Cubs vs. Reds
Prediction, Odds & Props
May 25 | MLB AI Picks

Updated: 2025-05-23T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The Chicago Cubs (30–20) and Cincinnati Reds (25–26) conclude their three-game series on Sunday, May 25, 2025, at Great American Ball Park. The Cubs aim to solidify their lead in the NL Central, while the Reds look to bounce back and reach the .500 mark.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: May 25, 2025

Start Time: 1:40 PM EST​

Venue: Great American Ball Park​

Reds Record: (26-27)

Cubs Record: (31-21)

OPENING ODDS

CHC Moneyline: -118

CIN Moneyline: -101

CHC Spread: -1.5

CIN Spread: +1.5

Over/Under: 9

CHC
Betting Trends

  • The Cubs have covered the run line in 8 of their last 10 road games against NL Central opponents.

CIN
Betting Trends

  • The Reds are 2–4 against the spread (ATS) in their last six games.

MATCHUP TRENDS

  • The Cubs are favored with -120 moneyline odds, while the Reds are at +100. The over/under for the game is set at 9 runs.

CHC vs. CIN
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: C. Joe under 4.5 Fantasy Score.

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Chicago Cubs vs Cincinnati Prediction & Odds:
Free MLB Betting Insights for 5/25/25

The Chicago Cubs and Cincinnati Reds close out their three-game series on Sunday, May 25, 2025, at Great American Ball Park in what shapes up to be a crucial divisional matchup for both clubs. The Cubs enter the finale with a 30–20 record, sitting atop the NL Central and looking to further distance themselves from the rest of the pack, while the Reds stand at 25–26, seeking to climb back to .500 and stay within striking distance. Chicago has been one of the most balanced and quietly dangerous teams in baseball this season, combining a consistent offense with dependable defense and pitching, particularly in matchups against divisional rivals. Sunday’s starter, Ben Brown, comes in with a 3–3 record and a 5.44 ERA, aiming to rebound after a stretch of uneven performances. Though Brown has been hit-or-miss, the Cubs have countered that volatility with a lineup that has torched left-handed pitching, holding an .827 OPS against southpaws—a stat that bodes well as they face Reds lefty Nick Lodolo (4–4, 3.22 ERA). Chicago’s offensive depth has been further boosted by the return of top prospect Matt Shaw, who rejoined the club after a short stint in Triple-A where he retooled his swing and now brings added versatility to the infield and lineup. Kyle Tucker continues to provide pop in the middle of the order, while Nico Hoerner, Seiya Suzuki, and Michael Busch round out a productive and well-disciplined lineup.

The Cubs have also been reliable defensively and effective on the basepaths, making them a complete team even when the power isn’t fully on display. The Reds, meanwhile, continue to battle through injury and inconsistency. Their pitching staff ranks third in the league in fWAR, led by strong performances from Lodolo and others in the rotation, but the offense hasn’t been able to support them consistently. Cincinnati has been shut out eight times this season and has scored one or fewer runs in 14 games—stark reminders of the team’s offensive volatility. The Reds’ lineup features Elly De La Cruz, one of the most dynamic young players in the league with his speed and power, but without key contributors like Christian Encarnacion-Strand and Jeimer Candelario—both sidelined due to injury—opposing pitchers have been able to pitch around him. The Reds’ defense has been solid, but their situational hitting remains a problem, particularly against well-rounded teams like the Cubs. Cincinnati has also struggled ATS lately, going just 2–4 in their last six games, while the Cubs have covered the run line in eight of their last ten road games against NL Central opponents. With Chicago favored on the moneyline at -120 and the over/under set at 9 runs, oddsmakers expect a competitive game that could tilt on a few key swings. For the Cubs, this is an opportunity to finish the series strong and maintain control of the division, while for the Reds, it’s a must-win to keep their season from slipping further into mediocrity. Both teams will lean heavily on their starters and timely hitting, but the Cubs’ overall depth and edge against left-handed pitching make them the more complete team heading into the finale.

Chicago Cubs Cubs MLB Preview

The Chicago Cubs head into the May 25 series finale against the Cincinnati Reds with a 30–20 record and the momentum of a team firmly entrenched at the top of the NL Central standings. After taking control of the series with consistent offensive execution and reliable defense, the Cubs are now positioned to close out the road set with another strong performance against a divisional rival they’ve historically handled well. Chicago has covered the spread in eight of their last ten road games against NL Central opponents, including a recent stretch that has showcased their ability to win both high- and low-scoring contests. On Sunday, the Cubs will send Ben Brown to the mound. While Brown enters with a 3–3 record and a 5.44 ERA, he remains a work-in-progress arm with elite strikeout potential who can be effective when he limits walks and avoids falling behind in counts. His performance will be key, especially against a Cincinnati lineup that has struggled to score consistently this season. The Cubs’ offense has been the team’s backbone, averaging over 5.5 runs per game and ranking among the best in the majors in OPS against left-handed pitchers, which is significant as they’ll face Reds southpaw Nick Lodolo.

The Cubs’ lineup is deep and balanced, anchored by Kyle Tucker’s power from the middle of the order and supported by dynamic contributors like Seiya Suzuki, Nico Hoerner, and Christopher Morel. Rookie Matt Shaw’s return has also added versatility to the infield and additional contact to the lineup, while Michael Busch continues to be a valuable asset with runners in scoring position. Manager Craig Counsell has expertly managed the club’s depth, putting hitters in favorable matchups and mixing aggressiveness on the basepaths with patient, disciplined plate approaches. The Cubs’ defense remains one of their quiet strengths—clean, efficient, and fundamentally sound—which has helped a pitching staff that’s seen its ups and downs but remains serviceable due to strong support behind them. The bullpen, led by Julian Merryweather and Adbert Alzolay, has settled into a solid rhythm and will be crucial if Brown’s outing is abbreviated. Facing a Reds team that has scored one or fewer runs in 14 games and been shut out eight times, the Cubs will look to take control early and avoid giving Cincinnati confidence or momentum. With division games carrying extra weight and every win pivotal in maintaining their lead over teams like the Brewers and Cardinals, this is a spot where Chicago’s focus and depth should shine. A win on Sunday would not only secure a key road series win but further validate the Cubs as one of the most complete and dangerous teams in the National League this season.

The Chicago Cubs (30–20) and Cincinnati Reds (25–26) conclude their three-game series on Sunday, May 25, 2025, at Great American Ball Park. The Cubs aim to solidify their lead in the NL Central, while the Reds look to bounce back and reach the .500 mark. Chicago Cubs vs Cincinnati AI Prediction: Free MLB Betting Insights for May 25. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Cincinnati Reds MLB Preview

The Cincinnati Reds enter Sunday’s series finale against the Chicago Cubs with a 25–26 record and mounting urgency to avoid falling further behind in the NL Central standings after a series filled with offensive inconsistency and missed opportunities. The Reds have struggled to generate runs consistently throughout the season and that issue has remained front and center against the Cubs, a team that’s used depth and timely pitching to keep Cincinnati’s offense quiet. Cincinnati has been shut out eight times in 2025 and has scored one or fewer runs in 14 games—numbers that speak volumes about a team struggling to produce under pressure, especially when facing above-average pitching. On Sunday, they’ll hand the ball to left-hander Nick Lodolo, their most dependable starter to date, who carries a 4–4 record and a sharp 3.22 ERA into the finale. Lodolo has shown improved command and excellent strikeout ability, but he’ll face a tough matchup against a Cubs lineup that leads the majors in OPS against left-handed pitching, making execution and early efficiency critical. Offensively, the Reds continue to lean heavily on Elly De La Cruz, whose electrifying speed and raw power have made him one of the league’s most entertaining young players, but without the injured Christian Encarnacion-Strand and Jeimer Candelario, the lineup around him has failed to provide consistent support.

While players like Spencer Steer and Tyler Stephenson have chipped in at times, the absence of multiple reliable bats has left De La Cruz exposed, often pitched around or targeted with high-velocity inside fastballs and breaking balls away. Defensively, the Reds have remained solid, playing clean infield defense and showing improved communication in the outfield, which has helped keep games close even when the offense lags. The bullpen has been decent but overworked, frequently asked to cover extended innings due to short outings from the rotation outside of Lodolo. Cincinnati is just 2–4 against the spread in their last six games and enters the finale as a slight underdog, with oddsmakers setting the moneyline at +100 and the over/under at nine runs. Manager David Bell will be looking for a spark—not just from his lineup but also from his dugout—to inspire the kind of urgency this team needs to break out of its funk. With a chance to even the series and climb back to .500, the Reds must find ways to scratch out runs early, support Lodolo with clean defense, and capitalize on any mistakes from a Cubs team that has out-executed them in nearly every facet so far. A win would not only stop the bleeding but could provide the momentum needed to stabilize a season that’s teetering between staying relevant in the division or slipping toward another rebuilding year. For Cincinnati, Sunday is less about standings and more about sending a message—that they’re still capable of competing with the division’s best when they play up to their potential.

