Cardinals vs. Reds
Prediction, Odds & Props
May 01 | MLB AI Picks

Updated: 2025-04-29T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The St. Louis Cardinals and Cincinnati Reds will conclude their four-game series on May 1, 2025, at Great American Ball Park. The Reds currently lead the series 2–1 and aim to secure the series win, while the Cardinals look to even the series before heading back home.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: May 01, 2025

Start Time: 12:40 PM EST​

Venue: Great American Ball Park​

Reds Record: (16-15)

Cardinals Record: (14-17)

OPENING ODDS

STL Moneyline: +102

CIN Moneyline: -122

STL Spread: +1.5

CIN Spread: -1.5

Over/Under: 8.5

STL
Betting Trends

  • The Cardinals have a 5–5 record against the spread (ATS) in their last 10 games.

CIN
Betting Trends

  • The Reds have covered the run line in 6 of their last 10 games.

MATCHUP TRENDS

  • The Reds are favored with a moneyline of -122, while the Cardinals stand at +102; the over/under is set at 8.5 runs.

STL vs. CIN
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: P. Pages over 0.5 Total Bases.

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St. Louis vs Cincinnati Prediction & Odds:
Free MLB Betting Insights for 5/1/25

The St. Louis Cardinals and Cincinnati Reds will square off in the finale of their four-game series on May 1, 2025, at Great American Ball Park, with Cincinnati holding a 2–1 series lead and looking to secure a valuable home-series win. For the Reds, who sit at 16–15, this game represents an opportunity to continue building momentum in the crowded NL Central, while the Cardinals, at 14–17, aim to salvage a split and avoid slipping further in the divisional standings. The pitching matchup features promising young arms, as left-hander Matthew Liberatore gets the nod for St. Louis with a 2–2 record and a sharp 3.19 ERA, while Cincinnati counters with Andrew Abbott, who has impressed with a 2–0 mark and a 3.60 ERA, consistently keeping his team in games with poise and location-focused pitching. Both starters have demonstrated the ability to work deep into games, which will be key in reducing pressure on bullpens that have shown signs of vulnerability throughout the first month of the season. The Cardinals are led offensively by Lars Nootbaar, who has been one of the few steady producers with 5 home runs and 18 RBIs, although inconsistent run support has hurt St. Louis in tight contests. By contrast, the Reds enter the game with a more productive and dynamic offense, averaging over five runs per game and demonstrating a knack for putting together multi-run innings thanks to speed on the bases, solid situational hitting, and a lineup that can threaten throughout.

Key players like Elly De La Cruz and Spencer Steer have been instrumental in sparking Cincinnati’s offense, while the team’s ability to capitalize on St. Louis’s defensive miscues—of which there have been 11 so far this season—could play a pivotal role in a game expected to be closely contested. From a statistical standpoint, the Reds hold the edge in recent form, having covered the run line in 6 of their last 10 games, while the Cardinals have gone just 5–5 ATS during that same stretch. Both teams have room for improvement defensively, with the Reds committing 17 errors to date, but their offensive upside has helped cover those shortcomings in most cases. Oddsmakers currently favor Cincinnati slightly at -122 on the moneyline, with an over/under set at 8.5 runs, suggesting the expectation of moderate scoring and a closely played battle. For the Cardinals, success in Game 4 will hinge on getting an early lead, maximizing run-scoring chances, and avoiding the bullpen collapse that has cost them games earlier in the series. Cincinnati, meanwhile, will look to maintain its offensive pressure, support Abbott with sharp defense, and finish the series strong in front of a home crowd. This game carries meaningful weight for both clubs—not only for series bragging rights but as a tone-setter heading into a new month in one of baseball’s most tightly contested divisions.

St. Louis Cardinals MLB Preview

The St. Louis Cardinals head into the final game of their four-game road series against the Cincinnati Reds with a 14–17 record and a clear objective: salvage a split and reset their trajectory in the tightly packed NL Central. Despite a dominant 9–1 win in Game 2 of the series, inconsistency has once again marred the Cardinals’ performance, with offensive surges followed by missed opportunities and defensive lapses. On the mound for the finale is left-hander Matthew Liberatore, who has quietly been one of the more encouraging stories for the Cardinals’ rotation this season. Liberatore enters with a 2–2 record and a 3.19 ERA, offering the type of steady presence and pitch efficiency that could serve as a stabilizer for a club still trying to find its identity one month into the season. Liberatore’s curveball continues to be his signature pitch, and his ability to keep the ball on the ground has allowed the defense to limit big innings when it remains sharp. However, defensive missteps have plagued St. Louis, who have committed 11 errors so far in 2025—mistakes that have often proved costly in tightly contested games, particularly against teams like Cincinnati that thrive on pressure and extra opportunities. Offensively, the Cardinals have been uneven, but not without bright spots.

