Giants vs Nationals Prediction — AI Finds CAN'T MISS MLB Lines & Props (May 24)

Updated: 2025-05-22T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

On May 24, 2025, the San Francisco Giants (29–21) will face the Washington Nationals (23–27) at Nationals Park in Washington, D.C. The Giants aim to solidify their position in the NL West, while the Nationals look to build on recent momentum in the NL East.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: May 24, 2025

Start Time: 4:05 PM EST​

Venue: Nationals Park​

Nationals Record: (23-28)

Giants Record: (30-21)

OPENING ODDS

SF Moneyline: -136

WAS Moneyline: +115

SF Spread: -1.5

WAS Spread: +1.5

Over/Under: 8.5

SF
Betting Trends

  • The Giants have a 29–21 record against the spread (ATS) this season.

WAS
Betting Trends

  • The Nationals hold a 23–27 record against the spread (ATS) this season.

MATCHUP TRENDS

  • In their last five head-to-head matchups, the Giants have covered the spread in 60% of the games, with 60% of those games going over the total runs line.

SF vs. WAS
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: J. Wood over 0.5 Total Bases.

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San Francisco vs Washington Prediction & Odds:
Free MLB Betting Insights for 5/24/25

The May 24, 2025 matchup between the San Francisco Giants and the Washington Nationals at Nationals Park features two National League clubs on different trajectories, yet both remain very much in the hunt within their respective divisions. The Giants come into this contest with a 29–21 record and sit firmly in the mix in the competitive NL West, thanks to a recent surge powered by an offense that’s clicking at the right time and a pitching staff that continues to find new contributors. Their lineup has seen a boost from the veteran presence of Wilmer Flores, who recently blasted three home runs in a single game, reaffirming his status as one of the Giants’ most dangerous bats in clutch spots. Heliot Ramos has also emerged as a force, especially on the road, where he’s slashing .301/.365/.602 and bringing much-needed consistency to the heart of the order. On the mound, San Francisco will give the ball to left-hander Kyle Harrison, who makes his first start of the season after showing promise in limited appearances; his development is key to maintaining rotation depth amid a long summer ahead. The Giants have been effective against the spread this season at 29–21 and have handled business in recent matchups against the Nationals, covering in 60% of their last five head-to-head meetings. Meanwhile, Washington enters the game at 23–27, hovering just below the .500 mark and looking to break through a logjam in the NL East by defending their home turf, where they’ve been a competitive 12–12.

The Nationals’ recent momentum has come largely from the explosive play of CJ Abrams and James Wood, two of the organization’s brightest young stars, each posting impressive offensive metrics with wRC+ numbers around 158. Abrams’ speed and power combo make him a threat at the top of the order, while Wood’s emerging bat continues to give Washington a formidable presence in the middle of the lineup. Jake Irvin, who will likely get the start, has delivered a solid 3.88 ERA this season, giving the Nationals a fighting chance whenever he’s on the bump, though the bullpen behind him has been less consistent. With recent additions like Jackson Rutledge and Cole Henry, Washington is experimenting with young arms to stabilize late-game scenarios, and if they can limit walks and avoid big innings, they can stay competitive against a deep San Francisco lineup. Defensively, the Nationals have played a clean brand of baseball lately, minimizing errors and executing well in key situations, giving manager Dave Martinez some positive building blocks to work with. Overall, this matchup pits a Giants team looking to maintain pressure on the Dodgers and Padres against a Nationals squad attempting to build around its youth and stay in the playoff conversation. If Kyle Harrison can give the Giants five or more strong innings and the bats continue to stay hot, San Francisco should be in a strong position to pick up another win on the road, but Washington’s improving offense and familiarity with their ballpark give them the tools to keep it close—and perhaps steal a statement win of their own.

San Francisco Giants MLB Preview

The San Francisco Giants arrive at Nationals Park for their May 24 matchup against the Washington Nationals with a 29–21 record and momentum on their side as they continue to climb the standings in a competitive National League West. The Giants have seen a recent surge in production from key players like Wilmer Flores, who delivered a three-home run performance earlier this week, cementing his role as the veteran spark plug in the middle of a lineup that has started to fire on all cylinders. Complementing him has been the emergence of Heliot Ramos, whose road splits have been particularly impressive—slashing .301/.365/.602 away from home—and his power surge and consistency have helped balance a San Francisco offense that has at times struggled for punch in earlier stretches of the season. The lineup has been patient and opportunistic, grinding out at-bats and forcing opposing pitchers into mistakes, a formula that has helped them consistently capitalize on scoring opportunities. Kyle Harrison is expected to make his first start of the season in this game, and while the left-hander is young, he brings plenty of upside with a lively fastball, developing off-speed pitches, and a competitive demeanor that fits well in the Giants’ rotation puzzle.

Manager Bob Melvin has shown confidence in Harrison and will likely pair him with a short leash and a bullpen plan, knowing that the Giants’ relievers have been solid in bridging middle innings, especially with the recent workload management approach they’ve adopted. Defensively, San Francisco has remained clean and efficient, avoiding unforced errors and backing up their pitching staff with strong infield coordination and timely double plays, a key factor in their road success this season. Their 29–21 record against the spread is a reflection of how consistently they’ve managed to stay competitive, especially in tight games and road environments where fundamentals and focus are often the difference-makers. In their last five head-to-head games against the Nationals, the Giants have covered the spread in three, and they’ll look to lean on their improved hitting and dependable pitching depth to maintain that edge. With a balanced lineup, rising contributions from younger players, and a manager in Melvin who thrives in tactical matchups, San Francisco comes into this contest poised and prepared to continue their push toward the top of the division. If Harrison can give them five solid innings and the offense continues to deliver early, the Giants are well-positioned to pick up another valuable road win and further solidify themselves as legitimate contenders in the National League.

On May 24, 2025, the San Francisco Giants (29–21) will face the Washington Nationals (23–27) at Nationals Park in Washington, D.C. The Giants aim to solidify their position in the NL West, while the Nationals look to build on recent momentum in the NL East. San Francisco vs Washington AI Prediction: Free MLB Betting Insights for May 24. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Washington Nationals MLB Preview

The Washington Nationals return home to Nationals Park for their May 24 contest against the San Francisco Giants with a 23–27 record and a clear sense of progress despite their sub-.500 standing, thanks in large part to a blossoming core of young talent and improved overall competitiveness. With a 12–12 home record, the Nationals have played scrappy, focused baseball in front of their home fans and have relied on emerging stars like CJ Abrams and James Wood to provide offensive spark. Abrams has taken a major step forward this season, flashing both power and speed while posting an elite-level wRC+ around 158, making him one of the most dangerous leadoff hitters in the National League. Wood, one of the organization’s top prospects, has lived up to the hype with consistent at-bats, gap-to-gap power, and a mature approach that has helped stretch the middle of the lineup. On the mound, Jake Irvin is expected to get the start and has quietly been one of the most stable arms in Washington’s rotation, holding a 3.88 ERA and showing excellent control while limiting hard contact and walks. Irvin’s ability to pitch deep into games has eased the burden on a young bullpen that has been bolstered by the recent additions of Jackson Rutledge and Cole Henry, both of whom are still finding their footing but have shown flashes of late-inning reliability.

Defensively, Washington has cleaned up many of the issues that plagued them earlier in the season, with sharper infield play and more consistent outfield reads that have helped them avoid costly innings. Manager Dave Martinez continues to lean into the youth movement, trusting his top prospects with high-leverage roles and letting them learn on the fly, and the team has responded with a renewed sense of purpose and energy. Though the Nationals have a 23–27 ATS record, they’ve been more competitive than their record suggests, often staying within striking distance thanks to improved run prevention and a lineup that can grind out runs with situational hitting. Against a strong Giants team, Washington will need to continue playing clean, aggressive baseball—taking advantage of any command issues from San Francisco starter Kyle Harrison, who’s making his first start of the season, and pressing the edges of the infield with speed and smart baserunning. If Irvin can keep the ball down and limit San Francisco’s hot bats—especially Wilmer Flores and Heliot Ramos, who have been on recent tears—Washington has a realistic path to securing a statement win. With momentum building behind a dynamic young core and the home crowd on their side, the Nationals are quietly becoming one of the more intriguing teams in the National League’s middle tier, and a win against the Giants would serve as another important step in their rebuilding journey.

