Giants vs Tigers Prediction — AI Finds CAN'T MISS MLB Lines & Props (May 27)
Updated: 2025-05-25T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
On Tuesday, May 27, 2025, the San Francisco Giants (31–22) will face the Detroit Tigers (34–20) at Comerica Park in Detroit. Both teams are performing well this season, with the Giants aiming to close the gap in the NL West and the Tigers leading the AL Central.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

GAME INFO
Date: May 27, 2025
Start Time: 6:40 PM EST
Venue: Comerica Park
Tigers Record: (35-20)
Giants Record: (31-23)
OPENING ODDS
SF Moneyline: -119
DET Moneyline: +100
SF Spread: -1.5
DET Spread: +1.5
Over/Under: 7
SF
Betting Trends
- The Giants have a 24–21 record against the spread (ATS) this season.
DET
Betting Trends
- The Tigers have a 24–14 record against the spread (ATS) this season.
MATCHUP TRENDS
- The Tigers have a 17–7 home record, indicating strong performance at Comerica Park.
SF vs. DET
Best Prop Bet
- Remi's searched hard and found the best prop for this matchup: W. Flores over 3.5 Fantasy Score.
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San Francisco vs Detroit Prediction & Odds:
Free MLB Betting Insights for 5/27/25
On the other side, Detroit has arguably been one of the league’s biggest stories, outperforming expectations thanks to a powerful lineup that’s hitting .262 as a team and has racked up 208 runs and 48 home runs while maintaining one of the best team ERAs in baseball at 2.95. Though starting pitcher Jack Flaherty comes into this contest with a 2–6 record and a 4.39 ERA, he’s still capable of turning in quality starts, especially with the run support his team tends to generate, particularly at home where the Tigers have gone 17–7. Detroit’s balance between explosive offense and reliable pitching has given them an edge in nearly every series they’ve played, and under A.J. Hinch’s leadership, they’ve shown the discipline and confidence of a team poised for a deep postseason run. Both teams come into this game with momentum and the potential to swing the contest in their favor quickly; the Giants will aim to control the tempo behind Birdsong’s hot hand and force the Tigers into early mistakes, while Detroit will look to seize control with early offense and continue their dominant play in front of the Comerica Park faithful. The game may ultimately be decided by who wins the early innings—if the Giants can build a lead behind their pitching, they can force Detroit to chase against a bullpen that has closed out games effectively all season. But if the Tigers jump ahead and get Flaherty some breathing room, their lineup could put this one away by the middle frames. With both clubs eyeing long-term success and trying to prove their legitimacy in strong divisions, Tuesday night’s showdown should provide high-level execution, playoff-style intensity, and a critical measuring stick for where each squad stands heading into the dog days of summer.
Today, we pause to honor the heroes who made the ultimate sacrifice in service to our country. We’re forever grateful for their courage and dedication — and they will never be forgotten. pic.twitter.com/HYPt8tOhTU
— SFGiants (@SFGiants) May 26, 2025
San Francisco Giants MLB Preview
The San Francisco Giants enter Tuesday’s road contest against the Detroit Tigers with a 31–22 record and plenty of confidence after stringing together a series of competitive performances that have kept them firmly in the hunt in the National League West. Under the steady guidance of manager Bob Melvin, the Giants have leaned heavily on their pitching depth and veteran leadership to navigate the ebbs and flows of a demanding season, and their current position reflects a team that knows how to win even when the offense isn’t overwhelming. Leading the charge at the plate is Wilmer Flores, who has provided timely power and production while helping to keep the lineup competitive despite a team batting average of just .231. While the Giants’ overall offensive numbers don’t jump off the page, their 54 home runs and 227 RBIs suggest a group that delivers when it matters, especially in late-inning scenarios or with runners in scoring position. Their offensive approach emphasizes situational awareness, disciplined at-bats, and small ball tactics when needed, a strategy that has kept them in games on the road, where they’ve posted a respectable 14–13 record. On the mound, the breakout of Hayden Birdsong has been one of the highlights of the season, as the young right-hander has posted outstanding numbers, allowing just six earned runs over 28 2/3 innings, and establishing himself as a legitimate weapon in the rotation.
Birdsong’s maturity and command have been especially impressive, and with Detroit’s dangerous lineup looming, the Giants will be counting on him to set the tone and keep the game under control through the early innings. The bullpen has also been a strength for San Francisco, providing reliable coverage late in games and giving Melvin the flexibility to mix and match based on matchups. Defensively, the Giants have remained sharp and fundamentally sound, a hallmark of Melvin-coached teams, and their ability to convert routine plays and avoid defensive lapses has played a key role in their success. Facing a Tigers team that is excelling both offensively and defensively, the Giants will need to play clean, opportunistic baseball—limiting free passes, controlling the running game, and capitalizing on any mistakes. The Giants’ formula this season has been rooted in resilience, and they’ll look to bring that same mentality into Comerica Park, where Detroit has been formidable with a 17–7 home record. For San Francisco, this game presents a chance to not only win a key interleague matchup but also to continue proving they are a legitimate playoff contender capable of beating quality opponents in any environment. If they can stay true to their identity—gritty pitching, clutch hitting, and sound execution—the Giants will be in strong position to notch another signature road win and continue building toward October.

