Orioles vs Red Sox Prediction — AI Finds CAN'T MISS MLB Lines & Props (May 25)

Updated: 2025-05-23T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The Baltimore Orioles and Boston Red Sox will conclude their four-game series on Sunday, May 25, 2025, at Fenway Park. The Red Sox, aiming to reach a .500 record, look to capitalize on their home-field advantage against the struggling Orioles.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: May 25, 2025

Start Time: 1:35 PM EST​

Venue: Fenway Park​

Red Sox Record: (27-27)

Orioles Record: (17-34)

OPENING ODDS

BAL Moneyline: +111

BOS Moneyline: -132

BAL Spread: +1.5

BOS Spread: -1.5

Over/Under: 9.5

BAL
Betting Trends

  • The Baltimore Orioles have a 15–33–0 record against the spread (ATS) this season.

BOS
Betting Trends

  • The Boston Red Sox hold a 25–26–0 record against the spread (ATS) this season.

MATCHUP TRENDS

  • The Red Sox are listed as -134 moneyline favorites in this matchup, with the Orioles at +112.

BAL vs. BOS
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: R. Urias over 0.5 Total Bases.

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Baltimore vs Boston Prediction & Odds:
Free MLB Betting Insights for 5/25/25

The May 25, 2025 matchup between the Baltimore Orioles and the Boston Red Sox at Fenway Park wraps up a four-game AL East series and highlights two clubs heading in very different directions. The Red Sox, entering the contest with a 26–26 record, have been fighting to get back above .500 and reassert themselves in the division race. Meanwhile, the Orioles, sitting at a disappointing 16–33, are in the midst of one of the worst starts in the American League, struggling mightily in both pitching and offensive categories. Boston’s offense has carried much of the load, ranking seventh in MLB in total runs per game at 4.7, driven by steady contributions from Jarren Duran, Rafael Devers, and Alex Bregman, who leads the team with a .297 average and 11 home runs. The Sox have also received a spark from top prospect Marcelo Mayer, who was recently called up and has added defensive flexibility and energy to the infield. On the mound, Lucas Giolito has delivered consistent outings, while the bullpen has stabilized after a shaky start to the year. The pitching staff holds a respectable 4.04 ERA, good enough to keep them in games while the offense goes to work. In contrast, the Orioles have endured a brutal stretch, ranking 25th in offense with only 183 total runs and last in team ERA at 5.93.

Their rotation has been unable to contain opposing lineups, and the bullpen has often entered games already out of reach. Key young talents like Adley Rutschman and Gunnar Henderson have yet to find their rhythm at the plate, and the team’s .232 batting average and .306 OBP reflect how rarely they’re able to generate sustained rallies. Baltimore’s road woes have compounded their problems, as they come into Fenway with a 7–16 away record and just a 15–33–0 ATS record on the season. In comparison, Boston holds a 13–11 home record and a 25–26–0 ATS mark, giving them a clear advantage in both recent form and matchup history. The betting lines also favor Boston, with the Red Sox entering the game as -134 moneyline favorites, and the over/under set at 9.5 runs—an indication of both teams’ volatile pitching. If the Red Sox continue to hit early and get a solid start from their rotation, they should be well-positioned to close out the series with another win. For the Orioles, the task is more than uphill—it’s about rediscovering their identity and finding ways to compete in a division that won’t wait for them to catch up. Sunday’s game could be a launching pad for Boston to gain momentum heading into June, while for Baltimore, it’s yet another test in a season that’s already asking far too many questions without providing many answers.

Baltimore Orioles MLB Preview

The Baltimore Orioles enter their May 25 matchup against the Boston Red Sox at Fenway Park reeling from a difficult stretch that has defined their 2025 campaign, holding a 16–33 record and sitting firmly at the bottom of the AL East. With a 15–33–0 mark against the spread and a dismal 7–16 road record, the Orioles are struggling to compete consistently both at home and away, and Sunday’s series finale represents more than just another game—it’s a chance to find a foothold in what has quickly become a lost season. Offensively, the Orioles have fallen far short of expectations, ranking 25th in the league with just 183 total runs and posting a team batting average of .232 and a .306 on-base percentage. The once-promising core of Adley Rutschman and Gunnar Henderson has been underwhelming, with both players yet to find the consistency needed to carry the offense, and their lack of production has left the lineup thin and vulnerable to even average pitching staffs. The Orioles have not only struggled to get runners on base, but they’ve also failed to cash in with men in scoring position, and their run differential reflects just how rarely they’ve been competitive for nine full innings. Pitching has been an even more glaring issue, with a league-worst 5.93 ERA that has put pressure on the offense to score early and often—something they haven’t been able to do.

