Guardians vs. Blue Jays
Prediction, Odds & Props
May 04 | MLB AI Picks

Updated: 2025-05-02T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The Cleveland Guardians (11-9) and Toronto Blue Jays (12-9) conclude their three-game series at Rogers Centre on Sunday, May 4, 2025, with both teams aiming to secure the series win. The Guardians look to build on their recent momentum, while the Blue Jays seek to rebound from a narrow loss in the previous game.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: May 04, 2025

Start Time: 1:37 PM EST​

Venue: Rogers Centre​

Blue Jays Record: (16-17)

Guardians Record: (19-14)

OPENING ODDS

CLE Moneyline: -103

TOR Moneyline: -117

CLE Spread: -1.5

TOR Spread: +1.5

Over/Under: 8

CLE
Betting Trends

  • The Guardians have covered the run line in 60% of their last five games, indicating a strong recent performance against the spread.

TOR
Betting Trends

  • The Blue Jays have covered the run line in 60% of their last five games, showcasing consistent performance in recent matchups.

MATCHUP TRENDS

  • In their last five head-to-head matchups, the Guardians and Blue Jays have each covered the run line in 60% of the games, reflecting a competitive series.

CLE vs. TOR
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: B. Naylor over 0.5 Hits+Runs+RBI.

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Cleveland vs Toronto Prediction & Odds:
Free MLB Betting Insights for 5/4/25

The Cleveland Guardians and Toronto Blue Jays face off in the rubber match of their three-game set at Rogers Centre on Sunday, May 4, 2025, with both teams aiming to leave the series with momentum heading into the next week of play. Cleveland enters with an 11-9 record, steadily gaining traction in the AL Central, while Toronto sits at 12-9 and continues to navigate the always difficult AL East landscape. Both clubs have split the first two games, setting up Sunday’s matchup as a potential tone-setter for early May. Cleveland has leaned on timely hitting and a reliable bullpen to stay competitive, led offensively by their cornerstone José Ramírez, who continues to deliver with runners on base and maintain a steady presence in the lineup. Supporting him has been a rotating cast of young contributors, including Steven Kwan and Josh Naylor, who offer consistency at the plate and hustle in the field. On the mound, the Guardians have been competitive with a team ERA just under 4.00, and their bullpen has emerged as a major strength, closing out tight games with poise. Meanwhile, the Blue Jays feature one of the most dangerous offensive duos in the league in Bo Bichette and Vladimir Guerrero Jr., both of whom are capable of flipping a game with one swing. Bichette provides the table-setting at the top of the order, while Guerrero Jr. has continued to punish mistakes in the heart of the lineup.

Toronto’s pitching staff, led by veteran Chris Bassitt who currently sports an outstanding 0.77 ERA, has found its rhythm, with solid performances from both starters and relievers keeping them in close contests. Their bullpen, anchored by Jordan Romano and Erik Swanson, has consistently locked down late innings, helping the Jays hold slim leads. Defensively, both teams have played clean baseball, minimizing errors and showcasing good range, particularly in the infield. The Guardians will look to counter Toronto’s right-handed power with aggressive baserunning and contact hitting, forcing the Jays to make plays in high-pressure moments. With both teams covering the run line in 60% of their recent games and trading wins in a tightly contested head-to-head history, this game is expected to be close and possibly decided in the final innings. Execution with runners in scoring position and bullpen command will likely be the deciding factors, especially in a ballpark like Rogers Centre where one big inning can shift the momentum dramatically. The Guardians have shown they can win on the road with disciplined at-bats and strong fundamentals, while the Blue Jays will look to reassert themselves behind their home crowd and top-end pitching. With early divisional jockeying underway and every win critical, Sunday’s matchup serves as both a test of depth and an opportunity to make a statement before heading deeper into the grind of May baseball. Expect a competitive, high-intensity game where small details and timely plays could spell the difference between victory and defeat.

Cleveland Guardians MLB Preview

The Cleveland Guardians enter Sunday’s series finale at Rogers Centre with an 11-9 record and a strong opportunity to secure a series win on the road against a tough AL East opponent. Under first-year manager Stephen Vogt, Cleveland has built its early-season success on a mix of veteran leadership, young talent, and one of the most reliable bullpens in the American League. José Ramírez continues to serve as the engine of the offense, producing clutch hits and maintaining a balanced approach at the plate that keeps pitchers on edge. He’s been supported by contact hitters like Steven Kwan, whose plate discipline and speed have generated opportunities at the top of the order, and Josh Naylor, whose left-handed power offers a middle-of-the-lineup threat. The Guardians haven’t relied on the long ball to win games—instead, they’ve focused on stringing together base hits, applying pressure on the bases, and executing in situational hitting, particularly in close contests. This small-ball approach has paid dividends, especially when paired with a pitching staff that minimizes damage and avoids big innings. Cleveland’s team ERA sits at 3.95, and while the rotation hasn’t produced overpowering strikeout numbers, it has consistently kept the team in games with quality starts and limited walks. The real backbone of the Guardians’ success has been their bullpen, led by closer Emmanuel Clase and a cadre of high-leverage arms who consistently shut the door late.

The relief corps has converted saves and maintained late-inning leads, allowing Cleveland to win tight games even when the offense isn’t clicking at full capacity. Defensively, the Guardians are among the league’s most dependable teams, turning double plays with efficiency and showcasing excellent range, particularly in the middle infield with Andrés Giménez and Brayan Rocchio. Heading into Sunday’s matchup, Cleveland knows they’ll be facing a Toronto lineup capable of producing instant offense, so execution and discipline will be critical—especially when pitching to Bo Bichette and Vladimir Guerrero Jr. For the Guardians to come away with the win, they’ll need solid innings from their starter, continued excellence from the bullpen, and the type of grind-it-out offensive performance that has defined their season so far. With a chance to improve their record and build momentum heading into their next series, Cleveland is poised to lean into its strengths—defense, pitching depth, and timely hitting—to finish this road trip on a high note. In a tight AL Central where every win counts, taking a series from a playoff-caliber team like the Blue Jays would be a meaningful early-season benchmark and reinforce the Guardians’ identity as a fundamentally sound, mentally tough club that thrives in high-leverage situations.

The Cleveland Guardians (11-9) and Toronto Blue Jays (12-9) conclude their three-game series at Rogers Centre on Sunday, May 4, 2025, with both teams aiming to secure the series win. The Guardians look to build on their recent momentum, while the Blue Jays seek to rebound from a narrow loss in the previous game. Cleveland vs Toronto AI Prediction: Free MLB Betting Insights for May 04. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Toronto Blue Jays MLB Preview

The Toronto Blue Jays come into Sunday’s series finale at Rogers Centre with a 12-9 record and the chance to secure a key series win over the Cleveland Guardians, a team that’s matched them step-for-step through the first two games. Led by manager John Schneider, the Blue Jays have leaned on a potent mix of star power and well-rounded roster depth to stay competitive in the ultra-demanding AL East. Offensively, the Jays continue to be anchored by Bo Bichette and Vladimir Guerrero Jr., who remain two of the most feared hitters in the league. Bichette has consistently set the tone at the top of the order with his blend of contact, speed, and gap-to-gap hitting, while Guerrero Jr. provides the thunder, capable of changing the course of any game with one swing. Alex Verdugo and Daulton Varsho have added key production and flexibility to the lineup, giving Toronto a deeper, more adaptable offensive identity than in recent years. While the lineup is certainly capable of overpowering opponents, what’s truly elevated the Blue Jays early this season has been their pitching. Right-hander Chris Bassitt has been outstanding, entering Sunday’s contest with a league-best 0.77 ERA, providing much-needed stability and leadership for a rotation that has faced its share of turnover. Bassitt’s ability to mix pitches and manage contact has kept opposing hitters off-balance and allowed Toronto to build early leads in many of his starts.

The bullpen has also stepped up, with Jordan Romano solidifying the closer role and Erik Swanson continuing to excel in late-inning setups. Defensively, the Blue Jays have remained sharp, with solid infield play from Matt Chapman and Bichette, and dependable outfield coverage from Kevin Kiermaier and Varsho, minimizing extra bases and keeping pressure off the pitching staff. Sunday’s matchup presents a different kind of challenge—a contact-heavy Guardians team that doesn’t rely on slugging but instead capitalizes on mistakes and plays tight, low-scoring games. For Toronto to prevail, they’ll need to be efficient in the field, execute defensively, and make the most of scoring opportunities, especially early against Cleveland’s typically strong bullpen. The Blue Jays have been particularly effective at home this season, feeding off the energy at Rogers Centre and building leads through aggressive base running and situational awareness. With an opportunity to claim a series win and keep pace in the AL East, Sunday’s game carries added weight. The Blue Jays will aim to ride their top-tier arms, capitalize on the power in their lineup, and continue their steady march toward postseason contention in what is shaping up to be a tightly contested division. A clean, focused effort on both sides of the ball could send a strong message that Toronto is not just a contender but a team capable of outdueling well-coached, fundamentally sound opponents like Cleveland.

