Cardinals vs Reds Prediction — AI Finds CAN'T MISS MLB Lines & Props (May 01)
Updated: 2025-04-29T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The St. Louis Cardinals and Cincinnati Reds will conclude their four-game series on May 1, 2025, at Great American Ball Park. The Reds currently lead the series 2–1 and aim to secure the series win, while the Cardinals look to even the series before heading back home.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.
GAME INFO
Date: May 01, 2025
Start Time: 12:40 PM EST
Venue: Great American Ball Park
Reds Record: (16-15)
Cardinals Record: (14-17)
OPENING ODDS
STL Moneyline: +102
CIN Moneyline: -122
STL Spread: +1.5
CIN Spread: -1.5
Over/Under: 8.5
STL
Betting Trends
- The Cardinals have a 5–5 record against the spread (ATS) in their last 10 games.
CIN
Betting Trends
- The Reds have covered the run line in 6 of their last 10 games.
MATCHUP TRENDS
- The Reds are favored with a moneyline of -122, while the Cardinals stand at +102; the over/under is set at 8.5 runs.
STL vs. CIN
Best Prop Bet
- Remi's searched hard and found the best prop for this matchup: P. Pages over 0.5 Total Bases.
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St. Louis vs Cincinnati Prediction & Odds:
Free MLB Betting Insights for 5/1/25
Key players like Elly De La Cruz and Spencer Steer have been instrumental in sparking Cincinnati’s offense, while the team’s ability to capitalize on St. Louis’s defensive miscues—of which there have been 11 so far this season—could play a pivotal role in a game expected to be closely contested. From a statistical standpoint, the Reds hold the edge in recent form, having covered the run line in 6 of their last 10 games, while the Cardinals have gone just 5–5 ATS during that same stretch. Both teams have room for improvement defensively, with the Reds committing 17 errors to date, but their offensive upside has helped cover those shortcomings in most cases. Oddsmakers currently favor Cincinnati slightly at -122 on the moneyline, with an over/under set at 8.5 runs, suggesting the expectation of moderate scoring and a closely played battle. For the Cardinals, success in Game 4 will hinge on getting an early lead, maximizing run-scoring chances, and avoiding the bullpen collapse that has cost them games earlier in the series. Cincinnati, meanwhile, will look to maintain its offensive pressure, support Abbott with sharp defense, and finish the series strong in front of a home crowd. This game carries meaningful weight for both clubs—not only for series bragging rights but as a tone-setter heading into a new month in one of baseball’s most tightly contested divisions.
Gordon Graceffo picks up his first MLB win! 👏 pic.twitter.com/LfHzzw29Jh
— St. Louis Cardinals (@Cardinals) May 1, 2025
St. Louis Cardinals MLB Preview
The St. Louis Cardinals head into the final game of their four-game road series against the Cincinnati Reds with a 14–17 record and a clear objective: salvage a split and reset their trajectory in the tightly packed NL Central. Despite a dominant 9–1 win in Game 2 of the series, inconsistency has once again marred the Cardinals’ performance, with offensive surges followed by missed opportunities and defensive lapses. On the mound for the finale is left-hander Matthew Liberatore, who has quietly been one of the more encouraging stories for the Cardinals’ rotation this season. Liberatore enters with a 2–2 record and a 3.19 ERA, offering the type of steady presence and pitch efficiency that could serve as a stabilizer for a club still trying to find its identity one month into the season. Liberatore’s curveball continues to be his signature pitch, and his ability to keep the ball on the ground has allowed the defense to limit big innings when it remains sharp. However, defensive missteps have plagued St. Louis, who have committed 11 errors so far in 2025—mistakes that have often proved costly in tightly contested games, particularly against teams like Cincinnati that thrive on pressure and extra opportunities. Offensively, the Cardinals have been uneven, but not without bright spots.
