Giants vs. Padres
Prediction, Odds & Props
Apr 29 | MLB AI Picks
Updated: 2025-04-27T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
On April 29, 2025, the San Francisco Giants (19–10) will face the San Diego Padres (17–11) at Petco Park in San Diego. This National League West matchup features two teams vying for division supremacy, with both sending their aces to the mound.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

GAME INFO
Date: Apr 29, 2025
Start Time: 9:40 PM EST
Venue: Petco Park
Padres Record: (17-11)
Giants Record: (19-10)
OPENING ODDS
SF Moneyline: -126
SD Moneyline: +105
SF Spread: -1.5
SD Spread: +1.5
Over/Under: 6.5
SF
Betting Trends
- The Giants have a 10–6 record against the spread (ATS) on the road this season, indicating strong performance in covering the run line during away games.
SD
Betting Trends
- The Padres boast a 12–4 ATS record at home, reflecting consistent success in covering the spread at Petco Park.
MATCHUP TRENDS
- The over/under for this game is set at 7.5 runs, suggesting expectations of a low-scoring affair between two strong pitching staffs.
SF vs. SD
Best Prop Bet
- Remi's searched hard and found the best prop for this matchup: M. Yastrzemski over 0.5 Total Bases.
LIVE MLB ODDS
MLB ODDS COMPARISON
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San Francisco vs San Diego Prediction & Odds:
Free MLB Betting Insights for 4/29/25
Their lineup, while dangerous, will have to adjust to the ground-ball heavy tendencies of Webb, who excels at forcing weak contact and keeping the ball in the park. Defensively, both teams have been solid, but the Padres’ athleticism and aggressiveness, especially in the outfield, could make a difference in turning hits into outs on the spacious Petco Park field. Strategically, the matchup leans toward a razor-thin margin, where managerial decisions, bullpen efficiency, and perhaps even a defensive gem could swing the outcome. Gabe Kapler’s Giants are known for their tactical flexibility and depth usage, while Mike Shildt’s Padres have thrived with a more traditional, star-driven approach. Given San Francisco’s recent 2-8 ATS slump and San Diego’s flawless home record, the Padres seem poised to hold the edge, but in a low-scoring environment with two elite pitchers starting, even a small mistake could tip the balance. Both bullpens will play a critical role late, especially if either starter exits early after taxing outings. In a game that could serve as an early measuring stick for postseason aspirations, the Giants and Padres will not only be battling for standings but also for a psychological advantage that could resonate throughout the grueling months ahead. Fans should expect a tense, strategic battle where every pitch and swing feels magnified under the weight of two heavyweight clubs colliding with pride and position on the line.
— SFGiants (@SFGiants) April 26, 2025
San Francisco Giants MLB Preview
The San Francisco Giants step into Petco Park for Tuesday’s critical divisional matchup carrying both the weight of expectation and the burden of inconsistency against the spread, having gone just 2-8 ATS over their last 10 games despite an impressive overall 17-9 record. Led by manager Gabe Kapler’s methodical, matchup-based approach, the Giants have found success this season through disciplined pitching, smart baserunning, and a contact-first offensive strategy that demands execution at a high level. Logan Webb, the Giants’ ace, will take the ball carrying a 3-1 record and a sparkling 1.98 ERA, giving San Francisco plenty of reason to believe they can cool off a scorching Padres squad that has yet to lose at home. Webb’s elite command, ability to induce ground balls at one of the highest rates in the league, and calm demeanor in high-leverage situations will be critical weapons against San Diego’s aggressive hitters. While the Giants have succeeded by playing sound, fundamental baseball, they know that a razor-thin margin for error exists against a team with the kind of firepower the Padres bring to the field every night. Offensively, the Giants have relied heavily on the consistency of Jung Hoo Lee, whose .324 batting average has provided a reliable spark at the top of the order, while Wilmer Flores continues to drive in runs with clutch power, contributing seven homers and 28 RBIs thus far. The offense, while capable of putting up crooked numbers, often thrives best when they manufacture runs through stringing hits together, moving runners over, and capitalizing on defensive miscues.
Against Nick Pivetta, who has been virtually untouchable with a 1.20 ERA, the Giants will need to stay patient, work deep counts, and make the most of any rare mistakes he offers over the plate. Defensively, San Francisco remains one of the more disciplined and technically sound units in the league, with crisp infield play and an outfield that excels at cutting down gaps and limiting extra bases, a skill that will be tested on the spacious dimensions of Petco Park. However, given the Padres’ aggression on the bases and penchant for creating chaos, the Giants must maintain sharp focus and clean execution throughout all nine innings. Despite the Padres’ flawless home record, the Giants have every reason to approach this game with the quiet confidence that comes from elite pitching and the knowledge that a single strong performance can flip the momentum in a season series. If Webb can keep the ball on the ground and avoid the big inning, and if the Giants’ offense can scratch across a few runs early to put pressure on Pivetta and the Padres’ bullpen, San Francisco could find themselves in prime position to hand San Diego their first home loss of the year. Kapler’s team is built for these kinds of tightly contested, low-scoring battles, and Tuesday’s game figures to be a test of patience, resilience, and timely execution — all attributes that, at their best, the Giants have shown in abundance. In a season where every divisional game carries enormous weight, the Giants know that stealing a win at Petco Park would not just pad the standings, but serve as a statement that San Francisco remains a legitimate force to be reckoned with in the National League West.

Credit: USA TODAY/IMAGN
San Diego Padres MLB Preview
The San Diego Padres enter Tuesday’s matchup against the San Francisco Giants carrying an immense wave of momentum, boasting an impeccable 10-0 record at Petco Park that has solidified their status as one of the National League’s most dangerous home teams. Sitting at 17-9 overall, the Padres have found their winning formula through a lethal combination of dominant starting pitching, opportunistic offense, and dynamic defense that makes life miserable for visiting clubs. On the mound, they will send Nick Pivetta, who has been nothing short of masterful so far this season, posting a 4-1 record with a microscopic 1.20 ERA, displaying excellent command, sharp secondary pitches, and the confidence of a pitcher who is finally realizing his full potential. Pivetta’s presence gives the Padres a significant boost, especially against a Giants team that thrives on contact but may find it difficult to square up his unpredictable arsenal. Offensively, the Padres have ridden the electric bat of Fernando Tatis Jr., who leads the way with a sizzling .346 batting average, eight home runs, and 18 RBIs, consistently providing clutch hits and game-changing moments. Beyond Tatis Jr., the Padres lineup is filled with players capable of creating havoc; Manny Machado, Xander Bogaerts, and Jake Cronenworth all bring professional, seasoned approaches to the plate, which will be critical against a ground-ball specialist like Logan Webb. Their ability to stay disciplined, wait for mistakes, and capitalize in key moments has separated San Diego from many teams during this hot stretch.
The Padres have also played aggressively on the bases, putting pressure on opposing defenses and manufacturing extra runs through hustle and smart situational awareness, a trait that will be vital against a disciplined Giants pitching staff. Defensively, the Padres shine with athleticism and awareness, particularly in the outfield where Tatis Jr. and Trent Grisham cover immense ground and have the arms to cut down overly ambitious baserunners. The bullpen has also been a strength, with closer Robert Suarez anchoring a group that has consistently slammed the door when called upon in the late innings. Given their recent form and undeniable home advantage, the Padres will approach this game with confidence but also with a necessary respect for a Giants team that, despite recent ATS struggles, has enough firepower and grit to upset even the hottest home squads. Mike Shildt’s managing style — trusting his players while making subtle, timely moves — has been critical in maintaining a positive clubhouse energy, even as expectations around the team have grown considerably. With the moneyline tipping slightly in the Giants’ favor, the Padres have a perfect opportunity to prove oddsmakers wrong once again by extending their flawless Petco Park run. If Pivetta continues his dominance, if the offense can scratch together just a few timely runs, and if the bullpen holds serve late, San Diego could very well walk away with a crucial win that not only maintains their unblemished home record but sends a powerful message to the rest of the league that winning in their house will be one of the season’s most difficult challenges. Expect a lively crowd, a highly focused team, and a Padres squad determined to continue setting the standard for home dominance in 2025.
