Padres vs Blue Jays Prediction — AI Finds CAN'T MISS MLB Lines & Props (May 22)
Updated: 2025-05-20T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
On May 22, 2025, the San Diego Padres (27–20) will face the Toronto Blue Jays (24–24) at Rogers Centre, concluding their three-game interleague series. The Padres aim to snap a four-game losing streak, while the Blue Jays look to capitalize on their recent momentum.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

GAME INFO
Date: May 22, 2025
Start Time: 1:07 PM EST
Venue: Rogers Centre
Blue Jays Record: (24-24)
Padres Record: (27-20)
OPENING ODDS
SD Moneyline: -114
TOR Moneyline: -105
SD Spread: -1.5
TOR Spread: +1.5
Over/Under: 9
SD
Betting Trends
- The Padres have a 27–19 record against the spread (ATS) this season, reflecting strong performance in covering the spread.
TOR
Betting Trends
- The Blue Jays have a 7–3 ATS record over their last 10 games, indicating a positive trend in covering the spread.
MATCHUP TRENDS
- The total has gone OVER in 5 of the Blue Jays’ last 6 home games, suggesting a trend toward high-scoring contests at Rogers Centre.
SD vs. TOR
Best Prop Bet
- Remi's searched hard and found the best prop for this matchup: D. Varsho over 5 Fantasy Score.
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San Diego vs Toronto Prediction & Odds:
Free MLB Betting Insights for 5/22/25
Vladimir Guerrero Jr. continues to anchor the offense with a .287 batting average and has been especially effective in driving in runs during this recent hot streak, while Bo Bichette has been quietly productive in setting the table and flashing leather in the field. The Jays have averaged over five runs per game during their recent home stretch, with the total going OVER in five of their last six games at Rogers Centre—an indication that their bats are waking up in a big way. Bowden Francis is scheduled to start for Toronto and has emerged as a dependable mid-rotation piece, limiting walks and mixing pitches well to keep hitters off balance. If he can provide five or more solid innings, the Blue Jays’ bullpen—led by the likes of Jordan Romano and Erik Swanson—can close the door. Defensively, Toronto has been sharp, particularly on the infield where double plays and crisp positioning have saved their pitching staff from further trouble. For San Diego, this game is a must-win to avoid a sweep and reset their momentum before the pressure builds further in a competitive NL West. They’ll need Kolek to keep the game within reach and the offense to capitalize on early opportunities before Francis settles in. For Toronto, a win would push them above .500 and signal that their early-season struggles are firmly in the rearview mirror. With both teams fighting for critical positioning in their respective leagues, this game could be decided by whichever starting pitcher settles in quicker and which bullpen holds under pressure. Expect high energy, aggressive baserunning, and fireworks early as both squads look to send a message heading into the weekend.
Game 2 on deck. pic.twitter.com/yfh8SMn8n0
— San Diego Padres (@Padres) May 21, 2025
San Diego Padres MLB Preview
The San Diego Padres enter their May 22 series finale against the Toronto Blue Jays desperate to halt a sudden and frustrating slide that has seen them drop four straight games and slip to 27–20 on the season. After holding steady near the top of the National League West, the Padres are now dealing with the kind of adversity that tests the depth and resilience of any contending team. While the talent is certainly present, recent offensive inconsistency and over-reliance on their bullpen have put strain on a roster that has otherwise performed above expectations in 2025. Fernando Tatis Jr. continues to be a dynamic force, producing at the plate with power and speed, but the supporting cast has failed to maintain a consistent level of contribution. Manny Machado has had flashes of brilliance, but San Diego’s offense has too often stalled in key moments, especially with runners in scoring position during this losing streak. With several starters struggling to pitch deep into games, the bullpen has absorbed more innings than expected, and the wear is beginning to show in late-inning performance. Stephen Kolek is expected to get the start for the Padres, and while he has shown signs of promise, he’s yet to establish the kind of consistency needed from a rotation arm in a playoff-hopeful club.
Kolek has the stuff to succeed—particularly with his fastball-slider combination—but command and stamina remain question marks, especially against a Blue Jays lineup that has been heating up at home. For San Diego to break their skid, Kolek will need to manage traffic effectively, limit long innings, and hand off the game in manageable shape to the bullpen, which still features dependable late-inning arms like Robert Suarez and Wandy Peralta. The defense has remained reliable and has not been the issue during the recent skid, but without run support, the pressure on every pitch has increased exponentially. From a betting perspective, the Padres have a solid 27–19 ATS record this season, reflecting their overall competitiveness, but the margin for error has narrowed lately. A win in this game would not only avoid a sweep but also send a necessary jolt through a clubhouse that has been flat since returning to the road. San Diego needs more than just Tatis Jr. carrying the offense—they need depth hitters to step up and Kolek to show that he can hold his own under pressure in an interleague road environment. The Padres are still very much in playoff contention, but how they respond in this series finale could go a long way in shaping the next phase of their season. A bounce-back performance could halt the slide, restore some swagger, and remind the rest of the NL that this team has staying power beyond a hot start.

Credit: USA TODAY/IMAGN
Toronto Blue Jays MLB Preview
The Toronto Blue Jays head into the May 22 finale against the San Diego Padres with confidence and momentum as they look to wrap up the series with a statement win and push themselves above .500 for the first time in weeks. Now 24–24 after a steady stretch of six wins in their last ten games, the Blue Jays are beginning to find rhythm on both sides of the ball. Their offense has shown marked improvement, particularly at home, where they’ve averaged over five runs per game during this recent run. Vladimir Guerrero Jr. remains the focal point of the lineup, batting .287 with timely power and a growing presence in clutch situations. Alongside him, Bo Bichette has rediscovered his offensive groove, providing consistency at the plate and leadership on the field. Emerging contributors like Davis Schneider and Alejandro Kirk have also helped balance the lineup, offering Toronto the kind of depth that was lacking earlier in the year. The Blue Jays’ power resurgence at Rogers Centre is reflected in a betting trend that shows the total has gone OVER in five of their last six home games—proof that this ballclub is back to generating runs and turning their home park into a legitimate advantage. On the mound for this game will be Bowden Francis, a right-hander who has quietly become one of the more dependable arms in the rotation.
Francis isn’t overpowering, but he’s effective at locating his pitches, minimizing walks, and working efficiently through lineups. Against a San Diego team that has scored three runs or fewer in multiple games during their current four-game skid, Francis will be tasked with keeping the ball in play, forcing ground balls, and getting through at least five solid innings to turn things over to the bullpen. The Toronto bullpen, anchored by Jordan Romano and supported by arms like Erik Swanson and Yimi García, has been solid when pitching with a lead, and they’ll be expected to shut the door if given a cushion late. Defensively, the Blue Jays have cleaned up many of the errors that plagued them in April, with strong infield defense from Matt Chapman and Bichette backing up their pitchers in high-leverage spots. More importantly, manager John Schneider has found a better balance in lineup construction and bullpen usage, allowing the club to thrive in close games and outlast opponents in high-scoring affairs. A win in this game would give Toronto a valuable series victory over a tough National League opponent and send them into their next set of matchups with both confidence and forward momentum. With Bowden Francis on the mound, the offense hot, and the bullpen rested, the Blue Jays are well-positioned to take advantage of a struggling Padres team and continue climbing the American League standings. If the offense delivers early and Francis keeps the Padres in check, Toronto could walk away from this series as one of the more quietly dangerous teams heading into the heart of the 2025 season.
Goodnight, #BlueJays fans 💙
— Toronto Blue Jays (@BlueJays) May 22, 2025
Let's get the sweep tomorrow: https://t.co/wqm8hkrOLr pic.twitter.com/6AdTudk6hK
San Diego vs. Toronto Prop Picks (AI)
San Diego vs. Toronto Prediction (AI)

Remi, our AI sports genius, has been pouring over exorbitant amounts of data from every past game between the Padres and Blue Jays and using recursive machine learning and kick-ass AI to analyze the data to a single cover probability.
Remi has been most fixated on the linear correlation of factor emotional bettors often put on San Diego’s strength factors between a Padres team going up against a possibly deflated Blue Jays team. It appears the true game analytics might reflect a slight lean against one Vegas line in particular.
Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.
Below is our current AI San Diego vs Toronto picks, computer picks Padres vs Blue Jays, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
---|---|---|---|---|---|---|
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.
Padres Betting Trends
The Padres have a 27–19 record against the spread (ATS) this season, reflecting strong performance in covering the spread.
Blue Jays Betting Trends
The Blue Jays have a 7–3 ATS record over their last 10 games, indicating a positive trend in covering the spread.
Padres vs. Blue Jays Matchup Trends
The total has gone OVER in 5 of the Blue Jays’ last 6 home games, suggesting a trend toward high-scoring contests at Rogers Centre.
San Diego vs. Toronto Game Info
What time does San Diego vs Toronto start on May 22, 2025?
San Diego vs Toronto starts on May 22, 2025 at 1:07 PM EST.
Where is San Diego vs Toronto being played?
Venue: Rogers Centre.
What are the opening odds for San Diego vs Toronto?
Spread: Toronto +1.5
Moneyline: San Diego -114, Toronto -105
Over/Under: 9
What are the records for San Diego vs Toronto?
San Diego: (27-20) | Toronto: (24-24)
What is the AI best bet for San Diego vs Toronto?
Remi's searched hard and found the best prop for this matchup: D. Varsho over 5 Fantasy Score.. Prices move—always shop for the best number.
What are San Diego vs Toronto trending bets?
The total has gone OVER in 5 of the Blue Jays’ last 6 home games, suggesting a trend toward high-scoring contests at Rogers Centre.
What are San Diego trending bets?
SD trend: The Padres have a 27–19 record against the spread (ATS) this season, reflecting strong performance in covering the spread.
What are Toronto trending bets?
TOR trend: The Blue Jays have a 7–3 ATS record over their last 10 games, indicating a positive trend in covering the spread.
Where can I find AI Picks for San Diego vs Toronto?
See our latest MLB picks and odds pages for 2025 to compare prices before you bet.
San Diego vs. Toronto Odds
AI algorithm Remi is pouring through mountains of stats on each team. In fact, anytime the San Diego vs Toronto trends are analyzed, there’s always several intriguing trends to key in on. Not to mention games played at extreme temps can often follow normal, predictable betting trends.
San Diego vs Toronto Opening Odds
SD Moneyline:
-114 TOR Moneyline: -105
SD Spread: -1.5
TOR Spread: +1.5
Over/Under: 9
San Diego vs Toronto Live Odds
Games | PTS | ML | SPR | O/U | |
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Oct 19, 2025 8:04PM EDT
Seattle Mariners
Toronto Blue Jays
10/19/25 8:04PM
Mariners
Blue Jays
|
–
–
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+107
-128
|
+1.5 (-195)
-1.5 (+165)
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O 7.5 (-115)
U 7.5 (-105)
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MLB Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers San Diego Padres vs. Toronto Blue Jays on May 22, 2025 at Rogers Centre.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.
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LEAN | %WIN | UNITS | RESULT |
---|---|---|---|---|
TOR@SEA | OVER 7 | 54.9% | 3 | WIN |
LAD@MIL | UNDER 7.5 | 56.6% | 6 | WIN |
TOR@NYY | OVER 8 | 54.9% | 4 | WIN |
TOR@NYY | CARLOS RODON OVER 1.5 TOTAL WALKS ALLOWED | 53.3% | 3 | WIN |
NYY@TOR | OVER 7.5 | 54.8% | 2 | WIN |
LAD@PHI | OVER 7 | 53.8% | 3 | WIN |
SD@CHC | CHC -109 | 53.8% | 3 | WIN |
SD@CHC | OVER 7.5 | 54.5% | 4 | LOSS |
SD@CHC | CHC -111 | 54.8% | 4 | LOSS |
CIN@LAD | SHOHEI OHTANI OVER 1.5 BASES | 53.5% | 3 | WIN |
BOS@NYY | OVER 7 | 53.8% | 3 | LOSS |
CIN@LAD | ELLY DE LA CRUZ OVER 0.5 BASES | 54.4% | 4 | LOSS |
ARI@SD | SD -131 | 57.3% | 4 | WIN |
DET@BOS | BOS -115 | 56.4% | 5 | WIN |
NYM@CHC | NYM -110 | 54.1% | 3 | WIN |
HOU@ATH | ATH +118 | 50.8% | 4 | WIN |
NYM@CHC | OVER 7 | 54.5% | 3 | WIN |
STL@SF | OVER 7.5 | 55.9% | 5 | LOSS |
KC@LAA | TYLER TOLBERT UNDER 1.5 BASES | 54.4% | 4 | WIN |
MIL@SD | UNDER 9 | 54.7% | 4 | WIN |
MIA@PHI | KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS | 53.3% | 3 | WIN |
WAS@NYM | OVER 8.5 | 56.1% | 6 | LOSS |
LAA@COL | COL +108 | 50.5% | 3 | WIN |
TOR@KC | UNDER 9 | 54.7% | 4 | LOSS |
SEA@KC | KC +1.5 | 62.3% | 5 | LOSS |
NYY@MIN | OVER 9 | 55.1% | 4 | WIN |
MIA@COL | OVER 10.5 | 55.0% | 4 | WIN |
MIA@COL | AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS | 54.3% | 4 | WIN |
SEA@KC | BOBBY WITT UNDER 0.5 SINGLES | 54.4% | 4 | LOSS |
PHI@LAD | LAD -113 | 54.7% | 4 | LOSS |
NYY@BOS | OVER 7.5 | 54.3% | 3 | WIN |
KC@PHI | PHI -130 | 58.3% | 4 | WIN |
LAD@SF | OVER 7.5 | 54.7% | 4 | LOSS |
NYM@PHI | PHI -122 | 55.6% | 4 | WIN |
KC@CLE | KC -104 | 52.0% | 3 | WIN |
CIN@SD | JAKE CRONEWORTH OVER 0.5 HITS | 53.1% | 3 | WIN |
WAS@MIA | MIA -123 | 55.2% | 4 | LOSS |
LAA@KC | UNDER 9.5 | 54.9% | 3 | WIN |
TEX@ARI | UNDER 9 | 54.2% | 4 | WIN |
SF@COL | UNDER 11.5 | 56.4% | 6 | LOSS |
SF@COL | RAFAEL DEVERS OVER 1.5 BASES | 56.1% | 6 | WIN |
MIA@WAS | WAS -110 | 54.4% | 4 | WIN |
NYM@DET | OVER 8.5 | 54.5% | 4 | WIN |
TEX@ARI | UNDER 9.5 | 56.4% | 6 | WIN |
TEX@ARI | ALEJANDRO OSUNA UNDER 1.5 BASES | 54.1% | 4 | LOSS |
ATL@CHC | CHC -116 | 55.1% | 3 | WIN |
PHI@MIL | OVER 8.5 | 55.0% | 3 | WIN |
ARI@LAD | SHOHEI OHTANI OVER 2.5 BASES | 54.2% | 4 | WIN |
SEA@CLE | CLE +1.5 | 57.2% | 3 | WIN |
CHC@SF | CHC -105 | 54.1% | 4 | LOSS |
NYY@CHW | RYAN MCMAHON OVER 0.5 BASES | 54.1% | 4 | WIN |