Chicago Cubs vs. Cincinnati Prop Picks (AI)

AI algorithm Remi is pouring through mountains of data on each player. In fact, anytime the Cubs and Reds play there’s always several intriguing trends to key in on. Not to mention games played at Great American Ball Park in May seemingly never follow normal, predictable betting trends.
Remi's searched hard and found the best prop for this matchup: C. Joe under 4.5 Fantasy Score.

Chicago Cubs vs. Cincinnati Prediction (AI)

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Remi, our AI sports algorithm, has been pouring over tons of data from every angle between the Cubs and Reds and using recursive machine learning and kick-ass AI to crunch the data to a single cover probability.

Oddly enough, we’ve seen the AI has been most watching on the unproportionally assigned emphasis knucklehead sportsbettors regularly put on player performance factors between a Cubs team going up against a possibly tired Reds team. It appears the true game analytics appear to reflect a strong lean against one Vegas line specifically.

Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.

Below is our current AI Chicago Cubs vs Cincinnati picks, computer picks Cubs vs Reds, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
MLB 9/26 DET@BOS UNLOCK THIS PICK 5 EXECUTIVE Locked EXECUTIVE
MLB 9/26 BAL@NYY UNLOCK THIS PICK 4 INTEL Locked INTEL
MLB 9/26 ARI@SD UNLOCK THIS PICK 4 EXECUTIVE Locked EXECUTIVE
MLB 9/26 NYM@MIA UNLOCK THIS PICK 1 INTEL Locked INTEL
MLB 9/26 NYM@MIA GET FREE PICK NOW 1
MLB 9/26 COL@SF UNLOCK THIS PICK 0 INTEL Locked INTEL

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.

Cubs Betting Trends

The Cubs have covered the run line in 8 of their last 10 road games against NL Central opponents.

Reds Betting Trends

The Reds are 2–4 against the spread (ATS) in their last six games.

Cubs vs. Reds Matchup Trends

The Cubs are favored with -120 moneyline odds, while the Reds are at +100. The over/under for the game is set at 9 runs.

Chicago Cubs vs. Cincinnati Game Info

Chicago Cubs vs Cincinnati starts on May 25, 2025 at 1:40 PM EST.

Venue: Great American Ball Park.

Spread: Cincinnati +1.5
Moneyline: Chicago Cubs -118, Cincinnati -101
Over/Under: 9

Chicago Cubs: (31-21)  |  Cincinnati: (26-27)

Remi's searched hard and found the best prop for this matchup: C. Joe under 4.5 Fantasy Score.. Prices move—always shop for the best number.

The Cubs are favored with -120 moneyline odds, while the Reds are at +100. The over/under for the game is set at 9 runs.

CHC trend: The Cubs have covered the run line in 8 of their last 10 road games against NL Central opponents.

CIN trend: The Reds are 2–4 against the spread (ATS) in their last six games.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

Chicago Cubs vs. Cincinnati Odds

AI algorithm Remi is pouring through tons of data points on each player. In fact, anytime the Chicago Cubs vs Cincinnati trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme hostile environments seemingly never follow normal, predictable patterns.

Chicago Cubs vs Cincinnati Opening Odds

CHC Moneyline: -118
CIN Moneyline: -101
CHC Spread: -1.5
CIN Spread: +1.5
Over/Under: 9

Chicago Cubs vs Cincinnati Live Odds

Games PTS ML SPR O/U
Sep 27, 2025 1:06PM EDT
Baltimore Orioles
New York Yankees
9/27/25 1:06PM
Orioles
Yankees
+190
-235
+1.5 (-110)
-1.5 (-110)
O 8.5 (-120)
U 8.5 (+100)
Sep 27, 2025 2:21PM EDT
St Louis Cardinals
Chicago Cubs
9/27/25 2:21PM
Cardinals
Cubs
 
