76ers vs. Spurs
Prediction, Odds & Props
Mar 21 | NBA AI Picks

Updated: 2025-03-19T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The San Antonio Spurs (29-38) will host the Philadelphia 76ers (23-46) on March 21, 2025, at Frost Bank Center. Both teams are dealing with significant injuries, including the absences of key players such as Victor Wembanyama and Joel Embiid.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Mar 21, 2025

Start Time: 8:00 PM EST​

Venue: Frost Bank Center​

Spurs Record: (29-39)

76ers Record: (23-46)

OPENING ODDS

PHI Moneyline: +182

SA Moneyline: -221

PHI Spread: +5.5

SA Spread: -5.5

Over/Under: 240.5

PHI
Betting Trends

  • Specific recent against-the-spread (ATS) data for the 76ers is not available in the provided sources.

SA
Betting Trends

  • Specific recent ATS data for the Spurs is not available in the provided sources.

MATCHUP TRENDS

  • Detailed ATS statistics for this specific matchup are not available in the provided sources.

PHI vs. SA
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: K. Johnson under 23.5 Pts + Ast + Reb

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Philadelphia vs San Antonio Prediction & Odds:
Free NBA Betting Insights for 3/21/25

As the NBA regular season progresses, the San Antonio Spurs are set to host the Philadelphia 76ers on March 21, 2025, at Frost Bank Center. Both teams have faced challenges this season, with the Spurs holding a 29-38 record and the 76ers at 23-46. Injuries have significantly impacted both rosters, with notable absences including Victor Wembanyama and De’Aaron Fox for the Spurs, and Joel Embiid and Paul George for the 76ers. These injuries have forced both teams to rely on their depth and adapt their strategies accordingly. The Spurs have shown resilience, with players like Devin Vassell stepping up in scoring, averaging 16.0 points per game. Chris Paul, despite his veteran status, continues to be a pivotal playmaker, averaging 7.8 assists per game. Jeremy Sochan has been effective on the boards, leading the team with 6.6 rebounds per game. A recent standout performance came from Sandro Mamukelashvili, who scored a career-high 34 points in a win against the New York Knicks, showcasing the potential within the Spurs’ roster. The 76ers, meanwhile, have seen Quentin Grimes emerge as a key offensive contributor, averaging 21.8 points per game. In March, Grimes has elevated his performance, averaging 28.5 points over ten games, ranking ninth in the NBA during that span. However, the team has struggled with consistency, partly due to the absence of star players like Embiid and George.

The 76ers’ lineup has seen contributions from players such as Jared Butler and Oshea Brissett, but the lack of their primary scorers has been evident in their recent performances. Both teams have had fluctuating performances recently. The Spurs aim to secure consecutive wins for the first time since January, indicating their struggle with maintaining momentum. The 76ers have faced their own challenges, with a recent loss to the Oklahoma City Thunder highlighting the impact of their injury-depleted roster. From a betting perspective, specific recent ATS data for both teams is not available in the provided sources. However, the Spurs’ recent victory and the 76ers’ injury woes may influence betting lines and public perception leading up to the game. In their previous matchup, the 76ers secured a 111-106 victory over the Spurs, with both teams fielding more complete rosters at that time. The upcoming game presents a different scenario, with both teams adjusting to significant player absences. This matchup offers an opportunity for both teams to evaluate their depth and resilience. The Spurs will look to capitalize on their home-court advantage and recent positive performances from emerging players. The 76ers, on the other hand, will aim to overcome their recent struggles by relying on the offensive prowess of players like Grimes. The outcome of this game may hinge on which team can better adapt to their current roster limitations and execute their game plan effectively.

Philadelphia 76ers NBA Preview

The Philadelphia 76ers enter their March 21, 2025 matchup against the San Antonio Spurs in the midst of one of the most injury-plagued and turbulent stretches of their season, holding a disappointing 23-46 record that has left them clinging to faint hopes of salvaging a lost campaign. The absence of former MVP Joel Embiid—who has missed extended time with a left meniscus injury—has been the most significant blow to the team’s competitiveness, stripping the Sixers of their primary scorer, rim protector, and emotional leader. Compounding the issue, offseason acquisition Paul George is also out indefinitely with a right foot fracture, removing another key two-way weapon from the floor. In response, Philadelphia has shifted into a developmental mode of sorts, offering expanded opportunities to its younger rotation players and emerging contributors. Quentin Grimes has seized that opportunity in spectacular fashion, emerging as the team’s leading scorer during the month of March with a blistering average of 28.5 points per game, including several 30-point outings that highlight his ability to create off the dribble and shoot effectively from range. Grimes has become the focal point of the offense out of necessity, carrying the scoring load and drawing top perimeter defenders nightly. Supporting him are role players like Jared Butler and Oshea Brissett, who have seen their minutes and usage increase as the 76ers attempt to compensate for their missing stars.

Butler has added occasional scoring punch off the bench, while Brissett brings energy and defensive versatility, though neither has consistently provided the production needed to lift the team over the top. Veteran guard Tyrese Maxey, typically a central figure in the team’s offense, has also been battling minor injuries and inconsistency, leaving the team without a clear second scoring option. Head coach Nick Nurse, known for his tactical creativity and defensive schemes, has had to retool his game plans significantly, often deploying unconventional lineups and emphasizing switch-heavy defenses to maximize effort and versatility from his available personnel. Despite those efforts, the Sixers’ defense has suffered, giving up an average of 114.6 points per game, as their ability to guard the paint and protect the rim without Embiid has plummeted. Offensively, the team now relies heavily on isolation plays and perimeter shooting, with varying results. Their three-point percentage remains respectable at 35.8%, but poor ball movement and a lack of reliable post play have caused extended scoring droughts. From a betting standpoint, Philadelphia has been inconsistent against the spread this season, and their current injury issues have made them a risky play, particularly on the road where their offense tends to falter under pressure. Their last meeting with the Spurs resulted in a 111-106 win, but with the rosters for both sides now drastically different due to injuries, this rematch is likely to be a far less predictable affair. The 76ers will need another huge night from Grimes and a committed defensive effort to have a shot at winning in San Antonio, but with their depth being tested and fatigue setting in, the odds are not in their favor. Still, the game provides a meaningful opportunity for the younger core to gain reps, showcase their growth, and perhaps deliver a morale-boosting road win in what has otherwise been a frustrating and injury-riddled season.

The San Antonio Spurs (29-38) will host the Philadelphia 76ers (23-46) on March 21, 2025, at Frost Bank Center. Both teams are dealing with significant injuries, including the absences of key players such as Victor Wembanyama and Joel Embiid. Philadelphia vs San Antonio AI Prediction: Free NBA Betting Insights for Mar 21. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

San Antonio Spurs NBA Preview

The San Antonio Spurs enter their March 21, 2025, matchup against the Philadelphia 76ers with a 29-38 record, reflecting a season of challenges and adjustments, particularly due to significant injuries that have tested the team’s depth and resilience. The absence of key players like Victor Wembanyama, sidelined with deep vein thrombosis, and De’Aaron Fox, recovering from left little finger surgery, has necessitated a shift in roles and responsibilities among the remaining roster. Veteran point guard Chris Paul, in his 20th NBA season, has been instrumental in guiding the team’s offense, averaging 7.8 assists per game, showcasing his enduring playmaking abilities. Shooting guard Stephon Castle, a rookie, has stepped into a starting role, bringing fresh energy and contributing on both ends of the court. Small forward Devin Vassell leads the team in scoring with 16.0 points per game, demonstrating consistency and growth in his offensive game. Power forward Harrison Barnes, with 13 years of experience, provides stability and veteran leadership, while center Jeremy Sochan, in his third year, anchors the defense with 6.6 rebounds per game. The Spurs’ bench has also been pivotal, with players like Sandro Mamukelashvili delivering standout performances, including a career-high 34 points in a recent victory over the New York Knicks. This depth has been crucial in maintaining competitiveness despite the team’s injury woes. Defensively, the Spurs have faced challenges, particularly in the absence of Wembanyama, who leads the league with an average of 3.6 blocks per game. His defensive presence has been sorely missed, impacting the team’s ability to protect the rim and deter opposing offenses. Interim coach Mitch Johnson has emphasized a collective defensive effort, encouraging players to step up in Wembanyama’s absence. The team’s recent performance—a 130-126 win over the New York Knicks—offered a glimpse of the Spurs’ offensive potential when their rotation players find rhythm. That victory snapped a four-game losing streak and may serve as a confidence boost heading into the matchup with Philadelphia. The Spurs displayed strong ball movement and spacing in that game, with Mamukelashvili’s surprising scoring surge supported by efficient contributions from Keldon Johnson and Tre Jones, who continue to offer steady play off the bench. Despite their struggles this season, the Spurs have managed to remain competitive in spurts, often pushing more talented opponents to the brink when executing their system cleanly.

