Padres vs Blue Jays Prediction — AI Finds CAN'T MISS MLB Lines & Props (May 22)

Updated: 2025-05-20T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

On May 22, 2025, the San Diego Padres (27–20) will face the Toronto Blue Jays (24–24) at Rogers Centre, concluding their three-game interleague series. The Padres aim to snap a four-game losing streak, while the Blue Jays look to capitalize on their recent momentum.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: May 22, 2025

Start Time: 1:07 PM EST​

Venue: Rogers Centre​

Blue Jays Record: (24-24)

Padres Record: (27-20)

OPENING ODDS

SD Moneyline: -114

TOR Moneyline: -105

SD Spread: -1.5

TOR Spread: +1.5

Over/Under: 9

SD
Betting Trends

  • The Padres have a 27–19 record against the spread (ATS) this season, reflecting strong performance in covering the spread.

TOR
Betting Trends

  • The Blue Jays have a 7–3 ATS record over their last 10 games, indicating a positive trend in covering the spread.

MATCHUP TRENDS

  • The total has gone OVER in 5 of the Blue Jays’ last 6 home games, suggesting a trend toward high-scoring contests at Rogers Centre.

SD vs. TOR
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: D. Varsho over 5 Fantasy Score.

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San Diego vs Toronto Prediction & Odds:
Free MLB Betting Insights for 5/22/25

The May 22, 2025 matchup between the San Diego Padres and the Toronto Blue Jays at Rogers Centre concludes an interleague series that has been a tale of two teams moving in opposite directions. The Padres enter the final game on a four-game losing streak that has dropped them to 27–20 and third in the National League West, a sudden skid for a club that had previously shown consistency on both sides of the ball. Their offense, built around stars like Fernando Tatis Jr. and Manny Machado, has recently fallen into a slump, struggling to produce timely hits despite maintaining decent contact rates. San Diego has relied heavily on its bullpen throughout the season, but their recent overuse has exposed cracks, particularly in late innings where leads have evaporated or deficits widened. Right-hander Stephen Kolek is expected to start for the Padres, a relative newcomer still seeking to establish consistency at the major league level. Kolek’s performance in this game is critical, not only for the series outcome but also for helping stabilize a rotation that’s struggled with depth. The Blue Jays, on the other hand, are back to .500 at 24–24 and trending upward after winning six of their last ten games, thanks to timely hitting and improved pitching.

Vladimir Guerrero Jr. continues to anchor the offense with a .287 batting average and has been especially effective in driving in runs during this recent hot streak, while Bo Bichette has been quietly productive in setting the table and flashing leather in the field. The Jays have averaged over five runs per game during their recent home stretch, with the total going OVER in five of their last six games at Rogers Centre—an indication that their bats are waking up in a big way. Bowden Francis is scheduled to start for Toronto and has emerged as a dependable mid-rotation piece, limiting walks and mixing pitches well to keep hitters off balance. If he can provide five or more solid innings, the Blue Jays’ bullpen—led by the likes of Jordan Romano and Erik Swanson—can close the door. Defensively, Toronto has been sharp, particularly on the infield where double plays and crisp positioning have saved their pitching staff from further trouble. For San Diego, this game is a must-win to avoid a sweep and reset their momentum before the pressure builds further in a competitive NL West. They’ll need Kolek to keep the game within reach and the offense to capitalize on early opportunities before Francis settles in. For Toronto, a win would push them above .500 and signal that their early-season struggles are firmly in the rearview mirror. With both teams fighting for critical positioning in their respective leagues, this game could be decided by whichever starting pitcher settles in quicker and which bullpen holds under pressure. Expect high energy, aggressive baserunning, and fireworks early as both squads look to send a message heading into the weekend.

San Diego Padres MLB Preview

The San Diego Padres enter their May 22 series finale against the Toronto Blue Jays desperate to halt a sudden and frustrating slide that has seen them drop four straight games and slip to 27–20 on the season. After holding steady near the top of the National League West, the Padres are now dealing with the kind of adversity that tests the depth and resilience of any contending team. While the talent is certainly present, recent offensive inconsistency and over-reliance on their bullpen have put strain on a roster that has otherwise performed above expectations in 2025. Fernando Tatis Jr. continues to be a dynamic force, producing at the plate with power and speed, but the supporting cast has failed to maintain a consistent level of contribution. Manny Machado has had flashes of brilliance, but San Diego’s offense has too often stalled in key moments, especially with runners in scoring position during this losing streak. With several starters struggling to pitch deep into games, the bullpen has absorbed more innings than expected, and the wear is beginning to show in late-inning performance. Stephen Kolek is expected to get the start for the Padres, and while he has shown signs of promise, he’s yet to establish the kind of consistency needed from a rotation arm in a playoff-hopeful club.