-175
 
-1.5 (+115)
O 9.5 (-105)
U 9.5 (-115)
Sep 27, 2025 3:09PM EDT
Tampa Bay Rays
Toronto Blue Jays
9/27/25 3:09PM
Rays
Blue Jays
+130
-155
+1.5 (-155)
-1.5 (+130)
O 8.5 (-110)
U 8.5 (-110)
Sep 27, 2025 4:06PM EDT
Chicago White Sox
Washington Nationals
9/27/25 4:06PM
White Sox
Nationals
+100
-120
-1.5 (+165)
+1.5 (-200)
O 8.5 (-110)
U 8.5 (-110)
Sep 27, 2025 4:06PM EDT
Colorado Rockies
San Francisco Giants
9/27/25 4:06PM
Rockies
Giants
+185
-225
+1.5 (-110)
-1.5 (-110)
O 8 (-105)
U 8 (-115)
Sep 27, 2025 4:11PM EDT
New York Mets
Miami Marlins
9/27/25 4:11PM
Mets
Marlins
-130
+110
-1.5 (+125)
+1.5 (-150)
O 8.5 (-105)
U 8.5 (-115)
Sep 27, 2025 6:05PM EDT
Minnesota Twins
Philadelphia Phillies
9/27/25 6:05PM
Twins
Phillies
+170
-205
+1.5 (-120)
-1.5 (+100)
O 8.5 (-115)
U 8.5 (-105)
Sep 27, 2025 7:11PM EDT
Cincinnati Reds
Milwaukee Brewers
9/27/25 7:11PM
Reds
Brewers
+125
-150
+1.5 (-180)
-1.5 (+150)
O 8 (-105)
U 8 (-115)
Sep 27, 2025 7:15PM EDT
Pittsburgh Pirates
Atlanta Braves
9/27/25 7:15PM
Pirates
Braves
+140
-170
+1.5 (-155)
-1.5 (+130)
O 8 (-110)
U 8 (-110)
Sep 27, 2025 7:16PM EDT
Texas Rangers
Cleveland Guardians
9/27/25 7:16PM
Rangers
Guardians
+135
-165
+1.5 (-180)
-1.5 (+150)
O 7 (-120)
U 7 (+100)
Sep 27, 2025 8:40PM EDT
Arizona Diamondbacks
San Diego Padres
9/27/25 8:40PM
Diamondbacks
Padres
+115
-140
+1.5 (-190)
-1.5 (+155)
O 7.5 (-120)
U 7.5 (+100)
Sep 27, 2025 9:39PM EDT
Houston Astros
Los Angeles Angels
9/27/25 9:39PM
Astros
Angels
-165
+135
-1.5 (+105)
+1.5 (-125)
O 9 (+100)
U 9 (-120)
Sep 27, 2025 9:41PM EDT
Los Angeles Dodgers
Seattle Mariners
9/27/25 9:41PM
Dodgers
Mariners
+100
-120
-1.5 (+170)
+1.5 (-205)
O 7.5 (-110)
U 7.5 (-110)
Sep 27, 2025 10:05PM EDT
Kansas City Royals
Oakland Athletics
9/27/25 10:05PM
Royals
Athletics
+100
-120
-1.5 (+150)
+1.5 (-180)
O 10 (-110)
U 10 (-110)

MLB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Chicago Cubs Cubs vs. Cincinnati Reds on May 25, 2025 at Great American Ball Park.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN
CHC@SF CHC -105 54.1% 4 LOSS
NYY@CHW RYAN MCMAHON OVER 0.5 BASES 54.1% 4 WIN
PHI@NYM OVER 8.5 55.6% 4 LOSS
LAA@TEX LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS 54.1% 4 LOSS
KC@CHW KC -109 54.2% 4 WIN
SD@SEA DYLAN CEASE OVER 16.5 OUTS 53.9% 3 LOSS
SD@SEA UNDER 8.5 54.4% 4 LOSS
MIN@TOR JOE RYAN UNDER 2.5 EARNED RUNS 54.1% 4 LOSS
SF@MIL MIL +100 54.0% 6 LOSS
TOR@MIA MIA +1.5 62.0% 6 WIN
CHC@LAA OVER 9.5 54.9% 4 LOSS
BOS@NYY CARLOS RODON UNDER 4.5 HITS ALLOWED 54.2% 4 WIN
KC@DET DET -115 56.1% 5 WIN
CHC@LAA LAA +1.5 57.6% 5 LOSS
CIN@ARI KEBRYAN HAYES STRIKEOUTS UNDER 0.5 56.2% 6 WIN
LAD@SD SD +110 50.9% 6 WIN