Giants vs Padres Prediction — AI Finds CAN'T MISS MLB Lines & Props (Apr 29)

Updated: 2025-04-27T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

On April 29, 2025, the San Francisco Giants (19–10) will face the San Diego Padres (17–11) at Petco Park in San Diego. This National League West matchup features two teams vying for division supremacy, with both sending their aces to the mound.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Apr 29, 2025

Start Time: 9:40 PM EST​

Venue: Petco Park​

Padres Record: (17-11)

Giants Record: (19-10)

OPENING ODDS

SF Moneyline: -126

SD Moneyline: +105

SF Spread: -1.5

SD Spread: +1.5

Over/Under: 6.5

SF
Betting Trends

  • The Giants have a 10–6 record against the spread (ATS) on the road this season, indicating strong performance in covering the run line during away games.

SD
Betting Trends

  • The Padres boast a 12–4 ATS record at home, reflecting consistent success in covering the spread at Petco Park.

MATCHUP TRENDS

  • The over/under for this game is set at 7.5 runs, suggesting expectations of a low-scoring affair between two strong pitching staffs.

SF vs. SD
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: M. Yastrzemski over 0.5 Total Bases.

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San Francisco vs San Diego Prediction & Odds:
Free MLB Betting Insights for 4/29/25

The upcoming clash between the San Francisco Giants and the San Diego Padres on April 29, 2025, at Petco Park offers an enticing National League West showdown between two evenly matched rivals. Both teams enter the contest with identical 17-9 records, highlighting just how closely they have mirrored each other’s success in the early part of the season. The Padres, riding an immaculate 10-0 home record, are banking on their dominance at Petco Park to continue against a Giants squad that has battled admirably but struggled somewhat against the spread on the road. Taking the mound for San Francisco will be ace Logan Webb, who has been spectacular so far with a 3-1 record and a 1.98 ERA, demonstrating his usual precision and command. Opposing him will be Nick Pivetta, a revelation for the Padres this season with a sparkling 4-1 record and a minuscule 1.20 ERA, showcasing an ability to stifle hitters with a combination of movement and velocity. With an over/under line set at just 6.5 runs, bookmakers are clearly expecting a pitching duel, where offense will come at a premium and each run will be hard-earned. The Giants’ offense has been steady rather than explosive, led by Jung Hoo Lee’s .324 batting average at the top of the lineup, providing consistency and energy, and Wilmer Flores’ timely power, with seven home runs and 28 RBIs to his name. San Francisco has leaned on manufacturing runs through stringing hits together rather than relying solely on the long ball, a style that will be tested against Pivetta’s precision. Meanwhile, the Padres have flexed more power, driven by the dynamic Fernando Tatis Jr., who is hitting .346 with eight home runs and 18 RBIs, providing a constant spark and threat whenever he steps into the batter’s box.

Their lineup, while dangerous, will have to adjust to the ground-ball heavy tendencies of Webb, who excels at forcing weak contact and keeping the ball in the park. Defensively, both teams have been solid, but the Padres’ athleticism and aggressiveness, especially in the outfield, could make a difference in turning hits into outs on the spacious Petco Park field. Strategically, the matchup leans toward a razor-thin margin, where managerial decisions, bullpen efficiency, and perhaps even a defensive gem could swing the outcome. Gabe Kapler’s Giants are known for their tactical flexibility and depth usage, while Mike Shildt’s Padres have thrived with a more traditional, star-driven approach. Given San Francisco’s recent 2-8 ATS slump and San Diego’s flawless home record, the Padres seem poised to hold the edge, but in a low-scoring environment with two elite pitchers starting, even a small mistake could tip the balance. Both bullpens will play a critical role late, especially if either starter exits early after taxing outings. In a game that could serve as an early measuring stick for postseason aspirations, the Giants and Padres will not only be battling for standings but also for a psychological advantage that could resonate throughout the grueling months ahead. Fans should expect a tense, strategic battle where every pitch and swing feels magnified under the weight of two heavyweight clubs colliding with pride and position on the line.

San Francisco Giants MLB Preview

The San Francisco Giants step into Petco Park for Tuesday’s critical divisional matchup carrying both the weight of expectation and the burden of inconsistency against the spread, having gone just 2-8 ATS over their last 10 games despite an impressive overall 17-9 record. Led by manager Gabe Kapler’s methodical, matchup-based approach, the Giants have found success this season through disciplined pitching, smart baserunning, and a contact-first offensive strategy that demands execution at a high level. Logan Webb, the Giants’ ace, will take the ball carrying a 3-1 record and a sparkling 1.98 ERA, giving San Francisco plenty of reason to believe they can cool off a scorching Padres squad that has yet to lose at home. Webb’s elite command, ability to induce ground balls at one of the highest rates in the league, and calm demeanor in high-leverage situations will be critical weapons against San Diego’s aggressive hitters. While the Giants have succeeded by playing sound, fundamental baseball, they know that a razor-thin margin for error exists against a team with the kind of firepower the Padres bring to the field every night. Offensively, the Giants have relied heavily on the consistency of Jung Hoo Lee, whose .324 batting average has provided a reliable spark at the top of the order, while Wilmer Flores continues to drive in runs with clutch power, contributing seven homers and 28 RBIs thus far. The offense, while capable of putting up crooked numbers, often thrives best when they manufacture runs through stringing hits together, moving runners over, and capitalizing on defensive miscues.

Against Nick Pivetta, who has been virtually untouchable with a 1.20 ERA, the Giants will need to stay patient, work deep counts, and make the most of any rare mistakes he offers over the plate. Defensively, San Francisco remains one of the more disciplined and technically sound units in the league, with crisp infield play and an outfield that excels at cutting down gaps and limiting extra bases, a skill that will be tested on the spacious dimensions of Petco Park. However, given the Padres’ aggression on the bases and penchant for creating chaos, the Giants must maintain sharp focus and clean execution throughout all nine innings. Despite the Padres’ flawless home record, the Giants have every reason to approach this game with the quiet confidence that comes from elite pitching and the knowledge that a single strong performance can flip the momentum in a season series. If Webb can keep the ball on the ground and avoid the big inning, and if the Giants’ offense can scratch across a few runs early to put pressure on Pivetta and the Padres’ bullpen, San Francisco could find themselves in prime position to hand San Diego their first home loss of the year. Kapler’s team is built for these kinds of tightly contested, low-scoring battles, and Tuesday’s game figures to be a test of patience, resilience, and timely execution — all attributes that, at their best, the Giants have shown in abundance. In a season where every divisional game carries enormous weight, the Giants know that stealing a win at Petco Park would not just pad the standings, but serve as a statement that San Francisco remains a legitimate force to be reckoned with in the National League West.

On April 29, 2025, the San Francisco Giants (19–10) will face the San Diego Padres (17–11) at Petco Park in San Diego. This National League West matchup features two teams vying for division supremacy, with both sending their aces to the mound. San Francisco vs San Diego AI Prediction: Free MLB Betting Insights for Apr 29. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

San Diego Padres MLB Preview

The San Diego Padres enter Tuesday’s matchup against the San Francisco Giants carrying an immense wave of momentum, boasting an impeccable 10-0 record at Petco Park that has solidified their status as one of the National League’s most dangerous home teams. Sitting at 17-9 overall, the Padres have found their winning formula through a lethal combination of dominant starting pitching, opportunistic offense, and dynamic defense that makes life miserable for visiting clubs. On the mound, they will send Nick Pivetta, who has been nothing short of masterful so far this season, posting a 4-1 record with a microscopic 1.20 ERA, displaying excellent command, sharp secondary pitches, and the confidence of a pitcher who is finally realizing his full potential. Pivetta’s presence gives the Padres a significant boost, especially against a Giants team that thrives on contact but may find it difficult to square up his unpredictable arsenal. Offensively, the Padres have ridden the electric bat of Fernando Tatis Jr., who leads the way with a sizzling .346 batting average, eight home runs, and 18 RBIs, consistently providing clutch hits and game-changing moments. Beyond Tatis Jr., the Padres lineup is filled with players capable of creating havoc; Manny Machado, Xander Bogaerts, and Jake Cronenworth all bring professional, seasoned approaches to the plate, which will be critical against a ground-ball specialist like Logan Webb. Their ability to stay disciplined, wait for mistakes, and capitalize in key moments has separated San Diego from many teams during this hot stretch.

The Padres have also played aggressively on the bases, putting pressure on opposing defenses and manufacturing extra runs through hustle and smart situational awareness, a trait that will be vital against a disciplined Giants pitching staff. Defensively, the Padres shine with athleticism and awareness, particularly in the outfield where Tatis Jr. and Trent Grisham cover immense ground and have the arms to cut down overly ambitious baserunners. The bullpen has also been a strength, with closer Robert Suarez anchoring a group that has consistently slammed the door when called upon in the late innings. Given their recent form and undeniable home advantage, the Padres will approach this game with confidence but also with a necessary respect for a Giants team that, despite recent ATS struggles, has enough firepower and grit to upset even the hottest home squads. Mike Shildt’s managing style — trusting his players while making subtle, timely moves — has been critical in maintaining a positive clubhouse energy, even as expectations around the team have grown considerably. With the moneyline tipping slightly in the Giants’ favor, the Padres have a perfect opportunity to prove oddsmakers wrong once again by extending their flawless Petco Park run. If Pivetta continues his dominance, if the offense can scratch together just a few timely runs, and if the bullpen holds serve late, San Diego could very well walk away with a crucial win that not only maintains their unblemished home record but sends a powerful message to the rest of the league that winning in their house will be one of the season’s most difficult challenges. Expect a lively crowd, a highly focused team, and a Padres squad determined to continue setting the standard for home dominance in 2025.

San Francisco vs. San Diego Prop Picks (AI)

AI algorithm Remi is pouring through mountains of data on each player. In fact, anytime the Giants and Padres play there’s always several intriguing observations to key in on. Not to mention games played at Petco Park in Apr rarely follow normal, predictable patterns.
Remi's searched hard and found the best prop for this matchup: M. Yastrzemski over 0.5 Total Bases.

San Francisco vs. San Diego Prediction (AI)

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Remi, our AI sports algorithm, has been pouring over millions of data from every past game between the Giants and Padres and using recursive machine learning and kick-ass AI to crunch the data to a single cover probability.

Interestingly enough, the data has been most fixated on the trending factor knucklehead sportsbettors regularly put on coaching factors between a Giants team going up against a possibly tired Padres team. We’ve found the true game analytics might reflect a moderate lean against one Vegas line in particular.

Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.

Below is our current AI San Francisco vs San Diego picks, computer picks Giants vs Padres, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.

Giants Betting Trends

The Giants have a 10–6 record against the spread (ATS) on the road this season, indicating strong performance in covering the run line during away games.

Padres Betting Trends

The Padres boast a 12–4 ATS record at home, reflecting consistent success in covering the spread at Petco Park.

Giants vs. Padres Matchup Trends

The over/under for this game is set at 7.5 runs, suggesting expectations of a low-scoring affair between two strong pitching staffs.

San Francisco vs. San Diego Game Info

San Francisco vs San Diego starts on April 29, 2025 at 9:40 PM EST.

Spread: San Diego +1.5
Moneyline: San Francisco -126, San Diego +105
Over/Under: 6.5

San Francisco: (19-10)  |  San Diego: (17-11)

Remi's searched hard and found the best prop for this matchup: M. Yastrzemski over 0.5 Total Bases.. Prices move—always shop for the best number.

The over/under for this game is set at 7.5 runs, suggesting expectations of a low-scoring affair between two strong pitching staffs.

SF trend: The Giants have a 10–6 record against the spread (ATS) on the road this season, indicating strong performance in covering the run line during away games.

SD trend: The Padres boast a 12–4 ATS record at home, reflecting consistent success in covering the spread at Petco Park.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

San Francisco vs. San Diego Odds

Remi is pouring through loads of data on each team. In fact, anytime the San Francisco vs San Diego trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme travel distance almost always follow normal, predictable patterns.

San Francisco vs San Diego Opening Odds

SF Moneyline: -126
SD Moneyline: +105
SF Spread: -1.5
SD Spread: +1.5
Over/Under: 6.5

San Francisco vs San Diego Live Odds

Games PTS ML SPR O/U

MLB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers San Francisco Giants vs. San Diego Padres on April 29, 2025 at Petco Park.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
LAD@TOR TOR +1.5 56.7% 2 WIN
TOR@LAD TOR +1.5 55.3% 4 WIN
TOR@SEA OVER 7 54.9% 3 WIN
LAD@MIL UNDER 7.5 56.6% 6 WIN
TOR@NYY OVER 8 54.9% 4 WIN
TOR@NYY CARLOS RODON OVER 1.5 TOTAL WALKS ALLOWED 53.3% 3 WIN
NYY@TOR OVER 7.5 54.8% 2 WIN
LAD@PHI OVER 7 53.8% 3 WIN
SD@CHC CHC -109 53.8% 3 WIN
SD@CHC OVER 7.5 54.5% 4 LOSS
SD@CHC CHC -111 54.8% 4 LOSS
CIN@LAD SHOHEI OHTANI OVER 1.5 BASES 53.5% 3 WIN
BOS@NYY OVER 7 53.8% 3 LOSS
CIN@LAD ELLY DE LA CRUZ OVER 0.5 BASES 54.4% 4 LOSS
ARI@SD SD -131 57.3% 4 WIN
DET@BOS BOS -115 56.4% 5 WIN
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN