Nuggets vs Trail Blazers Prediction — AI Finds CAN'T MISS NBA Lines & Props (Mar 21)

Updated: 2025-03-19T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

On March 21, 2025, the Denver Nuggets (44-26) will face the Portland Trail Blazers (31-39) at the Moda Center in Portland. The Trail Blazers aim to bolster their play-in tournament aspirations, while the Nuggets seek to maintain their strong standing in the Western Conference.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Mar 21, 2025

Start Time: 10:00 PM EST​

Venue: Moda Center at the Rose Quarter​

Trail Blazers Record: (31-39)

Nuggets Record: (44-26)

OPENING ODDS

DEN Moneyline: -105

POR Moneyline: -114

DEN Spread: +1.5

POR Spread: -1.5

Over/Under: 225.5

DEN
Betting Trends

  • The Nuggets are 33-36 against the spread (ATS) this season.

POR
Betting Trends

  • The Trail Blazers hold a 39-31 ATS record this season.

MATCHUP TRENDS

  • In their last matchup on February 12, 2025, the Nuggets covered the spread in a 132-121 victory over the Trail Blazers, with Jamal Murray scoring a career-high 55 points.

DEN vs. POR
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: S. Sharpe over 25.5 Pts + Ast + Reb

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Denver vs Portland Prediction & Odds:
Free NBA Betting Insights for 3/21/25

As the NBA regular season approaches its climax, the Denver Nuggets (44-26) are set to face the Portland Trail Blazers (31-39) on March 21, 2025, at the Moda Center in Portland. This matchup holds significant implications for both teams, albeit for different reasons. The Nuggets, currently occupying a strong position in the Western Conference standings, aim to solidify their playoff seeding and continue their pursuit of championship aspirations. Conversely, the Trail Blazers are embroiled in a fierce battle for a play-in tournament spot, striving to keep their postseason hopes alive. The Nuggets have been a formidable force this season, boasting a balanced roster led by the dynamic duo of Nikola Jokić and Jamal Murray. Jokić, a perennial MVP candidate, orchestrates the offense with his exceptional playmaking abilities and scoring prowess, while Murray provides a potent scoring punch from the perimeter. Their synergy has been instrumental in Denver’s success, enabling them to navigate the rigors of a competitive Western Conference. However, the Nuggets have encountered recent injury concerns, with Jokić sidelined due to a left ankle issue and Murray listed as questionable with a right ankle sprain. Their availability for the upcoming game remains uncertain, potentially impacting Denver’s offensive fluidity and defensive stability. The Trail Blazers, under the guidance of head coach Chauncey Billups, have experienced an up-and-down season, marked by periods of inconsistency and resilience. Currently, they are 3-1 on a seven-game homestand, showcasing a renewed sense of urgency in their quest for a play-in spot. Their recent 115-99 victory over the Memphis Grizzlies highlighted their defensive tenacity, as they limited Memphis to a dismal shooting performance in the fourth quarter. Deni Avdija’s stellar play has been a catalyst for Portland, with the forward delivering a 31-point, 16-rebound, and eight-assist performance against the Grizzlies.

His versatility and energy have provided a much-needed spark for the Trail Blazers during this critical stretch. From a betting perspective, the Trail Blazers have been relatively reliable against the spread (ATS), holding a 39-31 record this season. In contrast, the Nuggets are 33-36 ATS, reflecting occasional challenges in meeting betting expectations. The over/under trends indicate that the Trail Blazers have a 32-36-0 record, while the Nuggets stand at 37-29-1, suggesting a propensity for higher-scoring games in Denver’s matchups. In their previous encounter on February 12, 2025, the Nuggets secured a 132-121 victory over the Trail Blazers, with Jamal Murray erupting for a career-high 55 points. This performance underscored Denver’s offensive capabilities and highlighted areas where Portland’s defense struggled to contain elite scorers. As the teams prepare to face off again, several factors will be pivotal in determining the outcome. The health status of Jokić and Murray looms large; their absence could tilt the scales in favor of Portland, providing an opportunity to exploit Denver’s potential vulnerabilities. Conversely, if both are available, the Nuggets’ offensive versatility and experience could pose significant challenges for the Trail Blazers. Portland’s defense will need to replicate its recent intensity, particularly in limiting second-chance points and defending the perimeter, to counter Denver’s multifaceted attack. Offensively, the Trail Blazers will rely on Avdija’s continued excellence, alongside contributions from Anfernee Simons and other key players, to generate a balanced scoring effort. Ball movement and shot selection will be critical, especially against a Nuggets defense that can be disruptive when engaged. Additionally, controlling the tempo and minimizing turnovers will be essential for Portland to prevent Denver from capitalizing in transition. In conclusion, this matchup presents a compelling narrative of a surging team fighting for playoff survival against an established contender managing health concerns. The outcome will hinge on player availability, execution on both ends of the court, and the ability to adapt to in-game developments. For bettors and fans alike, the game offers intrigue, with ATS trends and recent performances providing insights into potential dynamics. As the Trail Blazers and Nuggets clash at the Moda Center, the stakes are undeniably high, promising an engaging contest with significant postseason implications.