San Francisco vs. Washington Prop Picks (AI)

AI algorithm Remi is pouring through tons of stats on each player. In fact, anytime the Giants and Nationals play there’s always several intriguing observations to key in on. Not to mention games played at Nationals Park in May seemingly never follow normal, predictable patterns.
Remi's searched hard and found the best prop for this matchup: J. Wood over 0.5 Total Bases.

San Francisco vs. Washington Prediction (AI)

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Remi, our AI sports genius, has been pouring over tons of data from every angle between the Giants and Nationals and using recursive machine learning and cutting-edge AI to analyze the data to a single cover probability.

Interestingly enough, the data has been most keyed in on the trending weight human bettors often put on San Francisco’s strength factors between a Giants team going up against a possibly rested Nationals team. Trends look to say the true game analytics might reflect a slight lean against one Vegas line in particular.

Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.

Below is our current AI San Francisco vs Washington picks, computer picks Giants vs Nationals, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.

Giants Betting Trends

The Giants have a 29–21 record against the spread (ATS) this season.

Nationals Betting Trends

The Nationals hold a 23–27 record against the spread (ATS) this season.

Giants vs. Nationals Matchup Trends

In their last five head-to-head matchups, the Giants have covered the spread in 60% of the games, with 60% of those games going over the total runs line.

San Francisco vs. Washington Game Info

San Francisco vs Washington starts on May 24, 2025 at 4:05 PM EST.

Spread: Washington +1.5
Moneyline: San Francisco -136, Washington +115
Over/Under: 8.5

San Francisco: (30-21)  |  Washington: (23-28)

Remi's searched hard and found the best prop for this matchup: J. Wood over 0.5 Total Bases.. Prices move—always shop for the best number.

In their last five head-to-head matchups, the Giants have covered the spread in 60% of the games, with 60% of those games going over the total runs line.

SF trend: The Giants have a 29–21 record against the spread (ATS) this season.

WAS trend: The Nationals hold a 23–27 record against the spread (ATS) this season.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

San Francisco vs. Washington Odds

AI algorithm Remi is pouring through loads of data points on each player. In fact, anytime the San Francisco vs Washington trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme altitude can often follow normal, predictable patterns.

San Francisco vs Washington Opening Odds

SF Moneyline: -136
WAS Moneyline: +115
SF Spread: -1.5
WAS Spread: +1.5
Over/Under: 8.5

San Francisco vs Washington Live Odds

Games PTS ML SPR O/U

MLB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers San Francisco Giants vs. Washington Nationals on May 24, 2025 at Nationals Park.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
LAD@TOR TOR +1.5 56.7% 2 WIN
TOR@LAD TOR +1.5 55.3% 4 WIN
TOR@SEA OVER 7 54.9% 3 WIN
LAD@MIL UNDER 7.5 56.6% 6 WIN
TOR@NYY OVER 8 54.9% 4 WIN
TOR@NYY CARLOS RODON OVER 1.5 TOTAL WALKS ALLOWED 53.3% 3 WIN
NYY@TOR OVER 7.5 54.8% 2 WIN
LAD@PHI OVER 7 53.8% 3 WIN
SD@CHC CHC -109 53.8% 3 WIN
SD@CHC OVER 7.5 54.5% 4 LOSS
SD@CHC CHC -111 54.8% 4 LOSS
CIN@LAD SHOHEI OHTANI OVER 1.5 BASES 53.5% 3 WIN
BOS@NYY OVER 7 53.8% 3 LOSS
CIN@LAD ELLY DE LA CRUZ OVER 0.5 BASES 54.4% 4 LOSS
ARI@SD SD -131 57.3% 4 WIN
DET@BOS BOS -115 56.4% 5 WIN
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN