Cardinals vs Orioles Prediction — AI Finds CAN'T MISS MLB Lines & Props (May 28)

Updated: 2025-05-26T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The St. Louis Cardinals (31–24) face the Baltimore Orioles (19–35) on Wednesday, May 28, 2025, at Oriole Park at Camden Yards, aiming to secure a series victory. The Orioles are slight favorites with a -125 moneyline, while the Cardinals are listed at +105, and the over/under is set at 8.5 runs.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: May 28, 2025

Start Time: 6:35 PM EST​

Venue: Oriole Park at Camden Yards​

Orioles Record: (19-35)

Cardinals Record: (31-24)

OPENING ODDS

STL Moneyline: +104

BAL Moneyline: -124

STL Spread: +1.5

BAL Spread: -1.5

Over/Under: 8.5

STL
Betting Trends

  • The Cardinals have a 33–22 record against the spread (ATS) this season.

BAL
Betting Trends

  • The Orioles hold a 21–33 ATS record for the current season.

MATCHUP TRENDS

  • The Cardinals have won 11 of 19 games (57.9%) as favorites this season. Conversely, the Orioles have secured victory in 9 of 23 games (39.1%) when listed as underdogs.

STL vs. BAL
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: R. O'Hearn over 5.5 Fantasy Score.

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St. Louis vs Baltimore Prediction & Odds:
Free MLB Betting Insights for 5/28/25

The St. Louis Cardinals and Baltimore Orioles will square off on Wednesday, May 28, 2025, in the final game of their interleague series at Oriole Park at Camden Yards, with both teams entering the matchup with vastly different momentum and expectations. The Cardinals have emerged as one of the more quietly consistent teams in the National League, currently holding a 31–24 record and making a strong push in the NL Central with contributions coming from both seasoned veterans and young talent. Their offense, anchored by the versatile Lars Nootbaar and the always-reliable Brendan Donovan, has delivered timely hits and sustained rallies against both right- and left-handed pitching, maintaining a team batting average of .261 that ranks among the league’s best. Complemented by defensive precision and a bullpen that has shown the ability to close out tight contests, the Cardinals have posted a 33–22 ATS record and have won nearly 58% of their games as betting favorites, proving they can both perform and cover expectations. On the mound, St. Louis has found a rhythm, with a reliable rotation limiting early damage and the bullpen consistently converting leads into wins. In contrast, the Baltimore Orioles are enduring a tumultuous 2025 season, entering the series finale with a disappointing 19–35 record that reflects both an unreliable pitching staff and a lack of sustained offensive output.

The team’s ERA hovers near the bottom of the league at 5.52, with starters struggling to get deep into games and relievers frequently giving up inherited runners or faltering under pressure. Offensively, Cedric Mullins has provided some spark with power-speed balance at the top of the order, but the Orioles have struggled to string together multi-run innings and often leave runners in scoring position. Their .231 team batting average is among the lowest in MLB, and defensive miscues have further complicated their efforts, leading to extended innings and additional strain on the pitching staff. From a betting standpoint, Baltimore has failed to cover consistently, posting a 21–33 ATS mark and winning just 39% of their games as underdogs, signaling a team that not only loses but often fails to meet expectations. With the Cardinals in control and riding a wave of balanced play, the odds favor St. Louis finishing the series with a statement win. The Orioles, meanwhile, will hope to snap out of their funk with a focused, clean effort that minimizes mistakes and gives their offense a chance to shine. While the home crowd will look for a spark, it may take a breakout performance or a strong showing from a young arm to turn the tide in a season that’s already veering off track. For the Cardinals, this game is another opportunity to reinforce their postseason credentials and continue climbing the standings, while for the Orioles, it’s a chance to regroup, reclaim pride, and try to salvage something from a series that has so far tilted decisively in the visitors’ favor.

