Mariners vs. Padres
Prediction, Odds & Props
May 18 | MLB AI Picks

Updated: 2025-05-16T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The Seattle Mariners and San Diego Padres conclude their three-game series at Petco Park on Sunday, May 18, 2025, with first pitch scheduled for 4:10 PM ET. The Mariners aim for a series sweep, while the Padres look to salvage the finale and avoid a three-game skid.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: May 18, 2025

Start Time: 4:10 PM EST​

Venue: Petco Park​

Padres Record: (27-17)

Mariners Record: (25-19)

OPENING ODDS

SEA Moneyline: +120

SD Moneyline: -142

SEA Spread: +1.5

SD Spread: -1.5

Over/Under: 7.5

SEA
Betting Trends

  • The Mariners have covered the spread in 4 of their last 6 games, indicating a 66.7% cover rate.

SD
Betting Trends

  • The Padres have covered the spread in 3 of their last 5 home games, reflecting a 60% cover rate at Petco Park.

MATCHUP TRENDS

  • In their last 5 head-to-head matchups, the Mariners have covered the spread in 3 games, while the Padres have covered in 2. Additionally, the total has gone UNDER in 4 of those 5 games, suggesting a trend toward lower-scoring contests between these teams.

SEA vs. SD
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: C. Raleigh over 4.5 Fantasy Score.

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Seattle vs San Diego Prediction & Odds:
Free MLB Betting Insights for 5/18/25

The Seattle Mariners and San Diego Padres wrap up their three-game interleague series on Sunday, May 18, 2025, at Petco Park, with the Mariners looking to complete a series sweep and build momentum after a difficult stretch, while the Padres aim to salvage the finale and avoid their third straight home loss. Seattle has controlled the first two games of the series with a combination of dominant pitching, clutch hitting, and disciplined at-bats, winning 6–1 and 4–1 while showcasing the formula that made them early-season contenders in the AL West. In the second game, Emerson Hancock delivered his best outing of the season, reaching 97.6 mph on his fastball and navigating San Diego’s toughest hitters—including Manny Machado—with precision and confidence, allowing just one run through six innings and setting the tone for the bullpen. On the offensive side, catcher Cal Raleigh has continued his breakout campaign, hitting a go-ahead home run and showing advanced plate discipline with multiple walks, while Julio Rodríguez and J.P. Crawford have contributed with timely hits and pressure on the basepaths. The Mariners’ bullpen has been another key factor, with lefty Gabe Speier, right-hander Matt Brash, and middle reliever Casey Legumina bridging the gap to closer Andrés Muñoz, who has locked down late-inning opportunities with overpowering stuff and sharp command. Seattle has also shown its offensive versatility, adding late insurance runs by working counts and exploiting Padres pitching fatigue in the later innings.

San Diego, meanwhile, has seen its offense go cold at the wrong time, managing just two runs in the series despite a lineup packed with stars like Fernando Tatis Jr., Manny Machado, and Xander Bogaerts. Starter Nick Pivetta’s struggles with pitch efficiency in Game 2 forced an early exit and left the bullpen overexposed, while the offense failed to mount any sustained threats outside of scattered base runners. As the Padres hand the ball to Michael King in the finale, they’ll need more than just a quality start—they’ll need timely hits, better approaches with runners in scoring position, and sharper defensive execution, especially in the late innings. King, who has been reliable for most of the season, will look to reverse San Diego’s slide and contain a Mariners team that’s regained its confidence and swagger. The outcome of Sunday’s finale could swing momentum for both clubs as they approach the midpoint of the season: a sweep would give Seattle a much-needed boost heading into a difficult upcoming schedule, while a win for the Padres could steady the ship and help restore belief in their NL West campaign. With strong pitching matchups, superstar names on both sides, and contrasting recent form, the rubber match of the Vedder Cup series promises playoff-like energy and high-stakes execution between two teams hungry to prove they can consistently compete with the league’s best.

