Cardinals vs. Royals
Prediction, Odds & Props
May 17 | MLB AI Picks

Updated: 2025-05-15T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The St. Louis Cardinals and Kansas City Royals renew their I-70 Series rivalry on Saturday, May 17, 2025, at Kauffman Stadium. Both teams are in tight divisional races, with the Cardinals trailing the Chicago Cubs by one game in the NL Central and the Royals 4.5 games behind the Detroit Tigers in the AL Central.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: May 17, 2025

Start Time: 7:10 PM EST​

Venue: Kauffman Stadium​

Royals Record: (25-21)

Cardinals Record: (25-20)

OPENING ODDS

STL Moneyline: +105

KC Moneyline: -124

STL Spread: +1.5

KC Spread: -1.5

Over/Under: 8.5

STL
Betting Trends

  • The Cardinals have a 10–12 record on the road this season, reflecting challenges in away games.

KC
Betting Trends

  • The Royals hold a 13–9 record at home, showcasing strength at Kauffman Stadium.

MATCHUP TRENDS

  • The Cardinals’ road challenges contrast with the Royals’ solid home performance, suggesting a potential advantage for Kansas City in this matchup.

STL vs. KC
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: M. Mikolas over 2.5 Pitcher Strikeouts.

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St. Louis vs Kansas City Prediction & Odds:
Free MLB Betting Insights for 5/17/25

The St. Louis Cardinals and Kansas City Royals meet on Saturday, May 17, 2025, at Kauffman Stadium in a renewal of their cross-state rivalry known as the I-70 Series, a nod to the interstate that connects the two cities and the history that binds them, dating back to their memorable 1985 World Series encounter. This edition of the series arrives at a pivotal time for both clubs, each clinging to playoff aspirations in competitive divisions. The Cardinals, at 24–20, are just one game behind the NL Central-leading Cubs and have used a balanced attack of veteran leadership and emerging talent to stay firmly in the race. They’ve been consistent at home but less so on the road, holding a 10–12 away record, a point of concern as they venture into a hostile Kansas City environment. On the mound, they’ll send Andre Pallante to start, who is 3–2 with a 4.36 ERA through 43.1 innings and is coming off an efficient performance against Washington in which he allowed just two runs over 7.1 innings. Pallante’s sinker-heavy arsenal is built to induce ground balls, which plays well in spacious Kauffman Stadium. He’ll be challenged by a Royals lineup led by Bobby Witt Jr., whose blend of speed and pop makes him the most dynamic offensive threat on either roster. The Royals come in at 21–24, sitting 4.5 games behind the Tigers in the AL Central, and despite a sub-.500 record, they’ve been strong at home with a 13–9 mark at Kauffman Stadium.

Cole Ragans will start for Kansas City, entering with a 2–2 record and a 4.20 ERA along with 65 strikeouts, though he struggled in his last outing against Boston. Ragans has shown electric stuff at times, especially from the left side, and will look to bounce back in a pressure-filled divisional rivalry game. Offensively, the Royals have had to rely heavily on Witt Jr. with Salvador Perez aging and the rest of the lineup lacking consistency. Defensively, both teams are solid, with the Cardinals traditionally fielding one of the league’s sharpest infields and the Royals showing reliability, especially up the middle. Bullpen depth could prove critical late in the game, as the Cardinals have leaned on closer Ryan Helsley and setup arms to finish tight contests, while the Royals’ relief corps has been more erratic, surrendering leads in multiple late-inning scenarios. Saturday’s contest is more than just a mid-May interleague meeting—it’s a tone-setting moment for two teams trying to claw their way into more secure postseason contention. For the Cardinals, it’s about proving they can win key games on the road and keep pace in the division, while for the Royals, it’s a chance to claw back toward .500 and show they’re more than a middling team in transition. Expect a tightly played matchup with playoff-style urgency, emotional investment from both dugouts, and the kind of regional rivalry intensity that often elevates performance on both sides.