Final. pic.twitter.com/izBXkcGcrh
— San Diego Padres (@Padres) April 27, 2025
San Francisco vs. San Diego Prop Picks (AI)
San Francisco vs. San Diego Prediction (AI)

Remi, our AI sports wizard, has been pouring over tons of data from every simulation between the Giants and Padres and using recursive machine learning and impressive AI to examine the data to a single cover probability.
Oddly enough, we’ve seen the AI has been most keyed in on the unproportionally assigned factor knucklehead sportsbettors regularly put on player performance factors between a Giants team going up against a possibly tired Padres team. It appears the true game analytics appear to reflect a strong lean against one Vegas line specifically.
Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.
Below is our current AI San Francisco vs San Diego picks, computer picks Giants vs Padres, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
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Giants Betting Trends
The Giants have a 10–6 record against the spread (ATS) on the road this season, indicating strong performance in covering the run line during away games.
Padres Betting Trends
The Padres boast a 12–4 ATS record at home, reflecting consistent success in covering the spread at Petco Park.
Giants vs. Padres Matchup Trends
The over/under for this game is set at 7.5 runs, suggesting expectations of a low-scoring affair between two strong pitching staffs.
San Francisco vs. San Diego Game Info
What time does San Francisco vs San Diego start on April 29, 2025?
San Francisco vs San Diego starts on April 29, 2025 at 9:40 PM EST.
Where is San Francisco vs San Diego being played?
Venue: Petco Park.
What are the opening odds for San Francisco vs San Diego?
Spread: San Diego +1.5
Moneyline: San Francisco -126, San Diego +105
Over/Under: 6.5
What are the records for San Francisco vs San Diego?
San Francisco: (19-10) | San Diego: (17-11)
What is the AI best bet for San Francisco vs San Diego?
Remi's searched hard and found the best prop for this matchup: M. Yastrzemski over 0.5 Total Bases.. Prices move—always shop for the best number.
What are San Francisco vs San Diego trending bets?
The over/under for this game is set at 7.5 runs, suggesting expectations of a low-scoring affair between two strong pitching staffs.
What are San Francisco trending bets?
SF trend: The Giants have a 10–6 record against the spread (ATS) on the road this season, indicating strong performance in covering the run line during away games.
What are San Diego trending bets?
SD trend: The Padres boast a 12–4 ATS record at home, reflecting consistent success in covering the spread at Petco Park.
Where can I find AI Picks for San Francisco vs San Diego?
See our latest MLB picks and odds pages for 2025 to compare prices before you bet.
San Francisco vs. San Diego Odds
Remi is pouring through tons of data points on each team. In fact, anytime the San Francisco vs San Diego trends are analyzed, there’s always several intriguing trends to key in on. Not to mention games played at extreme travel distance almost always follow normal, predictable betting trends.
