Diamondbacks vs Cardinals Prediction — AI Finds CAN'T MISS MLB Lines & Props (May 25)
Updated: 2025-05-23T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The Arizona Diamondbacks (26–26) and the St. Louis Cardinals (28–23) conclude their three-game series on Sunday, May 25, 2025, at Busch Stadium. The Cardinals aim for a sweep, while the Diamondbacks look to snap a four-game losing streak.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

GAME INFO
Date: May 25, 2025
Start Time: 2:15 PM EST
Venue: Busch Stadium
Cardinals Record: (29-23)
Diamondbacks Record: (26-26)
OPENING ODDS
ARI Moneyline: +106
STL Moneyline: -125
ARI Spread: +1.5
STL Spread: -1.5
Over/Under: 7.5
ARI
Betting Trends
- The Diamondbacks have a 21–21 record against the run line this season.
STL
Betting Trends
- The Cardinals have a 20–18 record against the run line this season.
MATCHUP TRENDS
- The Cardinals are favored with a moneyline of -120, while the Diamondbacks are at +100. The over/under for the game is set at 8.5 runs.
ARI vs. STL
Best Prop Bet
- Remi's searched hard and found the best prop for this matchup: K. Marte over 0.5 Total Bases.
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Arizona vs St. Louis Prediction & Odds:
Free MLB Betting Insights for 5/25/25
However, the Diamondbacks’ offense has been inconsistent recently, struggling to cash in runners in scoring position during the first two games of the series. On the flip side, the Cardinals have found timely hitting from Brendan Donovan, who leads the team with 51 hits, and Lars Nootbaar, who has clubbed seven home runs and added energy to the lineup with his patient approach and defensive versatility. The Cardinals’ defense has also played a major role in their recent success, committing few errors and supporting their pitchers effectively. From a betting perspective, both teams are nearly even against the spread on the season—Arizona is 21–21 ATS and St. Louis is 20–18—but the current form clearly favors the Cardinals, who are slight -120 favorites. The over/under is set at 8.5 runs, a reasonable figure given both pitchers’ effectiveness and the potential for mid-game bullpen swings. If the Diamondbacks can get an early lead behind Pfaadt and avoid the defensive miscues that have plagued them recently, they’ll have a chance to salvage the finale. But if the Cardinals continue to ride their offensive momentum and get another quality start from Gray, they’re well-positioned to complete the sweep and tighten the NL Central race. Both teams need this game for different reasons—St. Louis to build on momentum and Arizona to stop the bleeding—making this a high-stakes contest as both eye playoff contention.
Final. pic.twitter.com/yOCssB2PzY
— Arizona Diamondbacks (@Dbacks) May 24, 2025
Arizona Diamondbacks MLB Preview
The Arizona Diamondbacks enter Sunday’s series finale against the St. Louis Cardinals in urgent need of a turnaround, riding a four-game losing streak that has dropped them to an even 26–26 on the season and threatening to undo some of the progress they’ve made in a competitive NL West. This skid has exposed some of the underlying inconsistencies in Arizona’s game, particularly on offense, where the team has struggled to convert scoring chances and failed to produce timely hits in key moments throughout the first two games of the series. Despite those issues, the Diamondbacks remain a resilient group led by dynamic outfielder Corbin Carroll, who paces the team with 58 hits and 34 RBIs and brings a mix of power, speed, and high-contact ability to the top of the lineup. Josh Naylor has also provided a strong presence in the middle of the order, consistently driving in runs and helping to anchor a lineup that, when clicking, can manufacture offense from multiple spots. To stop their current slide, Arizona will turn to right-hander Brandon Pfaadt, who has been one of their most dependable starters this season with a 7–3 record and a 3.81 ERA.
Pfaadt brings both strikeout stuff and the ability to pitch deep into games, which will be key in preserving a bullpen that has been overworked during the team’s recent struggles. The Diamondbacks’ pitching staff has been solid for most of the season, but in the past few games, the lack of offensive run support has put too much pressure on their arms to be near-perfect. Defensively, Arizona has shown the athleticism and efficiency to compete with any team, but defensive lapses and base-running mistakes have proven costly during their losing streak. Manager Torey Lovullo is likely to shake things up if the team falls behind early again, especially given the importance of avoiding a sweep against a red-hot St. Louis team on the road. From a betting standpoint, the Diamondbacks enter the game with a 21–21 record against the spread, indicating they’ve generally kept games close even when the results haven’t gone their way. Sunday’s game is critical not just for halting their losing streak but also for regaining their footing in the standings, with divisional rivals beginning to create separation. A win would not only salvage the series but also provide a much-needed reset as the D-backs head into the final week of May. For Arizona, the key will be early offense, strong command from Pfaadt, and playing a clean game defensively—if those three boxes are checked, they have the talent to avoid the sweep and reestablish momentum heading into June.