Credit: USA TODAY/IMAGN
Detroit Tigers MLB Preview
The Detroit Tigers return home to Comerica Park for Tuesday’s clash with the San Francisco Giants sitting atop the AL Central at 34–20, riding a wave of balanced, high-performance baseball that has reenergized their fanbase and turned them into one of the most exciting stories of the 2025 MLB season. Under manager A.J. Hinch, the Tigers have embraced a blend of youth, power, and pitching excellence that has translated into a 17–7 home record and one of the most well-rounded team profiles in the American League. Offensively, Detroit ranks among the league’s elite with a team batting average of .262, 208 runs scored, and 48 home runs, making them dangerous from top to bottom in the lineup. Riley Greene has emerged as a catalyst, combining speed and pop to set the tone, while Spencer Torkelson has provided the raw power in the heart of the order, keeping opposing pitchers honest and capitalizing on mistakes. The Tigers’ approach at the plate focuses on working counts, making consistent contact, and manufacturing runs through a combination of aggressive base running and timely hitting, making them difficult to shut down for an entire game. On the mound, Detroit boasts a sparkling 2.95 team ERA—third-best in all of baseball—a testament to both the strength of their rotation and the depth of their bullpen.
Jack Flaherty is expected to take the mound for this matchup and while his 2–6 record and 4.39 ERA suggest some inconsistency, he’s had several outings where he’s displayed ace-caliber stuff and the ability to dominate lineups when his control is sharp. The bullpen, anchored by steady late-inning arms, has held leads and shut down rallies, giving Hinch the flexibility to pull starters early if needed and trust his relievers to finish the job. Defensively, the Tigers have also been solid, with improved infield range and reliable outfield coverage contributing to their success in run prevention and closing innings without costly miscues. As they prepare to host a battle-tested Giants squad, Detroit knows it must maintain its disciplined approach, especially against Hayden Birdsong, who has been lights-out for San Francisco in recent starts. The key for the Tigers will be to establish offensive momentum early, get Flaherty some run support, and challenge the Giants’ bullpen with a steady dose of baserunners and long innings. At 34–20, Detroit is playing with confidence, and every win at home adds to their case as a legitimate postseason threat in the American League. With an opportunity to continue distancing themselves in the division and further assert their dominance at Comerica Park, the Tigers will aim to dictate the pace from the first pitch and capitalize on their home-field advantage to take another step forward in their impressive 2025 campaign.
You know what time it is 🔊 pic.twitter.com/vWDDWusVUS
— Detroit Tigers (@tigers) May 26, 2025
San Francisco vs. Detroit Prop Picks (AI)
San Francisco vs. Detroit Prediction (AI)

Remi, our AI sports algorithm, has been pouring over millions of data from every facet between the Giants and Tigers and using recursive machine learning and impressive AI to crunch the data to a single cover probability.
Oddly enough, we’ve seen the AI has been most focused on the trending weight emotional bettors regularly put on Detroit’s strength factors between a Giants team going up against a possibly healthy Tigers team. In reality, the true game analytics might reflect a moderate lean against one Vegas line specifically.
Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.
Below is our current AI San Francisco vs Detroit picks, computer picks Giants vs Tigers, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
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Giants Betting Trends
The Giants have a 24–21 record against the spread (ATS) this season.
Tigers Betting Trends
The Tigers have a 24–14 record against the spread (ATS) this season.
Giants vs. Tigers Matchup Trends
The Tigers have a 17–7 home record, indicating strong performance at Comerica Park.
San Francisco vs. Detroit Game Info
What time does San Francisco vs Detroit start on May 27, 2025?
San Francisco vs Detroit starts on May 27, 2025 at 6:40 PM EST.
Where is San Francisco vs Detroit being played?
Venue: Comerica Park.
What are the opening odds for San Francisco vs Detroit?
Spread: Detroit +1.5
Moneyline: San Francisco -119, Detroit +100
Over/Under: 7
What are the records for San Francisco vs Detroit?
San Francisco: (31-23) | Detroit: (35-20)
What is the AI best bet for San Francisco vs Detroit?
Remi's searched hard and found the best prop for this matchup: W. Flores over 3.5 Fantasy Score.. Prices move—always shop for the best number.
What are San Francisco vs Detroit trending bets?
The Tigers have a 17–7 home record, indicating strong performance at Comerica Park.
What are San Francisco trending bets?
SF trend: The Giants have a 24–21 record against the spread (ATS) this season.
What are Detroit trending bets?
DET trend: The Tigers have a 24–14 record against the spread (ATS) this season.
Where can I find AI Picks for San Francisco vs Detroit?
See our latest MLB picks and odds pages for 2025 to compare prices before you bet.
San Francisco vs. Detroit Odds
AI algorithm Remi is pouring through tons of data points on each player. In fact, anytime the San Francisco vs Detroit trends are analyzed, there’s always several intriguing trends to key in on. Not to mention games played at extreme travel distance can often follow normal, predictable betting trends.
