Cardinals vs. Royals
Prediction, Odds & Props
May 18 | MLB AI Picks

Updated: 2025-05-16T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The St. Louis Cardinals (25–20) and Kansas City Royals (25–21) conclude their three-game I-70 Series at Kauffman Stadium on Sunday, May 18, 2025. With the series tied at one game apiece, both teams aim to secure the series victory and gain momentum as they approach the season’s midpoint.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: May 18, 2025

Start Time: 2:10 PM EST​

Venue: Kauffman Stadium​

Royals Record: (25-22)

Cardinals Record: (26-20)

OPENING ODDS

STL Moneyline: -103

KC Moneyline: -116

STL Spread: -1.5

KC Spread: +1.5

Over/Under: 8.5

STL
Betting Trends

  • The Cardinals have covered the spread in 5 of their last 10 games, reflecting a 50% cover rate.

KC
Betting Trends

  • The Royals have covered the spread in 6 of their last 10 games, indicating a 60% cover rate.

MATCHUP TRENDS

  • In their last 10 head-to-head matchups, the Royals have covered the spread in 6 games, while the Cardinals have covered in 4. Additionally, the total has gone OVER in 7 of those 10 games, suggesting a trend toward higher-scoring contests between these teams.

STL vs. KC
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: W. Contreras over 5 Fantasy Score.

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St. Louis vs Kansas City Prediction & Odds:
Free MLB Betting Insights for 5/18/25

The St. Louis Cardinals and Kansas City Royals will meet on Sunday, May 18, 2025, in the rubber match of their I-70 Series at Kauffman Stadium, with both clubs entering the day near the top of their respective divisions and looking to build momentum in the tightly packed middle of the MLB season. The series is currently tied at one game apiece after the Royals evened things with a win on Saturday, setting the stage for a high-stakes finale between two evenly matched teams that share similar records and a shared regional rivalry. The Cardinals, sitting at 25–20, have leaned heavily on their veteran cornerstones Paul Goldschmidt and Nolan Arenado, who have combined for 22 home runs and 65 RBIs while continuing to play elite defense at their respective infield spots. St. Louis will send right-hander Andre Pallante to the mound for Sunday’s game, carrying a 3–2 record and a solid 3.45 ERA into the start, backed by his ability to keep the ball on the ground and manage contact effectively. Pallante’s sinker-heavy approach has helped him avoid big innings, and his success often hinges on staying ahead in counts and letting his infield defense—one of the best in baseball—do the heavy lifting. On the other side, the Royals match up with their own left-handed ace, Cole Ragans, who has emerged as one of the most consistent pitchers in the AL Central with a 4–3 record, 3.60 ERA, and impressive 9.5 strikeouts per nine innings.

Ragans will have his hands full with a Cardinals lineup that punishes mistakes, particularly with runners in scoring position, but his swing-and-miss stuff has proven effective against righty-heavy lineups like St. Louis. Kansas City’s offense is anchored by the electric Bobby Witt Jr., who continues to evolve into a franchise player with a .295 batting average, 11 home runs, and 33 RBIs while providing elite defense at shortstop and threat-level speed on the basepaths. Witt is supported by veteran catcher Salvador Perez, who remains a dangerous bat in the middle of the lineup with nine homers of his own and a knack for driving in runs in big moments. Both teams play fundamentally sound defense—the Cardinals lead with a .985 fielding percentage, closely followed by Kansas City at .983—and the bullpens are similarly reliable, with St. Louis holding a slight edge in ERA (3.80 to Kansas City’s 4.10). Offensively, this game could swing on whichever team gets the big hit with runners on base, and with both lineups capable of manufacturing runs or delivering with power, execution will be critical. Sunday’s finale is not just about winning a series; it’s about setting a tone for the weeks ahead, as both clubs face key divisional matchups and postseason positioning starts to come into focus. With local pride on the line and two competitive teams featuring a blend of veteran leadership and rising stars, fans can expect a well-played, tightly contested finale to one of MLB’s more underrated rivalries.

St. Louis Cardinals MLB Preview

The St. Louis Cardinals enter Sunday’s I-70 Series finale against the Kansas City Royals with a 25–20 record and a mission to bounce back from Saturday’s loss and secure a road series victory that would help them keep pace in the NL Central. After taking Friday’s opener, the Cardinals stumbled in Game 2 but remain one of the more balanced teams in the league, with solid pitching, consistent offensive output, and the kind of veteran leadership that allows them to rebound quickly from setbacks. Leading the way offensively are cornerstones Paul Goldschmidt and Nolan Arenado, who have combined for 22 home runs, 65 RBIs, and some of the most reliable middle-of-the-lineup production in baseball, while continuing to provide elite defense at first and third base, respectively. Goldschmidt, in particular, has been scorching, hitting .310 with 12 home runs and showing no signs of slowing down, while Arenado adds stability and pop with his .285 average and 10 long balls. Lars Nootbaar has added further depth, contributing eight home runs, 25 RBIs, and a .275 average, helping to round out a lineup that has the power to go deep and the discipline to grind out at-bats. On the mound, right-hander Andre Pallante will get the ball with a 3–2 record and a 3.45 ERA, showcasing a sinker-heavy arsenal that thrives on generating ground balls and keeping hitters off balance rather than overpowering them.

Pallante’s success has often come when he limits walks and works efficiently through the early innings, allowing the Cardinals’ strong infield defense to make plays behind him and keep pitch counts low. Defensively, the Cardinals remain among the league’s best with a .985 fielding percentage, and their ability to convert double plays and minimize miscues gives them a crucial edge in tight games. The bullpen has also played a key role in their early-season success, with a combined ERA of 3.80 and a dependable mix of strikeout arms and ground-ball specialists that have helped preserve narrow leads. As they prepare for a tough challenge against lefty Cole Ragans, who brings swing-and-miss stuff and has been dominant at times this year, the Cardinals will need to rely on their right-handed power and disciplined approach to generate scoring opportunities and support Pallante with early run support. Manager Oliver Marmol will also look for clean execution on the basepaths and timely two-out hitting, two elements that have helped St. Louis close out close games throughout the season. A win on Sunday would not only clinch the series on the road but also reinforce the Cardinals’ identity as a veteran club capable of handling business in tough environments, setting them up well for an upcoming stretch of key divisional games.

The St. Louis Cardinals (25–20) and Kansas City Royals (25–21) conclude their three-game I-70 Series at Kauffman Stadium on Sunday, May 18, 2025. With the series tied at one game apiece, both teams aim to secure the series victory and gain momentum as they approach the season’s midpoint. St. Louis vs Kansas City AI Prediction: Free MLB Betting Insights for May 18. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Kansas City Royals MLB Preview

The Kansas City Royals enter Sunday’s series finale at Kauffman Stadium with a 25–21 record and an opportunity to claim a home series win over their cross-state rivals, the St. Louis Cardinals, in what has become a tightly contested I-70 Series. After dropping the opener, the Royals bounced back on Saturday with a strong all-around performance and now look to continue their upward momentum behind left-hander Cole Ragans, who brings a 4–3 record and a 3.60 ERA into the start. Ragans has been one of Kansas City’s most consistent arms this season, averaging 9.5 strikeouts per nine innings while limiting hard contact with a well-located fastball and a sharp slider that’s been particularly tough on right-handed hitters. He’ll face a battle-tested Cardinals lineup that includes Paul Goldschmidt and Nolan Arenado, but Ragans has shown he can rise to the occasion, especially when backed by his home crowd and a defense that ranks among the best in the American League with a .983 fielding percentage. Offensively, the Royals have found their rhythm behind the breakout campaign of Bobby Witt Jr., who enters Sunday batting .295 with 11 home runs and 33 RBIs, while providing elite defense and game-changing speed on the bases.

Witt has set the tone at the top of the order, and his ability to create chaos with his legs and power has given Kansas City a dangerous weapon in close games. Veteran Salvador Perez continues to deliver in key moments as well, with a .270 average and 9 homers, anchoring the heart of the lineup with his leadership and clutch bat. The supporting cast, including MJ Melendez and Vinnie Pasquantino, has also chipped in with timely hits, giving the Royals one of the more well-rounded and quietly effective offenses in the AL Central. The bullpen has improved steadily over the past few weeks, lowering its ERA to 4.10 and showing more reliability in late-inning situations, which could be key in a game expected to be tightly contested. Manager Matt Quatraro has emphasized aggressive base running, quality at-bats, and pressure defense, all of which have helped the Royals stay competitive in tight matchups and secure wins in close contests. Sunday’s game offers a valuable opportunity not only to take the series from a potential playoff team but also to continue building momentum in a division that remains open behind the early-season leaders. With Ragans on the mound, Witt and Perez leading the charge, and the team playing sound baseball, the Royals have the tools to close out this rivalry series in front of a fired-up home crowd and push their record even further above .500 as they eye a strong summer run.

