Angels vs. Athletics
Prediction, Odds & Props
May 22 | MLB AI Picks

Updated: 2025-05-20T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

On May 22, 2025, the Los Angeles Angels (18–25) will face the Oakland Athletics (22–27) at Sutter Health Park in Sacramento, concluding their four-game series. The Angels aim to secure a series split, while the Athletics look to capitalize on their home-field advantage to clinch the series.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: May 22, 2025

Start Time: 3:35 PM EST​

Venue: Sutter Health Park​

Athletics Record: (22-28)

Angels Record: (23-25)

OPENING ODDS

LAA Moneyline: +132

ATH Moneyline: -157

LAA Spread: +1.5

ATH Spread: -1.5

Over/Under: 10

LAA
Betting Trends

  • The Angels have covered the spread in 4 of their last 5 games, showing a profit of 3.01 units.

ATH
Betting Trends

  • The Athletics have a 4–6 record against the spread over their past 10 games.

MATCHUP TRENDS

  • The total has gone OVER in 7 of the Athletics’ last 10 games, indicating a trend toward high-scoring contests.

LAA vs. ATH
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: T. Ward over 5.5 Fantasy Score.

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Los Angeles Angels vs Athletics Prediction & Odds:
Free MLB Betting Insights for 5/22/25

The May 22, 2025 matchup between the Los Angeles Angels and the Oakland Athletics at Sutter Health Park wraps up a competitive four-game AL West series with both teams fighting for momentum amid up-and-down seasons. The Angels enter the contest at 18–25, looking to secure a series split and bounce back from a stretch of inconsistencies that have held them near the bottom of the division. Despite the losing record, Los Angeles has shown some encouraging signs, especially at the plate, where Taylor Ward has emerged as the team’s most reliable offensive weapon. Ward enters the finale with 12 home runs and 25 RBIs, providing much-needed middle-of-the-order production. The Angels have covered the spread in 4 of their last 5 games, indicating a trend of improved competitiveness despite their overall record. On the mound, Los Angeles will look to get stability from its starter early, aiming to limit damage and avoid the kind of bullpen overexposure that has hampered them in previous games. The Athletics, meanwhile, hold a 22–27 record and are fighting to remain relevant in the AL West despite serious pitching issues and lingering injuries. Oakland has a 4–6 ATS record over its last 10 games and has allowed an alarming 7.41 ERA during that stretch.

The rotation has struggled to pitch deep into games, and the bullpen has been inconsistent, forcing the offense to carry more than its fair share of the burden. Offensively, the A’s have averaged 4 runs per game behind the efforts of Brent Rooker and Zack Gelof, two of the team’s most consistent run producers. Rooker’s power bat and Gelof’s on-base ability have been pivotal in keeping Oakland competitive even when their pitching falters. The total has gone OVER in 7 of their last 10 games, a testament to both their ability to generate offense and their inability to suppress it on the other end. Playing in front of their home crowd at Sutter Health Park, the Athletics will attempt to use the hitter-friendly conditions to their advantage and pressure an Angels team still struggling to find consistency. This game is a crucial opportunity for both clubs: the Angels need the win to avoid another series defeat and gain traction in the division, while the Athletics can notch a valuable series win that might help them reset after a rocky two-week stretch. With both teams showcasing offensive upside and significant pitching vulnerabilities, the conditions are ripe for another high-scoring affair. The key will be which team’s starter can navigate the early innings and hand a lead to a bullpen capable of closing the door. Expect aggressive baserunning, quick hooks for starting pitchers, and a focus on run prevention in what could be a chaotic and entertaining series finale. With neither side boasting dominant arms, the bats will likely dictate the outcome, and whichever team capitalizes on mistakes will have the upper hand in this all-important divisional matchup.

Los Angeles Angels Angels MLB Preview

The Los Angeles Angels head into the May 22 series finale against the Oakland Athletics looking to secure a much-needed split and continue building on what’s been an encouraging stretch of competitive play. Now 18–25, the Angels remain buried in the AL West standings, but they’ve covered the spread in four of their last five games, showing signs that the team is slowly beginning to stabilize after a rocky start to the season. Their offense has found life lately, thanks in large part to the emergence of Taylor Ward as the lineup’s most dependable threat. Ward leads the team with 12 home runs and 25 RBIs and has become the focal point of the Angels’ run production during a stretch where other stars have failed to produce consistently. His ability to handle both left- and right-handed pitching has made him a difficult matchup in the middle of the order, and his contributions will be key against an Oakland pitching staff that has surrendered a 7.41 ERA over its last 10 games. The Angels’ overall offensive average of 3.76 runs per game may not stand out, but recent games have been more productive, and they’re increasingly capitalizing on scoring opportunities. On the mound, Los Angeles will need its starter to give them quality innings—something the club has lacked consistently throughout the season.

