Giants vs Tigers Prediction — AI Finds CAN'T MISS MLB Lines & Props (May 26)

Updated: 2025-05-24T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The San Francisco Giants (31–22) visit Comerica Park to face the Detroit Tigers (34–20) on May 26, 2025, in a compelling interleague matchup between two playoff-contending teams. The Giants aim to close the gap in the NL West, while the AL Central-leading Tigers look to maintain their division lead.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: May 26, 2025

Start Time: 1:10 PM EST​

Venue: Comerica Park​

Tigers Record: (34-20)

Giants Record: (31-22)

OPENING ODDS

SF Moneyline: -106

DET Moneyline: -112

SF Spread: -1.5

DET Spread: +1.5

Over/Under: 8

SF
Betting Trends

  • The Giants have a 24–21 record against the spread (ATS) this season, indicating a moderate performance in covering the spread. They have been consistent, with a 4–6 record in their last ten games, reflecting some variability in recent performances.

DET
Betting Trends

  • The Tigers boast a 30–18 ATS record, demonstrating strong performance in covering the spread. Their home record is particularly impressive, with an 18–8 mark at Comerica Park, suggesting a significant home-field advantage.

MATCHUP TRENDS

  • The Tigers’ 30–18 ATS record ranks among the best in MLB, highlighting their reliability for bettors. Conversely, the Giants’ 24–21 ATS record indicates a more unpredictable performance, especially on the road. The Tigers’ strong home record (18–8) further emphasizes their dominance at Comerica Park, making them a formidable opponent for visiting teams.

SF vs. DET
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: M. Chapman over 0.5 Total Bases.

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San Francisco vs Detroit Prediction & Odds:
Free MLB Betting Insights for 5/26/25

The May 26, 2025 interleague clash between the San Francisco Giants and the Detroit Tigers at Comerica Park promises to be a compelling matchup between two playoff-contending teams with distinctly different strengths. The Giants enter the game with a solid 31–22 record and are in close pursuit of the Dodgers in the National League West, while the Tigers, currently holding a 34–20 mark, lead the American League Central and have established themselves as one of the strongest home teams in baseball. Detroit’s explosive offense, averaging 5.24 runs per game, is spearheaded by Spencer Torkelson, whose power has fueled many of the team’s victories this season. With 13 home runs and 40 RBIs, Torkelson has been supported by a well-rounded lineup that puts constant pressure on opposing pitchers. The Tigers’ overall consistency at the plate and their 18–8 home record demonstrate both comfort and confidence in their home environment, and Comerica Park has become a fortress where they routinely outslug and outmaneuver their opponents. Keider Montero is expected to start for Detroit and will aim to bounce back from a somewhat shaky 5.28 ERA, hoping to contain a Giants lineup that, while not overly explosive, has shown the ability to manufacture runs through timely hitting and situational awareness.

The Giants, averaging 4.6 runs per game, rely heavily on the production of Wilmer Flores, whose 10 home runs and 43 RBIs have kept them competitive in tight games. Though their team batting average sits at a modest .232, San Francisco has found ways to win with sharp pitching and a capable bullpen. Hayden Birdsong has been especially impressive on the mound, posting a 2–0 record with a sparkling 1.91 ERA and 29 strikeouts in 28.1 innings, and he represents the Giants’ best chance to slow down Detroit’s offense. San Francisco’s approach will likely focus on pitching to contact, keeping hitters off balance, and avoiding the big innings that Detroit thrives on. The Giants’ defense and bullpen execution will be critical, as Detroit has shown a knack for late-inning comebacks and clutch hitting. Strategically, this game sets up as a battle between Detroit’s ability to strike early and often with the bat and San Francisco’s effort to control the pace with their arms. Both teams understand the postseason implications of every game at this point in the season, and momentum, particularly for San Francisco on the road, can swing with a strong outing. Detroit will look to continue building its lead in the Central, while the Giants aim to stay close in the ultra-competitive West. If Birdsong can continue his dominance and the Giants can get on the board early, they’ll have a real chance to steal a win on the road. But if the Tigers’ bats get going, especially with Torkelson anchoring the heart of the lineup, Detroit could once again prove why they’ve been one of the best teams in baseball through the first two months of the season.