San Francisco vs San Diego Opening Odds
SF Moneyline:
-126 SD Moneyline: +105
SF Spread: -1.5
SD Spread: +1.5
Over/Under: 6.5
San Francisco vs San Diego Live Odds
Games | PTS | ML | SPR | O/U | |
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In Progress
Baltimore Orioles
New York Yankees
In Progress
Orioles
Yankees
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0
3
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+1200
-2800
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+4.5 (-115)
-4.5 (-115)
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O 7.5 (-130)
U 7.5 (+100)
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In Progress
St Louis Cardinals
Chicago Cubs
In Progress
Cardinals
Cubs
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0
1
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-300
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-1.5 (-140)
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O 9.5 (+100)
U 9.5 (-130)
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Sep 27, 2025 3:09PM EDT
Tampa Bay Rays
Toronto Blue Jays
9/27/25 3:09PM
Rays
Blue Jays
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–
–
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+140
-170
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+1.5 (-155)
-1.5 (+130)
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O 8.5 (-105)
U 8.5 (-115)
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Sep 27, 2025 4:05PM EDT
Chicago White Sox
Washington Nationals
9/27/25 4:05PM
White Sox
Nationals
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–
–
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-105
-115
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-1.5 (+155)
+1.5 (-190)
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O 8.5 (-115)
U 8.5 (-105)
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Sep 27, 2025 4:06PM EDT
Colorado Rockies
San Francisco Giants
9/27/25 4:06PM
Rockies
Giants
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–
–
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+190
-235
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+1.5 (-105)
-1.5 (-115)
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O 8 (-105)
U 8 (-115)
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Sep 27, 2025 4:11PM EDT
New York Mets
Miami Marlins
9/27/25 4:11PM
Mets
Marlins
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–
–
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-140
+115
|
-1.5 (+125)
+1.5 (-150)
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O 8 (-105)
U 8 (-115)
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Sep 27, 2025 4:11PM EDT
Detroit Tigers
Boston Red Sox
9/27/25 4:11PM
Tigers
Red Sox
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–
–
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+105
-125
|
-1.5 (+165)
+1.5 (-200)
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O 8.5 (-110)
U 8.5 (-110)
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|
Sep 27, 2025 6:05PM EDT
Minnesota Twins
Philadelphia Phillies
9/27/25 6:05PM
Twins
Phillies
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–
–
|
+185
-225
|
+1.5 (-110)
-1.5 (-110)
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O 8.5 (-115)
U 8.5 (-105)
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Sep 27, 2025 7:11PM EDT
Cincinnati Reds
Milwaukee Brewers
9/27/25 7:11PM
Reds
Brewers
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–
–
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+110
-130
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+1.5 (-190)
-1.5 (+155)
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O 8 (-110)
U 8 (-110)
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Sep 27, 2025 7:15PM EDT
Pittsburgh Pirates
Atlanta Braves
9/27/25 7:15PM
Pirates
Braves
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–
–
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+145
-175
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+1.5 (-150)
-1.5 (+125)
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O 8 (-105)
U 8 (-115)
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Sep 27, 2025 7:16PM EDT
Texas Rangers
Cleveland Guardians
9/27/25 7:16PM
Rangers
Guardians
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–
–
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+120
-145
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+1.5 (-190)
-1.5 (+155)
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O 7 (-120)
U 7 (+100)
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Sep 27, 2025 8:40PM EDT
Arizona Diamondbacks
San Diego Padres
9/27/25 8:40PM
Diamondbacks
Padres
|
–
–
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+115
-140
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+1.5 (-180)
-1.5 (+150)
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O 7.5 (-120)
U 7.5 (+100)
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|
Sep 27, 2025 9:39PM EDT
Houston Astros
Los Angeles Angels
9/27/25 9:39PM
Astros
Angels
|
–
–
|
-145
+120
|
-1.5 (+110)
+1.5 (-130)
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O 9 (-110)
U 9 (-110)
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|
Sep 27, 2025 9:41PM EDT
Los Angeles Dodgers
Seattle Mariners
9/27/25 9:41PM
Dodgers
Mariners
|
–
–
|
+100
-120
|
-1.5 (+175)
+1.5 (-215)
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O 7 (-115)
U 7 (-105)
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Sep 27, 2025 10:05PM EDT
Kansas City Royals
Oakland Athletics
9/27/25 10:05PM
Royals
Athletics
|
–
–
|
+100
-120
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-1.5 (+155)
+1.5 (-190)
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O 10 (-115)
U 10 (-105)
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MLB Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers San Francisco Giants vs. San Diego Padres on April 29, 2025 at Petco Park.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.