San Francisco vs Detroit Opening Odds
SF Moneyline:
-119 DET Moneyline: +100
SF Spread: -1.5
DET Spread: +1.5
Over/Under: 7
San Francisco vs Detroit Live Odds
Games | PTS | ML | SPR | O/U | |
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Oct 19, 2025 8:04PM EDT
Seattle Mariners
Toronto Blue Jays
10/19/25 8:04PM
Mariners
Blue Jays
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–
–
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+108
-130
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+1.5 (-215)
-1.5 (+165)
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O 7.5 (-121)
U 7.5 (-106)
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MLB Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers San Francisco Giants vs. Detroit Tigers on May 27, 2025 at Comerica Park.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.
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LEAN | %WIN | UNITS | RESULT |
---|---|---|---|---|
TOR@SEA | OVER 7 | 54.9% | 3 | WIN |
LAD@MIL | UNDER 7.5 | 56.6% | 6 | WIN |
TOR@NYY | OVER 8 | 54.9% | 4 | WIN |
TOR@NYY | CARLOS RODON OVER 1.5 TOTAL WALKS ALLOWED | 53.3% | 3 | WIN |
NYY@TOR | OVER 7.5 | 54.8% | 2 | WIN |
LAD@PHI | OVER 7 | 53.8% | 3 | WIN |
SD@CHC | CHC -109 | 53.8% | 3 | WIN |
SD@CHC | OVER 7.5 | 54.5% | 4 | LOSS |
SD@CHC | CHC -111 | 54.8% | 4 | LOSS |
CIN@LAD | SHOHEI OHTANI OVER 1.5 BASES | 53.5% | 3 | WIN |
BOS@NYY | OVER 7 | 53.8% | 3 | LOSS |
CIN@LAD | ELLY DE LA CRUZ OVER 0.5 BASES | 54.4% | 4 | LOSS |
ARI@SD | SD -131 | 57.3% | 4 | WIN |
DET@BOS | BOS -115 | 56.4% | 5 | WIN |
NYM@CHC | NYM -110 | 54.1% | 3 | WIN |
HOU@ATH | ATH +118 | 50.8% | 4 | WIN |
NYM@CHC | OVER 7 | 54.5% | 3 | WIN |
STL@SF | OVER 7.5 | 55.9% | 5 | LOSS |
KC@LAA | TYLER TOLBERT UNDER 1.5 BASES | 54.4% | 4 | WIN |
MIL@SD | UNDER 9 | 54.7% | 4 | WIN |
MIA@PHI | KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS | 53.3% | 3 | WIN |
WAS@NYM | OVER 8.5 | 56.1% | 6 | LOSS |
LAA@COL | COL +108 | 50.5% | 3 | WIN |
TOR@KC | UNDER 9 | 54.7% | 4 | LOSS |
SEA@KC | KC +1.5 | 62.3% | 5 | LOSS |
NYY@MIN | OVER 9 | 55.1% | 4 | WIN |
MIA@COL | OVER 10.5 | 55.0% | 4 | WIN |
MIA@COL | AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS | 54.3% | 4 | WIN |
SEA@KC | BOBBY WITT UNDER 0.5 SINGLES | 54.4% | 4 | LOSS |
PHI@LAD | LAD -113 | 54.7% | 4 | LOSS |
NYY@BOS | OVER 7.5 | 54.3% | 3 | WIN |
KC@PHI | PHI -130 | 58.3% | 4 | WIN |
LAD@SF | OVER 7.5 | 54.7% | 4 | LOSS |
NYM@PHI | PHI -122 | 55.6% | 4 | WIN |
KC@CLE | KC -104 | 52.0% | 3 | WIN |
CIN@SD | JAKE CRONEWORTH OVER 0.5 HITS | 53.1% | 3 | WIN |
WAS@MIA | MIA -123 | 55.2% | 4 | LOSS |
LAA@KC | UNDER 9.5 | 54.9% | 3 | WIN |
TEX@ARI | UNDER 9 | 54.2% | 4 | WIN |
SF@COL | UNDER 11.5 | 56.4% | 6 | LOSS |
SF@COL | RAFAEL DEVERS OVER 1.5 BASES | 56.1% | 6 | WIN |
MIA@WAS | WAS -110 | 54.4% | 4 | WIN |
NYM@DET | OVER 8.5 | 54.5% | 4 | WIN |
TEX@ARI | UNDER 9.5 | 56.4% | 6 | WIN |
TEX@ARI | ALEJANDRO OSUNA UNDER 1.5 BASES | 54.1% | 4 | LOSS |
ATL@CHC | CHC -116 | 55.1% | 3 | WIN |
PHI@MIL | OVER 8.5 | 55.0% | 3 | WIN |
ARI@LAD | SHOHEI OHTANI OVER 2.5 BASES | 54.2% | 4 | WIN |
SEA@CLE | CLE +1.5 | 57.2% | 3 | WIN |
CHC@SF | CHC -105 | 54.1% | 4 | LOSS |
NYY@CHW | RYAN MCMAHON OVER 0.5 BASES | 54.1% | 4 | WIN |