San Francisco Giants MLB Preview

The San Francisco Giants enter their May 26, 2025 road matchup against the Detroit Tigers with a 31–22 record, positioned near the top of the competitive National League West and looking to gain ground on the division-leading Los Angeles Dodgers. On the surface, the Giants have been an above-average club with strengths centered around their pitching staff and a lineup that delivers in key moments despite middling overall batting statistics. Offensively, the Giants average 4.6 runs per game and have leaned heavily on veteran Wilmer Flores, who leads the team with 10 home runs and 43 RBIs, acting as the glue in an otherwise inconsistent lineup. Their collective .232 team batting average reflects a broader trend of offensive inconsistency, but they’ve found ways to scratch out wins thanks to timely hitting, situational base running, and discipline at the plate when it counts. On the mound, the Giants have received a major boost from Hayden Birdsong, who has emerged as one of the most reliable arms in the rotation with a 2–0 record, 1.91 ERA, and 29 strikeouts over 28.1 innings pitched. Birdsong’s command and ability to limit damage have allowed the Giants to stay in games even when the offense lags, and he’ll be instrumental in attempting to contain Detroit’s potent lineup. San Francisco’s bullpen has also been a strength, often tasked with protecting slim leads or keeping deficits manageable, and they’ve answered that call more often than not.

On the road, the Giants have been serviceable, holding a 14–13 record away from Oracle Park, showing they can compete in hostile environments but also highlighting the thin margin for error they typically face. Manager Gabe Kapler continues to push the right buttons tactically, frequently leveraging matchups and platoons to optimize performance even with limited power output across the roster. The challenge in this game will be slowing down a Tigers team that ranks among the league’s best at home and features a high-octane offense led by Spencer Torkelson. Kapler will likely look to mix in off-speed pitches and rely on his defense to stifle the Tigers’ rhythm, while also hoping for a few key hits early to put pressure on Keider Montero, Detroit’s young right-hander with a 5.28 ERA. Given Detroit’s strong record at Comerica Park, the Giants will need to play a clean game—limiting walks, avoiding defensive miscues, and finding a way to chip away offensively without relying on the long ball. For San Francisco, this matchup is less about overpowering the opponent and more about dictating tempo, controlling the strike zone, and executing in high-leverage moments. If they can keep the score tight and bring the bullpen into a close contest late, their road-tested resilience could make the difference. While the Tigers have the edge on paper, the Giants’ balance of experienced leadership and emerging pitching talent makes them a formidable opponent capable of pulling off a key road victory that could have meaningful implications in their divisional chase.

The San Francisco Giants (31–22) visit Comerica Park to face the Detroit Tigers (34–20) on May 26, 2025, in a compelling interleague matchup between two playoff-contending teams. The Giants aim to close the gap in the NL West, while the AL Central-leading Tigers look to maintain their division lead. San Francisco vs Detroit AI Prediction: Free MLB Betting Insights for May 26. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Detroit Tigers MLB Preview

The Detroit Tigers host the San Francisco Giants on May 26, 2025, at Comerica Park riding a wave of confidence built on a strong 34–20 record and a commanding position atop the American League Central. Detroit has established itself as one of the league’s most consistent and balanced clubs this season, and its dominance at home—evidenced by an 18–8 record—has made Comerica Park a tough venue for visiting teams. The Tigers’ offensive engine is fueled by Spencer Torkelson, whose breakout campaign has included 13 home runs and 40 RBIs, placing him among the most productive hitters in the AL through the first two months of the season. His power threat in the middle of the lineup is complemented by a deep supporting cast capable of creating runs with both long balls and small ball tactics, as evidenced by their 5.24 runs per game average. Their lineup doesn’t rely solely on one star but rather gets contributions from top to bottom, making it difficult for opposing pitchers to navigate. The Tigers’ aggressive approach at the plate, coupled with good discipline and situational awareness, allows them to apply pressure throughout games and put pitchers in high-stress scenarios. On the mound, Detroit will turn to Keider Montero, a young arm still refining his game, who comes into the start with a 1–1 record and a 5.28 ERA.

While his numbers are not elite, Montero has flashed potential with strikeout ability and a fastball that plays well when he stays ahead in counts, and the Tigers will be looking for him to deliver five solid innings before turning things over to a capable bullpen. Detroit’s bullpen has quietly been a strength, frequently called upon to hold slim leads or stop rallies, and they’ve delivered with reliable late-game performances. Manager A.J. Hinch continues to push all the right buttons, blending analytics with a feel for momentum and matchups, and he’s guided the team with clarity and confidence. Defensively, the Tigers are fundamentally sound, rarely beating themselves with errors or mental lapses, and that consistency in the field has backed up their pitchers and reduced the pressure on Montero and company. Facing a Giants team that leans on strong pitching but has shown inconsistency at the plate, Detroit will likely look to strike early, setting the tone and forcing San Francisco into a reactive game plan. The Tigers have done a great job all season of punishing mistakes and capitalizing on free passes, and if they can continue that trend, they’ll put themselves in a favorable position to notch another win and extend their home success. With the crowd behind them and their confidence high, Detroit has every reason to believe they can handle business and continue building momentum toward a playoff push. As long as they stay focused and don’t overlook a capable San Francisco squad, the Tigers have all the tools to keep asserting their dominance in the American League and protect their home turf.

San Francisco vs. Detroit Prop Picks (AI)

AI algorithm Remi is pouring through mountains of stats on each team. In fact, anytime the Giants and Tigers play there’s always several intriguing angles to key in on. Not to mention games played at Comerica Park in May can often follow normal, predictable patterns.
Remi's searched hard and found the best prop for this matchup: M. Chapman over 0.5 Total Bases.

San Francisco vs. Detroit Prediction (AI)

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Remi, our AI sports wizard, has been pouring over exorbitant amounts of data from every angle between the Giants and Tigers and using recursive machine learning and impressive AI to crunch the data to a single cover probability.

The Algorithm has been most focused on the linear correlation of factor knucklehead sportsbettors tend to put on coaching factors between a Giants team going up against a possibly rested Tigers team. We’ve found the true game analytics appear to reflect a moderate lean against one Vegas line in particular.

Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.

Below is our current AI San Francisco vs Detroit picks, computer picks Giants vs Tigers, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
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Giants Betting Trends

The Giants have a 24–21 record against the spread (ATS) this season, indicating a moderate performance in covering the spread. They have been consistent, with a 4–6 record in their last ten games, reflecting some variability in recent performances.

Tigers Betting Trends

The Tigers boast a 30–18 ATS record, demonstrating strong performance in covering the spread. Their home record is particularly impressive, with an 18–8 mark at Comerica Park, suggesting a significant home-field advantage.

Giants vs. Tigers Matchup Trends

The Tigers’ 30–18 ATS record ranks among the best in MLB, highlighting their reliability for bettors. Conversely, the Giants’ 24–21 ATS record indicates a more unpredictable performance, especially on the road. The Tigers’ strong home record (18–8) further emphasizes their dominance at Comerica Park, making them a formidable opponent for visiting teams.

San Francisco vs. Detroit Game Info

San Francisco vs Detroit starts on May 26, 2025 at 1:10 PM EST.

Spread: Detroit +1.5
Moneyline: San Francisco -106, Detroit -112
Over/Under: 8

San Francisco: (31-22)  |  Detroit: (34-20)

Remi's searched hard and found the best prop for this matchup: M. Chapman over 0.5 Total Bases.. Prices move—always shop for the best number.

The Tigers’ 30–18 ATS record ranks among the best in MLB, highlighting their reliability for bettors. Conversely, the Giants’ 24–21 ATS record indicates a more unpredictable performance, especially on the road. The Tigers’ strong home record (18–8) further emphasizes their dominance at Comerica Park, making them a formidable opponent for visiting teams.

SF trend: The Giants have a 24–21 record against the spread (ATS) this season, indicating a moderate performance in covering the spread. They have been consistent, with a 4–6 record in their last ten games, reflecting some variability in recent performances.

DET trend: The Tigers boast a 30–18 ATS record, demonstrating strong performance in covering the spread. Their home record is particularly impressive, with an 18–8 mark at Comerica Park, suggesting a significant home-field advantage.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

San Francisco vs. Detroit Odds

AI algorithm Remi is pouring through loads of data on each player. In fact, anytime the San Francisco vs Detroit trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme altitude rarely follow normal, predictable patterns.

San Francisco vs Detroit Opening Odds

SF Moneyline: -106
DET Moneyline: -112
SF Spread: -1.5
DET Spread: +1.5
Over/Under: 8

San Francisco vs Detroit Live Odds

Games PTS ML SPR O/U

MLB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers San Francisco Giants vs. Detroit Tigers on May 26, 2025 at Comerica Park.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
LAD@TOR TOR +1.5 56.7% 2 WIN
TOR@LAD TOR +1.5 55.3% 4 WIN
TOR@SEA OVER 7 54.9% 3 WIN
LAD@MIL UNDER 7.5 56.6% 6 WIN
TOR@NYY OVER 8 54.9% 4 WIN
TOR@NYY CARLOS RODON OVER 1.5 TOTAL WALKS ALLOWED 53.3% 3 WIN
NYY@TOR OVER 7.5 54.8% 2 WIN
LAD@PHI OVER 7 53.8% 3 WIN
SD@CHC CHC -109 53.8% 3 WIN
SD@CHC OVER 7.5 54.5% 4 LOSS
SD@CHC CHC -111 54.8% 4 LOSS
CIN@LAD SHOHEI OHTANI OVER 1.5 BASES 53.5% 3 WIN
BOS@NYY OVER 7 53.8% 3 LOSS
CIN@LAD ELLY DE LA CRUZ OVER 0.5 BASES 54.4% 4 LOSS
ARI@SD SD -131 57.3% 4 WIN
DET@BOS BOS -115 56.4% 5 WIN
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN