Pistons vs. Knicks
Prediction, Odds & Props
Apr 21 | NBA AI Picks

Updated: 2025-04-19T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The New York Knicks host the Detroit Pistons at Madison Square Garden for Game 2 of their Eastern Conference first-round playoff series. The Knicks lead the series 1–0 after a strong fourth-quarter performance in Game 1, overcoming a late deficit to secure a 113–105 victory.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Apr 21, 2025

Start Time: 7:30 PM EST​

Venue: Madison Square Garden​

Knicks Record: (51-31)

Pistons Record: (44-38)

OPENING ODDS

DET Moneyline: +213

NY Moneyline: -263

DET Spread: +6.5

NY Spread: -6.5

Over/Under: 220.5

DET
Betting Trends

  • The Pistons have covered the spread in 53.9% of their games this season, with a 42–36–3 ATS record, indicating consistent performance against the spread.

NY
Betting Trends

  • The Knicks have covered the spread in 48.8% of their games this season, holding a 39–41–1 ATS record, reflecting some inconsistency in meeting betting expectations at home.

MATCHUP TRENDS

  • In their last five head-to-head matchups, the Pistons have covered the spread in three games against the Knicks, suggesting a competitive trend in recent meetings.

DET vs. NY
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: J. Duren over 23.5 PTS+REB+AST.

LIVE NBA ODDS

NBA ODDS COMPARISON

WANT MORE AI PICKS?

VAULT
VS. SPREAD
308-221
VAULT
NET UNITS
(INCL VIG)
+418
VAULT
NET PROFIT
(INCL VIG)
$100/UNIT
$41,803
EXECUTIVE
VS. SPREAD
1551-1329
EXECUTIVE
NET UNITS
(INCL VIG)
+365.7
EXECUTIVE
NET PROFIT
(INCL VIG)
$100/UNIT
$36,569

AI SPORTS PICK PRODUCTS

Create a Free Account

‘Create an Account’ to Get Remi’s Picks Today.

Remi Finds New Picks

Remi calculates the probability a team will cover the line.

Remi Works 24/7

Remi uses this probability to assign units to each pick.

Get Remi's AI Picks

Get Remi’s Top AI Sports Picks sent direct to your inbox.

Detroit vs New York Prediction & Odds:
Free NBA Betting Insights for 4/21/25

The New York Knicks and Detroit Pistons will square off once again on April 21, 2025, in Game 2 of their Eastern Conference first-round playoff series at Madison Square Garden. After falling behind in the second half of Game 1, the Knicks rallied with a dominant fourth-quarter performance to pull out a 113–105 victory, showcasing the grit and composure that has defined their late-season surge. The win was anchored by Jalen Brunson’s leadership and shot-making under pressure, while Karl-Anthony Towns provided a strong interior presence that helped tilt the rebounding battle in New York’s favor. The Pistons, meanwhile, showed tremendous poise for a young team making its return to postseason action, led by Cade Cunningham, who posted 27 points and seven assists in a near-flawless three quarters before late turnovers and offensive stagnation allowed the Knicks to swing momentum. Detroit’s strategy of using its youthful speed and spacing to attack mismatches worked well for much of the game, but their late-game execution exposed some inexperience that New York exploited with veteran savvy and defensive discipline. As both teams prepare for Game 2, the adjustments will center on execution in the final minutes—whether Detroit can hold onto leads, and whether New York can maintain defensive intensity without waiting for desperation time. The Pistons outpaced the Knicks in transition early in Game 1, with Jaden Ivey and Ausar Thompson applying constant pressure off turnovers and defensive rebounds. Their ability to push the pace caught New York’s defense off guard, and for stretches, the Pistons appeared to control the rhythm of the game.