Cleveland vs. Toronto Prop Picks (AI)

Remi is pouring through mountains of stats on each team. In fact, anytime the Guardians and Blue Jays play there’s always several intriguing observations to key in on. Not to mention games played at Rogers Centre in May rarely follow normal, predictable betting trends.
Remi's searched hard and found the best prop for this matchup: B. Naylor over 0.5 Hits+Runs+RBI.

Cleveland vs. Toronto Prediction (AI)

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Remi, our AI sports genius, has been pouring over millions of data from every past game between the Guardians and Blue Jays and using recursive machine learning and impressive AI to boil down the data to a single cover probability.

Interestingly enough, the data has been most fixated on the growing weight emotional bettors often put on coaching factors between a Guardians team going up against a possibly tired Blue Jays team. Trends look to say the true game analytics might reflect a moderate lean against one Vegas line in particular.

Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.

Below is our current AI Cleveland vs Toronto picks, computer picks Guardians vs Blue Jays, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
MLB 9/26 DET@BOS UNLOCK THIS PICK 5 EXECUTIVE Locked EXECUTIVE
MLB 9/26 BAL@NYY UNLOCK THIS PICK 4 INTEL Locked INTEL
MLB 9/26 ARI@SD UNLOCK THIS PICK 4 EXECUTIVE Locked EXECUTIVE
MLB 9/26 NYM@MIA UNLOCK THIS PICK 1 INTEL Locked INTEL
MLB 9/26 NYM@MIA GET FREE PICK NOW 1
MLB 9/26 COL@SF UNLOCK THIS PICK 0 INTEL Locked INTEL

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.

Guardians Betting Trends

The Guardians have covered the run line in 60% of their last five games, indicating a strong recent performance against the spread.

Blue Jays Betting Trends

The Blue Jays have covered the run line in 60% of their last five games, showcasing consistent performance in recent matchups.

Guardians vs. Blue Jays Matchup Trends

In their last five head-to-head matchups, the Guardians and Blue Jays have each covered the run line in 60% of the games, reflecting a competitive series.

Cleveland vs. Toronto Game Info

Cleveland vs Toronto starts on May 04, 2025 at 1:37 PM EST.

Spread: Toronto +1.5
Moneyline: Cleveland -103, Toronto -117
Over/Under: 8

Cleveland: (19-14)  |  Toronto: (16-17)

Remi's searched hard and found the best prop for this matchup: B. Naylor over 0.5 Hits+Runs+RBI.. Prices move—always shop for the best number.

In their last five head-to-head matchups, the Guardians and Blue Jays have each covered the run line in 60% of the games, reflecting a competitive series.

CLE trend: The Guardians have covered the run line in 60% of their last five games, indicating a strong recent performance against the spread.

TOR trend: The Blue Jays have covered the run line in 60% of their last five games, showcasing consistent performance in recent matchups.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

Cleveland vs. Toronto Odds

Remi is pouring through mountains of data points on each team. In fact, anytime the Cleveland vs Toronto trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme altitude almost always follow normal, predictable betting trends.

Cleveland vs Toronto Opening Odds

CLE Moneyline: -103
TOR Moneyline: -117
CLE Spread: -1.5
TOR Spread: +1.5
Over/Under: 8

Cleveland vs Toronto Live Odds

Games PTS ML SPR O/U
Sep 27, 2025 1:06PM EDT
Baltimore Orioles
New York Yankees
9/27/25 1:06PM
Orioles
Yankees
+190
-235
+1.5 (-110)
-1.5 (-110)
O 8.5 (-120)
U 8.5 (+100)
Sep 27, 2025 2:21PM EDT
St Louis Cardinals
Chicago Cubs
9/27/25 2:21PM
Cardinals
Cubs
 