St. Louis Cardinals MLB Preview

The St. Louis Cardinals head into Wednesday’s series finale against the Baltimore Orioles at Oriole Park at Camden Yards riding a wave of consistency that has elevated them to a 31–24 record and firmly into contention in the NL Central, thanks to a balanced blend of offensive output, solid pitching, and clean defensive execution. They have quietly become one of the most reliable teams in the National League, delivering both run production and late-game poise, with a 33–22 ATS record underscoring their ability to meet and exceed expectations in various betting scenarios. Offensively, the Cardinals have relied on the dependable bats of Lars Nootbaar and Brendan Donovan, both of whom have provided versatility, timely hitting, and the ability to reach base consistently to set the table for middle-order threats like Nolan Arenado and Paul Goldschmidt. Their team batting average of .261 places them among the top-tier offenses in baseball, and they’ve managed to stay productive regardless of matchup, blending power and contact with disciplined approaches that stretch out at-bats and wear down opposing pitchers. On the mound, the rotation has stabilized after early-season turbulence, with starters giving the team a solid chance every night and the bullpen continuing to lock things down in the later innings.

Closer Ryan Helsley has been dominant in high-leverage situations, supported by setup men who have avoided big innings and managed inherited runners effectively. Defensively, the Cardinals have maintained sharp fundamentals, minimizing errors and giving pitchers the support needed to navigate tough innings—an often overlooked but critical component of their success this season. Heading into the finale, manager Oliver Marmol is likely to rely on a pitching plan that includes aggressive early strikes and challenging Baltimore’s hitters to beat them rather than giving away free passes, especially given the Orioles’ struggles with runners in scoring position. St. Louis has also shown the ability to adapt in-game, with bench players stepping up and delivering quality at-bats when called upon, which has added to the team’s depth and flexibility. From a matchup perspective, the Cardinals are well-positioned to take advantage of Baltimore’s pitching woes, particularly their vulnerability in the later innings, where command and control issues have repeatedly flipped close games. With a win on Wednesday, the Cardinals can not only take the series but continue their steady climb toward the top of the division standings while building confidence and reinforcing the consistency that has defined their 2025 campaign. This game offers another opportunity to capitalize on a struggling opponent, and the Cardinals appear poised to do just that, leveraging their momentum, balanced roster, and ability to execute in all phases to close out May on a strong note.

The St. Louis Cardinals (31–24) face the Baltimore Orioles (19–35) on Wednesday, May 28, 2025, at Oriole Park at Camden Yards, aiming to secure a series victory. The Orioles are slight favorites with a -125 moneyline, while the Cardinals are listed at +105, and the over/under is set at 8.5 runs. St. Louis vs Baltimore AI Prediction: Free MLB Betting Insights for May 28. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Baltimore Orioles MLB Preview

The Baltimore Orioles return to Oriole Park at Camden Yards for the series finale against the St. Louis Cardinals hoping to salvage a game in what has been a frustrating and disjointed 2025 campaign, marked by a 19–35 record that reflects their ongoing struggles in virtually every phase of the game. Once viewed as a young team on the rise, the Orioles have been mired in inconsistency and underperformance, particularly on the mound, where their pitching staff has failed to provide stability or confidence. With a team ERA of 5.52, among the worst in Major League Baseball, the rotation has struggled to pitch beyond the fifth inning, often surrendering early leads and putting excessive pressure on a bullpen that has been unable to hold back opposing offenses. This lack of pitching depth has frequently erased any momentum the offense tries to build, with the Orioles regularly playing from behind and forced into high-risk decisions just to stay competitive. Offensively, the team has received sporadic production from a few bright spots, with Cedric Mullins continuing to contribute at the top of the lineup with his blend of power and speed, and occasional help from young hitters like Colton Cowser or Jordan Westburg when healthy, but these performances have been overshadowed by the lineup’s overall inability to drive in runs when it matters most.

The Orioles’ .231 team batting average and struggles with runners in scoring position have made it difficult to sustain rallies or apply pressure in tight games, while defensive miscues have further limited their ability to control innings and manage pace. Manager Brandon Hyde has experimented with various lineup adjustments and bullpen strategies, but the lack of execution and consistency has left the Orioles chasing games instead of setting the tone, especially against playoff-caliber opponents like the Cardinals. From a betting and performance standpoint, Baltimore has failed to cover spreads consistently, going 21–33 ATS and winning just 39.1% of their games when listed as underdogs—evidence that they not only lose more often than not but also fail to meet even modest expectations in the market. Despite playing at home, where they’ve struggled to build momentum or leverage crowd support, the Orioles face an uphill battle against a disciplined and efficient Cardinals team that thrives in close games and doesn’t beat itself. For Baltimore to end the series on a positive note, they’ll need a strong start on the mound to limit early damage, improved plate discipline to extend innings, and error-free defense to support what’s been a fragile pitching staff. A win wouldn’t erase the challenges of the season, but it could offer a much-needed morale boost for a clubhouse searching for anything positive to build on. With the calendar nearing June, the pressure is mounting to stop the slide, reestablish fundamentals, and rediscover some of the spark that defined their more hopeful seasons in recent years. Wednesday’s finale is an opportunity to reset the tone, even if just for one day.

The Boston Red Sox and Milwaukee Brewers are set to wrap up their three-game interleague series on Wednesday, May 28, 2025, at American Family Field, with Milwaukee looking to complete a sweep and Boston desperately seeking a bounce-back performance to salvage the finale. The Brewers come into the game at an even 28–28, surging off the momentum of back-to-back wins and a 7–3 record over their last ten outings, while the Red Sox have slipped to 27–29 after falling short in close contests throughout the series. Milwaukee has found its stride at home, holding a 17–10 record at American Family Field, where timely hitting, solid pitching, and steady defense have kept them competitive in a tightly packed National League Central. Their lineup has been anchored by Rhys Hoskins, who leads the club in key offensive categories with a .287 batting average, a .387 OBP, and a .467 slugging mark, while his situational hitting has been crucial in generating runs in clutch moments. On the mound, the Brewers have been equally effective, boasting a 3.22 ERA over their last ten games and averaging 9.1 strikeouts per nine innings, showing an ability to limit damage and overpower batters when needed. Their bullpen has been sharp, consistently locking down late leads and helping manager Pat Murphy manage high-leverage innings with confidence. For Boston, injuries have taken their toll with stars like Alex Bregman and Triston Casas sidelined, leaving the offense to lean heavily on Rafael Devers and a few emerging contributors who have struggled to sustain momentum against top-tier pitching. Devers remains a bright spot with his power and plate discipline, but the lack of consistent production from the rest of the lineup has made it difficult for the Red Sox to rally or protect slim leads. The pitching staff has also struggled, posting a 4.39 ERA over their recent stretch, and that vulnerability has been exposed by Milwaukee’s aggressive approach at the plate. Boston’s bullpen has been hit-or-miss, with too many outings defined by walks and poorly timed hits allowed in close games, putting extra pressure on the offense to overcompensate. Defensively, the Red Sox have committed key errors in this series, extending innings and allowing the Brewers to capitalize on extra outs—an area that must be tightened if they hope to avoid a sweep. From a betting angle, Milwaukee enters the finale as a -156 moneyline favorite, reflective of their recent form and home-field advantage, while the over/under set at eight runs suggests expectations of moderate scoring. The Red Sox have a 7–9 record as underdogs this season and are just 11–15 on the road, underscoring the challenge they face in snapping Milwaukee’s momentum. If Boston wants to come away with a win, they’ll need sharper execution across all phases—limit free passes, get timely hits with runners in scoring position, and avoid defensive lapses that have plagued their recent efforts. For Milwaukee, another well-rounded performance could push them above .500 and serve as a launchpad for a sustained push in the division. With both teams eyeing postseason relevance, the outcome of this series finale carries added weight as June approaches and margins for error shrink.

St. Louis vs. Baltimore Prop Picks (AI)

Remi is pouring through loads of stats on each player. In fact, anytime the Cardinals and Orioles play there’s always several intriguing angles to key in on. Not to mention games played at Oriole Park at Camden Yards in May can often follow normal, predictable patterns.
Remi's searched hard and found the best prop for this matchup: R. O'Hearn over 5.5 Fantasy Score.

St. Louis vs. Baltimore Prediction (AI)

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Remi, our AI sports wizard, has been pouring over mountains of data from every facet between the Cardinals and Orioles and using recursive machine learning and kick-ass AI to crunch the data to a single cover probability.

Oddly enough, we’ve seen the AI has been most fixated on the growing emphasis emotional bettors often put on St. Louis’s strength factors between a Cardinals team going up against a possibly improved Orioles team. Trends look to say the true game analytics might reflect a slight lean against one Vegas line specifically.

Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.

Below is our current AI St. Louis vs Baltimore picks, computer picks Cardinals vs Orioles, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
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Cardinals Betting Trends

The Cardinals have a 33–22 record against the spread (ATS) this season.

Orioles Betting Trends

The Orioles hold a 21–33 ATS record for the current season.

Cardinals vs. Orioles Matchup Trends

The Cardinals have won 11 of 19 games (57.9%) as favorites this season. Conversely, the Orioles have secured victory in 9 of 23 games (39.1%) when listed as underdogs.

St. Louis vs. Baltimore Game Info

St. Louis vs Baltimore starts on May 28, 2025 at 6:35 PM EST.

Venue: Oriole Park at Camden Yards.

Spread: Baltimore -1.5
Moneyline: St. Louis +104, Baltimore -124
Over/Under: 8.5

St. Louis: (31-24)  |  Baltimore: (19-35)

Remi's searched hard and found the best prop for this matchup: R. O'Hearn over 5.5 Fantasy Score.. Prices move—always shop for the best number.

The Cardinals have won 11 of 19 games (57.9%) as favorites this season. Conversely, the Orioles have secured victory in 9 of 23 games (39.1%) when listed as underdogs.

STL trend: The Cardinals have a 33–22 record against the spread (ATS) this season.

BAL trend: The Orioles hold a 21–33 ATS record for the current season.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

St. Louis vs. Baltimore Odds

Remi is pouring through loads of data points on each team. In fact, anytime the St. Louis vs Baltimore trends are analyzed, there’s always several intriguing trends to key in on. Not to mention games played at extreme temps seemingly never follow normal, predictable betting trends.

St. Louis vs Baltimore Opening Odds

STL Moneyline: +104
BAL Moneyline: -124
STL Spread: +1.5
BAL Spread: -1.5
Over/Under: 8.5

St. Louis vs Baltimore Live Odds

Games PTS ML SPR O/U
Oct 19, 2025 8:04PM EDT
Seattle Mariners
Toronto Blue Jays
10/19/25 8:04PM
Mariners
Blue Jays
+112
-123
+1.5 (-195)
-1.5 (+171)
O 7.5 (-114)
U 7.5 (-101)

MLB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers St. Louis Cardinals vs. Baltimore Orioles on May 28, 2025 at Oriole Park at Camden Yards.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
TOR@SEA OVER 7 54.9% 3 WIN
LAD@MIL UNDER 7.5 56.6% 6 WIN
TOR@NYY OVER 8 54.9% 4 WIN
TOR@NYY CARLOS RODON OVER 1.5 TOTAL WALKS ALLOWED 53.3% 3 WIN
NYY@TOR OVER 7.5 54.8% 2 WIN
LAD@PHI OVER 7 53.8% 3 WIN
SD@CHC CHC -109 53.8% 3 WIN
SD@CHC OVER 7.5 54.5% 4 LOSS
SD@CHC CHC -111 54.8% 4 LOSS
CIN@LAD SHOHEI OHTANI OVER 1.5 BASES 53.5% 3 WIN
BOS@NYY OVER 7 53.8% 3 LOSS
CIN@LAD ELLY DE LA CRUZ OVER 0.5 BASES 54.4% 4 LOSS
ARI@SD SD -131 57.3% 4 WIN
DET@BOS BOS -115 56.4% 5 WIN
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN
CHC@SF CHC -105 54.1% 4 LOSS
NYY@CHW RYAN MCMAHON OVER 0.5 BASES 54.1% 4 WIN