However, that early burst gave way to rushed possessions and contested perimeter shots as the Knicks tightened up defensively in the final 12 minutes. Coach Tom Thibodeau adjusted his rotations late in the game, opting for a smaller, switch-heavy defensive lineup that stifled Detroit’s half-court sets and turned stagnant possessions into fast-break opportunities for New York. Bench contributions also played a pivotal role, with Miles McBride and Donte DiVincenzo making key hustle plays and connecting on timely jumpers that kept the Knicks within striking distance before they pulled ahead. Rebounding also played a key role in swinging momentum, with Towns and Isaiah Hartenstein combining for 22 boards and limiting Detroit’s second-chance opportunities in the closing stages. For the Pistons, reasserting their early-game ball movement, limiting turnovers, and maintaining composure when the game slows down in the half-court will be essential adjustments for Game 2. Heading into Monday night’s contest, both teams will be fully aware that Game 2 could set the trajectory for the rest of the series—especially if the Knicks are able to head to Detroit with a 2–0 lead. For New York, the blueprint is simple: stay aggressive defensively, move the ball with pace, and continue leveraging Brunson’s ability to create separation late in games. For Detroit, a bounce-back will hinge on executing their game plan for a full 48 minutes, maintaining defensive discipline, and avoiding the late-game lapses that cost them in Game 1. Given the competitiveness of the opener, Game 2 has all the makings of another tightly contested battle, and the winner will hold more than just a statistical edge—it’ll claim crucial momentum in a series that’s proving to be more even than the seeding might suggest. With rising stars on one side and seasoned playoff veterans on the other, this series continues to blend youth and experience, energy and execution, with every possession magnified and every run potentially decisive. Expect another gritty, playoff-style fight where adjustments, rotations, and poise under pressure determine who walks away with the edge.

Detroit Pistons NBA Preview

The Detroit Pistons return to Madison Square Garden for Game 2 of their first-round playoff series against the New York Knicks with both urgency and optimism, despite letting a valuable opportunity slip through their fingers in Game 1. Detroit led for much of the contest and looked poised to steal a road win before faltering in the fourth quarter, where turnovers and stagnant half-court offense allowed the Knicks to surge ahead late. The Pistons were carried by the stellar play of Cade Cunningham, who continues to prove he’s ready for the playoff stage, posting 27 points, seven assists, and four rebounds while controlling the tempo for three quarters. His ability to read defensive schemes, initiate pick-and-roll action, and deliver accurate passes into tight windows gave Detroit a rhythm that kept the Knicks off balance early. But when New York’s defense intensified and the pace slowed in the final stretch, Cunningham lacked support from a young supporting cast that struggled under the pressure of Madison Square Garden in playoff mode. Players like Jaden Ivey, Ausar Thompson, and Jalen Duren showed promise but also inexperience—particularly in managing possessions during critical moments and defending without fouling. For Detroit to even the series, it must execute with more precision in the clutch and minimize the self-inflicted damage that came from empty trips and ill-timed fouls. Turnovers—especially live-ball ones—became costly in Game 1, and the Knicks converted several of them into transition points that flipped momentum late. The Pistons’ spacing also suffered in crunch time, as New York closed out aggressively on shooters and forced Detroit into iso-heavy, low-percentage looks.

That said, there were plenty of positives for head coach Monty Williams to build on, including the team’s ability to push the pace, move the ball in the open court, and take advantage of mismatches when executing properly. Defensively, Detroit did well to contain the Knicks’ perimeter shooting for much of the game and held Julius Randle in check, but they failed to consistently keep New York off the glass—an area where the Pistons must improve to limit second-chance points. Securing rebounds and controlling tempo will be key in Game 2, as it will allow Cunningham to dictate the flow and keep the Knicks from imposing their physical, grind-it-out style. Mentally, Game 2 becomes a test of maturity for this young Pistons squad—whether they can absorb the lessons of a narrow loss, adjust without overreacting, and remain poised under pressure. Cunningham must continue to lead by example, but Detroit will need more from Ivey and Thompson in particular—both in decision-making and shot selection. If the Pistons can maintain their composure, hit open threes, and compete with urgency on the defensive glass, they’re capable of stealing this game and flipping home-court advantage before returning to Detroit. Their 42–36–3 ATS record this season proves they’ve consistently competed above expectations, and their effort in Game 1 showed they’re not simply happy to be here—they’re here to challenge. With one game under their belts and a better feel for playoff intensity, the Pistons now have an opportunity to punch back and make a statement that this series is far from over.

The New York Knicks host the Detroit Pistons at Madison Square Garden for Game 2 of their Eastern Conference first-round playoff series. The Knicks lead the series 1–0 after a strong fourth-quarter performance in Game 1, overcoming a late deficit to secure a 113–105 victory. Detroit vs New York AI Prediction: Free NBA Betting Insights for Apr 21. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

New York Knicks NBA Preview

The New York Knicks enter Game 2 of their first-round playoff series against the Detroit Pistons with momentum in hand and a renewed sense of urgency after narrowly escaping with a 113–105 win in Game 1. While they were favored entering the series, the Knicks had to rally from behind in the fourth quarter to secure the victory, leaning heavily on Jalen Brunson’s poise and shot-making under pressure, as well as timely defensive stops that swung momentum in the final minutes. New York’s late-game execution was sharp, with Tom Thibodeau’s squad tightening its rotations, locking down on defense, and displaying the type of veteran savvy that has become a trademark of their postseason identity. Brunson finished with a game-high 28 points, navigating Detroit’s defensive schemes with patience and precision, while Karl-Anthony Towns provided a vital interior presence, grabbing key rebounds and stretching the floor offensively with his perimeter shooting. The Knicks found another gear in the final frame, ramping up their physicality, getting second-chance opportunities on the offensive glass, and forcing Detroit into rushed, low-efficiency possessions—effectively turning defense into offense when it mattered most. Despite their win, the Knicks will enter Game 2 with a firm understanding that improvements are still necessary if they hope to maintain control of the series. The team struggled early on with Detroit’s speed and transition game, allowing the Pistons to dictate pace and control much of the first three quarters. Thibodeau is likely to emphasize better communication on defensive switches and more disciplined closeouts, as Detroit’s young core—led by Cade Cunningham and Jaden Ivey—found success attacking off the dribble and creating open looks.

Offensively, the Knicks will look to reduce their reliance on isolation play by increasing ball movement and finding easier scoring opportunities in the half-court. Bench players like Donte DiVincenzo and Miles McBride made meaningful contributions in Game 1, and their energy on both ends will continue to be crucial, especially when the starters rest. Julius Randle had a relatively quiet game by his standards, and a more assertive performance from him in Game 2 could provide a valuable scoring boost and help the Knicks build an early lead instead of playing from behind. With Game 2 once again at Madison Square Garden, the Knicks will benefit from the roaring support of their home crowd, which proved to be a major factor during their fourth-quarter comeback in the opener. The team has gone 39–41–1 ATS this season, reflecting some inconsistency, but their veteran composure and ability to close games have remained a constant. If they can clean up their defensive rotations, dominate the rebounding battle, and limit careless turnovers, the Knicks have the tools to put this young Pistons team in a 2–0 hole and shift the series dynamic firmly in their favor before heading to Detroit. Game 2 is as much about maintaining momentum as it is about sharpening execution, and for New York, this matchup offers a critical opportunity to reinforce their standing as a legitimate playoff threat while sending a clear message that they intend to control this series on their terms.

Detroit vs. New York Prop Picks (AI)

Remi is pouring through tons of datapoints on each line. In fact, anytime the Pistons and Knicks play there’s always several intriguing trends to key in on. Not to mention games played at Madison Square Garden in Apr seemingly never follow normal, predictable patterns.
Remi's searched hard and found the best prop for this matchup: J. Duren over 23.5 PTS+REB+AST.

Detroit vs. New York Prediction (AI)

Remi Robot Icon

Remi, our AI sports wizard, has been pouring over tons of data from every facet between the Pistons and Knicks and using recursive machine learning and industry leading AI to boil down the data to a single cover probability.

Interestingly enough, the data has been most watching on the unproportionally assigned weight emotional bettors regularly put on New York’s strength factors between a Pistons team going up against a possibly deflated Knicks team. In reality, the true game analytics might reflect a strong lean against one Vegas line specifically.

Unlock this in-depth AI prediction and all of our NBA AI picks for FREE now.

Below is our current AI Detroit vs New York picks, computer picks Pistons vs Knicks, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
ACTIVE PICKS LOCKED - SEE NOW

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full NBA schedule.

Pistons Betting Trends

The Pistons have covered the spread in 53.9% of their games this season, with a 42–36–3 ATS record, indicating consistent performance against the spread.

Knicks Betting Trends

The Knicks have covered the spread in 48.8% of their games this season, holding a 39–41–1 ATS record, reflecting some inconsistency in meeting betting expectations at home.

Pistons vs. Knicks Matchup Trends

In their last five head-to-head matchups, the Pistons have covered the spread in three games against the Knicks, suggesting a competitive trend in recent meetings.

Detroit vs. New York Game Info

Detroit vs New York starts on April 21, 2025 at 7:30 PM EST.

Venue: Madison Square Garden.

Spread: New York -6.5
Moneyline: Detroit +213, New York -263
Over/Under: 220.5

Detroit: (44-38)  |  New York: (51-31)

Remi's searched hard and found the best prop for this matchup: J. Duren over 23.5 PTS+REB+AST.. Prices move—always shop for the best number.

In their last five head-to-head matchups, the Pistons have covered the spread in three games against the Knicks, suggesting a competitive trend in recent meetings.

DET trend: The Pistons have covered the spread in 53.9% of their games this season, with a 42–36–3 ATS record, indicating consistent performance against the spread.

NY trend: The Knicks have covered the spread in 48.8% of their games this season, holding a 39–41–1 ATS record, reflecting some inconsistency in meeting betting expectations at home.

See our latest NBA picks and odds pages for 2025 to compare prices before you bet.

Detroit vs. New York Odds

AI algorithm Remi is pouring through loads of stats on each line. In fact, anytime the Detroit vs New York trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme altitude seemingly never follow normal, predictable betting trends.

Detroit vs New York Opening Odds

DET Moneyline: +213
NY Moneyline: -263
DET Spread: +6.5
NY Spread: -6.5
Over/Under: 220.5

Detroit vs New York Live Odds

Games PTS ML SPR O/U
Oct 21, 2025 7:30PM EDT
Houston Rockets
Oklahoma City Thunder
10/21/25 7:30PM
Rockets
Thunder
+260
-320
+8 (-115)
-8 (-105)
O 225.5 (-110)
U 225.5 (-110)
Oct 21, 2025 10:00PM EDT
Golden State Warriors
Los Angeles Lakers
10/21/25 10PM
Warriors
Lakers
+150
-175
+4 (-110)
-4 (-110)
O 225.5 (-110)
U 225.5 (-110)
Oct 22, 2025 7:10PM EDT
Brooklyn Nets
Charlotte Hornets
10/22/25 7:10PM
Nets
Hornets
+145
-182
+4 (-115)
-4 (-110)
O 221 (-113)
U 221 (-113)
Oct 22, 2025 7:10PM EDT
Cleveland Cavaliers
New York Knicks
10/22/25 7:10PM
Cavaliers
Knicks
+140
-170
+3.5 (-110)
-3.5 (-110)
O 229.5 (+105)
U 229.5 (-125)
Oct 22, 2025 7:10PM EDT
Miami Heat
Orlando Magic
10/22/25 7:10PM
Heat
Magic
+240
-315
+7.5 (-113)
-7.5 (-113)
O 207 (-113)
U 207 (-112)
Oct 22, 2025 7:40PM EDT
Philadelphia 76ers
Boston Celtics
10/22/25 7:40PM
76ers
Celtics
+107
-132
+2 (-110)
-2 (-115)
O 221.5 (-115)
U 221.5 (-110)
Oct 22, 2025 7:40PM EDT
Toronto Raptors
Atlanta Hawks
10/22/25 7:40PM
Raptors
Hawks
+190
-245
+6 (-113)
-6 (-112)
O 236.5 (-114)
U 236.5 (-112)
Oct 22, 2025 8:10PM EDT
Washington Wizards
Milwaukee Bucks
10/22/25 8:10PM
Wizards
Bucks
+285
-385
+8.5 (-115)
-8.5 (-109)
O 225 (-110)
U 225 (-115)
Oct 22, 2025 8:10PM EDT
Detroit Pistons
Chicago Bulls
10/22/25 8:10PM
Pistons
Bulls
-132
+106
-2 (-114)
+2 (-112)
O 236.5 (-114)
U 236.5 (-112)
Oct 22, 2025 8:10PM EDT
New Orleans Pelicans
Memphis Grizzlies
10/22/25 8:10PM
Pelicans
Grizzlies
+150
-190
+4.5 (-112)
-4.5 (-113)
O 238.5 (-113)
U 238.5 (-113)
Oct 22, 2025 9:10PM EDT
Los Angeles Clippers
Utah Jazz
10/22/25 9:10PM
Clippers
Jazz
-345
+260
-8 (-113)
+8 (-112)
O 227.5 (-112)
U 227.5 (-114)
Oct 22, 2025 9:40PM EDT
San Antonio Spurs
Dallas Mavericks
10/22/25 9:40PM
Spurs
Mavericks
-110
-110
-1 (-105)
+1 (-115)
O 226.5 (-110)
U 226.5 (-110)
Oct 22, 2025 10:10PM EDT
Sacramento Kings
Phoenix Suns
10/22/25 10:10PM
Kings
Suns
-103
-121
+1.5 (-114)
-1.5 (-110)
O 229.5 (-112)
U 229.5 (-114)
Oct 22, 2025 10:10PM EDT
Minnesota Timberwolves
Portland Trail Blazers
10/22/25 10:10PM
Timberwolves
Trail Blazers
-143
+115
-2.5 (-114)
+2.5 (-112)
O 216 (-114)
U 216 (-112)
Oct 23, 2025 7:40PM EDT
Oklahoma City Thunder
Indiana Pacers
10/23/25 7:40PM
Thunder
Pacers
-325
+250
-7.5 (-110)
+7.5 (-110)
O 225.5 (-110)
U 225.5 (-110)
Oct 23, 2025 10:10PM EDT
Denver Nuggets
Golden State Warriors
10/23/25 10:10PM
Nuggets
Warriors
-105
-115
+1 (-110)
-1 (-110)
O 234.5 (-110)
U 234.5 (-110)