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LEAN | %WIN | UNITS | RESULT |
---|---|---|---|---|
ARI@SD | SD -131 | 57.3% | 4 | WIN |
DET@BOS | BOS -115 | 56.4% | 5 | WIN |
NYM@CHC | NYM -110 | 54.1% | 3 | WIN |
HOU@ATH | ATH +118 | 50.8% | 4 | WIN |
NYM@CHC | OVER 7 | 54.5% | 3 | WIN |
STL@SF | OVER 7.5 | 55.9% | 5 | LOSS |
KC@LAA | TYLER TOLBERT UNDER 1.5 BASES | 54.4% | 4 | WIN |
MIL@SD | UNDER 9 | 54.7% | 4 | WIN |
MIA@PHI | KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS | 53.3% | 3 | WIN |
WAS@NYM | OVER 8.5 | 56.1% | 6 | LOSS |
LAA@COL | COL +108 | 50.5% | 3 | WIN |
TOR@KC | UNDER 9 | 54.7% | 4 | LOSS |
SEA@KC | KC +1.5 | 62.3% | 5 | LOSS |
NYY@MIN | OVER 9 | 55.1% | 4 | WIN |
MIA@COL | OVER 10.5 | 55.0% | 4 | WIN |
MIA@COL | AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS | 54.3% | 4 | WIN |
SEA@KC | BOBBY WITT UNDER 0.5 SINGLES | 54.4% | 4 | LOSS |
PHI@LAD | LAD -113 | 54.7% | 4 | LOSS |
NYY@BOS | OVER 7.5 | 54.3% | 3 | WIN |
KC@PHI | PHI -130 | 58.3% | 4 | WIN |
LAD@SF | OVER 7.5 | 54.7% | 4 | LOSS |
NYM@PHI | PHI -122 | 55.6% | 4 | WIN |
KC@CLE | KC -104 | 52.0% | 3 | WIN |
CIN@SD | JAKE CRONEWORTH OVER 0.5 HITS | 53.1% | 3 | WIN |
WAS@MIA | MIA -123 | 55.2% | 4 | LOSS |
LAA@KC | UNDER 9.5 | 54.9% | 3 | WIN |
TEX@ARI | UNDER 9 | 54.2% | 4 | WIN |
SF@COL | UNDER 11.5 | 56.4% | 6 | LOSS |
SF@COL | RAFAEL DEVERS OVER 1.5 BASES | 56.1% | 6 | WIN |
MIA@WAS | WAS -110 | 54.4% | 4 | WIN |
NYM@DET | OVER 8.5 | 54.5% | 4 | WIN |
TEX@ARI | UNDER 9.5 | 56.4% | 6 | WIN |
TEX@ARI | ALEJANDRO OSUNA UNDER 1.5 BASES | 54.1% | 4 | LOSS |
ATL@CHC | CHC -116 | 55.1% | 3 | WIN |
PHI@MIL | OVER 8.5 | 55.0% | 3 | WIN |
ARI@LAD | SHOHEI OHTANI OVER 2.5 BASES | 54.2% | 4 | WIN |
SEA@CLE | CLE +1.5 | 57.2% | 3 | WIN |
CHC@SF | CHC -105 | 54.1% | 4 | LOSS |
NYY@CHW | RYAN MCMAHON OVER 0.5 BASES | 54.1% | 4 | WIN |
PHI@NYM | OVER 8.5 | 55.6% | 4 | LOSS |
LAA@TEX | LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS | 54.1% | 4 | LOSS |
KC@CHW | KC -109 | 54.2% | 4 | WIN |
SD@SEA | DYLAN CEASE OVER 16.5 OUTS | 53.9% | 3 | LOSS |
SD@SEA | UNDER 8.5 | 54.4% | 4 | LOSS |
MIN@TOR | JOE RYAN UNDER 2.5 EARNED RUNS | 54.1% | 4 | LOSS |
SF@MIL | MIL +100 | 54.0% | 6 | LOSS |
TOR@MIA | MIA +1.5 | 62.0% | 6 | WIN |
CHC@LAA | OVER 9.5 | 54.9% | 4 | LOSS |
BOS@NYY | CARLOS RODON UNDER 4.5 HITS ALLOWED | 54.2% | 4 | WIN |
KC@DET | DET -115 | 56.1% | 5 | WIN |
CHC@LAA | LAA +1.5 | 57.6% | 5 | LOSS |