Seattle Mariners MLB Preview

The Seattle Mariners enter Sunday’s series finale at Petco Park with a 25–20 record and a golden opportunity to complete a three-game sweep over the San Diego Padres, a win that would not only cap off a strong rebound from a tough homestand but also send a message that this team is built to handle adversity and respond with poise. After back-to-back wins by scores of 6–1 and 4–1, the Mariners have outperformed the Padres in every phase—getting exceptional starting pitching, timely hitting, and sharp defense that has neutralized San Diego’s high-profile offense. In Game 2, Emerson Hancock delivered his best start of the season, touching 97.6 mph on the radar gun and limiting the Padres to just one run over six innings while striking out Manny Machado in a pivotal moment that set the tone for the rest of the game. Offensively, catcher Cal Raleigh continues to be a breakout star, blasting a go-ahead home run and drawing multiple walks to spark the lineup, while J.P. Crawford and Julio Rodríguez have supplied clutch hits and helped drive the team’s aggressive approach on the bases. The Mariners’ bullpen has been lights out in this series, with Gabe Speier, Matt Brash, Casey Legumina, and closer Andrés Muñoz all delivering clean innings and locking down leads without drama.

This resurgence from Seattle’s pitching staff is especially encouraging given the heavy workload they endured earlier in the month, and Sunday’s game presents a chance for the club to extend its dominance and return to the AL West with momentum firmly in hand. Offensively, Seattle has also benefited from better pitch selection and execution in big moments, showing an ability to string together walks, opposite-field hits, and deep counts to wear down Padres starters and break games open late. Manager Scott Servais has preached patience and balance at the plate, and the team is responding with more consistency from top to bottom of the order. If the Mariners can get another quality outing on Sunday—whether from a spot starter or bullpen game—their bullpen depth and surging offense give them the edge in the finale. With the club finding success through contributions from both veterans and rising stars, the Mariners have the tools to make this a statement win and continue proving they’re more than just a pitching-first team. A sweep at Petco Park would not only cap a dominant weekend but also reinforce Seattle’s status as a team capable of competing with any lineup in either league, provided they maintain the balance, discipline, and execution they’ve displayed over the last two games.

The Seattle Mariners and San Diego Padres conclude their three-game series at Petco Park on Sunday, May 18, 2025, with first pitch scheduled for 4:10 PM ET. The Mariners aim for a series sweep, while the Padres look to salvage the finale and avoid a three-game skid. Seattle vs San Diego AI Prediction: Free MLB Betting Insights for May 18. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

San Diego Padres MLB Preview

The San Diego Padres enter Sunday’s series finale at Petco Park with a 27–20 record and in need of a bounce-back performance to avoid a sweep at the hands of the Seattle Mariners, who have dictated the pace in the first two games of the series with dominant pitching and timely execution. The Padres’ offense, which has generally been a strength in 2025, has been quieted by Seattle’s rotation and bullpen, managing just two total runs over the last 18 innings and struggling to cash in on limited scoring opportunities. In Game 2, starter Nick Pivetta lasted only 4.1 innings after seeing his pitch count spike early, forcing the bullpen into another extended outing that ended with a 4–1 defeat despite some hard-hit outs and scattered base runners. Fernando Tatis Jr. and Manny Machado have both been contained effectively this weekend, and while Xander Bogaerts and Jake Cronenworth have chipped in singles and walks, the lack of extra-base hits and overall traffic has made it difficult for San Diego to apply sustained pressure. Heading into Sunday’s matchup, right-hander Michael King will get the start, bringing a mid-3.00s ERA and solid strikeout numbers, and he’ll be tasked with slowing down a Mariners team that has consistently found ways to score late in games by grinding out at-bats and putting pressure on opposing bullpens.

King has been reliable this season when ahead in counts, using a mix of fastball, cutter, and changeup to neutralize both lefties and righties, but he’ll need to work efficiently and avoid deep counts if the Padres want to stay in control early. The Padres’ bullpen, which includes Robert Suarez and Wandy Peralta, has been solid overall but has struggled when forced into early action, and the team’s recent trend of short starts has taxed the middle relief core. Defensively, San Diego has been clean this series, with no errors and solid infield positioning, but the lack of run support has made even minor lapses feel magnified. Manager Mike Shildt will be looking for more energy and urgency at the plate, particularly from the top of the order, where Tatis and Ha-Seong Kim need to get on base to create RBI chances for the middle bats. A win on Sunday would stop a three-game skid and reestablish the Padres’ confidence before heading back into division play, and with King on the mound and their full bullpen available, the blueprint is clear: control the tempo early, score first, and avoid the mental and physical fatigue that has plagued them over the last 48 hours. If San Diego can break through early and force the Mariners into a bullpen scramble, they’ll have a strong chance to close out the series on a high note and remind the league why they remain a serious contender in the National League.

Seattle vs. San Diego Prop Picks (AI)

AI algorithm Remi is pouring through loads of stats on each team. In fact, anytime the Mariners and Padres play there’s always several intriguing observations to key in on. Not to mention games played at Petco Park in May rarely follow normal, predictable betting trends.
Remi's searched hard and found the best prop for this matchup: C. Raleigh over 4.5 Fantasy Score.

Seattle vs. San Diego Prediction (AI)

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Remi, our AI sports genius, has been pouring over mountains of data from every past game between the Mariners and Padres and using recursive machine learning and kick-ass AI to analyze the data to a single cover probability.

Interestingly enough, the data has been most focused on the growing weight emotional bettors regularly put on player performance factors between a Mariners team going up against a possibly deflated Padres team. We’ve found the true game analytics appear to reflect a moderate lean against one Vegas line specifically.

Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.

Below is our current AI Seattle vs San Diego picks, computer picks Mariners vs Padres, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
MLB 9/26 DET@BOS UNLOCK THIS PICK 5 EXECUTIVE Locked EXECUTIVE
MLB 9/26 BAL@NYY UNLOCK THIS PICK 4 INTEL Locked INTEL
MLB 9/26 ARI@SD UNLOCK THIS PICK 4 EXECUTIVE Locked EXECUTIVE
MLB 9/26 NYM@MIA UNLOCK THIS PICK 1 INTEL Locked INTEL
MLB 9/26 NYM@MIA GET FREE PICK NOW 1
MLB 9/26 COL@SF UNLOCK THIS PICK 0 INTEL Locked INTEL

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.

Mariners Betting Trends

The Mariners have covered the spread in 4 of their last 6 games, indicating a 66.7% cover rate.

Padres Betting Trends

The Padres have covered the spread in 3 of their last 5 home games, reflecting a 60% cover rate at Petco Park.

Mariners vs. Padres Matchup Trends

In their last 5 head-to-head matchups, the Mariners have covered the spread in 3 games, while the Padres have covered in 2. Additionally, the total has gone UNDER in 4 of those 5 games, suggesting a trend toward lower-scoring contests between these teams.

Seattle vs. San Diego Game Info

Seattle vs San Diego starts on May 18, 2025 at 4:10 PM EST.

Spread: San Diego -1.5
Moneyline: Seattle +120, San Diego -142
Over/Under: 7.5

Seattle: (25-19)  |  San Diego: (27-17)

Remi's searched hard and found the best prop for this matchup: C. Raleigh over 4.5 Fantasy Score.. Prices move—always shop for the best number.

In their last 5 head-to-head matchups, the Mariners have covered the spread in 3 games, while the Padres have covered in 2. Additionally, the total has gone UNDER in 4 of those 5 games, suggesting a trend toward lower-scoring contests between these teams.

SEA trend: The Mariners have covered the spread in 4 of their last 6 games, indicating a 66.7% cover rate.

SD trend: The Padres have covered the spread in 3 of their last 5 home games, reflecting a 60% cover rate at Petco Park.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

Seattle vs. San Diego Odds

AI algorithm Remi is pouring through loads of data points on each team. In fact, anytime the Seattle vs San Diego trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme travel distance rarely follow normal, predictable patterns.

Seattle vs San Diego Opening Odds

SEA Moneyline: +120
SD Moneyline: -142
SEA Spread: +1.5
SD Spread: -1.5
Over/Under: 7.5

Seattle vs San Diego Live Odds

Games PTS ML SPR O/U
Sep 27, 2025 1:06PM EDT
Baltimore Orioles
New York Yankees
9/27/25 1:06PM
Orioles
Yankees
+190
-235
+1.5 (-110)
-1.5 (-110)
O 8.5 (-120)
U 8.5 (+100)
Sep 27, 2025 2:21PM EDT
St Louis Cardinals
Chicago Cubs
9/27/25 2:21PM
Cardinals
Cubs
 
-175
 
-1.5 (+115)
O 9.5 (-105)
U 9.5 (-115)
Sep 27, 2025 3:09PM EDT
Tampa Bay Rays
Toronto Blue Jays
9/27/25 3:09PM
Rays
Blue Jays
+130
-155
+1.5 (-155)
-1.5 (+130)
O 8.5 (-110)
U 8.5 (-110)
Sep 27, 2025 4:06PM EDT
Chicago White Sox
Washington Nationals
9/27/25 4:06PM
White Sox
Nationals
+100
-120
-1.5 (+165)
+1.5 (-200)
O 8.5 (-110)
U 8.5 (-110)
Sep 27, 2025 4:06PM EDT
Colorado Rockies
San Francisco Giants
9/27/25 4:06PM
Rockies
Giants
+185
-225
+1.5 (-110)
-1.5 (-110)
O 8 (-105)
U 8 (-115)
Sep 27, 2025 4:11PM EDT
New York Mets
Miami Marlins
9/27/25 4:11PM
Mets
Marlins
-130
+110
-1.5 (+125)
+1.5 (-150)
O 8.5 (-105)
U 8.5 (-115)
Sep 27, 2025 6:05PM EDT
Minnesota Twins
Philadelphia Phillies
9/27/25 6:05PM
Twins
Phillies
+170
-205
+1.5 (-120)
-1.5 (+100)
O 8.5 (-115)
U 8.5 (-105)
Sep 27, 2025 7:11PM EDT
Cincinnati Reds
Milwaukee Brewers
9/27/25 7:11PM
Reds
Brewers
+125
-150
+1.5 (-180)
-1.5 (+150)
O 8 (-105)
U 8 (-115)
Sep 27, 2025 7:15PM EDT
Pittsburgh Pirates
Atlanta Braves
9/27/25 7:15PM
Pirates
Braves
+140
-170
+1.5 (-155)
-1.5 (+130)
O 8 (-110)
U 8 (-110)
Sep 27, 2025 7:16PM EDT
Texas Rangers
Cleveland Guardians
9/27/25 7:16PM
Rangers
Guardians
+135
-165
+1.5 (-180)
-1.5 (+150)
O 7 (-120)
U 7 (+100)
Sep 27, 2025 8:40PM EDT
Arizona Diamondbacks
San Diego Padres
9/27/25 8:40PM
Diamondbacks
Padres
+115
-140
+1.5 (-190)
-1.5 (+155)
O 7.5 (-120)
U 7.5 (+100)
Sep 27, 2025 9:39PM EDT
Houston Astros
Los Angeles Angels
9/27/25 9:39PM
Astros
Angels
-165
+135
-1.5 (+105)
+1.5 (-125)
O 9 (+100)
U 9 (-120)
Sep 27, 2025 9:41PM EDT
Los Angeles Dodgers
Seattle Mariners
9/27/25 9:41PM
Dodgers
Mariners
+100
-120
-1.5 (+170)
+1.5 (-205)
O 7.5 (-110)
U 7.5 (-110)
Sep 27, 2025 10:05PM EDT
Kansas City Royals
Oakland Athletics
9/27/25 10:05PM
Royals
Athletics
+100
-120
-1.5 (+150)
+1.5 (-180)
O 10 (-110)
U 10 (-110)

MLB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Seattle Mariners vs. San Diego Padres on May 18, 2025 at Petco Park.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN
CHC@SF CHC -105 54.1% 4 LOSS
NYY@CHW RYAN MCMAHON OVER 0.5 BASES 54.1% 4 WIN
PHI@NYM OVER 8.5 55.6% 4 LOSS
LAA@TEX LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS 54.1% 4 LOSS
KC@CHW KC -109 54.2% 4 WIN
SD@SEA DYLAN CEASE OVER 16.5 OUTS 53.9% 3 LOSS
SD@SEA UNDER 8.5 54.4% 4 LOSS
MIN@TOR JOE RYAN UNDER 2.5 EARNED RUNS 54.1% 4 LOSS
SF@MIL MIL +100 54.0% 6 LOSS
TOR@MIA MIA +1.5 62.0% 6 WIN
CHC@LAA OVER 9.5 54.9% 4 LOSS
BOS@NYY CARLOS RODON UNDER 4.5 HITS ALLOWED 54.2% 4 WIN
KC@DET DET -115 56.1% 5 WIN
CHC@LAA LAA +1.5 57.6% 5 LOSS
CIN@ARI KEBRYAN HAYES STRIKEOUTS UNDER 0.5 56.2% 6 WIN
LAD@SD SD +110 50.9% 6 WIN