Credit: USA TODAY/IMAGN
St. Louis Cardinals MLB Preview
The St. Louis Cardinals enter Sunday’s series finale against the Arizona Diamondbacks riding a surge of confidence and consistency that has propelled them to a 28–23 record and within striking distance of first place in the NL Central. Winners of the first two games in this series, the Cardinals are aiming for a sweep to further cement their status as one of the league’s most quietly effective clubs over the past few weeks. A combination of timely hitting, dependable pitching, and fundamentally sound defense has defined St. Louis’ recent stretch, and Sunday presents another opportunity to showcase that formula in front of a home crowd at Busch Stadium. The offense continues to be anchored by Brendan Donovan, who leads the team with 51 hits and consistently sets the tone at the top of the order with his ability to get on base and spark rallies. Lars Nootbaar has provided power and energy, launching seven home runs while continuing to play excellent defense in the outfield, and Paul Goldschmidt has started to heat up after a slower start to the year, giving the Cardinals the heart-of-the-lineup presence they’ve relied on in recent seasons. This lineup may not be the most explosive in the National League, but it’s one of the most disciplined, rarely giving away at-bats and finding ways to manufacture runs even without the long ball.
On the mound, St. Louis will turn to veteran right-hander Sonny Gray, who brings a 5–1 record and 4.02 ERA into the start and has proven once again to be a reliable presence in the rotation. Gray mixes speeds effectively and has a strong track record against teams like Arizona, making him an ideal choice to finish off the series sweep. The Cardinals’ bullpen has also been sharp, with closer Ryan Helsley and setup men Giovanny Gallegos and JoJo Romero combining to lock down late leads with consistency. Defensively, St. Louis has been among the league’s best, limiting mistakes and providing excellent support for the pitching staff through strong infield play and outfield positioning. From a betting angle, the Cardinals have gone 20–18 against the spread this season and are favored on the moneyline at -120, a nod to both their current form and home-field advantage. A win Sunday would give the Redbirds a clean sweep and further boost their standing in a division that remains tightly contested. Manager Oliver Marmol has his club playing with urgency and discipline, and if they can continue to execute in all three phases—hitting, pitching, and defense—they’ll be in strong position to maintain momentum into a crucial June schedule. For a team that started the season with questions about its consistency, the Cardinals have begun to find their rhythm, and Sunday’s game offers a chance to show just how far they’ve come with another composed and complete team effort.
Step on snek pic.twitter.com/M83fzPZSxM
— St. Louis Cardinals (@Cardinals) May 24, 2025
Arizona vs. St. Louis Prop Picks (AI)
Arizona vs. St. Louis Prediction (AI)

Remi, our AI sports wizard, has been pouring over mountains of data from every simulation between the Diamondbacks and Cardinals and using recursive machine learning and cutting-edge AI to analyze the data to a single cover probability.
The Algorithm has been most keyed in on the growing emphasis emotional bettors regularly put on player performance factors between a Diamondbacks team going up against a possibly rested Cardinals team. It appears the true game analytics appear to reflect a moderate lean against one Vegas line in particular.
Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.
Below is our current AI Arizona vs St. Louis picks, computer picks Diamondbacks vs Cardinals, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.
Diamondbacks Betting Trends
The Diamondbacks have a 21–21 record against the run line this season.
Cardinals Betting Trends
The Cardinals have a 20–18 record against the run line this season.
Diamondbacks vs. Cardinals Matchup Trends
The Cardinals are favored with a moneyline of -120, while the Diamondbacks are at +100. The over/under for the game is set at 8.5 runs.
Arizona vs. St. Louis Game Info
What time does Arizona vs St. Louis start on May 25, 2025?
Arizona vs St. Louis starts on May 25, 2025 at 2:15 PM EST.
Where is Arizona vs St. Louis being played?
Venue: Busch Stadium.
What are the opening odds for Arizona vs St. Louis?
Spread: St. Louis -1.5
Moneyline: Arizona +106, St. Louis -125
Over/Under: 7.5
What are the records for Arizona vs St. Louis?
Arizona: (26-26) | St. Louis: (29-23)
What is the AI best bet for Arizona vs St. Louis?
Remi's searched hard and found the best prop for this matchup: K. Marte over 0.5 Total Bases.. Prices move—always shop for the best number.
What are Arizona vs St. Louis trending bets?
The Cardinals are favored with a moneyline of -120, while the Diamondbacks are at +100. The over/under for the game is set at 8.5 runs.
What are Arizona trending bets?
ARI trend: The Diamondbacks have a 21–21 record against the run line this season.
What are St. Louis trending bets?
STL trend: The Cardinals have a 20–18 record against the run line this season.
Where can I find AI Picks for Arizona vs St. Louis?
See our latest MLB picks and odds pages for 2025 to compare prices before you bet.
Arizona vs. St. Louis Odds
AI algorithm Remi is pouring through mountains of data points on each line. In fact, anytime the Arizona vs St. Louis trends are analyzed, there’s always several intriguing trends to key in on. Not to mention games played at extreme altitude rarely follow normal, predictable betting trends.