Denver Nuggets NBA Preview

The Denver Nuggets head into their March 21, 2025 road contest against the Portland Trail Blazers with a 44-26 record and their sights firmly set on maintaining a top-four seed in the Western Conference, though recent injury concerns and a turbulent stretch of play have raised some questions about the team’s short-term outlook heading into the final few weeks of the regular season. The reigning NBA champions remain one of the most structurally sound and well-balanced rosters in the league, built around the transcendent play of two-time MVP Nikola Jokić, who is averaging 26.4 points, 11.9 rebounds, and 8.6 assists per game while continuing to serve as the offensive hub for everything Denver runs. His impact on the floor cannot be overstated—his court vision, high-efficiency scoring, and defensive rebounding form the backbone of Denver’s elite half-court execution—but he has recently been sidelined with a left ankle sprain, and his availability for Friday night’s game remains questionable. Similarly, Jamal Murray, who exploded for a career-high 55 points in Denver’s 132-121 win over Portland on February 12, is also nursing a right ankle issue and is listed as day-to-day. Without their two stars, Denver has struggled to maintain offensive rhythm, as backup guards Reggie Jackson and Christian Braun have been serviceable but not game-changing, while Michael Porter Jr., though still averaging nearly 17 points per game on elite shooting splits, has been inconsistent in his aggressiveness when asked to shoulder a larger role. Aaron Gordon continues to be a reliable two-way presence, offering defensive versatility and rim-running value, but his offensive impact wanes when the team lacks its primary playmakers.

Denver’s bench, while improved from previous years, has not consistently delivered under pressure, and the team’s three-point shooting has cooled slightly since the All-Star break. Defensively, Denver still ranks in the top ten in points allowed per game, anchored by Jokić’s improved positioning and Gordon’s ability to guard wings and forwards alike, but their perimeter defense remains vulnerable, particularly when forced into late switches against quicker guards. From a betting standpoint, Denver is 33-36 against the spread, reflecting the market’s continued expectation for them to dominate even when dealing with lineup issues or road fatigue, and they’ve underperformed in games where Jokić or Murray have been limited or absent. Their ability to cover in Portland will hinge largely on health, as a fully intact Nuggets squad remains among the most efficient and dangerous in the NBA, while a depleted lineup leans heavily on role players who lack the offensive creation needed to sustain leads or engineer comebacks. Head coach Michael Malone continues to preach focus and defensive discipline, but the team’s recent 3-4 stretch suggests that continuity is critical for Denver’s success. Facing a Blazers team that is scrapping for a play-in spot and playing with visible urgency, the Nuggets will need to match intensity early, avoid careless turnovers, and re-establish their interior dominance if they want to replicate their earlier victory. Whether Jokić and Murray suit up or not, the game offers a meaningful test for the defending champs to show their championship pedigree, execute through adversity, and reclaim the sharpness that made them the league’s most formidable team just a season ago.

On March 21, 2025, the Denver Nuggets (44-26) will face the Portland Trail Blazers (31-39) at the Moda Center in Portland. The Trail Blazers aim to bolster their play-in tournament aspirations, while the Nuggets seek to maintain their strong standing in the Western Conference. Denver vs Portland AI Prediction: Free NBA Betting Insights for Mar 21. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Portland Trail Blazers NBA Preview

The Portland Trail Blazers, entering their March 21, 2025 matchup against the Denver Nuggets with a 31-39 record, find themselves in a critical juncture of the season as they strive to secure a spot in the Western Conference play-in tournament. Currently, they are 3-1 on a pivotal seven-game homestand, demonstrating renewed focus, defensive intensity, and cohesive play that has sparked hope for a late-season push toward the postseason. Head coach Chauncey Billups has leaned heavily on a blend of young talent and emerging leaders, and the team’s recent form—most notably a 115-99 win over the Memphis Grizzlies—illustrates a rising sense of urgency and belief within the locker room. Deni Avdija has been one of the brightest revelations for Portland in recent weeks, coming off a monster performance where he tallied 31 points, 16 rebounds, and eight assists while shooting with confidence and showcasing his versatility on both ends. His ability to guard multiple positions, facilitate in transition, and contribute as a secondary ball-handler has been instrumental in keeping the Blazers competitive. Alongside him, Anfernee Simons remains a reliable offensive weapon, averaging over 20 points per game with his quick release and dynamic off-the-dribble shooting, while young forward Shaedon Sharpe continues to contribute as an athletic slasher and improving perimeter defender. The Trail Blazers have also seen meaningful growth from their bench, with players like Toumani Camara and Dalano Banton bringing energy and defensive hustle in key rotational minutes, giving Billups flexibility to adjust matchups. Despite being statistically underwhelming across the season defensively—allowing nearly 116 points per game—Portland has tightened up during their current homestand, showing better discipline in closing out on shooters, limiting second-chance opportunities, and switching with purpose, especially late in games.

Offensively, they average 110.8 points per game, and while their shooting efficiency has fluctuated, they’ve leaned on improved ball movement and a commitment to paint touches to balance their perimeter-heavy approach. The Trail Blazers’ 39-31 record against the spread reflects their tendency to outperform expectations, particularly when at home and facing playoff-bound teams where they often play with an underdog’s edge and chip-on-the-shoulder mentality. In their previous matchup with the Nuggets on February 12, Portland fell 132-121 despite a strong collective effort, overwhelmed by a career-high 55-point night from Jamal Murray, underscoring the need to contain Denver’s dynamic guard play and execute better perimeter defense. Friday night’s rematch presents both a challenge and an opportunity for the Blazers, who will look to ride their recent momentum while taking advantage of potential absences for Denver, as Nikola Jokić and Murray are both nursing ankle injuries and may be limited or unavailable. For Portland to pull off the upset and keep their postseason hopes alive, they’ll need a balanced scoring attack, a continued commitment to defensive pressure, and another big night from Avdija, who has emerged as a legitimate two-way presence. The Moda Center crowd has been increasingly engaged during this late-season stretch, providing the kind of energy that could fuel a playoff-level effort from a team still trying to forge its identity. With just a handful of games remaining and every result carrying weight, the Blazers will approach this contest with the urgency of a team whose season is very much on the line, hoping to capitalize on a vulnerable Nuggets squad and push one step closer to extending their year into late April.

Denver vs. Portland Prop Picks (AI)

AI algorithm Remi is pouring through mountains of stats on each player. In fact, anytime the Nuggets and Trail Blazers play there’s always several intriguing angles to key in on. Not to mention games played at Moda Center at the Rose Quarter in Mar can often follow normal, predictable betting trends.
Remi's searched hard and found the best prop for this matchup: S. Sharpe over 25.5 Pts + Ast + Reb

Denver vs. Portland Prediction (AI)

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Remi, our AI sports genius, has been pouring over exorbitant amounts of data from every facet between the Nuggets and Trail Blazers and using recursive machine learning and industry leading AI to boil down the data to a single cover probability.

Remi has been most watching on the unproportionally assigned weight human bettors regularly put on Portland’s strength factors between a Nuggets team going up against a possibly tired Trail Blazers team. It appears the true game analytics appear to reflect a slight lean against one Vegas line specifically.

Unlock this in-depth AI prediction and all of our NBA AI picks for FREE now.

Below is our current AI Denver vs Portland picks, computer picks Nuggets vs Trail Blazers, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
NBA 11/8 POR@MIA UNLOCK THIS PICK 7 VAULT v3 Locked VAULT v3
NBA 11/8 LAL@ATL UNLOCK THIS PICK 6 VAULT v2 Locked VAULT v2
NBA 11/8 IND@DEN UNLOCK THIS PICK 0 INTEL Locked INTEL
NBA 11/8 CHI@CLE UNLOCK THIS PICK 0 INTEL Locked INTEL

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full NBA schedule.

Nuggets Betting Trends

The Nuggets are 33-36 against the spread (ATS) this season.

Trail Blazers Betting Trends

The Trail Blazers hold a 39-31 ATS record this season.

Nuggets vs. Trail Blazers Matchup Trends

In their last matchup on February 12, 2025, the Nuggets covered the spread in a 132-121 victory over the Trail Blazers, with Jamal Murray scoring a career-high 55 points.

Denver vs. Portland Game Info

Denver vs Portland starts on March 21, 2025 at 10:00 PM EST.

Venue: Moda Center at the Rose Quarter.

Spread: Portland -1.5
Moneyline: Denver -105, Portland -114
Over/Under: 225.5

Denver: (44-26)  |  Portland: (31-39)

Remi's searched hard and found the best prop for this matchup: S. Sharpe over 25.5 Pts + Ast + Reb. Prices move—always shop for the best number.

In their last matchup on February 12, 2025, the Nuggets covered the spread in a 132-121 victory over the Trail Blazers, with Jamal Murray scoring a career-high 55 points.

DEN trend: The Nuggets are 33-36 against the spread (ATS) this season.

POR trend: The Trail Blazers hold a 39-31 ATS record this season.

See our latest NBA picks and odds pages for 2025 to compare prices before you bet.

Denver vs. Portland Odds

Remi is pouring through tons of stats on each line. In fact, anytime the Denver vs Portland trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme hostile environments seemingly never follow normal, predictable betting trends.

Denver vs Portland Opening Odds

DEN Moneyline: -105
POR Moneyline: -114
DEN Spread: +1.5
POR Spread: -1.5
Over/Under: 225.5

Denver vs Portland Live Odds

Games PTS ML SPR O/U
Nov 9, 2025 3:30PM EST
Houston Rockets
Milwaukee Bucks
11/9/25 3:30PM
Rockets
Bucks
-172
+139
-4 (-110)
+4 (-110)
O 232.5 (-110)
U 232.5 (-110)
Nov 9, 2025 6:00PM EST
Brooklyn Nets
New York Knicks
11/9/25 6PM
Nets
Knicks
+703
-1250
+15.5 (-110)
-15.5 (-110)
O 229 (-110)
U 229 (-110)
Nov 9, 2025 6:10PM EST
Oklahoma City Thunder
Memphis Grizzlies
11/9/25 6:10PM
Thunder
Grizzlies
-526
+382
-10.5 (-110)
+10.5 (-110)
O 234 (-110)
U 234 (-110)
Nov 9, 2025 6:10PM EST
Boston Celtics
Orlando Magic
11/9/25 6:10PM
Celtics
Magic
+127
-156
+3 (-110)
-3 (-110)
O 226.5 (-110)
U 226.5 (-110)
Nov 9, 2025 7:30PM EST
Detroit Pistons
Philadelphia 76ers
11/9/25 7:30PM
Pistons
76ers
-161
+132
-3.5 (-110)
+3.5 (-110)
O 233 (-110)
U 233 (-110)
Nov 9, 2025 8:40PM EST
Indiana Pacers
Golden State Warriors
11/9/25 8:40PM
Pacers
Warriors
+487
-714
+12.5 (-110)
-12.5 (-110)
O 227 (-110)
U 227 (-110)
Nov 9, 2025 9:10PM EST
Minnesota Timberwolves
Sacramento Kings
11/9/25 9:10PM
Timberwolves
Kings
-222
+178
-5.5 (-110)
+5.5 (-110)
O 235 (-110)
U 235 (-110)
Dec 25, 2025 12:00PM EST
Cleveland Cavaliers
New York Knicks
12/25/25 12PM
Cavaliers
Knicks
+117
-143
+2.5 (-113)
-2.5 (-113)
O 229.5 (-113)
U 229.5 (-113)
Dec 25, 2025 5:00PM EST
Dallas Mavericks
Golden State Warriors
12/25/25 5PM
Mavericks
Warriors
+150
-195
+4.5 (-112)
-4.5 (-114)
O 227 (-115)
U 227 (-110)
Dec 25, 2025 10:30PM EST
Minnesota Timberwolves
Denver Nuggets
12/25/25 10:30PM
Timberwolves
Nuggets
+175
-220
+5 (-109)
-5 (-117)
O 229.5 (-112)
U 229.5 (-114)

NBA Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Denver Nuggets vs. Portland Trail Blazers on March 21, 2025 at Moda Center at the Rose Quarter.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our NBA odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
DAL@MEM MEM -4 56.3% 6 WIN
TOR@ATL TOR +118 48.0% 3 WIN
CHA@MIA OVER 235.5 54.3% 3 LOSS
LAC@PHX PHX -135 58.9% 7 WIN
PHI@CLE PHI +10.5 53.3% 3 LOSS
MIA@DEN MIA +9.5 53.7% 3 LOSS
OKC@POR POR +4.5 52.9% 3 WIN
HOU@MEM MEM +8.5 54.7% 4 LOSS
UTA@DET UTA +10 56.8% 6 LOSS
NO@DAL TREY MURPHY III OVER 25.5 PTS & REB 55.5% 5 LOSS
ORL@ATL ORL -3.5 56.5% 6 LOSS
MIL@TOR MIL +3.5 56.5% 4 LOSS
PHX@GS STEPH CURRY UNDER 4.5 THREE PTRS MADE 53.3% 3 LOSS
OKC@LAC JAMES HARDEN OVER 12.5 REBOUNDS + ASSTS 56.1% 6 LOSS
LAL@POR POR -2.5 54.7% 4 LOSS
SA@PHX SA -5.5 56.6% 6 LOSS
ORL@WAS WAS +9 54.2% 4 LOSS
DAL@DET DAL +8 58.7% 8 LOSS
NY@CHI NY -4.5 54.7% 4 LOSS
BOS@PHI BOS +1.5 54.6% 4 WIN
TOR@CLE TOR +6 56.2% 6 WIN
DEN@POR JERAMI GRANT OVER 1.5 TURNOVERS 56.6% 6 WIN
WAS@OKC WAS +15.5 54.9% 4 LOSS
NO@DEN DEN -12.5 53.6% 3 WIN
NO@DEN NIKOLA JOKIC OVER 26.5 POINTS 56.6% 6 LOSS
SAC@OKC SAC +10 54.7% 4 WIN
NY@MIL MIL +3 56.6% 6 WIN
LAC@GS GS +2.5 56.8% 6 WIN
LAC@GS BRANDIN PODZIEMSKI UNDER 1.5 THREE POINTERS MADE 55.5% 5 LOSS
CLE@DET DET +2.5 53.5% 3 LOSS
ORL@PHI ORL -5 54.7% 4 LOSS
OKC@DAL DAL +9 66.4% 6 WIN
BOS@NO NO +2 55.6% 5 LOSS
BKN@HOU BKN +16.5 57.0% 7 LOSS
BOS@NO TREY MURPHY III UNDER 25.5 PTS + REB 54.4% 4 WIN
MIL@CLE MIL +6.5 56.1% 6 WIN
POR@LAC POR +8.5 56.5% 6 WIN
ATL@ORL ATL +5 54.6% 4 WIN
WAS@DAL WAS +10 55.3% 5 WIN
PHX@LAC IVICA ZUBAC OVER 6.5 MADE FIELD GOALS 55.5% 5 LOSS
OKC@IND IND +8 56.5% 6 WIN
CLE@NY CLE -116 55.0% 4 LOSS
LAC@UTA UTA +9.5 54.1% 4 WIN
WAS@MIL KYLE KUZMA OVER 1.5 ASSTS 55.5% 5 WIN
HOU@OKC HOU +6.5 54.8% 4 WIN
GS@LAL STEPHEN CURRY UNDER 2.5 TURNOVERS 54.4 4 WIN
IND@OKC SHAI GILGEOUS-ALEXANDER OVER 1.5 STEALS 54.90% 4 LOSS
IND@OKC JALEN WILLIAMS OVER 0.5 1Q REBOUNDS 55.70% 5 WIN
OKC@IND TJ MCCONNELL UNDER 7.5 TWO POINT ATT 55.70% 5 LOSS
IND@OKC CHET HOLMGREN OVER 1.5 SHOTS BLOCKED 53.40% 3 WIN
OKC@IND TJ MCCONNELL OVER 1.5 TURNOVERS 53.00% 3 LOSS