Kolek has the stuff to succeed—particularly with his fastball-slider combination—but command and stamina remain question marks, especially against a Blue Jays lineup that has been heating up at home. For San Diego to break their skid, Kolek will need to manage traffic effectively, limit long innings, and hand off the game in manageable shape to the bullpen, which still features dependable late-inning arms like Robert Suarez and Wandy Peralta. The defense has remained reliable and has not been the issue during the recent skid, but without run support, the pressure on every pitch has increased exponentially. From a betting perspective, the Padres have a solid 27–19 ATS record this season, reflecting their overall competitiveness, but the margin for error has narrowed lately. A win in this game would not only avoid a sweep but also send a necessary jolt through a clubhouse that has been flat since returning to the road. San Diego needs more than just Tatis Jr. carrying the offense—they need depth hitters to step up and Kolek to show that he can hold his own under pressure in an interleague road environment. The Padres are still very much in playoff contention, but how they respond in this series finale could go a long way in shaping the next phase of their season. A bounce-back performance could halt the slide, restore some swagger, and remind the rest of the NL that this team has staying power beyond a hot start.

On May 22, 2025, the San Diego Padres (27–20) will face the Toronto Blue Jays (24–24) at Rogers Centre, concluding their three-game interleague series. The Padres aim to snap a four-game losing streak, while the Blue Jays look to capitalize on their recent momentum. San Diego vs Toronto AI Prediction: Free MLB Betting Insights for May 22. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Toronto Blue Jays MLB Preview

The Toronto Blue Jays head into the May 22 finale against the San Diego Padres with confidence and momentum as they look to wrap up the series with a statement win and push themselves above .500 for the first time in weeks. Now 24–24 after a steady stretch of six wins in their last ten games, the Blue Jays are beginning to find rhythm on both sides of the ball. Their offense has shown marked improvement, particularly at home, where they’ve averaged over five runs per game during this recent run. Vladimir Guerrero Jr. remains the focal point of the lineup, batting .287 with timely power and a growing presence in clutch situations. Alongside him, Bo Bichette has rediscovered his offensive groove, providing consistency at the plate and leadership on the field. Emerging contributors like Davis Schneider and Alejandro Kirk have also helped balance the lineup, offering Toronto the kind of depth that was lacking earlier in the year. The Blue Jays’ power resurgence at Rogers Centre is reflected in a betting trend that shows the total has gone OVER in five of their last six home games—proof that this ballclub is back to generating runs and turning their home park into a legitimate advantage. On the mound for this game will be Bowden Francis, a right-hander who has quietly become one of the more dependable arms in the rotation.

Francis isn’t overpowering, but he’s effective at locating his pitches, minimizing walks, and working efficiently through lineups. Against a San Diego team that has scored three runs or fewer in multiple games during their current four-game skid, Francis will be tasked with keeping the ball in play, forcing ground balls, and getting through at least five solid innings to turn things over to the bullpen. The Toronto bullpen, anchored by Jordan Romano and supported by arms like Erik Swanson and Yimi García, has been solid when pitching with a lead, and they’ll be expected to shut the door if given a cushion late. Defensively, the Blue Jays have cleaned up many of the errors that plagued them in April, with strong infield defense from Matt Chapman and Bichette backing up their pitchers in high-leverage spots. More importantly, manager John Schneider has found a better balance in lineup construction and bullpen usage, allowing the club to thrive in close games and outlast opponents in high-scoring affairs. A win in this game would give Toronto a valuable series victory over a tough National League opponent and send them into their next set of matchups with both confidence and forward momentum. With Bowden Francis on the mound, the offense hot, and the bullpen rested, the Blue Jays are well-positioned to take advantage of a struggling Padres team and continue climbing the American League standings. If the offense delivers early and Francis keeps the Padres in check, Toronto could walk away from this series as one of the more quietly dangerous teams heading into the heart of the 2025 season.

San Diego vs. Toronto Prop Picks (AI)

Remi is pouring through tons of data on each line. In fact, anytime the Padres and Blue Jays play there’s always several intriguing trends to key in on. Not to mention games played at Rogers Centre in May rarely follow normal, predictable patterns.
Remi's searched hard and found the best prop for this matchup: D. Varsho over 5 Fantasy Score.

San Diego vs. Toronto Prediction (AI)

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Remi, our AI sports genius, has been pouring over exorbitant amounts of data from every past game between the Padres and Blue Jays and using recursive machine learning and kick-ass AI to analyze the data to a single cover probability.

Remi has been most fixated on the linear correlation of factor emotional bettors often put on San Diego’s strength factors between a Padres team going up against a possibly deflated Blue Jays team. It appears the true game analytics might reflect a slight lean against one Vegas line in particular.

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Below is our current AI San Diego vs Toronto picks, computer picks Padres vs Blue Jays, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.

Padres Betting Trends

The Padres have a 27–19 record against the spread (ATS) this season, reflecting strong performance in covering the spread.

Blue Jays Betting Trends

The Blue Jays have a 7–3 ATS record over their last 10 games, indicating a positive trend in covering the spread.

Padres vs. Blue Jays Matchup Trends

The total has gone OVER in 5 of the Blue Jays’ last 6 home games, suggesting a trend toward high-scoring contests at Rogers Centre.

San Diego vs. Toronto Game Info

San Diego vs Toronto starts on May 22, 2025 at 1:07 PM EST.

Spread: Toronto +1.5
Moneyline: San Diego -114, Toronto -105
Over/Under: 9

San Diego: (27-20)  |  Toronto: (24-24)

Remi's searched hard and found the best prop for this matchup: D. Varsho over 5 Fantasy Score.. Prices move—always shop for the best number.

The total has gone OVER in 5 of the Blue Jays’ last 6 home games, suggesting a trend toward high-scoring contests at Rogers Centre.

SD trend: The Padres have a 27–19 record against the spread (ATS) this season, reflecting strong performance in covering the spread.

TOR trend: The Blue Jays have a 7–3 ATS record over their last 10 games, indicating a positive trend in covering the spread.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

San Diego vs. Toronto Odds

AI algorithm Remi is pouring through mountains of stats on each team. In fact, anytime the San Diego vs Toronto trends are analyzed, there’s always several intriguing trends to key in on. Not to mention games played at extreme temps can often follow normal, predictable betting trends.

San Diego vs Toronto Opening Odds

SD Moneyline: -114
TOR Moneyline: -105
SD Spread: -1.5
TOR Spread: +1.5
Over/Under: 9

San Diego vs Toronto Live Odds

Games PTS ML SPR O/U
Oct 19, 2025 8:04PM EDT
Seattle Mariners
Toronto Blue Jays
10/19/25 8:04PM
Mariners
Blue Jays
+107
-128
+1.5 (-195)
-1.5 (+165)
O 7.5 (-115)
U 7.5 (-105)

MLB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers San Diego Padres vs. Toronto Blue Jays on May 22, 2025 at Rogers Centre.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
TOR@SEA OVER 7 54.9% 3 WIN
LAD@MIL UNDER 7.5 56.6% 6 WIN
TOR@NYY OVER 8 54.9% 4 WIN
TOR@NYY CARLOS RODON OVER 1.5 TOTAL WALKS ALLOWED 53.3% 3 WIN
NYY@TOR OVER 7.5 54.8% 2 WIN
LAD@PHI OVER 7 53.8% 3 WIN
SD@CHC CHC -109 53.8% 3 WIN
SD@CHC OVER 7.5 54.5% 4 LOSS
SD@CHC CHC -111 54.8% 4 LOSS
CIN@LAD SHOHEI OHTANI OVER 1.5 BASES 53.5% 3 WIN
BOS@NYY OVER 7 53.8% 3 LOSS
CIN@LAD ELLY DE LA CRUZ OVER 0.5 BASES 54.4% 4 LOSS
ARI@SD SD -131 57.3% 4 WIN
DET@BOS BOS -115 56.4% 5 WIN
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN
CHC@SF CHC -105 54.1% 4 LOSS
NYY@CHW RYAN MCMAHON OVER 0.5 BASES 54.1% 4 WIN