The San Francisco Giants and Chicago Cubs will collide on Tuesday, May 6, 2025, at Wrigley Field in a marquee National League matchup between two teams off to strong starts and looking to maintain momentum in their respective divisions. The Giants, at 22–13, have been especially formidable on the road, boasting a stellar 18–7 record against the spread in their last 25 games away from Oracle Park, and much of their success can be attributed to the combination of consistent run production and an efficient, well-managed pitching staff. San Francisco is averaging 5.20 runs per game and has leaned into a balanced offensive strategy—mixing contact hitting with timely power—while getting strong performances from the rotation and bullpen, which together hold a 3.44 team ERA. They’ve also been involved in high-scoring affairs on the road, with totals going over in 8 of their last 9 road games, indicating an aggressive, opportunistic approach that’s translated into crooked innings and pressure on opposing pitchers. On the other side, the Cubs are off to a similarly encouraging 21–14 start, leading the NL Central, and have been dominant in their home park with a 9–6 record at Wrigley Field. Chicago’s offensive output has been among the best in baseball so far, leading the league with 208 runs scored and carrying a strong .262 team batting average, fueled by a combination of veteran production and rising stars who’ve stepped up in big moments.

Their pitching has also held up well, with a 3.82 ERA that has been good enough to back up their run-scoring capabilities, giving manager Craig Counsell flexibility in late-game strategy and bullpen deployment. Both teams have excelled ATS overall, with the Cubs covering in 21 of their 35 games and San Francisco consistently outperforming expectations on the road. The matchup projects to be tightly contested and will likely come down to execution in key moments—particularly with runners in scoring position and defensive efficiency, as both clubs have managed to limit errors and give their pitchers a clean backdrop. While San Francisco holds a slight edge in pitching efficiency, the Cubs’ offense has been relentless, often jumping out early and forcing opposing teams into catch-up mode, which could challenge a Giants bullpen that has been reliable but more effective when pitching with a lead. For the Giants to continue their road dominance, they’ll need to contain Chicago’s early-inning surge, steal outs on defense, and apply pressure at the top of the order. For the Cubs, maintaining patience at the plate and continuing to capitalize on scoring chances will be key, especially with San Francisco’s knack for clawing back late in games. With playoff implications already looming in early May and two high-performing rosters squaring off, this matchup sets the tone for a potential postseason preview and will be one of the most compelling games on the Tuesday slate.