Starters like Cade Povich have failed to establish themselves, often putting the team in early deficits that the lineup simply doesn’t have the firepower to overcome. The bullpen hasn’t fared much better, frequently entering games in damage control mode and allowing opponents to extend leads or pull away late. Manager Brandon Hyde has tried shuffling the rotation and lineup card, but with no significant improvements, frustration has begun to mount both in the clubhouse and among the fanbase. Defensively, the Orioles have been average, but defensive stability hasn’t translated into wins due to the imbalance in their overall play. As they head into a tough environment at Fenway Park, facing a Red Sox team with strong offensive metrics and better starting pitching, the Orioles need a near-flawless game to stay competitive. If Rutschman or Henderson can finally break out and the pitching staff can limit damage through the first five innings, Baltimore might be able to avoid a sweep and leave Boston with some positives to build on. Otherwise, it risks being yet another chapter in a season that has spiraled early and may continue to do so without clear improvement in all facets of the game. For the Orioles, this matchup isn’t just about closing out a series—it’s about finding answers and signs of life before the division slips completely out of reach.

The Baltimore Orioles and Boston Red Sox will conclude their four-game series on Sunday, May 25, 2025, at Fenway Park. The Red Sox, aiming to reach a .500 record, look to capitalize on their home-field advantage against the struggling Orioles. Baltimore vs Boston AI Prediction: Free MLB Betting Insights for May 25. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Boston Red Sox MLB Preview

The Boston Red Sox head into their May 25 home matchup against the Baltimore Orioles with a 26–26 record and the chance to climb back above .500 while completing a series win over their division rival. With a 13–11 home record and sitting just outside the playoff picture in the AL East, the Red Sox are quietly piecing together a competitive 2025 campaign thanks to a strong offensive core, improved pitching, and the emergence of key young talent. Boston’s offense ranks seventh in MLB, averaging 4.7 runs per game, and it has been propelled by the consistent production of Alex Bregman, who leads the team with a .297 batting average and 11 home runs. Jarren Duran and Rafael Devers have formed an effective 1-2 punch alongside Bregman, combining for over 100 hits and 68 RBIs, giving the Red Sox a well-rounded top of the order capable of putting immediate pressure on opposing starters. On the mound, Lucas Giolito has emerged as a reliable presence in the rotation, providing depth and stability to a pitching staff that now owns a 4.04 team ERA—good enough to keep games manageable when the bats go cold. The bullpen has also shown signs of growth, with key relievers executing in high-leverage spots and preserving slim leads more consistently than they did earlier in the season.

Perhaps the most exciting development for Red Sox fans has been the promotion of top infield prospect Marcelo Mayer, who adds athleticism, defense, and long-term upside at shortstop while also injecting new energy into the dugout. Boston’s defense has been steady, avoiding the costly miscues that plagued them in previous years, and their execution in situational hitting has allowed them to thrive in close games. Their 25–26–0 ATS record reflects a team that often competes in tightly contested matchups, and against a struggling Orioles team, they have the upper hand in nearly every key statistical category. Baltimore enters the contest with a league-worst 5.93 ERA and a bottom-five offense in both runs scored and batting average, creating a favorable setup for the Red Sox to build an early lead and control tempo throughout the game. Manager Alex Cora has done an excellent job balancing veteran leadership and youth development, keeping Boston competitive in a stacked division while still preparing the franchise for long-term success. If the Red Sox can continue to get quality at-bats from the middle of the order and another dependable start from their rotation, they should be well-positioned to close out the series with a win. For Boston, this game is more than a single W—it’s a chance to generate momentum heading into a crucial stretch of the schedule, solidify their place in the division race, and reinforce their identity as a team that plays smart, hard-nosed, winning baseball.