St. Louis vs. Kansas City Prop Picks (AI)

AI algorithm Remi is pouring through tons of data on each player. In fact, anytime the Cardinals and Royals play there’s always several intriguing observations to key in on. Not to mention games played at Kauffman Stadium in May almost always follow normal, predictable betting trends.
Remi's searched hard and found the best prop for this matchup: W. Contreras over 5 Fantasy Score.

St. Louis vs. Kansas City Prediction (AI)

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Remi, our AI sports algorithm, has been pouring over exorbitant amounts of data from every past game between the Cardinals and Royals and using recursive machine learning and kick-ass AI to crunch the data to a single cover probability.

The Algorithm has been most watching on the linear correlation of weight knucklehead sportsbettors tend to put on Kansas City’s strength factors between a Cardinals team going up against a possibly strong Royals team. Trends look to say the true game analytics might reflect a slight lean against one Vegas line in particular.

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Below is our current AI St. Louis vs Kansas City picks, computer picks Cardinals vs Royals, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
MLB 9/26 DET@BOS UNLOCK THIS PICK 5 EXECUTIVE Locked EXECUTIVE
MLB 9/26 BAL@NYY UNLOCK THIS PICK 4 INTEL Locked INTEL
MLB 9/26 ARI@SD UNLOCK THIS PICK 4 EXECUTIVE Locked EXECUTIVE
MLB 9/26 NYM@MIA UNLOCK THIS PICK 1 INTEL Locked INTEL
MLB 9/26 NYM@MIA GET FREE PICK NOW 1
MLB 9/26 COL@SF UNLOCK THIS PICK 0 INTEL Locked INTEL

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.

Cardinals Betting Trends

The Cardinals have covered the spread in 5 of their last 10 games, reflecting a 50% cover rate.

Royals Betting Trends

The Royals have covered the spread in 6 of their last 10 games, indicating a 60% cover rate.

Cardinals vs. Royals Matchup Trends

In their last 10 head-to-head matchups, the Royals have covered the spread in 6 games, while the Cardinals have covered in 4. Additionally, the total has gone OVER in 7 of those 10 games, suggesting a trend toward higher-scoring contests between these teams.

St. Louis vs. Kansas City Game Info

St. Louis vs Kansas City starts on May 18, 2025 at 2:10 PM EST.

Spread: Kansas City +1.5
Moneyline: St. Louis -103, Kansas City -116
Over/Under: 8.5

St. Louis: (26-20)  |  Kansas City: (25-22)

Remi's searched hard and found the best prop for this matchup: W. Contreras over 5 Fantasy Score.. Prices move—always shop for the best number.

In their last 10 head-to-head matchups, the Royals have covered the spread in 6 games, while the Cardinals have covered in 4. Additionally, the total has gone OVER in 7 of those 10 games, suggesting a trend toward higher-scoring contests between these teams.

STL trend: The Cardinals have covered the spread in 5 of their last 10 games, reflecting a 50% cover rate.

KC trend: The Royals have covered the spread in 6 of their last 10 games, indicating a 60% cover rate.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

St. Louis vs. Kansas City Odds

AI algorithm Remi is pouring through tons of data points on each team. In fact, anytime the St. Louis vs Kansas City trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme hostile environments seemingly never follow normal, predictable patterns.

St. Louis vs Kansas City Opening Odds

STL Moneyline: -103
KC Moneyline: -116
STL Spread: -1.5
KC Spread: +1.5
Over/Under: 8.5

St. Louis vs Kansas City Live Odds

Games PTS ML SPR O/U
Sep 27, 2025 1:06PM EDT
Baltimore Orioles
New York Yankees
9/27/25 1:06PM
Orioles
Yankees
+190
-235
+1.5 (-110)
-1.5 (-110)
O 8.5 (-120)
U 8.5 (+100)
Sep 27, 2025 2:21PM EDT
St Louis Cardinals
Chicago Cubs
9/27/25 2:21PM
Cardinals
Cubs
 