On the offensive end, San Antonio averages 112.1 points per game, ranking them in the bottom third of the league, but their scoring has seen slight improvement in recent weeks due to the emergence of secondary scorers stepping up in the absence of primary options. Their shooting splits—46.2% from the field and 34.1% from three—show a team capable of decent efficiency when ball movement is prioritized. The defensive side remains a concern, however, as the Spurs allow 119.7 points per game, placing them near the bottom of the league defensively, with rebounding and defensive transition execution being ongoing problem areas. From a betting perspective, while the Spurs’ ATS stats are not readily available for this specific stretch, their home games have generally offered better value for bettors due to more consistent energy levels and the occasional standout effort from young contributors looking to prove their long-term value. The matchup with Philadelphia comes at a crucial point in the season where, mathematically still alive in the play-in race, the Spurs are seeking back-to-back wins for the first time since January, a streak that could be broken with a focused effort on Friday night. While missing their generational rookie star has significantly dampened expectations, the Spurs have adapted by leaning on veterans and increasing the usage of rising contributors who are gaining valuable minutes. The key for San Antonio in this matchup will be maintaining tempo, limiting turnovers, and exploiting Philadelphia’s injury-riddled lineup with aggressive drives and interior scoring. Given the 76ers’ recent defensive lapses and lack of rim protection without Embiid, the Spurs will look to attack inside early and often, while relying on perimeter shooting from Vassell and Castle to stretch the floor. Ultimately, this game serves as both a developmental platform and a litmus test for the franchise’s depth, resolve, and growth under adversity. Even without their stars, the Spurs have enough talent and structure to make this a competitive contest—especially if they replicate the energy, unselfishness, and shot-making they showcased in their most recent victory. A win here not only lifts morale but also reaffirms the value of their young core and the stability brought by veterans, reinforcing the foundation for the Spurs’ long-term future beyond this turbulent season.

Philadelphia vs. San Antonio Prop Picks (AI)

AI algorithm Remi is pouring through tons of stats on each team. In fact, anytime the 76ers and Spurs play there’s always several intriguing angles to key in on. Not to mention games played at Frost Bank Center in Mar can often follow normal, predictable betting trends.
Remi's searched hard and found the best prop for this matchup: K. Johnson under 23.5 Pts + Ast + Reb

Philadelphia vs. San Antonio Prediction (AI)

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Remi, our AI sports algorithm, has been pouring over millions of data from every angle between the 76ers and Spurs and using recursive machine learning and industry leading AI to analyze the data to a single cover probability.

Remi has been most keyed in on the growing weight emotional bettors often put on coaching factors between a 76ers team going up against a possibly deflated Spurs team. Trends look to say the true game analytics appear to reflect a moderate lean against one Vegas line specifically.

Unlock this in-depth AI prediction and all of our NBA AI picks for FREE now.

Below is our current AI Philadelphia vs San Antonio picks, computer picks 76ers vs Spurs, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full NBA schedule.

76ers Betting Trends

Specific recent against-the-spread (ATS) data for the 76ers is not available in the provided sources.

Spurs Betting Trends

Specific recent ATS data for the Spurs is not available in the provided sources.

76ers vs. Spurs Matchup Trends

Detailed ATS statistics for this specific matchup are not available in the provided sources.

Philadelphia vs. San Antonio Game Info

Philadelphia vs San Antonio starts on March 21, 2025 at 8:00 PM EST.

Spread: San Antonio -5.5
Moneyline: Philadelphia +182, San Antonio -221
Over/Under: 240.5

Philadelphia: (23-46)  |  San Antonio: (29-39)

Remi's searched hard and found the best prop for this matchup: K. Johnson under 23.5 Pts + Ast + Reb. Prices move—always shop for the best number.

Detailed ATS statistics for this specific matchup are not available in the provided sources.

PHI trend: Specific recent against-the-spread (ATS) data for the 76ers is not available in the provided sources.

SA trend: Specific recent ATS data for the Spurs is not available in the provided sources.

See our latest NBA picks and odds pages for 2025 to compare prices before you bet.

Philadelphia vs. San Antonio Odds

Remi is pouring through mountains of data on each team. In fact, anytime the Philadelphia vs San Antonio trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme hostile environments rarely follow normal, predictable patterns.