Baltimore vs. Boston Prop Picks (AI)

Remi is pouring through mountains of data on each team. In fact, anytime the Orioles and Red Sox play there’s always several intriguing observations to key in on. Not to mention games played at Fenway Park in May rarely follow normal, predictable betting trends.
Remi's searched hard and found the best prop for this matchup: R. Urias over 0.5 Total Bases.

Baltimore vs. Boston Prediction (AI)

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Remi, our AI sports genius, has been pouring over millions of data from every angle between the Orioles and Red Sox and using recursive machine learning and kick-ass AI to boil down the data to a single cover probability.

Remi has been most watching on the trending weight emotional bettors often put on coaching factors between a Orioles team going up against a possibly unhealthy Red Sox team. We’ve found the true game analytics might reflect a slight lean against one Vegas line in particular.

Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.

Below is our current AI Baltimore vs Boston picks, computer picks Orioles vs Red Sox, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
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Orioles Betting Trends

The Baltimore Orioles have a 15–33–0 record against the spread (ATS) this season.

Red Sox Betting Trends

The Boston Red Sox hold a 25–26–0 record against the spread (ATS) this season.

Orioles vs. Red Sox Matchup Trends

The Red Sox are listed as -134 moneyline favorites in this matchup, with the Orioles at +112.

Baltimore vs. Boston Game Info

Baltimore vs Boston starts on May 25, 2025 at 1:35 PM EST.

Spread: Boston -1.5
Moneyline: Baltimore +111, Boston -132
Over/Under: 9.5

Baltimore: (17-34)  |  Boston: (27-27)

Remi's searched hard and found the best prop for this matchup: R. Urias over 0.5 Total Bases.. Prices move—always shop for the best number.

The Red Sox are listed as -134 moneyline favorites in this matchup, with the Orioles at +112.

BAL trend: The Baltimore Orioles have a 15–33–0 record against the spread (ATS) this season.

BOS trend: The Boston Red Sox hold a 25–26–0 record against the spread (ATS) this season.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

Baltimore vs. Boston Odds

Remi is pouring through tons of data on each team. In fact, anytime the Baltimore vs Boston trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme temps can often follow normal, predictable patterns.

Baltimore vs Boston Opening Odds

BAL Moneyline: +111
BOS Moneyline: -132
BAL Spread: +1.5
BOS Spread: -1.5
Over/Under: 9.5

Baltimore vs Boston Live Odds

Games PTS ML SPR O/U
Oct 19, 2025 8:04PM EDT
Seattle Mariners
Toronto Blue Jays
10/19/25 8:04PM
Mariners
Blue Jays
+107
-128
+1.5 (-195)
-1.5 (+165)
O 7.5 (-115)
U 7.5 (-105)

MLB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Baltimore Orioles vs. Boston Red Sox on May 25, 2025 at Fenway Park.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
TOR@SEA OVER 7 54.9% 3 WIN
LAD@MIL UNDER 7.5 56.6% 6 WIN
TOR@NYY OVER 8 54.9% 4 WIN
TOR@NYY CARLOS RODON OVER 1.5 TOTAL WALKS ALLOWED 53.3% 3 WIN
NYY@TOR OVER 7.5 54.8% 2 WIN
LAD@PHI OVER 7 53.8% 3 WIN
SD@CHC CHC -109 53.8% 3 WIN
SD@CHC OVER 7.5 54.5% 4 LOSS
SD@CHC CHC -111 54.8% 4 LOSS
CIN@LAD SHOHEI OHTANI OVER 1.5 BASES 53.5% 3 WIN
BOS@NYY OVER 7 53.8% 3 LOSS
CIN@LAD ELLY DE LA CRUZ OVER 0.5 BASES 54.4% 4 LOSS
ARI@SD SD -131 57.3% 4 WIN
DET@BOS BOS -115 56.4% 5 WIN
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN
CHC@SF CHC -105 54.1% 4 LOSS
NYY@CHW RYAN MCMAHON OVER 0.5 BASES 54.1% 4 WIN