Arizona vs St. Louis Opening Odds
ARI Moneyline:
+106 STL Moneyline: -125
ARI Spread: +1.5
STL Spread: -1.5
Over/Under: 7.5
Arizona vs St. Louis Live Odds
Games | PTS | ML | SPR | O/U | |
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Oct 19, 2025 8:04PM EDT
Seattle Mariners
Toronto Blue Jays
10/19/25 8:04PM
Mariners
Blue Jays
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–
–
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+108
-130
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+1.5 (-215)
-1.5 (+165)
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O 7.5 (-121)
U 7.5 (-106)
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MLB Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers Arizona Diamondbacks vs. St. Louis Cardinals on May 25, 2025 at Busch Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.
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LEAN | %WIN | UNITS | RESULT |
---|---|---|---|---|
TOR@SEA | OVER 7 | 54.9% | 3 | WIN |
LAD@MIL | UNDER 7.5 | 56.6% | 6 | WIN |
TOR@NYY | OVER 8 | 54.9% | 4 | WIN |
TOR@NYY | CARLOS RODON OVER 1.5 TOTAL WALKS ALLOWED | 53.3% | 3 | WIN |
NYY@TOR | OVER 7.5 | 54.8% | 2 | WIN |
LAD@PHI | OVER 7 | 53.8% | 3 | WIN |
SD@CHC | CHC -109 | 53.8% | 3 | WIN |
SD@CHC | OVER 7.5 | 54.5% | 4 | LOSS |
SD@CHC | CHC -111 | 54.8% | 4 | LOSS |
CIN@LAD | SHOHEI OHTANI OVER 1.5 BASES | 53.5% | 3 | WIN |
BOS@NYY | OVER 7 | 53.8% | 3 | LOSS |
CIN@LAD | ELLY DE LA CRUZ OVER 0.5 BASES | 54.4% | 4 | LOSS |
ARI@SD | SD -131 | 57.3% | 4 | WIN |
DET@BOS | BOS -115 | 56.4% | 5 | WIN |
NYM@CHC | NYM -110 | 54.1% | 3 | WIN |
HOU@ATH | ATH +118 | 50.8% | 4 | WIN |
NYM@CHC | OVER 7 | 54.5% | 3 | WIN |
STL@SF | OVER 7.5 | 55.9% | 5 | LOSS |
KC@LAA | TYLER TOLBERT UNDER 1.5 BASES | 54.4% | 4 | WIN |
MIL@SD | UNDER 9 | 54.7% | 4 | WIN |
MIA@PHI | KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS | 53.3% | 3 | WIN |
WAS@NYM | OVER 8.5 | 56.1% | 6 | LOSS |
LAA@COL | COL +108 | 50.5% | 3 | WIN |
TOR@KC | UNDER 9 | 54.7% | 4 | LOSS |
SEA@KC | KC +1.5 | 62.3% | 5 | LOSS |
NYY@MIN | OVER 9 | 55.1% | 4 | WIN |
MIA@COL | OVER 10.5 | 55.0% | 4 | WIN |
MIA@COL | AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS | 54.3% | 4 | WIN |
SEA@KC | BOBBY WITT UNDER 0.5 SINGLES | 54.4% | 4 | LOSS |
PHI@LAD | LAD -113 | 54.7% | 4 | LOSS |
NYY@BOS | OVER 7.5 | 54.3% | 3 | WIN |
KC@PHI | PHI -130 | 58.3% | 4 | WIN |
LAD@SF | OVER 7.5 | 54.7% | 4 | LOSS |
NYM@PHI | PHI -122 | 55.6% | 4 | WIN |
KC@CLE | KC -104 | 52.0% | 3 | WIN |
CIN@SD | JAKE CRONEWORTH OVER 0.5 HITS | 53.1% | 3 | WIN |
WAS@MIA | MIA -123 | 55.2% | 4 | LOSS |
LAA@KC | UNDER 9.5 | 54.9% | 3 | WIN |
TEX@ARI | UNDER 9 | 54.2% | 4 | WIN |
SF@COL | UNDER 11.5 | 56.4% | 6 | LOSS |
SF@COL | RAFAEL DEVERS OVER 1.5 BASES | 56.1% | 6 | WIN |
MIA@WAS | WAS -110 | 54.4% | 4 | WIN |
NYM@DET | OVER 8.5 | 54.5% | 4 | WIN |
TEX@ARI | UNDER 9.5 | 56.4% | 6 | WIN |
TEX@ARI | ALEJANDRO OSUNA UNDER 1.5 BASES | 54.1% | 4 | LOSS |
ATL@CHC | CHC -116 | 55.1% | 3 | WIN |
PHI@MIL | OVER 8.5 | 55.0% | 3 | WIN |
ARI@LAD | SHOHEI OHTANI OVER 2.5 BASES | 54.2% | 4 | WIN |
SEA@CLE | CLE +1.5 | 57.2% | 3 | WIN |
CHC@SF | CHC -105 | 54.1% | 4 | LOSS |
NYY@CHW | RYAN MCMAHON OVER 0.5 BASES | 54.1% | 4 | WIN |