Cardinals vs. Royals
Prediction, Odds & Props
May 17 | MLB AI Picks
Updated: 2025-05-15T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The St. Louis Cardinals and Kansas City Royals renew their I-70 Series rivalry on Saturday, May 17, 2025, at Kauffman Stadium. Both teams are in tight divisional races, with the Cardinals trailing the Chicago Cubs by one game in the NL Central and the Royals 4.5 games behind the Detroit Tigers in the AL Central.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

GAME INFO
Date: May 17, 2025
Start Time: 7:10 PM EST
Venue: Kauffman Stadium
Royals Record: (25-21)
Cardinals Record: (25-20)
OPENING ODDS
STL Moneyline: +105
KC Moneyline: -124
STL Spread: +1.5
KC Spread: -1.5
Over/Under: 8.5
STL
Betting Trends
- The Cardinals have a 10–12 record on the road this season, reflecting challenges in away games.
KC
Betting Trends
- The Royals hold a 13–9 record at home, showcasing strength at Kauffman Stadium.
MATCHUP TRENDS
- The Cardinals’ road challenges contrast with the Royals’ solid home performance, suggesting a potential advantage for Kansas City in this matchup.
STL vs. KC
Best Prop Bet
- Remi's searched hard and found the best prop for this matchup: M. Mikolas over 2.5 Pitcher Strikeouts.
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St. Louis vs Kansas City Prediction & Odds:
Free MLB Betting Insights for 5/17/25
Cole Ragans will start for Kansas City, entering with a 2–2 record and a 4.20 ERA along with 65 strikeouts, though he struggled in his last outing against Boston. Ragans has shown electric stuff at times, especially from the left side, and will look to bounce back in a pressure-filled divisional rivalry game. Offensively, the Royals have had to rely heavily on Witt Jr. with Salvador Perez aging and the rest of the lineup lacking consistency. Defensively, both teams are solid, with the Cardinals traditionally fielding one of the league’s sharpest infields and the Royals showing reliability, especially up the middle. Bullpen depth could prove critical late in the game, as the Cardinals have leaned on closer Ryan Helsley and setup arms to finish tight contests, while the Royals’ relief corps has been more erratic, surrendering leads in multiple late-inning scenarios. Saturday’s contest is more than just a mid-May interleague meeting—it’s a tone-setting moment for two teams trying to claw their way into more secure postseason contention. For the Cardinals, it’s about proving they can win key games on the road and keep pace in the division, while for the Royals, it’s a chance to claw back toward .500 and show they’re more than a middling team in transition. Expect a tightly played matchup with playoff-style urgency, emotional investment from both dugouts, and the kind of regional rivalry intensity that often elevates performance on both sides.
Iván Herrera stays hot and has 4 RBI tonight! pic.twitter.com/9vaVKVdwi8
— St. Louis Cardinals (@Cardinals) May 17, 2025
St. Louis Cardinals MLB Preview
The St. Louis Cardinals head into Saturday’s matchup against the Kansas City Royals with a 24–20 record, sitting just one game behind the division-leading Chicago Cubs and showcasing a blend of seasoned veterans and emerging contributors that has kept them firmly in the NL Central race. While their overall performance has been strong, their road record of 10–12 signals an area in need of improvement, particularly as they face a Royals team that has played well at home. Manager Oliver Marmol has relied heavily on the proven leadership and production of sluggers Nolan Arenado and Paul Goldschmidt, both of whom continue to deliver in key moments and anchor the middle of the lineup with power, plate discipline, and veteran poise. Arenado remains a defensive wizard at third base, while Goldschmidt provides timely extra-base hits and maintains one of the league’s most consistent bats. Complementing the veteran core, young outfielder Jordan Walker has emerged as a dynamic presence, bringing energy, athleticism, and run-producing capability in the lower half of the order. On the mound, Andre Pallante will get the start for St. Louis, entering with a 3–2 record and a 4.36 ERA across 43.1 innings of work. Pallante’s game relies on inducing ground balls through a heavy sinker-slider combo, and he’s coming off one of his best outings of the season—a 7.1-inning effort against Washington in which he allowed just two earned runs.
The Cardinals’ bullpen has also been a steady asset, led by closer Ryan Helsley, whose high-velocity fastball and sharp breaking pitches have helped lock down late leads and convert tight games into wins. Defensively, the Cardinals remain among the league’s most reliable units, known for limiting mistakes and converting routine plays into momentum-sustaining outs. This defensive backbone, combined with efficient pitching and timely offense, has allowed St. Louis to weather stretches of inconsistency and stay in the mix. Facing a Royals team that’s been more successful at home, the Cardinals will need a focused road effort—especially early—to avoid falling behind against a confident Kansas City squad. Marmol’s message to his players has remained consistent: play sharp, limit free passes, and capitalize on scoring chances. If Pallante can neutralize Bobby Witt Jr. and keep the ball in the park, the Cardinals’ offense has more than enough firepower to push past the Royals and keep pressure on the Cubs in the division. For a team with postseason expectations, games like these—interleague matchups against beatable but gritty opponents—become crucial to building consistency, proving road resilience, and gaining ground in what’s shaping up to be a tight NL Central race. With momentum from recent wins and a roster capable of handling high-pressure situations, the Cardinals approach Saturday’s contest as a business trip with clear stakes and a prime opportunity to further their divisional ambitions.

Credit: USA TODAY/IMAGN
Kansas City Royals MLB Preview
The Kansas City Royals enter Saturday’s matchup against the St. Louis Cardinals with a 21–24 record and a clear mission to reestablish themselves as serious contenders in the AL Central by capitalizing on their strength at home, where they’ve posted a respectable 13–9 mark at Kauffman Stadium. Despite some early-season inconsistency, the Royals remain only 4.5 games behind the first-place Tigers, and Saturday’s I-70 Series clash presents both a regional bragging rights opportunity and a chance to gain ground in the standings. Leading the charge offensively is Bobby Witt Jr., who continues to emerge as one of the most exciting young stars in baseball, combining elite bat speed, base-running aggression, and Gold Glove-caliber defense at shortstop. Witt Jr. has been the Royals’ engine at the top of the lineup, and his ability to set the table, steal bases, and spark rallies has been crucial to their success. Behind him, the Royals have leaned on solid contributors like Vinnie Pasquantino and Michael Massey, who have provided timely hits and helped lengthen a lineup that still seeks consistent power production. On the mound, Kansas City hands the ball to left-hander Cole Ragans, who enters the contest with a 2–2 record and a 4.20 ERA over 40.2 innings, showing flashes of brilliance despite some recent hiccups, including a rough five-inning start against the Red Sox where he allowed four earned runs.
Ragans, acquired from Texas in 2023, possesses swing-and-miss stuff when locked in and will be tasked with quieting a dangerous St. Louis lineup anchored by Arenado and Goldschmidt. The Royals’ bullpen, while talented, has been a bit erratic, especially in high-leverage innings, and manager Matt Quatraro continues to search for consistency in his late-inning roles. On defense, Kansas City has been sharp, particularly in the infield where Witt Jr. and Massey form a dependable tandem capable of shutting down opponents’ small-ball efforts. Quatraro’s emphasis on defensive fundamentals, aggressive baserunning, and contact-first offense has helped keep the Royals competitive, even when their power numbers lag behind league averages. Saturday’s game presents a crucial moment for the team to demonstrate its progress against a quality opponent, and with a strong home crowd behind them, the Royals will look to strike early, support Ragans with solid glove work, and use their speed to pressure St. Louis’ pitching and defense. A win in this game would not only give Kansas City an edge in the I-70 Series but also keep them within striking distance in a division that remains wide open. The Royals know they must string together consistent efforts at home if they want to rise above .500 and keep pace in the AL Central, and Saturday’s contest is a perfect stage to prove they are ready to take that next step forward. With Bobby Witt Jr. leading the charge and a rotation that’s shown promise, Kansas City has all the tools to challenge even the NL’s top-tier teams when playing their brand of baseball.
Vinnie Pasquanti-no-doubter. pic.twitter.com/vJuD4D9LOs
— Kansas City Royals (@Royals) May 17, 2025
St. Louis vs. Kansas City Prop Picks (AI)
St. Louis vs. Kansas City Prediction (AI)

Remi, our AI sports genius, has been pouring over millions of data from every angle between the Cardinals and Royals and using recursive machine learning and kick-ass AI to boil down the data to a single cover probability.
Remi has been most fixated on the unproportionally assigned weight knucklehead sportsbettors tend to put on coaching factors between a Cardinals team going up against a possibly deflated Royals team. In reality, the true game analytics might reflect a strong lean against one Vegas line specifically.
Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.
Below is our current AI St. Louis vs Kansas City picks, computer picks Cardinals vs Royals, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
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MLB | 9/26 | DET@BOS | UNLOCK THIS PICK | 5 |
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MLB | 9/26 | BAL@NYY | UNLOCK THIS PICK | 4 |
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MLB | 9/26 | ARI@SD | UNLOCK THIS PICK | 4 |
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MLB | 9/26 | NYM@MIA | UNLOCK THIS PICK | 1 |
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MLB | 9/26 | NYM@MIA | GET FREE PICK NOW | 1 | – | |
MLB | 9/26 | COL@SF | UNLOCK THIS PICK | 0 |
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.
Cardinals Betting Trends
The Cardinals have a 10–12 record on the road this season, reflecting challenges in away games.
Royals Betting Trends
The Royals hold a 13–9 record at home, showcasing strength at Kauffman Stadium.
Cardinals vs. Royals Matchup Trends
The Cardinals’ road challenges contrast with the Royals’ solid home performance, suggesting a potential advantage for Kansas City in this matchup.
St. Louis vs. Kansas City Game Info
What time does St. Louis vs Kansas City start on May 17, 2025?
St. Louis vs Kansas City starts on May 17, 2025 at 7:10 PM EST.
Where is St. Louis vs Kansas City being played?
Venue: Kauffman Stadium.
What are the opening odds for St. Louis vs Kansas City?
Spread: Kansas City -1.5
Moneyline: St. Louis +105, Kansas City -124
Over/Under: 8.5
What are the records for St. Louis vs Kansas City?
St. Louis: (25-20) | Kansas City: (25-21)
What is the AI best bet for St. Louis vs Kansas City?
Remi's searched hard and found the best prop for this matchup: M. Mikolas over 2.5 Pitcher Strikeouts.. Prices move—always shop for the best number.
What are St. Louis vs Kansas City trending bets?
The Cardinals’ road challenges contrast with the Royals’ solid home performance, suggesting a potential advantage for Kansas City in this matchup.
What are St. Louis trending bets?
STL trend: The Cardinals have a 10–12 record on the road this season, reflecting challenges in away games.
What are Kansas City trending bets?
KC trend: The Royals hold a 13–9 record at home, showcasing strength at Kauffman Stadium.
Where can I find AI Picks for St. Louis vs Kansas City?
See our latest MLB picks and odds pages for 2025 to compare prices before you bet.
St. Louis vs. Kansas City Odds
Remi is pouring through mountains of data points on each line. In fact, anytime the St. Louis vs Kansas City trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme temps almost always follow normal, predictable betting trends.
St. Louis vs Kansas City Opening Odds
STL Moneyline:
+105 KC Moneyline: -124
STL Spread: +1.5
KC Spread: -1.5
Over/Under: 8.5
St. Louis vs Kansas City Live Odds
Games | PTS | ML | SPR | O/U | |
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Sep 27, 2025 1:06PM EDT
Baltimore Orioles
New York Yankees
9/27/25 1:06PM
Orioles
Yankees
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–
–
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+190
-235
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+1.5 (-110)
-1.5 (-110)
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O 8.5 (-120)
U 8.5 (+100)
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Sep 27, 2025 2:21PM EDT
St Louis Cardinals
Chicago Cubs
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Cardinals
Cubs
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–
–
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-180
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-1.5 (+115)
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O 9.5 (-105)
U 9.5 (-115)
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Sep 27, 2025 3:09PM EDT
Tampa Bay Rays
Toronto Blue Jays
9/27/25 3:09PM
Rays
Blue Jays
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–
–
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+130
-155
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+1.5 (-155)
-1.5 (+130)
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O 8.5 (-110)
U 8.5 (-110)
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Sep 27, 2025 4:06PM EDT
Chicago White Sox
Washington Nationals
9/27/25 4:06PM
White Sox
Nationals
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–
–
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+100
-120
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-1.5 (+165)
+1.5 (-200)
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O 8.5 (-110)
U 8.5 (-110)
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Sep 27, 2025 4:06PM EDT
Colorado Rockies
San Francisco Giants
9/27/25 4:06PM
Rockies
Giants
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–
–
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+185
-225
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+1.5 (-110)
-1.5 (-110)
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O 8 (-105)
U 8 (-115)
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Sep 27, 2025 4:11PM EDT
New York Mets
Miami Marlins
9/27/25 4:11PM
Mets
Marlins
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–
–
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-130
+110
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-1.5 (+125)
+1.5 (-150)
|
O 8 (-115)
U 8 (-105)
|
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Sep 27, 2025 4:11PM EDT
Detroit Tigers
Boston Red Sox
9/27/25 4:11PM
Tigers
Red Sox
|
–
–
|
+125
-150
|
+1.5 (-180)
-1.5 (+150)
|
O 9 (+100)
U 9 (-120)
|
|
Sep 27, 2025 6:05PM EDT
Minnesota Twins
Philadelphia Phillies
9/27/25 6:05PM
Twins
Phillies
|
–
–
|
+170
-205
|
+1.5 (-120)
-1.5 (+100)
|
O 8.5 (-115)
U 8.5 (-105)
|
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Sep 27, 2025 7:11PM EDT
Cincinnati Reds
Milwaukee Brewers
9/27/25 7:11PM
Reds
Brewers
|
–
–
|
+125
-150
|
+1.5 (-180)
-1.5 (+150)
|
O 8 (-105)
U 8 (-115)
|
|
Sep 27, 2025 7:15PM EDT
Pittsburgh Pirates
Atlanta Braves
9/27/25 7:15PM
Pirates
Braves
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–
–
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+145
-175
|
+1.5 (-155)
-1.5 (+130)
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O 8 (-110)
U 8 (-110)
|
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Sep 27, 2025 7:16PM EDT
Texas Rangers
Cleveland Guardians
9/27/25 7:16PM
Rangers
Guardians
|
–
–
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+135
-165
|
+1.5 (-180)
-1.5 (+150)
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O 7 (-120)
U 7 (+100)
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Sep 27, 2025 8:40PM EDT
Arizona Diamondbacks
San Diego Padres
9/27/25 8:40PM
Diamondbacks
Padres
|
–
–
|
+115
-140
|
+1.5 (-195)
-1.5 (+160)
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O 7.5 (-120)
U 7.5 (+100)
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Sep 27, 2025 9:39PM EDT
Houston Astros
Los Angeles Angels
9/27/25 9:39PM
Astros
Angels
|
–
–
|
-165
+135
|
-1.5 (+105)
+1.5 (-125)
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O 9 (+100)
U 9 (-120)
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Sep 27, 2025 9:41PM EDT
Los Angeles Dodgers
Seattle Mariners
9/27/25 9:41PM
Dodgers
Mariners
|
–
–
|
+105
-125
|
+1.5 (-205)
-1.5 (+170)
|
O 7.5 (+105)
U 7.5 (-125)
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Sep 27, 2025 10:05PM EDT
Kansas City Royals
Oakland Athletics
9/27/25 10:05PM
Royals
Athletics
|
–
–
|
+100
-120
|
-1.5 (+150)
+1.5 (-180)
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O 10 (-110)
U 10 (-110)
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MLB Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers St. Louis Cardinals vs. Kansas City Royals on May 17, 2025 at Kauffman Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.
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LEAN | %WIN | UNITS | RESULT |
---|---|---|---|---|
NYM@CHC | NYM -110 | 54.1% | 3 | WIN |
HOU@ATH | ATH +118 | 50.8% | 4 | WIN |
NYM@CHC | OVER 7 | 54.5% | 3 | WIN |
STL@SF | OVER 7.5 | 55.9% | 5 | LOSS |
KC@LAA | TYLER TOLBERT UNDER 1.5 BASES | 54.4% | 4 | WIN |
MIL@SD | UNDER 9 | 54.7% | 4 | WIN |
MIA@PHI | KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS | 53.3% | 3 | WIN |
WAS@NYM | OVER 8.5 | 56.1% | 6 | LOSS |
LAA@COL | COL +108 | 50.5% | 3 | WIN |
TOR@KC | UNDER 9 | 54.7% | 4 | LOSS |
SEA@KC | KC +1.5 | 62.3% | 5 | LOSS |
NYY@MIN | OVER 9 | 55.1% | 4 | WIN |
MIA@COL | OVER 10.5 | 55.0% | 4 | WIN |
MIA@COL | AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS | 54.3% | 4 | WIN |
SEA@KC | BOBBY WITT UNDER 0.5 SINGLES | 54.4% | 4 | LOSS |
PHI@LAD | LAD -113 | 54.7% | 4 | LOSS |
NYY@BOS | OVER 7.5 | 54.3% | 3 | WIN |
KC@PHI | PHI -130 | 58.3% | 4 | WIN |
LAD@SF | OVER 7.5 | 54.7% | 4 | LOSS |
NYM@PHI | PHI -122 | 55.6% | 4 | WIN |
KC@CLE | KC -104 | 52.0% | 3 | WIN |
CIN@SD | JAKE CRONEWORTH OVER 0.5 HITS | 53.1% | 3 | WIN |
WAS@MIA | MIA -123 | 55.2% | 4 | LOSS |
LAA@KC | UNDER 9.5 | 54.9% | 3 | WIN |
TEX@ARI | UNDER 9 | 54.2% | 4 | WIN |
SF@COL | UNDER 11.5 | 56.4% | 6 | LOSS |
SF@COL | RAFAEL DEVERS OVER 1.5 BASES | 56.1% | 6 | WIN |
MIA@WAS | WAS -110 | 54.4% | 4 | WIN |
NYM@DET | OVER 8.5 | 54.5% | 4 | WIN |
TEX@ARI | UNDER 9.5 | 56.4% | 6 | WIN |
TEX@ARI | ALEJANDRO OSUNA UNDER 1.5 BASES | 54.1% | 4 | LOSS |
ATL@CHC | CHC -116 | 55.1% | 3 | WIN |
PHI@MIL | OVER 8.5 | 55.0% | 3 | WIN |
ARI@LAD | SHOHEI OHTANI OVER 2.5 BASES | 54.2% | 4 | WIN |
SEA@CLE | CLE +1.5 | 57.2% | 3 | WIN |
CHC@SF | CHC -105 | 54.1% | 4 | LOSS |
NYY@CHW | RYAN MCMAHON OVER 0.5 BASES | 54.1% | 4 | WIN |
PHI@NYM | OVER 8.5 | 55.6% | 4 | LOSS |
LAA@TEX | LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS | 54.1% | 4 | LOSS |
KC@CHW | KC -109 | 54.2% | 4 | WIN |
SD@SEA | DYLAN CEASE OVER 16.5 OUTS | 53.9% | 3 | LOSS |
SD@SEA | UNDER 8.5 | 54.4% | 4 | LOSS |
MIN@TOR | JOE RYAN UNDER 2.5 EARNED RUNS | 54.1% | 4 | LOSS |
SF@MIL | MIL +100 | 54.0% | 6 | LOSS |
TOR@MIA | MIA +1.5 | 62.0% | 6 | WIN |
CHC@LAA | OVER 9.5 | 54.9% | 4 | LOSS |
BOS@NYY | CARLOS RODON UNDER 4.5 HITS ALLOWED | 54.2% | 4 | WIN |
KC@DET | DET -115 | 56.1% | 5 | WIN |
CHC@LAA | LAA +1.5 | 57.6% | 5 | LOSS |
CIN@ARI | KEBRYAN HAYES STRIKEOUTS UNDER 0.5 | 56.2% | 6 | WIN |
LAD@SD | SD +110 | 50.9% | 6 | WIN |