St. Louis Cardinals MLB Preview

The St. Louis Cardinals head into Saturday’s matchup against the Kansas City Royals with a 24–20 record, sitting just one game behind the division-leading Chicago Cubs and showcasing a blend of seasoned veterans and emerging contributors that has kept them firmly in the NL Central race. While their overall performance has been strong, their road record of 10–12 signals an area in need of improvement, particularly as they face a Royals team that has played well at home. Manager Oliver Marmol has relied heavily on the proven leadership and production of sluggers Nolan Arenado and Paul Goldschmidt, both of whom continue to deliver in key moments and anchor the middle of the lineup with power, plate discipline, and veteran poise. Arenado remains a defensive wizard at third base, while Goldschmidt provides timely extra-base hits and maintains one of the league’s most consistent bats. Complementing the veteran core, young outfielder Jordan Walker has emerged as a dynamic presence, bringing energy, athleticism, and run-producing capability in the lower half of the order. On the mound, Andre Pallante will get the start for St. Louis, entering with a 3–2 record and a 4.36 ERA across 43.1 innings of work. Pallante’s game relies on inducing ground balls through a heavy sinker-slider combo, and he’s coming off one of his best outings of the season—a 7.1-inning effort against Washington in which he allowed just two earned runs.

The Cardinals’ bullpen has also been a steady asset, led by closer Ryan Helsley, whose high-velocity fastball and sharp breaking pitches have helped lock down late leads and convert tight games into wins. Defensively, the Cardinals remain among the league’s most reliable units, known for limiting mistakes and converting routine plays into momentum-sustaining outs. This defensive backbone, combined with efficient pitching and timely offense, has allowed St. Louis to weather stretches of inconsistency and stay in the mix. Facing a Royals team that’s been more successful at home, the Cardinals will need a focused road effort—especially early—to avoid falling behind against a confident Kansas City squad. Marmol’s message to his players has remained consistent: play sharp, limit free passes, and capitalize on scoring chances. If Pallante can neutralize Bobby Witt Jr. and keep the ball in the park, the Cardinals’ offense has more than enough firepower to push past the Royals and keep pressure on the Cubs in the division. For a team with postseason expectations, games like these—interleague matchups against beatable but gritty opponents—become crucial to building consistency, proving road resilience, and gaining ground in what’s shaping up to be a tight NL Central race. With momentum from recent wins and a roster capable of handling high-pressure situations, the Cardinals approach Saturday’s contest as a business trip with clear stakes and a prime opportunity to further their divisional ambitions.

The St. Louis Cardinals and Kansas City Royals renew their I-70 Series rivalry on Saturday, May 17, 2025, at Kauffman Stadium. Both teams are in tight divisional races, with the Cardinals trailing the Chicago Cubs by one game in the NL Central and the Royals 4.5 games behind the Detroit Tigers in the AL Central. St. Louis vs Kansas City AI Prediction: Free MLB Betting Insights for May 17. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Kansas City Royals MLB Preview

The Kansas City Royals enter Saturday’s matchup against the St. Louis Cardinals with a 21–24 record and a clear mission to reestablish themselves as serious contenders in the AL Central by capitalizing on their strength at home, where they’ve posted a respectable 13–9 mark at Kauffman Stadium. Despite some early-season inconsistency, the Royals remain only 4.5 games behind the first-place Tigers, and Saturday’s I-70 Series clash presents both a regional bragging rights opportunity and a chance to gain ground in the standings. Leading the charge offensively is Bobby Witt Jr., who continues to emerge as one of the most exciting young stars in baseball, combining elite bat speed, base-running aggression, and Gold Glove-caliber defense at shortstop. Witt Jr. has been the Royals’ engine at the top of the lineup, and his ability to set the table, steal bases, and spark rallies has been crucial to their success. Behind him, the Royals have leaned on solid contributors like Vinnie Pasquantino and Michael Massey, who have provided timely hits and helped lengthen a lineup that still seeks consistent power production. On the mound, Kansas City hands the ball to left-hander Cole Ragans, who enters the contest with a 2–2 record and a 4.20 ERA over 40.2 innings, showing flashes of brilliance despite some recent hiccups, including a rough five-inning start against the Red Sox where he allowed four earned runs.

Ragans, acquired from Texas in 2023, possesses swing-and-miss stuff when locked in and will be tasked with quieting a dangerous St. Louis lineup anchored by Arenado and Goldschmidt. The Royals’ bullpen, while talented, has been a bit erratic, especially in high-leverage innings, and manager Matt Quatraro continues to search for consistency in his late-inning roles. On defense, Kansas City has been sharp, particularly in the infield where Witt Jr. and Massey form a dependable tandem capable of shutting down opponents’ small-ball efforts. Quatraro’s emphasis on defensive fundamentals, aggressive baserunning, and contact-first offense has helped keep the Royals competitive, even when their power numbers lag behind league averages. Saturday’s game presents a crucial moment for the team to demonstrate its progress against a quality opponent, and with a strong home crowd behind them, the Royals will look to strike early, support Ragans with solid glove work, and use their speed to pressure St. Louis’ pitching and defense. A win in this game would not only give Kansas City an edge in the I-70 Series but also keep them within striking distance in a division that remains wide open. The Royals know they must string together consistent efforts at home if they want to rise above .500 and keep pace in the AL Central, and Saturday’s contest is a perfect stage to prove they are ready to take that next step forward. With Bobby Witt Jr. leading the charge and a rotation that’s shown promise, Kansas City has all the tools to challenge even the NL’s top-tier teams when playing their brand of baseball.

St. Louis vs. Kansas City Prop Picks (AI)

AI algorithm Remi is pouring through mountains of datapoints on each team. In fact, anytime the Cardinals and Royals play there’s always several intriguing observations to key in on. Not to mention games played at Kauffman Stadium in May can often follow normal, predictable patterns.
Remi's searched hard and found the best prop for this matchup: M. Mikolas over 2.5 Pitcher Strikeouts.

St. Louis vs. Kansas City Prediction (AI)

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Remi, our AI sports genius, has been pouring over millions of data from every angle between the Cardinals and Royals and using recursive machine learning and kick-ass AI to boil down the data to a single cover probability.

Remi has been most fixated on the unproportionally assigned weight knucklehead sportsbettors tend to put on coaching factors between a Cardinals team going up against a possibly deflated Royals team. In reality, the true game analytics might reflect a strong lean against one Vegas line specifically.

Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.

Below is our current AI St. Louis vs Kansas City picks, computer picks Cardinals vs Royals, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
MLB 9/26 DET@BOS UNLOCK THIS PICK 5 EXECUTIVE Locked EXECUTIVE
MLB 9/26 BAL@NYY UNLOCK THIS PICK 4 INTEL Locked INTEL
MLB 9/26 ARI@SD UNLOCK THIS PICK 4 EXECUTIVE Locked EXECUTIVE
MLB 9/26 NYM@MIA UNLOCK THIS PICK 1 INTEL Locked INTEL
MLB 9/26 NYM@MIA GET FREE PICK NOW 1
MLB 9/26 COL@SF UNLOCK THIS PICK 0 INTEL Locked INTEL

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.

Cardinals Betting Trends

The Cardinals have a 10–12 record on the road this season, reflecting challenges in away games.

Royals Betting Trends

The Royals hold a 13–9 record at home, showcasing strength at Kauffman Stadium.

Cardinals vs. Royals Matchup Trends

The Cardinals’ road challenges contrast with the Royals’ solid home performance, suggesting a potential advantage for Kansas City in this matchup.

St. Louis vs. Kansas City Game Info

St. Louis vs Kansas City starts on May 17, 2025 at 7:10 PM EST.

Spread: Kansas City -1.5
Moneyline: St. Louis +105, Kansas City -124
Over/Under: 8.5

St. Louis: (25-20)  |  Kansas City: (25-21)

Remi's searched hard and found the best prop for this matchup: M. Mikolas over 2.5 Pitcher Strikeouts.. Prices move—always shop for the best number.

The Cardinals’ road challenges contrast with the Royals’ solid home performance, suggesting a potential advantage for Kansas City in this matchup.

STL trend: The Cardinals have a 10–12 record on the road this season, reflecting challenges in away games.

KC trend: The Royals hold a 13–9 record at home, showcasing strength at Kauffman Stadium.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

St. Louis vs. Kansas City Odds

Remi is pouring through mountains of data points on each line. In fact, anytime the St. Louis vs Kansas City trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme temps almost always follow normal, predictable betting trends.

St. Louis vs Kansas City Opening Odds

STL Moneyline: +105
KC Moneyline: -124
STL Spread: +1.5
KC Spread: -1.5
Over/Under: 8.5

St. Louis vs Kansas City Live Odds

Games PTS ML SPR O/U
Sep 27, 2025 1:06PM EDT
Baltimore Orioles
New York Yankees
9/27/25 1:06PM
Orioles
Yankees
+190
-235
+1.5 (-110)
-1.5 (-110)
O 8.5 (-120)
U 8.5 (+100)
Sep 27, 2025 2:21PM EDT
St Louis Cardinals
Chicago Cubs
9/27/25 2:21PM
Cardinals
Cubs
 