NBA Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Detroit Pistons vs. New York Knicks on April 21, 2025 at Madison Square Garden.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our NBA odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
IND@OKC PASCAL SIAKAM OVER 2.5 PERSONAL FOULS 54.20% 4 WIN
IND@OKC IND +10 54.00% 3 WIN
IND@OKC BENNEDICT MATHURIN OVER 2.5 FREE THROW ATT 54.90% 4 WIN
NY@IND MYLES TURNER OVER 6 REBOUNDS + ASSTS 54.40% 4 LOSS
IND@NY IND +5 55.60% 5 LOSS
NY@IND JALEN BRUNSON UNDER 22 FIELD GOAL ATT 54.70% 4 WIN
OKC@MIN RUDY GOBERT OVER 1.5 FREE THROWS MADE 54.00% 4 WIN
OKC@MIN OKC -2.5 56.70% 6 LOSS
NY@IND KARL ANTHONY TOWNS OVER 32.5 POINTS + REBOUNDS 54.00% 4 WIN
OKC@MIN NAZ REID OVER 9.0 FIELD GOAL ATT 54.60% 4 LOSS
IND@NY MYLES TURNER OVER 5 MADE FIELD GOALS 53.60% 3 WIN
IND@NY NY -5.5 55.00% 4 LOSS
MIN@OKC ISAIAH HARTENSTEIN UNDER 7.5 REBOUNDS 53.00% 3 LOSS
MIN@OKC MIN +7.5 54.70% 4 LOSS
IND@NY TYRESE HALIBURTON ASSTS - UNDER 8.5 54.10% 4 LOSS
IND@NY IND +4.5 54.80% 4 WIN
MIN@OKC ALEX CARUSO UNDER 2.5 ASSTS 54.10% 4 WIN
DEN@OKC MICHAEL PORTER UNDER 7.5 REBS + AST 54.80% 4 WIN
BOS@NY NY -2.5 55.60% 5 WIN
GS@MIN DONTE DIVINCENZO OVER 1.5 TURNOVERS 54.80% 4 LOSS
GS@MIN GS +10.5 54.70% 4 LOSS
DEN@OKC NIKOLA JOKIC UNDER 22.5 REBOUNDS + ASSTS 54.00% 4 WIN
MIN@GS JIMMY BUTLER UNDER 33.5 POINTS + REBOUNDS 54.50% 4 WIN
BOS@NY BOS -5.5 54.70% 4 WIN
OKC@DEN OKC -5 55.70% 5 LOSS
DEN@OKC SHAI GILGEOUS-ALEXANDER UNDER 12.5 REBOUNDS + ASSTS 54.20% 4 WIN
IND@CLE IND +8 54.00% 3 WIN
GS@MIN ANTHONY EDWARDS UNDER 40.5 PTS+REB+AST 54.00% 4 WIN
GS@MIN MIN -6.5 54.40% 4 LOSS
DEN@OKC NIKOLA JOKIC UNDER 36.5 POINTS + ASSTS 53.20% 3 LOSS
IND@CLE IND +8.5 55.70% 5 WIN
HOU@GS GS -5 53.70% 3 LOSS
HOU@GS BRANDIN PODZIEMSKI UNDER 5.5 REBOUNDS 54.10% 4 LOSS
DEN@LAC MICHAEL PORTER UNDER 7.5 REBS + AST 53.20% 3 WIN
DEN@LAC UNDER 212.5 54.00% 3 LOSS
MIN@LAL MIN +6 53.80% 3 WIN
MIN@LAL NAZ REID OVER 1.5 ASSTS 54.80% 4 WIN
LAC@DEN IVICA ZUBAC OVER 1.5 TURNOVERS 53.50% 3 LOSS
DET@NY DET +5.5 53.90% 3 WIN
CLE@MIA EVAN MOBLEY UNDER 29.5 PTS+REB+AST 53.90% 3 WIN
BOS@ORL KRISTAPS PORZINGIS UNDER 8.5 REBOUNDS + ASSTS 53.10% 3 WIN
HOU@GS GS -3 53.70% 3 WIN
HOU@GS JALEN GREEN OVER 2.5 TURNOVERS 54.40% 4 LOSS
LAL@MIN LEBRON JAMES UNDER 31.5 POINTS + REBOUNDS 54.50% 4 LOSS
BOS@ORL BOS -3.5 54.70% 4 LOSS
DEN@LAC BOGDAN BOGDANOVIC OVER 2.5 THREE POINTERS ATTEMPTED 53.60% 3 LOSS
GS@HOU JALEN GREEN UNDER 3.5 FREE THROWS MADE 54.40% 4 LOSS
ORL@BOS ORL +10.5 54.70% 4 WIN
MEM@OKC ISAIAH HARTENSTEIN OVER 19.5 PTS + REB 53.80% 3 LOSS
MEM@OKC OKC -14.5 54.80% 4 WIN
LAC@DEN IVICA ZUBAC OVER 3.5 OFFENSIVE REBOUNDS 53.30% 3 LOSS