Diamondbacks vs. Cardinals
Prediction, Odds & Props
May 24 | MLB AI Picks

Updated: 2025-05-22T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

On May 24, 2025, the Arizona Diamondbacks will face the St. Louis Cardinals at Busch Stadium in St. Louis. Both teams are looking to gain momentum in their respective divisions, making this matchup crucial for their midseason aspirations.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: May 24, 2025

Start Time: 2:15 PM EST​

Venue: Busch Stadium​

Cardinals Record: (28-23)

Diamondbacks Record: (26-25)

OPENING ODDS

ARI Moneyline: -104

STL Moneyline: -116

ARI Spread: -1.5

STL Spread: +1.5

Over/Under: 8

ARI
Betting Trends

  • The Diamondbacks have a 23–25 record against the spread (ATS) this season.

STL
Betting Trends

  • The Cardinals hold a 24–18 record against the spread (ATS) this season.

MATCHUP TRENDS

  • In their last five head-to-head matchups, the Diamondbacks have covered the spread in 60% of the games, with 60% of those games going over the total runs line.

ARI vs. STL
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: I. Herrera over 4.5 Fantasy Score.

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Arizona vs St. Louis Prediction & Odds:
Free MLB Betting Insights for 5/24/25

The May 24, 2025 matchup between the Arizona Diamondbacks and St. Louis Cardinals at Busch Stadium features two National League contenders with postseason ambitions looking to gain traction as the season nears its midpoint. The Diamondbacks enter with a 26–24 record and a competitive position in the NL West, but they’ve been inconsistent of late, dropping key games due to spotty bullpen performance and occasional offensive lulls. Arizona’s offense has leaned on Ketel Marte and Gabriel Moreno for production, with both players offering consistent at-bats and timely hitting to stabilize a lineup that lacks overwhelming power but finds ways to manufacture runs. Zac Gallen, the ace of the Diamondbacks’ rotation, will be looking to bounce back after allowing four earned runs in his most recent outing, which ironically came against this same Cardinals squad. Gallen has the makeup and command to respond in big games, but he’ll need better support from a bullpen that has faltered in late innings, particularly when asked to protect narrow leads. On the other side, the Cardinals sit at 27–23 and have found their groove at home, where they boast a 15–6 record at Busch Stadium and have used strong starting pitching and clutch hitting to carry their recent success.

Nolan Arenado continues to be the anchor of their offense, delivering in key spots—most recently with a game-winning three-run triple against the Diamondbacks—while the lineup around him has seen improving contributions from Tommy Edman and Lars Nootbaar. Miles Mikolas, who allowed just one run over six efficient innings in his last outing, gives the Cardinals a veteran presence on the mound capable of setting the tone and challenging an Arizona team that can struggle against off-speed-heavy pitchers. The Cardinals’ bullpen has been solid, with JoJo Romero and Kyle Leahy posting scoreless innings and Ryan Helsley emerging as a consistent closer, already logging his 10th save of the season. Statistically, St. Louis has the edge against the spread at 24–18 compared to Arizona’s 23–25, and historically they’ve owned this head-to-head matchup with a 110–69 all-time record. Still, Arizona has covered the spread in three of the last five meetings, and with Gallen on the mound, they’ll believe they can steal a game from a surging Cardinals team. Expect a low-scoring affair early as both starters settle in, with the bullpens and defensive execution likely determining the final outcome. Both clubs are battling within crowded divisions where every win matters, so this game represents not just another midseason tilt, but a test of consistency and competitiveness between two teams that could very well cross paths again in the fall.

Arizona Diamondbacks MLB Preview

The Arizona Diamondbacks head into their May 24 road game against the St. Louis Cardinals with a 26–24 record and the urgent goal of regaining momentum in a tightly packed National League West. Having dropped a recent contest to the Cardinals, the D-backs are looking for redemption behind ace Zac Gallen, who was touched up for four earned runs in his last start against St. Louis but remains the foundation of Arizona’s rotation. Gallen has been largely dependable this season, combining pinpoint command with an elite pitch mix that keeps hitters off balance, and a bounce-back outing at Busch Stadium would go a long way toward steadying Arizona’s slightly shaky recent stretch. The Diamondbacks’ offense, while not explosive, has been opportunistic thanks to the consistency of Ketel Marte and Gabriel Moreno, who continue to deliver timely hits and keep the top and middle of the order productive. Marte, in particular, has been one of the club’s most reliable bats, driving in runs, hitting for average, and generating offense with his switch-hitting versatility. Moreno, known more for his glove than his bat early in his career, has become a dual threat, managing the pitching staff while also contributing crucial contact hitting in big moments. The rest of the lineup has seen mixed results—Christian Walker’s power has been inconsistent, and Corbin Carroll’s sophomore season hasn’t mirrored his rookie campaign—but there’s enough depth to manufacture runs when the core players are firing.

