff veterans on the other, this series continues to blend youth and experience, energy and execution, with every possession magnified and every run potentially decisive. Expect another gritty, playoff-style fight where adjustments, rotations, and poise under pressure determine who walks away with the edge.

Detroit Pistons NBA Preview

The Detroit Pistons return to Madison Square Garden for Game 2 of their first-round playoff series against the New York Knicks with both urgency and optimism, despite letting a valuable opportunity slip through their fingers in Game 1. Detroit led for much of the contest and looked poised to steal a road win before faltering in the fourth quarter, where turnovers and stagnant half-court offense allowed the Knicks to surge ahead late. The Pistons were carried by the stellar play of Cade Cunningham, who continues to prove he’s ready for the playoff stage, posting 27 points, seven assists, and four rebounds while controlling the tempo for three quarters. His ability to read defensive schemes, initiate pick-and-roll action, and deliver accurate passes into tight windows gave Detroit a rhythm that kept the Knicks off balance early. But when New York’s defense intensified and the pace slowed in the final stretch, Cunningham lacked support from a young supporting cast that struggled under the pressure of Madison Square Garden in playoff mode. Players like Jaden Ivey, Ausar Thompson, and Jalen Duren showed promise but also inexperience—particularly in managing possessions during critical moments and defending without fouling. For Detroit to even the series, it must execute with more precision in the clutch and minimize the self-inflicted damage that came from empty trips and ill-timed fouls. Turnovers—especially live-ball ones—became costly in Game 1, and the Knicks converted several of them into transition points that flipped momentum late. The Pistons’ spacing also suffered in crunch time, as New York closed out aggressively on shooters and forced Detroit into iso-heavy, low-percentage looks.

That said, there were plenty of positives for head coach Monty Williams to build on, including the team’s ability to push the pace, move the ball in the open court, and take advantage of mismatches when executing properly. Defensively, Detroit did well to contain the Knicks’ perimeter shooting for much of the game and held Julius Randle in check, but they failed to consistently keep New York off the glass—an area where the Pistons must improve to limit second-chance points. Securing rebounds and controlling tempo will be key in Game 2, as it will allow Cunningham to dictate the flow and keep the Knicks from imposing their physical, grind-it-out style. Mentally, Game 2 becomes a test of maturity for this young Pistons squad—whether they can absorb the lessons of a narrow loss, adjust without overreacting, and remain poised under pressure. Cunningham must continue to lead by example, but Detroit will need more from Ivey and Thompson in particular—both in decision-making and shot selection. If the Pistons can maintain their composure, hit open threes, and compete with urgency on the defensive glass, they’re capable of stealing this game and flipping home-court advantage before returning to Detroit. Their 42–36–3 ATS record this season proves they’ve consistently competed above expectations, and their effort in Game 1 showed they’re not simply happy to be here—they’re here to challenge. With one game under their belts and a better feel for playoff intensity, the Pistons now have an opportunity to punch back and make a statement that this series is far from over.

The New York Knicks host the Detroit Pistons at Madison Square Garden for Game 2 of their Eastern Conference first-round playoff series. The Knicks lead the series 1–0 after a strong fourth-quarter performance in Game 1, overcoming a late deficit to secure a 113–105 victory. Detroit vs New York AI Prediction: Free NBA Betting Insights for Apr 21. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