Short starts have placed pressure on a bullpen that has actually performed better than expected in recent outings. The relievers have helped the team close out tight contests during this recent run, and the Angels’ improved ability to win close games could be a crucial edge in what’s expected to be a high-scoring series finale. Against an A’s team that has seen the total go OVER in seven of its last 10 games, the Angels’ hitters must remain aggressive early in counts and avoid the quiet innings that have derailed them in previous series. Los Angeles has been more disciplined at the plate of late, and if they can generate traffic and force Oakland into its bullpen early, they could be in a strong position to control the game. The Angels’ defense has also stepped up its game, with solid infield play helping to suppress some of the damage when contact is made, and catcher Logan O’Hoppe’s game-calling has improved the consistency of the pitching staff’s performance. Though the Angels are still far from being contenders, this game is an opportunity to continue the trend of forward progress and head into the next series with momentum. A win wouldn’t just secure a series split—it would mark another step toward relevance in a division where they cannot afford to fall further behind. For manager Ron Washington, the message will be simple: continue the offensive push, stay aggressive, and lean on the few reliable arms they’ve found to put away a vulnerable Oakland team that has shown it’s beatable when pressure is applied early and often.

On May 22, 2025, the Los Angeles Angels (18–25) will face the Oakland Athletics (22–27) at Sutter Health Park in Sacramento, concluding their four-game series. The Angels aim to secure a series split, while the Athletics look to capitalize on their home-field advantage to clinch the series. Los Angeles Angels vs Athletics AI Prediction: Free MLB Betting Insights for May 22. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Athletics Athletics MLB Preview

The Oakland Athletics enter the May 22 series finale against the Los Angeles Angels with a 22–27 record and a prime opportunity to secure a series win at Sutter Health Park. After trading blows with the Angels over the past three games, the A’s will look to capitalize on their home-field advantage and rising offensive production to close out the set on a high note. While the pitching staff has been their Achilles’ heel throughout the season, Oakland has managed to keep games competitive thanks to a lineup that’s quietly averaging 4 runs per game and producing timely hits from young cornerstones like Brent Rooker and Zack Gelof. Rooker continues to be one of the team’s most dangerous power threats, showing a solid blend of patience and slugging, while Gelof has emerged as an on-base machine and dependable run scorer. The team’s recent scoring output has helped compensate for a rotation that has posted a brutal 7.41 ERA over its last 10 games, with starters struggling to pitch deep and often handing off multi-run deficits to a thin bullpen. Injuries have only made matters worse, with several key contributors unavailable and depth pieces forced into elevated roles they’ve not consistently filled. As a result, manager Mark Kotsay has had to get creative with bullpen usage, defensive alignments, and lineup combinations in an effort to spark momentum.

Despite those challenges, the A’s are still fighting, keeping many of their recent games within reach, even if the final results haven’t always gone their way. Their 4–6 ATS record in their last 10 reflects that trend—competitive but inconsistent. One major betting trend that has continued is the OVER hitting in seven of their last 10 games, especially at home, where the offensive conditions have benefited both their lineup and their opponents. That trend is expected to hold with the Angels bringing a hot bat in Taylor Ward and a lineup that has started to show signs of waking up. To win this series finale, the Athletics will need a rare strong start from their rotation—something they haven’t received with any regularity. The starter must avoid high pitch counts and walks early while limiting extra-base hits from the heart of the Angels’ lineup. Offensively, Oakland’s goal will be to jump on fastballs early in counts, extend innings with smart baserunning, and force the Angels’ bullpen into action before the middle innings. Defensively, sharper infield execution and outfield communication will be vital in containing Los Angeles’ aggressive approach. A win in this game wouldn’t just deliver a series victory—it would mark a needed boost in morale for a team that has flirted with .500 despite its flaws. With pressure growing to show improvement beyond moral victories, the A’s must lean on their offensive strengths and play mistake-free baseball in this finale if they hope to build momentum heading into a crucial stretch of the season.

Los Angeles Angels vs. Athletics Prop Picks (AI)

Remi is pouring through mountains of datapoints on each line. In fact, anytime the Angels and Athletics play there’s always several intriguing trends to key in on. Not to mention games played at Sutter Health Park in May almost always follow normal, predictable patterns.
Remi's searched hard and found the best prop for this matchup: T. Ward over 5.5 Fantasy Score.

Los Angeles Angels vs. Athletics Prediction (AI)

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Remi, our AI sports wizard, has been pouring over mountains of data from every angle between the Angels and Athletics and using recursive machine learning and impressive AI to analyze the data to a single cover probability.

Remi has been most fixated on the trending factor knucklehead sportsbettors often put on player performance factors between a Angels team going up against a possibly deflated Athletics team. We’ve found the true game analytics might reflect a moderate lean against one Vegas line in particular.

Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.

Below is our current AI Los Angeles Angels vs Athletics picks, computer picks Angels vs Athletics, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
MLB 9/26 DET@BOS UNLOCK THIS PICK 5 EXECUTIVE Locked EXECUTIVE
MLB 9/26 BAL@NYY UNLOCK THIS PICK 4 INTEL Locked INTEL
MLB 9/26 ARI@SD UNLOCK THIS PICK 4 EXECUTIVE Locked EXECUTIVE
MLB 9/26 NYM@MIA UNLOCK THIS PICK 1 INTEL Locked INTEL
MLB 9/26 NYM@MIA GET FREE PICK NOW 1
MLB 9/26 COL@SF UNLOCK THIS PICK 0 INTEL Locked INTEL

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.

Angels Betting Trends

The Angels have covered the spread in 4 of their last 5 games, showing a profit of 3.01 units.

Athletics Betting Trends

The Athletics have a 4–6 record against the spread over their past 10 games.

Angels vs. Athletics Matchup Trends

The total has gone OVER in 7 of the Athletics’ last 10 games, indicating a trend toward high-scoring contests.

Los Angeles Angels vs. Athletics Game Info

Los Angeles Angels vs Athletics starts on May 22, 2025 at 3:35 PM EST.

Spread: Athletics -1.5
Moneyline: Los Angeles Angels +132, Athletics -157
Over/Under: 10

Los Angeles Angels: (23-25)  |  Athletics: (22-28)

Remi's searched hard and found the best prop for this matchup: T. Ward over 5.5 Fantasy Score.. Prices move—always shop for the best number.

The total has gone OVER in 7 of the Athletics’ last 10 games, indicating a trend toward high-scoring contests.

LAA trend: The Angels have covered the spread in 4 of their last 5 games, showing a profit of 3.01 units.

ATH trend: The Athletics have a 4–6 record against the spread over their past 10 games.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

Los Angeles Angels vs. Athletics Odds

AI algorithm Remi is pouring through mountains of data points on each line. In fact, anytime the Los Angeles Angels vs Athletics trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme hostile environments rarely follow normal, predictable patterns.

Los Angeles Angels vs Athletics Opening Odds

LAA Moneyline: +132
ATH Moneyline: -157
LAA Spread: +1.5
ATH Spread: -1.5
Over/Under: 10

Los Angeles Angels vs Athletics Live Odds

Games PTS ML SPR O/U
Sep 27, 2025 1:06PM EDT
Baltimore Orioles
New York Yankees
9/27/25 1:06PM
Orioles
Yankees
+190
-235
+1.5 (-110)
-1.5 (-110)
O 8.5 (-120)
U 8.5 (+100)
Sep 27, 2025 2:21PM EDT
St Louis Cardinals
Chicago Cubs
9/27/25 2:21PM
Cardinals
Cubs
 
-180
 
-1.5 (+115)
O 9.5 (-105)
U 9.5 (-115)
Sep 27, 2025 3:09PM EDT
Tampa Bay Rays
Toronto Blue Jays
9/27/25 3:09PM
Rays
Blue Jays
+130
-155
+1.5 (-155)
-1.5 (+130)
O 8.5 (-110)
U 8.5 (-110)
Sep 27, 2025 4:06PM EDT
Chicago White Sox
Washington Nationals
9/27/25 4:06PM
White Sox
Nationals
+100
-120
-1.5 (+165)
+1.5 (-200)
O 8.5 (-110)
U 8.5 (-110)
Sep 27, 2025 4:06PM EDT
Colorado Rockies
San Francisco Giants
9/27/25 4:06PM
Rockies
Giants
+185
-225
+1.5 (-110)
-1.5 (-110)
O 8 (-105)
U 8 (-115)
Sep 27, 2025 4:11PM EDT
New York Mets
Miami Marlins
9/27/25 4:11PM
Mets
Marlins
-130
+110
-1.5 (+125)
+1.5 (-150)
O 8 (-115)
U 8 (-105)
Sep 27, 2025 4:11PM EDT
Detroit Tigers
Boston Red Sox
9/27/25 4:11PM
Tigers
Red Sox
+125
-150
+1.5 (-180)
-1.5 (+150)
O 9 (+100)
U 9 (-120)
Sep 27, 2025 6:05PM EDT
Minnesota Twins
Philadelphia Phillies
9/27/25 6:05PM
Twins
Phillies
+170
-205
+1.5 (-120)
-1.5 (+100)
O 8.5 (-115)
U 8.5 (-105)
Sep 27, 2025 7:11PM EDT
Cincinnati Reds
Milwaukee Brewers
9/27/25 7:11PM
Reds
Brewers
+125
-150
+1.5 (-180)
-1.5 (+150)
O 8 (-105)
U 8 (-115)
Sep 27, 2025 7:15PM EDT
Pittsburgh Pirates
Atlanta Braves
9/27/25 7:15PM
Pirates
Braves
+145
-175
+1.5 (-155)
-1.5 (+130)
O 8 (-110)
U 8 (-110)
Sep 27, 2025 7:16PM EDT
Texas Rangers
Cleveland Guardians
9/27/25 7:16PM
Rangers
Guardians
+135
-165
+1.5 (-180)
-1.5 (+150)
O 7 (-120)
U 7 (+100)
Sep 27, 2025 8:40PM EDT
Arizona Diamondbacks
San Diego Padres
9/27/25 8:40PM
Diamondbacks
Padres
+115
-140
+1.5 (-195)
-1.5 (+160)
O 7.5 (-120)
U 7.5 (+100)
Sep 27, 2025 9:39PM EDT
Houston Astros
Los Angeles Angels
9/27/25 9:39PM
Astros
Angels
-165
+135
-1.5 (+105)
+1.5 (-125)
O 9 (+100)
U 9 (-120)
Sep 27, 2025 9:41PM EDT
Los Angeles Dodgers
Seattle Mariners
9/27/25 9:41PM
Dodgers
Mariners
+105
-125
+1.5 (-205)
-1.5 (+170)
O 7.5 (+105)
U 7.5 (-125)
Sep 27, 2025 10:05PM EDT
Kansas City Royals
Oakland Athletics
9/27/25 10:05PM
Royals
Athletics
+100
-120
-1.5 (+150)
+1.5 (-180)
O 10 (-110)
U 10 (-110)

MLB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Los Angeles Angels Angels vs. Athletics Athletics on May 22, 2025 at Sutter Health Park.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN
CHC@SF CHC -105 54.1% 4 LOSS
NYY@CHW RYAN MCMAHON OVER 0.5 BASES 54.1% 4 WIN
PHI@NYM OVER 8.5 55.6% 4 LOSS
LAA@TEX LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS 54.1% 4 LOSS
KC@CHW KC -109 54.2% 4 WIN
SD@SEA DYLAN CEASE OVER 16.5 OUTS 53.9% 3 LOSS
SD@SEA UNDER 8.5 54.4% 4 LOSS
MIN@TOR JOE RYAN UNDER 2.5 EARNED RUNS 54.1% 4 LOSS
SF@MIL MIL +100 54.0% 6 LOSS
TOR@MIA MIA +1.5 62.0% 6 WIN
CHC@LAA OVER 9.5 54.9% 4 LOSS
BOS@NYY CARLOS RODON UNDER 4.5 HITS ALLOWED 54.2% 4 WIN
KC@DET DET -115 56.1% 5 WIN
CHC@LAA LAA +1.5 57.6% 5 LOSS
CIN@ARI KEBRYAN HAYES STRIKEOUTS UNDER 0.5 56.2% 6 WIN
LAD@SD SD +110 50.9% 6 WIN