-180
 
-1.5 (+115)
O 9.5 (-105)
U 9.5 (-115)
Sep 27, 2025 3:09PM EDT
Tampa Bay Rays
Toronto Blue Jays
9/27/25 3:09PM
Rays
Blue Jays
+130
-155
+1.5 (-155)
-1.5 (+130)
O 8.5 (-110)
U 8.5 (-110)
Sep 27, 2025 4:06PM EDT
Chicago White Sox
Washington Nationals
9/27/25 4:06PM
White Sox
Nationals
+100
-120
-1.5 (+165)
+1.5 (-200)
O 8.5 (-110)
U 8.5 (-110)
Sep 27, 2025 4:06PM EDT
Colorado Rockies
San Francisco Giants
9/27/25 4:06PM
Rockies
Giants
+185
-225
+1.5 (-110)
-1.5 (-110)
O 8 (-105)
U 8 (-115)
Sep 27, 2025 4:11PM EDT
New York Mets
Miami Marlins
9/27/25 4:11PM
Mets
Marlins
-130
+110
-1.5 (+125)
+1.5 (-150)
O 8 (-115)
U 8 (-105)
Sep 27, 2025 4:11PM EDT
Detroit Tigers
Boston Red Sox
9/27/25 4:11PM
Tigers
Red Sox
+125
-150
+1.5 (-180)
-1.5 (+150)
O 9 (+100)
U 9 (-120)
Sep 27, 2025 6:05PM EDT
Minnesota Twins
Philadelphia Phillies
9/27/25 6:05PM
Twins
Phillies
+170
-205
+1.5 (-120)
-1.5 (+100)
O 8.5 (-115)
U 8.5 (-105)
Sep 27, 2025 7:11PM EDT
Cincinnati Reds
Milwaukee Brewers
9/27/25 7:11PM
Reds
Brewers
+125
-150
+1.5 (-180)
-1.5 (+150)
O 8 (-105)
U 8 (-115)
Sep 27, 2025 7:15PM EDT
Pittsburgh Pirates
Atlanta Braves
9/27/25 7:15PM
Pirates
Braves
+145
-175
+1.5 (-155)
-1.5 (+130)
O 8 (-110)
U 8 (-110)
Sep 27, 2025 7:16PM EDT
Texas Rangers
Cleveland Guardians
9/27/25 7:16PM
Rangers
Guardians
+135
-165
+1.5 (-180)
-1.5 (+150)
O 7 (-120)
U 7 (+100)
Sep 27, 2025 8:40PM EDT
Arizona Diamondbacks
San Diego Padres
9/27/25 8:40PM
Diamondbacks
Padres
+115
-140
+1.5 (-195)
-1.5 (+160)
O 7.5 (-120)
U 7.5 (+100)
Sep 27, 2025 9:39PM EDT
Houston Astros
Los Angeles Angels
9/27/25 9:39PM
Astros
Angels
-165
+135
-1.5 (+105)
+1.5 (-125)
O 9 (+100)
U 9 (-120)
Sep 27, 2025 9:41PM EDT
Los Angeles Dodgers
Seattle Mariners
9/27/25 9:41PM
Dodgers
Mariners
+105
-125
+1.5 (-205)
-1.5 (+170)
O 7.5 (+105)
U 7.5 (-125)
Sep 27, 2025 10:05PM EDT
Kansas City Royals
Oakland Athletics
9/27/25 10:05PM
Royals
Athletics
+100
-120
-1.5 (+150)
+1.5 (-180)
O 10 (-110)
U 10 (-110)

MLB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers St. Louis Cardinals vs. Kansas City Royals on May 18, 2025 at Kauffman Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN
CHC@SF CHC -105 54.1% 4 LOSS
NYY@CHW RYAN MCMAHON OVER 0.5 BASES 54.1% 4 WIN
PHI@NYM OVER 8.5 55.6% 4 LOSS
LAA@TEX LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS 54.1% 4 LOSS
KC@CHW KC -109 54.2% 4 WIN
SD@SEA DYLAN CEASE OVER 16.5 OUTS 53.9% 3 LOSS
SD@SEA UNDER 8.5 54.4% 4 LOSS
MIN@TOR JOE RYAN UNDER 2.5 EARNED RUNS 54.1% 4 LOSS
SF@MIL MIL +100 54.0% 6 LOSS
TOR@MIA MIA +1.5 62.0% 6 WIN
CHC@LAA OVER 9.5 54.9% 4 LOSS
BOS@NYY CARLOS RODON UNDER 4.5 HITS ALLOWED 54.2% 4 WIN
KC@DET DET -115 56.1% 5 WIN
CHC@LAA LAA +1.5 57.6% 5 LOSS
CIN@ARI KEBRYAN HAYES STRIKEOUTS UNDER 0.5 56.2% 6 WIN
LAD@SD SD +110 50.9% 6 WIN