Outfielder Lars Nootbaar has been a spark plug, slashing consistently with 5 home runs and 18 RBIs to date, often setting the tone early in games and providing clutch hits in high-leverage spots. Veterans like Paul Goldschmidt and Nolan Arenado have shown flashes of their All-Star caliber form but have yet to string together sustained dominance in the heart of the order. That inconsistency has placed greater pressure on the lower half of the lineup, which has struggled to flip the order or extend innings with any regularity. The Cardinals are averaging 4.52 runs per game—respectable, but far from the firepower needed to consistently win in a division with high-octane offenses like the Reds and Brewers. The bullpen, which was a concern coming into the season, has delivered mixed results. Closer Ryan Helsley remains reliable in save situations, but middle relief has been shaky, often surrendering leads or failing to hold close deficits in check. For the Cardinals to even the series, they’ll need to support Liberatore early with run support, execute situationally at the plate, and clean up the defensive miscues that have plagued them during the series. St. Louis’s road struggles this season—just 4–12 away from Busch Stadium—have amplified their need to find urgency and rhythm in games like this, where the margin between winning and losing is often a single inning or mistake. If the Cardinals can play a clean game, get contributions from their core hitters, and avoid bullpen breakdowns, they’ll give themselves a strong chance to leave Cincinnati with a much-needed series split and a bit of momentum heading into May.

The St. Louis Cardinals and Cincinnati Reds will conclude their four-game series on May 1, 2025, at Great American Ball Park. The Reds currently lead the series 2–1 and aim to secure the series win, while the Cardinals look to even the series before heading back home. St. Louis vs Cincinnati AI Prediction: Free MLB Betting Insights for May 01. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Cincinnati Reds MLB Preview

The Cincinnati Reds enter the series finale against the St. Louis Cardinals with a 16–15 record and the opportunity to close out a key early-season divisional series with a win at Great American Ball Park. Holding a 2–1 edge in the four-game set, the Reds have leaned on a potent, high-energy offense and timely pitching to gain the upper hand, and they’ll now hand the ball to left-hander Andrew Abbott, who has emerged as one of the club’s more reliable starters. Abbott comes into the game with a 2–0 record and a 3.60 ERA, utilizing sharp command and an evolving mix of pitches to neutralize opposing hitters through six starts this season. He’s been especially effective at home, working deep into games and giving his team a chance to win in nearly every outing. The Reds’ lineup has been the engine behind their early-season success, averaging 5.28 runs per game and posting 33 home runs—solidifying their status as one of the more dangerous lineups in the National League. Elly De La Cruz has been a dynamic presence at the top of the order, combining raw speed, power, and defensive athleticism to impact games in multiple ways, while Spencer Steer, Christian Encarnacion-Strand, and Jonathan India have provided timely hits and depth throughout the lineup.

One of the Reds’ biggest strengths has been their ability to apply pressure on the basepaths, where aggressive running has led to extra bases, defensive mistakes, and disrupted rhythms for opposing pitchers. However, defensive inconsistency remains an area of concern—Cincinnati has committed 17 errors already this season, and those miscues have occasionally undercut strong offensive performances. With a relatively young roster, the challenge remains consistency on the defensive side and finishing games cleanly, especially against a Cardinals team capable of capitalizing on lapses. The bullpen has also been tested early this year, and while closer Alexis Díaz continues to provide late-inning stability, the bridge from starter to closer has been uneven, prompting manager David Bell to experiment with matchups and roles. To secure the series, the Reds will need Abbott to deliver at least six strong innings and the offense to strike early to alleviate late-game pressure. Containing St. Louis’s hot bats, particularly Lars Nootbaar and Nolan Arenado, will be a priority, and Cincinnati’s infield defense must tighten up to support their young starter. With the NL Central shaping up to be fiercely competitive, each divisional game carries increased weight, and the Reds have the chance to not only take the series but establish early-season legitimacy as contenders. A win here would keep them above .500 and send a strong message that their youth-driven roster is capable of both creating excitement and producing results. If they stay aggressive, protect the ball, and execute situationally, the Reds have all the ingredients to close out this series with authority.

St. Louis vs. Cincinnati Prop Picks (AI)

AI algorithm Remi is pouring through tons of datapoints on each team. In fact, anytime the Cardinals and Reds play there’s always several intriguing angles to key in on. Not to mention games played at Great American Ball Park in May can often follow normal, predictable betting trends.
Remi's searched hard and found the best prop for this matchup: P. Pages over 0.5 Total Bases.

St. Louis vs. Cincinnati Prediction (AI)

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Remi, our AI sports wizard, has been pouring over exorbitant amounts of data from every facet between the Cardinals and Reds and using recursive machine learning and cutting-edge AI to examine the data to a single cover probability.

The Algorithm has been most keyed in on the growing weight human bettors regularly put on coaching factors between a Cardinals team going up against a possibly unhealthy Reds team. It appears the true game analytics appear to reflect a strong lean against one Vegas line specifically.

Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.

Below is our current AI St. Louis vs Cincinnati picks, computer picks Cardinals vs Reds, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
MLB 9/26 DET@BOS UNLOCK THIS PICK 5 EXECUTIVE Locked EXECUTIVE
MLB 9/26 BAL@NYY UNLOCK THIS PICK 4 INTEL Locked INTEL
MLB 9/26 ARI@SD UNLOCK THIS PICK 4 EXECUTIVE Locked EXECUTIVE
MLB 9/26 NYM@MIA UNLOCK THIS PICK 1 INTEL Locked INTEL
MLB 9/26 NYM@MIA GET FREE PICK NOW 1
MLB 9/26 COL@SF UNLOCK THIS PICK 0 INTEL Locked INTEL

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.

Cardinals Betting Trends

The Cardinals have a 5–5 record against the spread (ATS) in their last 10 games.

Reds Betting Trends

The Reds have covered the run line in 6 of their last 10 games.

Cardinals vs. Reds Matchup Trends

The Reds are favored with a moneyline of -122, while the Cardinals stand at +102; the over/under is set at 8.5 runs.

St. Louis vs. Cincinnati Game Info

St. Louis vs Cincinnati starts on May 01, 2025 at 12:40 PM EST.

Venue: Great American Ball Park.

Spread: Cincinnati -1.5
Moneyline: St. Louis +102, Cincinnati -122
Over/Under: 8.5

St. Louis: (14-17)  |  Cincinnati: (16-15)

Remi's searched hard and found the best prop for this matchup: P. Pages over 0.5 Total Bases.. Prices move—always shop for the best number.

The Reds are favored with a moneyline of -122, while the Cardinals stand at +102; the over/under is set at 8.5 runs.

STL trend: The Cardinals have a 5–5 record against the spread (ATS) in their last 10 games.

CIN trend: The Reds have covered the run line in 6 of their last 10 games.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

St. Louis vs. Cincinnati Odds

Remi is pouring through mountains of data points on each line. In fact, anytime the St. Louis vs Cincinnati trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme travel distance seemingly never follow normal, predictable betting trends.

St. Louis vs Cincinnati Opening Odds

STL Moneyline: +102
CIN Moneyline: -122
STL Spread: +1.5
CIN Spread: -1.5
Over/Under: 8.5

St. Louis vs Cincinnati Live Odds

Games PTS ML SPR O/U
Sep 27, 2025 1:06PM EDT
Baltimore Orioles
New York Yankees
9/27/25 1:06PM
Orioles
Yankees
+190
-235
+1.5 (-110)
-1.5 (-110)
O 8.5 (-120)
U 8.5 (+100)
Sep 27, 2025 2:21PM EDT
St Louis Cardinals
Chicago Cubs
9/27/25 2:21PM
Cardinals
Cubs
 
-175
 
-1.5 (+115)
O 9.5 (-105)
U 9.5 (-115)
Sep 27, 2025 3:09PM EDT
Tampa Bay Rays
Toronto Blue Jays
9/27/25 3:09PM
Rays
Blue Jays
+130
-155
+1.5 (-155)
-1.5 (+130)
O 8.5 (-110)
U 8.5 (-110)
Sep 27, 2025 4:06PM EDT
Chicago White Sox
Washington Nationals
9/27/25 4:06PM
White Sox
Nationals
+100
-120
-1.5 (+165)
+1.5 (-200)
O 8.5 (-110)
U 8.5 (-110)
Sep 27, 2025 4:06PM EDT
Colorado Rockies
San Francisco Giants
9/27/25 4:06PM
Rockies
Giants
+185
-225
+1.5 (-110)
-1.5 (-110)
O 8 (-105)
U 8 (-115)
Sep 27, 2025 4:11PM EDT
New York Mets
Miami Marlins
9/27/25 4:11PM
Mets
Marlins
-130
+110
-1.5 (+125)
+1.5 (-150)
O 8.5 (-105)
U 8.5 (-115)
Sep 27, 2025 6:05PM EDT
Minnesota Twins
Philadelphia Phillies
9/27/25 6:05PM
Twins
Phillies
+170
-205
+1.5 (-120)
-1.5 (+100)
O 8.5 (-115)
U 8.5 (-105)
Sep 27, 2025 7:11PM EDT
Cincinnati Reds
Milwaukee Brewers
9/27/25 7:11PM
Reds
Brewers
+125
-150
+1.5 (-180)
-1.5 (+150)
O 8 (-105)
U 8 (-115)
Sep 27, 2025 7:15PM EDT
Pittsburgh Pirates
Atlanta Braves
9/27/25 7:15PM
Pirates
Braves
+140
-170
+1.5 (-155)
-1.5 (+130)
O 8 (-110)
U 8 (-110)
Sep 27, 2025 7:16PM EDT
Texas Rangers
Cleveland Guardians
9/27/25 7:16PM
Rangers
Guardians
+135
-165
+1.5 (-180)
-1.5 (+150)
O 7 (-120)
U 7 (+100)
Sep 27, 2025 8:40PM EDT
Arizona Diamondbacks
San Diego Padres
9/27/25 8:40PM
Diamondbacks
Padres
+115
-140
+1.5 (-190)
-1.5 (+155)
O 7.5 (-120)
U 7.5 (+100)
Sep 27, 2025 9:39PM EDT
Houston Astros
Los Angeles Angels
9/27/25 9:39PM
Astros
Angels
-165
+135
-1.5 (+105)
+1.5 (-125)
O 9 (+100)
U 9 (-120)
Sep 27, 2025 9:41PM EDT
Los Angeles Dodgers
Seattle Mariners
9/27/25 9:41PM
Dodgers
Mariners
+100
-120
-1.5 (+170)
+1.5 (-205)
O 7.5 (-110)
U 7.5 (-110)
Sep 27, 2025 10:05PM EDT
Kansas City Royals
Oakland Athletics
9/27/25 10:05PM
Royals
Athletics
+100
-120
-1.5 (+150)
+1.5 (-180)
O 10 (-110)
U 10 (-110)

MLB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers St. Louis Cardinals vs. Cincinnati Reds on May 01, 2025 at Great American Ball Park.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN
CHC@SF CHC -105 54.1% 4 LOSS
NYY@CHW RYAN MCMAHON OVER 0.5 BASES 54.1% 4 WIN
PHI@NYM OVER 8.5 55.6% 4 LOSS
LAA@TEX LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS 54.1% 4 LOSS
KC@CHW KC -109 54.2% 4 WIN
SD@SEA DYLAN CEASE OVER 16.5 OUTS 53.9% 3 LOSS
SD@SEA UNDER 8.5 54.4% 4 LOSS
MIN@TOR JOE RYAN UNDER 2.5 EARNED RUNS 54.1% 4 LOSS
SF@MIL MIL +100 54.0% 6 LOSS
TOR@MIA MIA +1.5 62.0% 6 WIN
CHC@LAA OVER 9.5 54.9% 4 LOSS
BOS@NYY CARLOS RODON UNDER 4.5 HITS ALLOWED 54.2% 4 WIN
KC@DET DET -115 56.1% 5 WIN
CHC@LAA LAA +1.5 57.6% 5 LOSS
CIN@ARI KEBRYAN HAYES STRIKEOUTS UNDER 0.5 56.2% 6 WIN
LAD@SD SD +110 50.9% 6 WIN