New York Knicks NBA Preview

The New York Knicks enter Game 2 of their first-round playoff series against the Detroit Pistons with momentum in hand and a renewed sense of urgency after narrowly escaping with a 113–105 win in Game 1. While they were favored entering the series, the Knicks had to rally from behind in the fourth quarter to secure the victory, leaning heavily on Jalen Brunson’s poise and shot-making under pressure, as well as timely defensive stops that swung momentum in the final minutes. New York’s late-game execution was sharp, with Tom Thibodeau’s squad tightening its rotations, locking down on defense, and displaying the type of veteran savvy that has become a trademark of their postseason identity. Brunson finished with a game-high 28 points, navigating Detroit’s defensive schemes with patience and precision, while Karl-Anthony Towns provided a vital interior presence, grabbing key rebounds and stretching the floor offensively with his perimeter shooting. The Knicks found another gear in the final frame, ramping up their physicality, getting second-chance opportunities on the offensive glass, and forcing Detroit into rushed, low-efficiency possessions—effectively turning defense into offense when it mattered most. Despite their win, the Knicks will enter Game 2 with a firm understanding that improvements are still necessary if they hope to maintain control of the series. The team struggled early on with Detroit’s speed and transition game, allowing the Pistons to dictate pace and control much of the first three quarters. Thibodeau is likely to emphasize better communication on defensive switches and more disciplined closeouts, as Detroit’s young core—led by Cade Cunningham and Jaden Ivey—found success attacking off the dribble and creating open looks.

Offensively, the Knicks will look to reduce their reliance on isolation play by increasing ball movement and finding easier scoring opportunities in the half-court. Bench players like Donte DiVincenzo and Miles McBride made meaningful contributions in Game 1, and their energy on both ends will continue to be crucial, especially when the starters rest. Julius Randle had a relatively quiet game by his standards, and a more assertive performance from him in Game 2 could provide a valuable scoring boost and help the Knicks build an early lead instead of playing from behind. With Game 2 once again at Madison Square Garden, the Knicks will benefit from the roaring support of their home crowd, which proved to be a major factor during their fourth-quarter comeback in the opener. The team has gone 39–41–1 ATS this season, reflecting some inconsistency, but their veteran composure and ability to close games have remained a constant. If they can clean up their defensive rotations, dominate the rebounding battle, and limit careless turnovers, the Knicks have the tools to put this young Pistons team in a 2–0 hole and shift the series dynamic firmly in their favor before heading to Detroit. Game 2 is as much about maintaining momentum as it is about sharpening execution, and for New York, this matchup offers a critical opportunity to reinforce their standing as a legitimate playoff threat while sending a clear message that they intend to control this series on their terms.

Detroit vs. New York Prop Picks (AI)

Remi is pouring through tons of datapoints on each line. In fact, anytime the Pistons and Knicks play there’s always several intriguing angles to key in on. Not to mention games played at Madison Square Garden in Apr almost always follow normal, predictable patterns.
Remi's searched hard and found the best prop for this matchup: J. Duren over 23.5 PTS+REB+AST.

Detroit vs. New York Prediction (AI)

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Remi, our AI sports wizard, has been pouring over tons of data from every facet between the Pistons and Knicks and using recursive machine learning and cutting-edge AI to analyze the data to a single cover probability.

Oddly enough, we’ve seen the AI has been most keyed in on the linear correlation of weight knucklehead sportsbettors often put on coaching factors between a Pistons team going up against a possibly rested Knicks team. We’ve found the true game analytics appear to reflect a moderate lean against one Vegas line specifically.

Unlock this in-depth AI prediction and all of our NBA AI picks for FREE now.

Below is our current AI Detroit vs New York picks, computer picks Pistons vs Knicks, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
NBA 11/8 POR@MIA UNLOCK THIS PICK 7 VAULT v3 Locked VAULT v3
NBA 11/8 LAL@ATL UNLOCK THIS PICK 6 VAULT v2 Locked VAULT v2
NBA 11/8 IND@DEN UNLOCK THIS PICK 0 INTEL Locked INTEL
NBA 11/8 CHI@CLE UNLOCK THIS PICK 0 INTEL Locked INTEL

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full NBA schedule.

Pistons Betting Trends

The Pistons have covered the spread in 53.9% of their games this season, with a 42–36–3 ATS record, indicating consistent performance against the spread.

Knicks Betting Trends

The Knicks have covered the spread in 48.8% of their games this season, holding a 39–41–1 ATS record, reflecting some inconsistency in meeting betting expectations at home.

Pistons vs. Knicks Matchup Trends

In their last five head-to-head matchups, the Pistons have covered the spread in three games against the Knicks, suggesting a competitive trend in recent meetings.

Detroit vs. New York Game Info

Detroit vs New York starts on April 21, 2025 at 7:30 PM EST.

Venue: Madison Square Garden.

Spread: New York -6.5
Moneyline: Detroit +213, New York -263
Over/Under: 220.5

Detroit: (44-38)  |  New York: (51-31)

Remi's searched hard and found the best prop for this matchup: J. Duren over 23.5 PTS+REB+AST.. Prices move—always shop for the best number.

In their last five head-to-head matchups, the Pistons have covered the spread in three games against the Knicks, suggesting a competitive trend in recent meetings.

DET trend: The Pistons have covered the spread in 53.9% of their games this season, with a 42–36–3 ATS record, indicating consistent performance against the spread.

NY trend: The Knicks have covered the spread in 48.8% of their games this season, holding a 39–41–1 ATS record, reflecting some inconsistency in meeting betting expectations at home.

See our latest NBA picks and odds pages for 2025 to compare prices before you bet.

Detroit vs. New York Odds

AI algorithm Remi is pouring through mountains of data on each line. In fact, anytime the Detroit vs New York trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme altitude seemingly never follow normal, predictable patterns.

Detroit vs New York Opening Odds

DET Moneyline: +213
NY Moneyline: -263
DET Spread: +6.5
NY Spread: -6.5
Over/Under: 220.5

Detroit vs New York Live Odds

Games PTS ML SPR O/U
Nov 9, 2025 3:30PM EST
Houston Rockets
Milwaukee Bucks
11/9/25 3:30PM
Rockets
Bucks
-175
+145
-4.5 (-102)
+4.5 (-118)
O 231.5 (-115)
U 231.5 (-105)
Nov 9, 2025 6:00PM EST
Brooklyn Nets
New York Knicks
11/9/25 6PM
Nets
Knicks
+750
-1200
+15.5 (-110)
-15.5 (-110)
O 227.5 (-115)
U 227.5 (-105)
Nov 9, 2025 6:10PM EST
Oklahoma City Thunder
Memphis Grizzlies
11/9/25 6:10PM
Thunder
Grizzlies
-500
+380
-10.5 (-108)
+10.5 (-112)
O 233.5 (-110)
U 233.5 (-110)
Nov 9, 2025 6:10PM EST
Boston Celtics
Orlando Magic
11/9/25 6:10PM
Celtics
Magic
+136
-162
+3.5 (-115)
-3.5 (-105)
O 226.5 (-110)
U 226.5 (-110)
Nov 9, 2025 7:30PM EST
Detroit Pistons
Philadelphia 76ers
11/9/25 7:30PM
Pistons
76ers
-162
+136
-3.5 (-112)
+3.5 (-108)
O 232.5 (-110)
U 232.5 (-110)
Nov 9, 2025 8:40PM EST
Indiana Pacers
Golden State Warriors
11/9/25 8:40PM
Pacers
Warriors
+500
-700
+12.5 (-108)
-12.5 (-112)
O 227.5 (-112)
U 227.5 (-108)
Nov 9, 2025 9:10PM EST
Minnesota Timberwolves
Sacramento Kings
11/9/25 9:10PM
Timberwolves
Kings
-218
+180
-5.5 (-105)
+5.5 (-115)
O 234.5 (-110)
U 234.5 (-110)
Dec 25, 2025 12:00PM EST
Cleveland Cavaliers
New York Knicks
12/25/25 12PM
Cavaliers
Knicks
+117
-143
+2.5 (-113)
-2.5 (-113)
O 229.5 (-113)
U 229.5 (-113)
Dec 25, 2025 5:00PM EST
Dallas Mavericks
Golden State Warriors
12/25/25 5PM
Mavericks
Warriors
+150
-195
+4.5 (-112)
-4.5 (-114)
O 227 (-115)
U 227 (-110)
Dec 25, 2025 10:30PM EST
Minnesota Timberwolves
Denver Nuggets
12/25/25 10:30PM
Timberwolves
Nuggets
+175
-220
+5 (-109)
-5 (-117)
O 229.5 (-112)
U 229.5 (-114)

NBA Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Detroit Pistons vs. New York Knicks on April 21, 2025 at Madison Square Garden.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our NBA odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
DAL@MEM MEM -4 56.3% 6 WIN
TOR@ATL TOR +118 48.0% 3 WIN
CHA@MIA OVER 235.5 54.3% 3 LOSS
LAC@PHX PHX -135 58.9% 7 WIN
PHI@CLE PHI +10.5 53.3% 3 LOSS
MIA@DEN MIA +9.5 53.7% 3 LOSS
OKC@POR POR +4.5 52.9% 3 WIN
HOU@MEM MEM +8.5 54.7% 4 LOSS
UTA@DET UTA +10 56.8% 6 LOSS
NO@DAL TREY MURPHY III OVER 25.5 PTS & REB 55.5% 5 LOSS
ORL@ATL ORL -3.5 56.5% 6 LOSS
MIL@TOR MIL +3.5 56.5% 4 LOSS
PHX@GS STEPH CURRY UNDER 4.5 THREE PTRS MADE 53.3% 3 LOSS
OKC@LAC JAMES HARDEN OVER 12.5 REBOUNDS + ASSTS 56.1% 6 LOSS
LAL@POR POR -2.5 54.7% 4 LOSS
SA@PHX SA -5.5 56.6% 6 LOSS
ORL@WAS WAS +9 54.2% 4 LOSS
DAL@DET DAL +8 58.7% 8 LOSS
NY@CHI NY -4.5 54.7% 4 LOSS
BOS@PHI BOS +1.5 54.6% 4 WIN
TOR@CLE TOR +6 56.2% 6 WIN
DEN@POR JERAMI GRANT OVER 1.5 TURNOVERS 56.6% 6 WIN
WAS@OKC WAS +15.5 54.9% 4 LOSS
NO@DEN DEN -12.5 53.6% 3 WIN
NO@DEN NIKOLA JOKIC OVER 26.5 POINTS 56.6% 6 LOSS
SAC@OKC SAC +10 54.7% 4 WIN
NY@MIL MIL +3 56.6% 6 WIN
LAC@GS GS +2.5 56.8% 6 WIN
LAC@GS BRANDIN PODZIEMSKI UNDER 1.5 THREE POINTERS MADE 55.5% 5 LOSS
CLE@DET DET +2.5 53.5% 3 LOSS
ORL@PHI ORL -5 54.7% 4 LOSS
OKC@DAL DAL +9 66.4% 6 WIN
BOS@NO NO +2 55.6% 5 LOSS
BKN@HOU BKN +16.5 57.0% 7 LOSS
BOS@NO TREY MURPHY III UNDER 25.5 PTS + REB 54.4% 4 WIN
MIL@CLE MIL +6.5 56.1% 6 WIN
POR@LAC POR +8.5 56.5% 6 WIN
ATL@ORL ATL +5 54.6% 4 WIN
WAS@DAL WAS +10 55.3% 5 WIN
PHX@LAC IVICA ZUBAC OVER 6.5 MADE FIELD GOALS 55.5% 5 LOSS
OKC@IND IND +8 56.5% 6 WIN
CLE@NY CLE -116 55.0% 4 LOSS
LAC@UTA UTA +9.5 54.1% 4 WIN
WAS@MIL KYLE KUZMA OVER 1.5 ASSTS 55.5% 5 WIN
HOU@OKC HOU +6.5 54.8% 4 WIN
GS@LAL STEPHEN CURRY UNDER 2.5 TURNOVERS 54.4 4 WIN
IND@OKC SHAI GILGEOUS-ALEXANDER OVER 1.5 STEALS 54.90% 4 LOSS
IND@OKC JALEN WILLIAMS OVER 0.5 1Q REBOUNDS 55.70% 5 WIN
OKC@IND TJ MCCONNELL UNDER 7.5 TWO POINT ATT 55.70% 5 LOSS
IND@OKC CHET HOLMGREN OVER 1.5 SHOTS BLOCKED 53.40% 3 WIN
OKC@IND TJ MCCONNELL OVER 1.5 TURNOVERS 53.00% 3 LOSS