Giants vs Tigers Prediction — AI Finds CAN'T MISS MLB Lines & Props (May 27)

Updated: 2025-05-25T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

On Tuesday, May 27, 2025, the San Francisco Giants (31–22) will face the Detroit Tigers (34–20) at Comerica Park in Detroit. Both teams are performing well this season, with the Giants aiming to close the gap in the NL West and the Tigers leading the AL Central.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: May 27, 2025

Start Time: 6:40 PM EST​

Venue: Comerica Park​

Tigers Record: (35-20)

Giants Record: (31-23)

OPENING ODDS

SF Moneyline: -119

DET Moneyline: +100

SF Spread: -1.5

DET Spread: +1.5

Over/Under: 7

SF
Betting Trends

  • The Giants have a 24–21 record against the spread (ATS) this season.

DET
Betting Trends

  • The Tigers have a 24–14 record against the spread (ATS) this season.

MATCHUP TRENDS

  • The Tigers have a 17–7 home record, indicating strong performance at Comerica Park.

SF vs. DET
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: W. Flores over 3.5 Fantasy Score.

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San Francisco vs Detroit Prediction & Odds:
Free MLB Betting Insights for 5/27/25

The upcoming matchup between the San Francisco Giants and the Detroit Tigers on Tuesday, May 27, 2025, at Comerica Park promises to be one of the more intriguing interleague games of the week, featuring two playoff-contending teams with different but equally effective formulas for success. The Giants arrive with a 31–22 record, placing them squarely in the NL West race behind a well-rounded roster that has excelled in key moments, while the Tigers are sitting atop the AL Central at 34–20, fueled by a blend of youthful power, steady pitching, and a dominant home record. San Francisco has leaned on pitching and timely hitting to stay afloat in a crowded division, with Hayden Birdsong emerging as a breakout arm, having allowed just six runs over 28 2/3 innings, showing impressive command and poise for a young pitcher. Offensively, while their team batting average sits at a modest .231, the Giants have managed to slug 54 home runs and drive in 227 RBIs, thanks in large part to the consistency of Wilmer Flores and others who have stepped up in clutch situations. Manager Bob Melvin’s group may not be flashy, but they play smart baseball, limiting mistakes, executing situational hitting, and getting key outs when needed, especially in tight, low-scoring contests.

On the other side, Detroit has arguably been one of the league’s biggest stories, outperforming expectations thanks to a powerful lineup that’s hitting .262 as a team and has racked up 208 runs and 48 home runs while maintaining one of the best team ERAs in baseball at 2.95. Though starting pitcher Jack Flaherty comes into this contest with a 2–6 record and a 4.39 ERA, he’s still capable of turning in quality starts, especially with the run support his team tends to generate, particularly at home where the Tigers have gone 17–7. Detroit’s balance between explosive offense and reliable pitching has given them an edge in nearly every series they’ve played, and under A.J. Hinch’s leadership, they’ve shown the discipline and confidence of a team poised for a deep postseason run. Both teams come into this game with momentum and the potential to swing the contest in their favor quickly; the Giants will aim to control the tempo behind Birdsong’s hot hand and force the Tigers into early mistakes, while Detroit will look to seize control with early offense and continue their dominant play in front of the Comerica Park faithful. The game may ultimately be decided by who wins the early innings—if the Giants can build a lead behind their pitching, they can force Detroit to chase against a bullpen that has closed out games effectively all season. But if the Tigers jump ahead and get Flaherty some breathing room, their lineup could put this one away by the middle frames. With both clubs eyeing long-term success and trying to prove their legitimacy in strong divisions, Tuesday night’s showdown should provide high-level execution, playoff-style intensity, and a critical measuring stick for where each squad stands heading into the dog days of summer.

San Francisco Giants MLB Preview

The San Francisco Giants enter Tuesday’s road contest against the Detroit Tigers with a 31–22 record and plenty of confidence after stringing together a series of competitive performances that have kept them firmly in the hunt in the National League West. Under the steady guidance of manager Bob Melvin, the Giants have leaned heavily on their pitching depth and veteran leadership to navigate the ebbs and flows of a demanding season, and their current position reflects a team that knows how to win even when the offense isn’t overwhelming. Leading the charge at the plate is Wilmer Flores, who has provided timely power and production while helping to keep the lineup competitive despite a team batting average of just .231. While the Giants’ overall offensive numbers don’t jump off the page, their 54 home runs and 227 RBIs suggest a group that delivers when it matters, especially in late-inning scenarios or with runners in scoring position. Their offensive approach emphasizes situational awareness, disciplined at-bats, and small ball tactics when needed, a strategy that has kept them in games on the road, where they’ve posted a respectable 14–13 record. On the mound, the breakout of Hayden Birdsong has been one of the highlights of the season, as the young right-hander has posted outstanding numbers, allowing just six earned runs over 28 2/3 innings, and establishing himself as a legitimate weapon in the rotation.

Birdsong’s maturity and command have been especially impressive, and with Detroit’s dangerous lineup looming, the Giants will be counting on him to set the tone and keep the game under control through the early innings. The bullpen has also been a strength for San Francisco, providing reliable coverage late in games and giving Melvin the flexibility to mix and match based on matchups. Defensively, the Giants have remained sharp and fundamentally sound, a hallmark of Melvin-coached teams, and their ability to convert routine plays and avoid defensive lapses has played a key role in their success. Facing a Tigers team that is excelling both offensively and defensively, the Giants will need to play clean, opportunistic baseball—limiting free passes, controlling the running game, and capitalizing on any mistakes. The Giants’ formula this season has been rooted in resilience, and they’ll look to bring that same mentality into Comerica Park, where Detroit has been formidable with a 17–7 home record. For San Francisco, this game presents a chance to not only win a key interleague matchup but also to continue proving they are a legitimate playoff contender capable of beating quality opponents in any environment. If they can stay true to their identity—gritty pitching, clutch hitting, and sound execution—the Giants will be in strong position to notch another signature road win and continue building toward October.

On Tuesday, May 27, 2025, the San Francisco Giants (31–22) will face the Detroit Tigers (34–20) at Comerica Park in Detroit. Both teams are performing well this season, with the Giants aiming to close the gap in the NL West and the Tigers leading the AL Central. San Francisco vs Detroit AI Prediction: Free MLB Betting Insights for May 27. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Detroit Tigers MLB Preview

The Detroit Tigers return home to Comerica Park for Tuesday’s clash with the San Francisco Giants sitting atop the AL Central at 34–20, riding a wave of balanced, high-performance baseball that has reenergized their fanbase and turned them into one of the most exciting stories of the 2025 MLB season. Under manager A.J. Hinch, the Tigers have embraced a blend of youth, power, and pitching excellence that has translated into a 17–7 home record and one of the most well-rounded team profiles in the American League. Offensively, Detroit ranks among the league’s elite with a team batting average of .262, 208 runs scored, and 48 home runs, making them dangerous from top to bottom in the lineup. Riley Greene has emerged as a catalyst, combining speed and pop to set the tone, while Spencer Torkelson has provided the raw power in the heart of the order, keeping opposing pitchers honest and capitalizing on mistakes. The Tigers’ approach at the plate focuses on working counts, making consistent contact, and manufacturing runs through a combination of aggressive base running and timely hitting, making them difficult to shut down for an entire game. On the mound, Detroit boasts a sparkling 2.95 team ERA—third-best in all of baseball—a testament to both the strength of their rotation and the depth of their bullpen.

Jack Flaherty is expected to take the mound for this matchup and while his 2–6 record and 4.39 ERA suggest some inconsistency, he’s had several outings where he’s displayed ace-caliber stuff and the ability to dominate lineups when his control is sharp. The bullpen, anchored by steady late-inning arms, has held leads and shut down rallies, giving Hinch the flexibility to pull starters early if needed and trust his relievers to finish the job. Defensively, the Tigers have also been solid, with improved infield range and reliable outfield coverage contributing to their success in run prevention and closing innings without costly miscues. As they prepare to host a battle-tested Giants squad, Detroit knows it must maintain its disciplined approach, especially against Hayden Birdsong, who has been lights-out for San Francisco in recent starts. The key for the Tigers will be to establish offensive momentum early, get Flaherty some run support, and challenge the Giants’ bullpen with a steady dose of baserunners and long innings. At 34–20, Detroit is playing with confidence, and every win at home adds to their case as a legitimate postseason threat in the American League. With an opportunity to continue distancing themselves in the division and further assert their dominance at Comerica Park, the Tigers will aim to dictate the pace from the first pitch and capitalize on their home-field advantage to take another step forward in their impressive 2025 campaign.

San Francisco vs. Detroit Prop Picks (AI)

AI algorithm Remi is pouring through loads of data on each player. In fact, anytime the Giants and Tigers play there’s always several intriguing observations to key in on. Not to mention games played at Comerica Park in May can often follow normal, predictable betting trends.
Remi's searched hard and found the best prop for this matchup: W. Flores over 3.5 Fantasy Score.

San Francisco vs. Detroit Prediction (AI)

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Remi, our AI sports algorithm, has been pouring over millions of data from every facet between the Giants and Tigers and using recursive machine learning and impressive AI to crunch the data to a single cover probability.

Oddly enough, we’ve seen the AI has been most focused on the trending weight emotional bettors regularly put on Detroit’s strength factors between a Giants team going up against a possibly healthy Tigers team. In reality, the true game analytics might reflect a moderate lean against one Vegas line specifically.

Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.

Below is our current AI San Francisco vs Detroit picks, computer picks Giants vs Tigers, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
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Giants Betting Trends

The Giants have a 24–21 record against the spread (ATS) this season.

Tigers Betting Trends

The Tigers have a 24–14 record against the spread (ATS) this season.

Giants vs. Tigers Matchup Trends

The Tigers have a 17–7 home record, indicating strong performance at Comerica Park.

San Francisco vs. Detroit Game Info

San Francisco vs Detroit starts on May 27, 2025 at 6:40 PM EST.

Spread: Detroit +1.5
Moneyline: San Francisco -119, Detroit +100
Over/Under: 7

San Francisco: (31-23)  |  Detroit: (35-20)

Remi's searched hard and found the best prop for this matchup: W. Flores over 3.5 Fantasy Score.. Prices move—always shop for the best number.

The Tigers have a 17–7 home record, indicating strong performance at Comerica Park.

SF trend: The Giants have a 24–21 record against the spread (ATS) this season.

DET trend: The Tigers have a 24–14 record against the spread (ATS) this season.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

San Francisco vs. Detroit Odds

AI algorithm Remi is pouring through tons of data points on each player. In fact, anytime the San Francisco vs Detroit trends are analyzed, there’s always several intriguing trends to key in on. Not to mention games played at extreme travel distance can often follow normal, predictable betting trends.

San Francisco vs Detroit Opening Odds

SF Moneyline: -119
DET Moneyline: +100
SF Spread: -1.5
DET Spread: +1.5
Over/Under: 7

San Francisco vs Detroit Live Odds

Games PTS ML SPR O/U
Oct 19, 2025 8:04PM EDT
Seattle Mariners
Toronto Blue Jays
10/19/25 8:04PM
Mariners
Blue Jays
+108
-130
+1.5 (-215)
-1.5 (+165)
O 7.5 (-121)
U 7.5 (-106)

MLB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers San Francisco Giants vs. Detroit Tigers on May 27, 2025 at Comerica Park.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
TOR@SEA OVER 7 54.9% 3 WIN
LAD@MIL UNDER 7.5 56.6% 6 WIN
TOR@NYY OVER 8 54.9% 4 WIN
TOR@NYY CARLOS RODON OVER 1.5 TOTAL WALKS ALLOWED 53.3% 3 WIN
NYY@TOR OVER 7.5 54.8% 2 WIN
LAD@PHI OVER 7 53.8% 3 WIN
SD@CHC CHC -109 53.8% 3 WIN
SD@CHC OVER 7.5 54.5% 4 LOSS
SD@CHC CHC -111 54.8% 4 LOSS
CIN@LAD SHOHEI OHTANI OVER 1.5 BASES 53.5% 3 WIN
BOS@NYY OVER 7 53.8% 3 LOSS
CIN@LAD ELLY DE LA CRUZ OVER 0.5 BASES 54.4% 4 LOSS
ARI@SD SD -131 57.3% 4 WIN
DET@BOS BOS -115 56.4% 5 WIN
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN
CHC@SF CHC -105 54.1% 4 LOSS
NYY@CHW RYAN MCMAHON OVER 0.5 BASES 54.1% 4 WIN