On the mound, the bullpen has been the most glaring issue in Arizona’s recent games, failing to hold leads and allowing opponents to capitalize late, which puts even more pressure on Gallen to go deep into the game and minimize exposure to the middle relievers. Manager Torey Lovullo has tried to stabilize the late innings with matchups and aggressive use of his top arms, but until the bullpen finds a reliable groove, close games will continue to present a challenge. Defensively, Arizona remains solid, with sound fundamentals and strong outfield coverage that supports their contact-heavy pitching approach. The Diamondbacks have a 23–25 record against the spread this season, illustrating their tendency to keep games close even in defeat, though they’ve struggled to consistently close the door on opponents. Recent head-to-head matchups against the Cardinals have been relatively even, but St. Louis has a significant historical edge, which adds urgency to Arizona’s mission to prove they can win tight games on the road against playoff-caliber teams. With Gallen on the bump, the D-backs have their best chance to level the series, but it will take a full team effort—early offense, error-free defense, and late-inning execution—to pull out a key win and stay within striking distance in the division. A strong showing in St. Louis could serve as a momentum swing, particularly if Arizona’s bats come alive and Gallen regains his dominant form on the mound.

On May 24, 2025, the Arizona Diamondbacks will face the St. Louis Cardinals at Busch Stadium in St. Louis. Both teams are looking to gain momentum in their respective divisions, making this matchup crucial for their midseason aspirations. Arizona vs St. Louis AI Prediction: Free MLB Betting Insights for May 24. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

St. Louis Cardinals MLB Preview

The St. Louis Cardinals enter their May 24 home matchup against the Arizona Diamondbacks riding a wave of confidence, boasting a 27–23 record and a formidable 15–6 home mark at Busch Stadium that has played a key role in their recent surge in the NL Central standings. After a dramatic late-inning win against the Diamondbacks earlier in the series—capped by a clutch three-run triple from Nolan Arenado—the Cardinals are looking to extend their momentum and secure another series victory behind the steady hand of veteran starter Miles Mikolas. Mikolas delivered one of his best outings of the season in his last start, allowing just one run over six strong innings against these same Diamondbacks, utilizing his signature control and movement to keep hitters off balance and limit hard contact. Offensively, the Cardinals have shown marked improvement over the past few weeks, with Arenado anchoring the middle of the lineup and continuing to deliver in high-leverage moments while Tommy Edman and Lars Nootbaar provide consistent on-base production and timely hits at the top of the order. Brendan Donovan has also been a key contributor, bringing energy and versatility to the lineup with his ability to hit to all fields and contribute in multiple defensive roles.

The Cardinals’ success this season has also been due to their bullpen’s steady performance, with JoJo Romero and Kyle Leahy logging important scoreless innings and closer Ryan Helsley already notching his 10th save, showcasing reliability in tight games. Defensively, St. Louis continues to excel, ranking among the league’s best in fielding percentage and turning timely double plays that have helped neutralize potential big innings by opponents. Their 24–18 ATS record speaks to their ability to not only win games but do so by multiple runs, particularly at home where their pitching and situational hitting have thrived. Manager Oliver Marmol has managed his rotation and bullpen skillfully, striking the right balance between veteran leadership and youthful energy, and he’ll look for his team to capitalize again against a Diamondbacks squad that has struggled with bullpen stability. With a long history of success against Arizona, including a dominant 110–69 all-time regular season record, the Cardinals know they have the psychological edge and will aim to apply pressure early, force Zac Gallen into long counts, and let their home crowd energy carry them through the middle and late innings. If Mikolas can replicate his recent success and the offense continues to execute in the clutch, the Cardinals are well-positioned to not only win this game but solidify their status as one of the most dangerous teams in the NL when playing at home. With every divisional win tightening the playoff picture, St. Louis understands that a strong finish to this series could be a springboard for a sustained run toward the top of the standings.

Arizona vs. St. Louis Prop Picks (AI)

Remi is pouring through tons of stats on each player. In fact, anytime the Diamondbacks and Cardinals play there’s always several intriguing observations to key in on. Not to mention games played at Busch Stadium in May rarely follow normal, predictable betting trends.
Remi's searched hard and found the best prop for this matchup: I. Herrera over 4.5 Fantasy Score.

Arizona vs. St. Louis Prediction (AI)

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Remi, our AI sports algorithm, has been pouring over millions of data from every past game between the Diamondbacks and Cardinals and using recursive machine learning and kick-ass AI to crunch the data to a single cover probability.

Remi has been most focused on the trending weight knucklehead sportsbettors regularly put on coaching factors between a Diamondbacks team going up against a possibly deflated Cardinals team. It appears the true game analytics might reflect a slight lean against one Vegas line in particular.

Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.

Below is our current AI Arizona vs St. Louis picks, computer picks Diamondbacks vs Cardinals, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
MLB 9/26 DET@BOS UNLOCK THIS PICK 5 EXECUTIVE Locked EXECUTIVE
MLB 9/26 BAL@NYY UNLOCK THIS PICK 4 INTEL Locked INTEL
MLB 9/26 ARI@SD UNLOCK THIS PICK 4 EXECUTIVE Locked EXECUTIVE
MLB 9/26 NYM@MIA UNLOCK THIS PICK 1 INTEL Locked INTEL
MLB 9/26 NYM@MIA GET FREE PICK NOW 1
MLB 9/26 COL@SF UNLOCK THIS PICK 0 INTEL Locked INTEL

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.

Diamondbacks Betting Trends

The Diamondbacks have a 23–25 record against the spread (ATS) this season.

Cardinals Betting Trends

The Cardinals hold a 24–18 record against the spread (ATS) this season.

Diamondbacks vs. Cardinals Matchup Trends

In their last five head-to-head matchups, the Diamondbacks have covered the spread in 60% of the games, with 60% of those games going over the total runs line.

Arizona vs. St. Louis Game Info

Arizona vs St. Louis starts on May 24, 2025 at 2:15 PM EST.

Spread: St. Louis +1.5
Moneyline: Arizona -104, St. Louis -116
Over/Under: 8

Arizona: (26-25)  |  St. Louis: (28-23)

Remi's searched hard and found the best prop for this matchup: I. Herrera over 4.5 Fantasy Score.. Prices move—always shop for the best number.

In their last five head-to-head matchups, the Diamondbacks have covered the spread in 60% of the games, with 60% of those games going over the total runs line.

ARI trend: The Diamondbacks have a 23–25 record against the spread (ATS) this season.

STL trend: The Cardinals hold a 24–18 record against the spread (ATS) this season.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

Arizona vs. St. Louis Odds

AI algorithm Remi is pouring through mountains of data points on each line. In fact, anytime the Arizona vs St. Louis trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme temps almost always follow normal, predictable betting trends.

Arizona vs St. Louis Opening Odds

ARI Moneyline: -104
STL Moneyline: -116
ARI Spread: -1.5
STL Spread: +1.5
Over/Under: 8

Arizona vs St. Louis Live Odds

Games PTS ML SPR O/U
Sep 27, 2025 1:06PM EDT
Baltimore Orioles
New York Yankees
9/27/25 1:06PM
Orioles
Yankees
+190
-235
+1.5 (-110)
-1.5 (-110)
O 8.5 (-120)
U 8.5 (+100)
Sep 27, 2025 2:21PM EDT
St Louis Cardinals
Chicago Cubs
9/27/25 2:21PM
Cardinals
Cubs
 
-180
 
-1.5 (+115)
O 9.5 (-105)
U 9.5 (-115)
Sep 27, 2025 3:09PM EDT
Tampa Bay Rays
Toronto Blue Jays
9/27/25 3:09PM
Rays
Blue Jays
+130
-155
+1.5 (-155)
-1.5 (+130)
O 8.5 (-110)
U 8.5 (-110)
Sep 27, 2025 4:06PM EDT
Chicago White Sox
Washington Nationals
9/27/25 4:06PM
White Sox
Nationals
+100
-120
-1.5 (+165)
+1.5 (-200)
O 8.5 (-110)
U 8.5 (-110)
Sep 27, 2025 4:06PM EDT
Colorado Rockies
San Francisco Giants
9/27/25 4:06PM
Rockies
Giants
+185
-225
+1.5 (-110)
-1.5 (-110)
O 8 (-105)
U 8 (-115)
Sep 27, 2025 4:11PM EDT
New York Mets
Miami Marlins
9/27/25 4:11PM
Mets
Marlins
-130
+110
-1.5 (+125)
+1.5 (-150)
O 8 (-115)
U 8 (-105)
Sep 27, 2025 4:11PM EDT
Detroit Tigers
Boston Red Sox
9/27/25 4:11PM
Tigers
Red Sox
+125
-150
+1.5 (-180)
-1.5 (+150)
O 9 (+100)
U 9 (-120)
Sep 27, 2025 6:05PM EDT
Minnesota Twins
Philadelphia Phillies
9/27/25 6:05PM
Twins
Phillies
+170
-205
+1.5 (-120)
-1.5 (+100)
O 8.5 (-115)
U 8.5 (-105)
Sep 27, 2025 7:11PM EDT
Cincinnati Reds
Milwaukee Brewers
9/27/25 7:11PM
Reds
Brewers
+125
-150
+1.5 (-180)
-1.5 (+150)
O 8 (-105)
U 8 (-115)
Sep 27, 2025 7:15PM EDT
Pittsburgh Pirates
Atlanta Braves
9/27/25 7:15PM
Pirates
Braves
+145
-175
+1.5 (-155)
-1.5 (+130)
O 8 (-110)
U 8 (-110)
Sep 27, 2025 7:16PM EDT
Texas Rangers
Cleveland Guardians
9/27/25 7:16PM
Rangers
Guardians
+135
-165
+1.5 (-180)
-1.5 (+150)
O 7 (-120)
U 7 (+100)
Sep 27, 2025 8:40PM EDT
Arizona Diamondbacks
San Diego Padres
9/27/25 8:40PM
Diamondbacks
Padres
+115
-140
+1.5 (-195)
-1.5 (+160)
O 7.5 (-120)
U 7.5 (+100)
Sep 27, 2025 9:39PM EDT
Houston Astros
Los Angeles Angels
9/27/25 9:39PM
Astros
Angels
-165
+135
-1.5 (+105)
+1.5 (-125)
O 9 (+100)
U 9 (-120)
Sep 27, 2025 9:41PM EDT
Los Angeles Dodgers
Seattle Mariners
9/27/25 9:41PM
Dodgers
Mariners
+105
-125
+1.5 (-205)
-1.5 (+170)
O 7.5 (+105)
U 7.5 (-125)
Sep 27, 2025 10:05PM EDT
Kansas City Royals
Oakland Athletics
9/27/25 10:05PM
Royals
Athletics
+100
-120
-1.5 (+150)
+1.5 (-180)
O 10 (-110)
U 10 (-110)

MLB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Arizona Diamondbacks vs. St. Louis Cardinals on May 24, 2025 at Busch Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN
CHC@SF CHC -105 54.1% 4 LOSS
NYY@CHW RYAN MCMAHON OVER 0.5 BASES 54.1% 4 WIN
PHI@NYM OVER 8.5 55.6% 4 LOSS
LAA@TEX LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS 54.1% 4 LOSS
KC@CHW KC -109 54.2% 4 WIN
SD@SEA DYLAN CEASE OVER 16.5 OUTS 53.9% 3 LOSS
SD@SEA UNDER 8.5 54.4% 4 LOSS
MIN@TOR JOE RYAN UNDER 2.5 EARNED RUNS 54.1% 4 LOSS
SF@MIL MIL +100 54.0% 6 LOSS
TOR@MIA MIA +1.5 62.0% 6 WIN
CHC@LAA OVER 9.5 54.9% 4 LOSS
BOS@NYY CARLOS RODON UNDER 4.5 HITS ALLOWED 54.2% 4 WIN
KC@DET DET -115 56.1% 5 WIN
CHC@LAA LAA +1.5 57.6% 5 LOSS
CIN@ARI KEBRYAN HAYES STRIKEOUTS UNDER 0.5 56.2% 6 WIN
LAD@SD SD +110 50.9% 6 WIN