The Seattle Mariners and Houston Astros will close out a four-game divisional set on Sunday, May 25, 2025, at Daikin Park, with the Mariners looking to build on their momentum and the Astros scrambling to stay afloat amid a string of injuries. Seattle enters the contest at 28–21 and sitting atop the AL West, having won five of their last six road games while averaging a robust 5.21 runs per game away from home. Their bats have come alive at the right time, with Cal Raleigh surging over the last week with a .250/.385/.800 slash line, three home runs, and eight RBIs, while shortstop JP Crawford has displayed elite plate discipline, drawing eight walks in his last seven games. That combination of power and patience has helped fuel a Mariners offense that has performed markedly better on the road than at home. On the mound, Seattle welcomes back right-hander George Kirby, who will be making his 2025 season debut following a shoulder injury. Kirby has a stellar history against Houston, boasting a 3–0 record and 1.55 ERA in seven career starts against the Astros, making his return particularly well-timed for the Mariners. Seattle’s overall pitching staff has been solid, holding a 3.74 ERA and benefiting from a deep and versatile bullpen that’s held leads and kept the team competitive in tight games. The Mariners are also 10–4 against the spread in their last 14 games, highlighting their consistency during this strong stretch of form. On the other side, the Houston Astros are struggling to maintain momentum in what’s been an injury-riddled campaign, coming into the series finale at 26–24 and facing increasing pressure to keep pace with Seattle in the division.

Their rotation has been decimated by injuries, with Ronel Blanco sidelined due to elbow soreness, and Hayden Wesneski and Spencer Arrighetti also on the IL. That has forced Houston to likely turn to a spot start from Colton Gordon or Brandon Walter, two young arms who may not be ready for high-leverage divisional matchups. Offensively, the loss of Yordan Alvarez since May 5 due to a hand injury has had a major impact—the Astros are averaging just 4.17 runs per game since his absence began. Still, Isaac Paredes has picked up some of the slack, hitting six home runs this month and maintaining a .983 OPS at Daikin Park, giving the Astros a much-needed source of power. Houston’s bullpen has remained competent and the defense sharp, but the lack of starting pitching depth and overall offensive inconsistency have become key vulnerabilities. The Astros are 2–4 ATS in their last six games and underdogs in this matchup at +110, reflecting the current imbalance in form and roster health between the two sides. Sunday’s finale will likely be decided by how deep George Kirby can go in his first outing back and whether the Mariners’ offense can strike early against an inexperienced Houston starter. Seattle’s recent form, stronger health, and road dominance give them a significant edge in this game, particularly with the return of their ace and a lineup that’s clicking from top to bottom. For the Astros, they’ll need a strong bullpen performance, big swings from Paredes and Alex Bregman, and a surprise gem from whoever takes the ball to avoid losing more ground in the division. With postseason positioning already in focus for Seattle and urgency rising in Houston, this is more than a series finale—it’s a tone-setter for how these two clubs will shape the AL West race heading into June.