Philadelphia vs San Antonio Opening Odds

PHI Moneyline: +182
SA Moneyline: -221
PHI Spread: +5.5
SA Spread: -5.5
Over/Under: 240.5

Philadelphia vs San Antonio Live Odds

Games PTS ML SPR O/U
Oct 21, 2025 7:30PM EDT
Houston Rockets
Oklahoma City Thunder
10/21/25 7:30PM
Rockets
Thunder
+230
-305
+7.5 (-114)
-7.5 (-112)
O 225.5 (-114)
U 225.5 (-112)
Oct 21, 2025 10:00PM EDT
Golden State Warriors
Los Angeles Lakers
10/21/25 10PM
Warriors
Lakers
+135
-167
+3.5 (-112)
-3.5 (-114)
O 224.5 (-112)
U 224.5 (-114)
Oct 22, 2025 7:10PM EDT
Brooklyn Nets
Charlotte Hornets
10/22/25 7:10PM
Nets
Hornets
+145
-182
+4 (-115)
-4 (-110)
O 221 (-113)
U 221 (-113)
Oct 22, 2025 7:10PM EDT
Cleveland Cavaliers
New York Knicks
10/22/25 7:10PM
Cavaliers
Knicks
+145
-182
+4 (-114)
-4 (-112)
O 227.5 (-112)
U 227.5 (-114)
Oct 22, 2025 7:10PM EDT
Miami Heat
Orlando Magic
10/22/25 7:10PM
Heat
Magic
+240
-315
+7.5 (-113)
-7.5 (-113)
O 207 (-113)
U 207 (-112)
Oct 22, 2025 7:40PM EDT
Philadelphia 76ers
Boston Celtics
10/22/25 7:40PM
76ers
Celtics
+107
-132
+2 (-110)
-2 (-115)
O 221.5 (-115)
U 221.5 (-110)
Oct 22, 2025 7:40PM EDT
Toronto Raptors
Atlanta Hawks
10/22/25 7:40PM
Raptors
Hawks
+190
-245
+6 (-113)
-6 (-112)
O 236.5 (-114)
U 236.5 (-112)
Oct 22, 2025 8:10PM EDT
Washington Wizards
Milwaukee Bucks
10/22/25 8:10PM
Wizards
Bucks
+285
-385
+8.5 (-115)
-8.5 (-109)
O 225 (-110)
U 225 (-115)
Oct 22, 2025 8:10PM EDT
Detroit Pistons
Chicago Bulls
10/22/25 8:10PM
Pistons
Bulls
-132
+106
-2 (-114)
+2 (-112)
O 236.5 (-114)
U 236.5 (-112)
Oct 22, 2025 8:10PM EDT
New Orleans Pelicans
Memphis Grizzlies
10/22/25 8:10PM
Pelicans
Grizzlies
+150
-190
+4.5 (-112)
-4.5 (-113)
O 238.5 (-113)
U 238.5 (-113)
Oct 22, 2025 9:10PM EDT
Los Angeles Clippers
Utah Jazz
10/22/25 9:10PM
Clippers
Jazz
-345
+260
-8 (-113)
+8 (-112)
O 227.5 (-112)
U 227.5 (-114)
Oct 22, 2025 9:40PM EDT
San Antonio Spurs
Dallas Mavericks
10/22/25 9:40PM
Spurs
Mavericks
-113
-110
-1 (-109)
+1 (-117)
O 226.5 (-112)
U 226.5 (-113)
Oct 22, 2025 10:10PM EDT
Sacramento Kings
Phoenix Suns
10/22/25 10:10PM
Kings
Suns
-103
-121
+1.5 (-114)
-1.5 (-110)
O 229.5 (-112)
U 229.5 (-114)
Oct 22, 2025 10:10PM EDT
Minnesota Timberwolves
Portland Trail Blazers
10/22/25 10:10PM
Timberwolves
Trail Blazers
-143
+115
-2.5 (-114)
+2.5 (-112)
O 216 (-114)
U 216 (-112)
Oct 23, 2025 7:40PM EDT
Oklahoma City Thunder
Indiana Pacers
10/23/25 7:40PM
Thunder
Pacers
-323
+240
-7.5 (-110)
+7.5 (-110)
O 226.5 (-110)
U 226.5 (-110)
Oct 23, 2025 10:10PM EDT
Denver Nuggets
Golden State Warriors
10/23/25 10:10PM
Nuggets
Warriors
-109
-116
+1 (-110)
-1 (-110)
O 232.5 (-110)
U 232.5 (-110)

NBA Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Philadelphia 76ers vs. San Antonio Spurs on March 21, 2025 at Frost Bank Center.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our NBA odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
IND@OKC PASCAL SIAKAM OVER 2.5 PERSONAL FOULS 54.20% 4 WIN
IND@OKC IND +10 54.00% 3 WIN
IND@OKC BENNEDICT MATHURIN OVER 2.5 FREE THROW ATT 54.90% 4 WIN
NY@IND MYLES TURNER OVER 6 REBOUNDS + ASSTS 54.40% 4 LOSS
IND@NY IND +5 55.60% 5 LOSS
NY@IND JALEN BRUNSON UNDER 22 FIELD GOAL ATT 54.70% 4 WIN
OKC@MIN RUDY GOBERT OVER 1.5 FREE THROWS MADE 54.00% 4 WIN
OKC@MIN OKC -2.5 56.70% 6 LOSS
NY@IND KARL ANTHONY TOWNS OVER 32.5 POINTS + REBOUNDS 54.00% 4 WIN
OKC@MIN NAZ REID OVER 9.0 FIELD GOAL ATT 54.60% 4 LOSS
IND@NY MYLES TURNER OVER 5 MADE FIELD GOALS 53.60% 3 WIN
IND@NY NY -5.5 55.00% 4 LOSS
MIN@OKC ISAIAH HARTENSTEIN UNDER 7.5 REBOUNDS 53.00% 3 LOSS
MIN@OKC MIN +7.5 54.70% 4 LOSS
IND@NY TYRESE HALIBURTON ASSTS - UNDER 8.5 54.10% 4 LOSS
IND@NY IND +4.5 54.80% 4 WIN
MIN@OKC ALEX CARUSO UNDER 2.5 ASSTS 54.10% 4 WIN
DEN@OKC MICHAEL PORTER UNDER 7.5 REBS + AST 54.80% 4 WIN
BOS@NY NY -2.5 55.60% 5 WIN
GS@MIN DONTE DIVINCENZO OVER 1.5 TURNOVERS 54.80% 4 LOSS
GS@MIN GS +10.5 54.70% 4 LOSS
DEN@OKC NIKOLA JOKIC UNDER 22.5 REBOUNDS + ASSTS 54.00% 4 WIN
MIN@GS JIMMY BUTLER UNDER 33.5 POINTS + REBOUNDS 54.50% 4 WIN
BOS@NY BOS -5.5 54.70% 4 WIN
OKC@DEN OKC -5 55.70% 5 LOSS
DEN@OKC SHAI GILGEOUS-ALEXANDER UNDER 12.5 REBOUNDS + ASSTS 54.20% 4 WIN
IND@CLE IND +8 54.00% 3 WIN
GS@MIN ANTHONY EDWARDS UNDER 40.5 PTS+REB+AST 54.00% 4 WIN
GS@MIN MIN -6.5 54.40% 4 LOSS
DEN@OKC NIKOLA JOKIC UNDER 36.5 POINTS + ASSTS 53.20% 3 LOSS
IND@CLE IND +8.5 55.70% 5 WIN
HOU@GS GS -5 53.70% 3 LOSS
HOU@GS BRANDIN PODZIEMSKI UNDER 5.5 REBOUNDS 54.10% 4 LOSS
DEN@LAC MICHAEL PORTER UNDER 7.5 REBS + AST 53.20% 3 WIN
DEN@LAC UNDER 212.5 54.00% 3 LOSS
MIN@LAL MIN +6 53.80% 3 WIN
MIN@LAL NAZ REID OVER 1.5 ASSTS 54.80% 4 WIN
LAC@DEN IVICA ZUBAC OVER 1.5 TURNOVERS 53.50% 3 LOSS
DET@NY DET +5.5 53.90% 3 WIN
CLE@MIA EVAN MOBLEY UNDER 29.5 PTS+REB+AST 53.90% 3 WIN
BOS@ORL KRISTAPS PORZINGIS UNDER 8.5 REBOUNDS + ASSTS 53.10% 3 WIN
HOU@GS GS -3 53.70% 3 WIN
HOU@GS JALEN GREEN OVER 2.5 TURNOVERS 54.40% 4 LOSS
LAL@MIN LEBRON JAMES UNDER 31.5 POINTS + REBOUNDS 54.50% 4 LOSS
BOS@ORL BOS -3.5 54.70% 4 LOSS
DEN@LAC BOGDAN BOGDANOVIC OVER 2.5 THREE POINTERS ATTEMPTED 53.60% 3 LOSS
GS@HOU JALEN GREEN UNDER 3.5 FREE THROWS MADE 54.40% 4 LOSS
ORL@BOS ORL +10.5 54.70% 4 WIN
MEM@OKC ISAIAH HARTENSTEIN OVER 19.5 PTS + REB 53.80% 3 LOSS
MEM@OKC OKC -14.5 54.80% 4 WIN
LAC@DEN IVICA ZUBAC OVER 3.5 OFFENSIVE REBOUNDS 53.30% 3 LOSS