Outfielder Lars Nootbaar has been a spark plug, slashing consistently with 5 home runs and 18 RBIs to date, often setting the tone early in games and providing clutch hits in high-leverage spots. Veterans like Paul Goldschmidt and Nolan Arenado have shown flashes of their All-Star caliber form but have yet to string together sustained dominance in the heart of the order. That inconsistency has placed greater pressure on the lower half of the lineup, which has struggled to flip the order or extend innings with any regularity. The Cardinals are averaging 4.52 runs per game—respectable, but far from the firepower needed to consistently win in a division with high-octane offenses like the Reds and Brewers. The bullpen, which was a concern coming into the season, has delivered mixed results. Closer Ryan Helsley remains reliable in save situations, but middle relief has been shaky, often surrendering leads or failing to hold close deficits in check. For the Cardinals to even the series, they’ll need to support Liberatore early with run support, execute situationally at the plate, and clean up the defensive miscues that have plagued them during the series. St. Louis’s road struggles this season—just 4–12 away from Busch Stadium—have amplified their need to find urgency and rhythm in games like this, where the margin between winning and losing is often a single inning or mistake. If the Cardinals can play a clean game, get contributions from their core hitters, and avoid bullpen breakdowns, they’ll give themselves a strong chance to leave Cincinnati with a much-needed series split and a bit of momentum heading into May.
Credit: USA TODAY/IMAGN
Cincinnati Reds MLB Preview
The Cincinnati Reds enter the series finale against the St. Louis Cardinals with a 16–15 record and the opportunity to close out a key early-season divisional series with a win at Great American Ball Park. Holding a 2–1 edge in the four-game set, the Reds have leaned on a potent, high-energy offense and timely pitching to gain the upper hand, and they’ll now hand the ball to left-hander Andrew Abbott, who has emerged as one of the club’s more reliable starters. Abbott comes into the game with a 2–0 record and a 3.60 ERA, utilizing sharp command and an evolving mix of pitches to neutralize opposing hitters through six starts this season. He’s been especially effective at home, working deep into games and giving his team a chance to win in nearly every outing. The Reds’ lineup has been the engine behind their early-season success, averaging 5.28 runs per game and posting 33 home runs—solidifying their status as one of the more dangerous lineups in the National League. Elly De La Cruz has been a dynamic presence at the top of the order, combining raw speed, power, and defensive athleticism to impact games in multiple ways, while Spencer Steer, Christian Encarnacion-Strand, and Jonathan India have provided timely hits and depth throughout the lineup.
One of the Reds’ biggest strengths has been their ability to apply pressure on the basepaths, where aggressive running has led to extra bases, defensive mistakes, and disrupted rhythms for opposing pitchers. However, defensive inconsistency remains an area of concern—Cincinnati has committed 17 errors already this season, and those miscues have occasionally undercut strong offensive performances. With a relatively young roster, the challenge remains consistency on the defensive side and finishing games cleanly, especially against a Cardinals team capable of capitalizing on lapses. The bullpen has also been tested early this year, and while closer Alexis Díaz continues to provide late-inning stability, the bridge from starter to closer has been uneven, prompting manager David Bell to experiment with matchups and roles. To secure the series, the Reds will need Abbott to deliver at least six strong innings and the offense to strike early to alleviate late-game pressure. Containing St. Louis’s hot bats, particularly Lars Nootbaar and Nolan Arenado, will be a priority, and Cincinnati’s infield defense must tighten up to support their young starter. With the NL Central shaping up to be fiercely competitive, each divisional game carries increased weight, and the Reds have the chance to not only take the series but establish early-season legitimacy as contenders. A win here would keep them above .500 and send a strong message that their youth-driven roster is capable of both creating excitement and producing results. If they stay aggressive, protect the ball, and execute situationally, the Reds have all the ingredients to close out this series with authority.
More baseball from GABP this evening.
— Cincinnati Reds (@Reds) April 30, 2025
Powered by @PNCBank pic.twitter.com/HFQC2QEOfs
St. Louis vs. Cincinnati Prop Picks (AI)
St. Louis vs. Cincinnati Prediction (AI)
Remi, our AI sports algorithm, has been pouring over mountains of data from every angle between the Cardinals and Reds and using recursive machine learning and kick-ass AI to analyze the data to a single cover probability.
Remi has been most focused on the growing weight knucklehead sportsbettors regularly put on Cincinnati’s strength factors between a Cardinals team going up against a possibly rested Reds team. Trends look to say the true game analytics appear to reflect a moderate lean against one Vegas line in particular.
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Below is our current AI St. Louis vs Cincinnati picks, computer picks Cardinals vs Reds, best bets, model edges, confidence ratings.
| DATE | GAME | LEAN | %WIN | UNITS | LEVEL | |
|---|---|---|---|---|---|---|
| ACTIVE PICKS LOCKED - SEE NOW | ||||||
These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.
Cardinals Betting Trends
The Cardinals have a 5–5 record against the spread (ATS) in their last 10 games.
Reds Betting Trends
The Reds have covered the run line in 6 of their last 10 games.
Cardinals vs. Reds Matchup Trends
The Reds are favored with a moneyline of -122, while the Cardinals stand at +102; the over/under is set at 8.5 runs.
St. Louis vs. Cincinnati Game Info
What time does St. Louis vs Cincinnati start on May 01, 2025?
St. Louis vs Cincinnati starts on May 01, 2025 at 12:40 PM EST.
Where is St. Louis vs Cincinnati being played?
Venue: Great American Ball Park.
What are the opening odds for St. Louis vs Cincinnati?
Spread: Cincinnati -1.5
Moneyline: St. Louis +102, Cincinnati -122
Over/Under: 8.5
What are the records for St. Louis vs Cincinnati?
St. Louis: (14-17) | Cincinnati: (16-15)
What is the AI best bet for St. Louis vs Cincinnati?
Remi's searched hard and found the best prop for this matchup: P. Pages over 0.5 Total Bases.. Prices move—always shop for the best number.
What are St. Louis vs Cincinnati trending bets?
The Reds are favored with a moneyline of -122, while the Cardinals stand at +102; the over/under is set at 8.5 runs.
What are St. Louis trending bets?
STL trend: The Cardinals have a 5–5 record against the spread (ATS) in their last 10 games.
What are Cincinnati trending bets?
CIN trend: The Reds have covered the run line in 6 of their last 10 games.
Where can I find AI Picks for St. Louis vs Cincinnati?
See our latest MLB picks and odds pages for 2025 to compare prices before you bet.
St. Louis vs. Cincinnati Odds
Remi is pouring through tons of data on each player. In fact, anytime the St. Louis vs Cincinnati trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme altitude rarely follow normal, predictable betting trends.
St. Louis vs Cincinnati Opening Odds
STL Moneyline:
+102 CIN Moneyline: -122
STL Spread: +1.5
CIN Spread: -1.5
Over/Under: 8.5
St. Louis vs Cincinnati Live Odds
| Games | PTS | ML | SPR | O/U |
|---|
MLB Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers St. Louis Cardinals vs. Cincinnati Reds on May 01, 2025 at Great American Ball Park.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.
| LEAN | %WIN | UNITS | RESULT | |
|---|---|---|---|---|
| LAD@TOR | TOR +1.5 | 56.7% | 2 | WIN |
| TOR@LAD | TOR +1.5 | 55.3% | 4 | WIN |
| TOR@SEA | OVER 7 | 54.9% | 3 | WIN |
| LAD@MIL | UNDER 7.5 | 56.6% | 6 | WIN |
| TOR@NYY | OVER 8 | 54.9% | 4 | WIN |
| TOR@NYY | CARLOS RODON OVER 1.5 TOTAL WALKS ALLOWED | 53.3% | 3 | WIN |
| NYY@TOR | OVER 7.5 | 54.8% | 2 | WIN |
| LAD@PHI | OVER 7 | 53.8% | 3 | WIN |
| SD@CHC | CHC -109 | 53.8% | 3 | WIN |
| SD@CHC | OVER 7.5 | 54.5% | 4 | LOSS |
| SD@CHC | CHC -111 | 54.8% | 4 | LOSS |
| CIN@LAD | SHOHEI OHTANI OVER 1.5 BASES | 53.5% | 3 | WIN |
| BOS@NYY | OVER 7 | 53.8% | 3 | LOSS |
| CIN@LAD | ELLY DE LA CRUZ OVER 0.5 BASES | 54.4% | 4 | LOSS |
| ARI@SD | SD -131 | 57.3% | 4 | WIN |
| DET@BOS | BOS -115 | 56.4% | 5 | WIN |
| NYM@CHC | NYM -110 | 54.1% | 3 | WIN |
| HOU@ATH | ATH +118 | 50.8% | 4 | WIN |
| NYM@CHC | OVER 7 | 54.5% | 3 | WIN |
| STL@SF | OVER 7.5 | 55.9% | 5 | LOSS |
| KC@LAA | TYLER TOLBERT UNDER 1.5 BASES | 54.4% | 4 | WIN |
| MIL@SD | UNDER 9 | 54.7% | 4 | WIN |
| MIA@PHI | KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS | 53.3% | 3 | WIN |
| WAS@NYM | OVER 8.5 | 56.1% | 6 | LOSS |
| LAA@COL | COL +108 | 50.5% | 3 | WIN |
| TOR@KC | UNDER 9 | 54.7% | 4 | LOSS |
| SEA@KC | KC +1.5 | 62.3% | 5 | LOSS |
| NYY@MIN | OVER 9 | 55.1% | 4 | WIN |
| MIA@COL | OVER 10.5 | 55.0% | 4 | WIN |
| MIA@COL | AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS | 54.3% | 4 | WIN |
| SEA@KC | BOBBY WITT UNDER 0.5 SINGLES | 54.4% | 4 | LOSS |
| PHI@LAD | LAD -113 | 54.7% | 4 | LOSS |
| NYY@BOS | OVER 7.5 | 54.3% | 3 | WIN |
| KC@PHI | PHI -130 | 58.3% | 4 | WIN |
| LAD@SF | OVER 7.5 | 54.7% | 4 | LOSS |
| NYM@PHI | PHI -122 | 55.6% | 4 | WIN |
| KC@CLE | KC -104 | 52.0% | 3 | WIN |
| CIN@SD | JAKE CRONEWORTH OVER 0.5 HITS | 53.1% | 3 | WIN |
| WAS@MIA | MIA -123 | 55.2% | 4 | LOSS |
| LAA@KC | UNDER 9.5 | 54.9% | 3 | WIN |
| TEX@ARI | UNDER 9 | 54.2% | 4 | WIN |
| SF@COL | UNDER 11.5 | 56.4% | 6 | LOSS |
| SF@COL | RAFAEL DEVERS OVER 1.5 BASES | 56.1% | 6 | WIN |
| MIA@WAS | WAS -110 | 54.4% | 4 | WIN |
| NYM@DET | OVER 8.5 | 54.5% | 4 | WIN |
| TEX@ARI | UNDER 9.5 | 56.4% | 6 | WIN |
| TEX@ARI | ALEJANDRO OSUNA UNDER 1.5 BASES | 54.1% | 4 | LOSS |
| ATL@CHC | CHC -116 | 55.1% | 3 | WIN |
| PHI@MIL | OVER 8.5 | 55.0% | 3 | WIN |
| ARI@LAD | SHOHEI OHTANI OVER 2.5 BASES | 54.2% | 4 | WIN |
| SEA@CLE | CLE +1.5 | 57.2% | 3 | WIN |