-175
 
-1.5 (+115)
O 9.5 (-105)
U 9.5 (-115)
Sep 27, 2025 3:09PM EDT
Tampa Bay Rays
Toronto Blue Jays
9/27/25 3:09PM
Rays
Blue Jays
+130
-155
+1.5 (-155)
-1.5 (+130)
O 8.5 (-110)
U 8.5 (-110)
Sep 27, 2025 4:06PM EDT
Chicago White Sox
Washington Nationals
9/27/25 4:06PM
White Sox
Nationals
+100
-120
-1.5 (+165)
+1.5 (-200)
O 8.5 (-110)
U 8.5 (-110)
Sep 27, 2025 4:06PM EDT
Colorado Rockies
San Francisco Giants
9/27/25 4:06PM
Rockies
Giants
+185
-225
+1.5 (-110)
-1.5 (-110)
O 8 (-105)
U 8 (-115)
Sep 27, 2025 4:11PM EDT
New York Mets
Miami Marlins
9/27/25 4:11PM
Mets
Marlins
-130
+110
-1.5 (+125)
+1.5 (-150)
O 8.5 (-105)
U 8.5 (-115)
Sep 27, 2025 6:05PM EDT
Minnesota Twins
Philadelphia Phillies
9/27/25 6:05PM
Twins
Phillies
+170
-205
+1.5 (-120)
-1.5 (+100)
O 8.5 (-115)
U 8.5 (-105)
Sep 27, 2025 7:11PM EDT
Cincinnati Reds
Milwaukee Brewers
9/27/25 7:11PM
Reds
Brewers
+125
-150
+1.5 (-180)
-1.5 (+150)
O 8 (-105)
U 8 (-115)
Sep 27, 2025 7:15PM EDT
Pittsburgh Pirates
Atlanta Braves
9/27/25 7:15PM
Pirates
Braves
+140
-170
+1.5 (-155)
-1.5 (+130)
O 8 (-110)
U 8 (-110)
Sep 27, 2025 7:16PM EDT
Texas Rangers
Cleveland Guardians
9/27/25 7:16PM
Rangers
Guardians
+135
-165
+1.5 (-180)
-1.5 (+150)
O 7 (-120)
U 7 (+100)
Sep 27, 2025 8:40PM EDT
Arizona Diamondbacks
San Diego Padres
9/27/25 8:40PM
Diamondbacks
Padres
+115
-140
+1.5 (-190)
-1.5 (+155)
O 7.5 (-120)
U 7.5 (+100)
Sep 27, 2025 9:39PM EDT
Houston Astros
Los Angeles Angels
9/27/25 9:39PM
Astros
Angels
-165
+135
-1.5 (+105)
+1.5 (-125)
O 9 (+100)
U 9 (-120)
Sep 27, 2025 9:41PM EDT
Los Angeles Dodgers
Seattle Mariners
9/27/25 9:41PM
Dodgers
Mariners
+100
-120
-1.5 (+170)
+1.5 (-205)
O 7.5 (-110)
U 7.5 (-110)
Sep 27, 2025 10:05PM EDT
Kansas City Royals
Oakland Athletics
9/27/25 10:05PM
Royals
Athletics
+100
-120
-1.5 (+150)
+1.5 (-180)
O 10 (-110)
U 10 (-110)

MLB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Cleveland Guardians vs. Toronto Blue Jays on May 04, 2025 at Rogers Centre.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN
CHC@SF CHC -105 54.1% 4 LOSS
NYY@CHW RYAN MCMAHON OVER 0.5 BASES 54.1% 4 WIN
PHI@NYM OVER 8.5 55.6% 4 LOSS
LAA@TEX LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS 54.1% 4 LOSS
KC@CHW KC -109 54.2% 4 WIN
SD@SEA DYLAN CEASE OVER 16.5 OUTS 53.9% 3 LOSS
SD@SEA UNDER 8.5 54.4% 4 LOSS
MIN@TOR JOE RYAN UNDER 2.5 EARNED RUNS 54.1% 4 LOSS
SF@MIL MIL +100 54.0% 6 LOSS
TOR@MIA MIA +1.5 62.0% 6 WIN
CHC@LAA OVER 9.5 54.9% 4 LOSS
BOS@NYY CARLOS RODON UNDER 4.5 HITS ALLOWED 54.2% 4 WIN
KC@DET DET -115 56.1% 5 WIN
CHC@LAA LAA +1.5 57.6% 5 LOSS
CIN@ARI KEBRYAN HAYES STRIKEOUTS UNDER 0.5 56.2% 6 WIN
LAD@SD SD +110 50.9% 6 WIN