-180
 
-1.5 (+115)
O 9.5 (-105)
U 9.5 (-115)
Sep 27, 2025 3:09PM EDT
Tampa Bay Rays
Toronto Blue Jays
9/27/25 3:09PM
Rays
Blue Jays
+130
-155
+1.5 (-155)
-1.5 (+130)
O 8.5 (-110)
U 8.5 (-110)
Sep 27, 2025 4:06PM EDT
Chicago White Sox
Washington Nationals
9/27/25 4:06PM
White Sox
Nationals
+100
-120
-1.5 (+165)
+1.5 (-200)
O 8.5 (-110)
U 8.5 (-110)
Sep 27, 2025 4:06PM EDT
Colorado Rockies
San Francisco Giants
9/27/25 4:06PM
Rockies
Giants
+185
-225
+1.5 (-110)
-1.5 (-110)
O 8 (-105)
U 8 (-115)
Sep 27, 2025 4:11PM EDT
New York Mets
Miami Marlins
9/27/25 4:11PM
Mets
Marlins
-130
+110
-1.5 (+125)
+1.5 (-150)
O 8 (-115)
U 8 (-105)
Sep 27, 2025 4:11PM EDT
Detroit Tigers
Boston Red Sox
9/27/25 4:11PM
Tigers
Red Sox
+125
-150
+1.5 (-180)
-1.5 (+150)
O 9 (+100)
U 9 (-120)
Sep 27, 2025 6:05PM EDT
Minnesota Twins
Philadelphia Phillies
9/27/25 6:05PM
Twins
Phillies
+170
-205
+1.5 (-120)
-1.5 (+100)
O 8.5 (-115)
U 8.5 (-105)
Sep 27, 2025 7:11PM EDT
Cincinnati Reds
Milwaukee Brewers
9/27/25 7:11PM
Reds
Brewers
+125
-150
+1.5 (-180)
-1.5 (+150)
O 8 (-105)
U 8 (-115)
Sep 27, 2025 7:15PM EDT
Pittsburgh Pirates
Atlanta Braves
9/27/25 7:15PM
Pirates
Braves
+145
-175
+1.5 (-155)
-1.5 (+130)
O 8 (-110)
U 8 (-110)
Sep 27, 2025 7:16PM EDT
Texas Rangers
Cleveland Guardians
9/27/25 7:16PM
Rangers
Guardians
+135
-165
+1.5 (-180)
-1.5 (+150)
O 7 (-120)
U 7 (+100)
Sep 27, 2025 8:40PM EDT
Arizona Diamondbacks
San Diego Padres
9/27/25 8:40PM
Diamondbacks
Padres
+115
-140
+1.5 (-195)
-1.5 (+160)
O 7.5 (-120)
U 7.5 (+100)
Sep 27, 2025 9:39PM EDT
Houston Astros
Los Angeles Angels
9/27/25 9:39PM
Astros
Angels
-165
+135
-1.5 (+105)
+1.5 (-125)
O 9 (+100)
U 9 (-120)
Sep 27, 2025 9:41PM EDT
Los Angeles Dodgers
Seattle Mariners
9/27/25 9:41PM
Dodgers
Mariners
+105
-125
+1.5 (-205)
-1.5 (+170)
O 7.5 (+105)
U 7.5 (-125)
Sep 27, 2025 10:05PM EDT
Kansas City Royals
Oakland Athletics
9/27/25 10:05PM
Royals
Athletics
+100
-120
-1.5 (+150)
+1.5 (-180)
O 10 (-110)
U 10 (-110)

MLB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers St. Louis Cardinals vs. Kansas City Royals on May 17, 2025 at Kauffman Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN
CHC@SF CHC -105 54.1% 4 LOSS
NYY@CHW RYAN MCMAHON OVER 0.5 BASES 54.1% 4 WIN
PHI@NYM OVER 8.5 55.6% 4 LOSS
LAA@TEX LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS 54.1% 4 LOSS
KC@CHW KC -109 54.2% 4 WIN
SD@SEA DYLAN CEASE OVER 16.5 OUTS 53.9% 3 LOSS
SD@SEA UNDER 8.5 54.4% 4 LOSS
MIN@TOR JOE RYAN UNDER 2.5 EARNED RUNS 54.1% 4 LOSS
SF@MIL MIL +100 54.0% 6 LOSS
TOR@MIA MIA +1.5 62.0% 6 WIN
CHC@LAA OVER 9.5 54.9% 4 LOSS
BOS@NYY CARLOS RODON UNDER 4.5 HITS ALLOWED 54.2% 4 WIN
KC@DET DET -115 56.1% 5 WIN
CHC@LAA LAA +1.5 57.6% 5 LOSS
CIN@ARI KEBRYAN HAYES STRIKEOUTS UNDER 0.5 56.2% 6 WIN
LAD@SD SD +110 50.9% 6 WIN