Yankees vs Orioles Prediction — AI Finds CAN'T MISS MLB Lines & Props (Apr 28)

Updated: 2025-04-26T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The New York Yankees (15–11) travel to Oriole Park at Camden Yards to face the Baltimore Orioles (10–16) on Monday, April 28, 2025, at 6:35 PM ET. The Yankees aim to build on their recent success, while the Orioles look to rebound from a challenging start to the season.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Apr 28, 2025

Start Time: 6:35 PM EST​

Venue: Oriole Park at Camden Yards​

Orioles Record: (10-17)

Yankees Record: (17-11)

OPENING ODDS

NYY Moneyline: -120

BAL Moneyline: +100

NYY Spread: -1.5

BAL Spread: +1.5

Over/Under: 9.5

NYY
Betting Trends

  • The Yankees have covered the run line in 8 of their last 12 games, reflecting a 66.7% success rate against the spread (ATS).

BAL
Betting Trends

  • The Orioles have struggled against the spread at home, covering in only 2 of their last 10 home games, yielding a 20% ATS success rate.

MATCHUP TRENDS

  • In their last 10 head-to-head matchups, the Yankees have covered the run line in 7 games against the Orioles, indicating a favorable trend for New York bettors.

NYY vs. BAL
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: C. Mullins over 0.5 Total Bases.

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New York Yankees vs Baltimore Prediction & Odds:
Free MLB Betting Insights for 4/28/25

The New York Yankees and Baltimore Orioles open a three-game series on Monday night at Oriole Park at Camden Yards, a matchup that brings two AL East rivals together under very different circumstances as the Yankees look to build on early-season momentum while the Orioles search for answers after a frustrating April. New York enters the contest with a strong 15–11 record, fueled by a balanced attack that has seen both their offense and pitching staff perform consistently at a high level, as the addition of Paul Goldschmidt to the lineup has paid immediate dividends alongside the reliable production of Aaron Judge, who continues to anchor the middle of the order with his trademark power and run production. The Yankees’ ability to hit for both power and average, paired with disciplined at-bats and aggressive baserunning, has allowed them to overcome occasional inconsistencies from their pitching staff, and heading into this series, they have covered the run line in eight of their last twelve games, reflecting a team that is not only winning but often doing so convincingly. On the mound, New York’s rotation has provided stability, while the bullpen, featuring a strong combination of power arms and finesse specialists, has been effective in protecting leads late in games. Meanwhile, the Orioles come into this series at 10–16, a mark that underscores the struggles they have faced both at the plate and on the mound, as inconsistency has plagued their efforts to string together wins despite flashes of individual brilliance from players like Gunnar Henderson, who leads the team with six home runs and eighteen RBIs.

Baltimore’s pitching staff has been a particular area of concern, with starters often unable to work deep into games and the bullpen facing additional pressure as a result, leading to a ballooning team ERA and a negative run differential that reflects their difficulties in both preventing runs and generating enough offense to compensate. Offensively, the Orioles have shown occasional bursts of power but have lacked consistent production from the middle and bottom of their lineup, contributing to a .226 team batting average that ranks among the lower third of the league. Recent ATS trends also favor New York heavily, as the Yankees have covered the run line in seven of the last ten meetings between these two teams, and Baltimore’s home ATS struggles — covering just twice in their last ten games at Camden Yards — suggest another uphill battle awaits for the Orioles unless they can find a way to flip the script early. For the Yankees, the path to victory is clear: continue to leverage their offensive firepower, capitalize on Baltimore’s pitching vulnerabilities, and rely on a deep, versatile bullpen to close out games efficiently. For the Orioles, success will hinge on finding stability on the mound, getting timely hits with runners in scoring position, and playing cleaner defense to avoid giving extra opportunities to a Yankees lineup that needs little help to do damage. As the series begins, all signs point to New York holding a decisive edge, but with divisional games often carrying an unpredictable edge, the Orioles will look to play spoiler and start turning their season around on home soil.

New York Yankees Yankees MLB Preview

The New York Yankees enter Monday’s series opener against the Baltimore Orioles riding a wave of momentum fueled by their strong 15–11 start to the 2025 season and the well-rounded, consistent play that has them firmly in the mix atop the American League East standings. Powered offensively by the continued brilliance of Aaron Judge, who already leads the team with seven home runs and twenty-six RBIs, and the incredible addition of Paul Goldschmidt, whose .364 batting average has provided a steady, clutch presence in the heart of the lineup, the Yankees have found the kind of balance they lacked at times last season. Ben Rice and Trent Grisham have also made valuable contributions, each providing timely home runs and maintaining pressure on opposing pitchers by offering quality at-bats throughout the lower half of the order. Manager Aaron Boone has emphasized a “next-man-up” mentality, and the team has responded by showing a depth of talent that allows the Yankees to score runs in bunches even when the top of the order is contained. On the mound, the Yankees’ rotation has been largely effective, delivering consistent quality starts that have allowed the bullpen — anchored by arms like Clay Holmes, Tommy Kahnle, and Jonathan Loáisiga — to protect leads with ruthless efficiency.

Defensively, the Yankees have remained sharp and fundamentally sound, minimizing errors and consistently turning double plays that have helped them escape tight situations and maintain momentum in close games. Entering this matchup against a struggling Orioles squad, the Yankees understand the importance of setting the tone early, applying offensive pressure, and not allowing Baltimore’s offense to gain confidence, especially given the Orioles’ recent struggles both at the plate and on the mound. Statistically, New York’s recent success against Baltimore — covering the run line in seven of their last ten meetings — suggests a strong likelihood that they can continue their dominance if they execute their game plan effectively. Boone will look for the Yankees to work counts, force Baltimore’s starters into deep pitch counts early, and seize opportunities with runners in scoring position, areas where the team has been particularly strong over the last few weeks. Monday’s game represents not only a chance to further pad their record but also an opportunity to continue building the kind of momentum that could serve them well as the early-season schedule intensifies; maintaining focus, discipline, and the aggressive, opportunistic style of baseball that has defined their April success will be key if New York hopes to continue their push for AL East supremacy.

The New York Yankees (15–11) travel to Oriole Park at Camden Yards to face the Baltimore Orioles (10–16) on Monday, April 28, 2025, at 6:35 PM ET. The Yankees aim to build on their recent success, while the Orioles look to rebound from a challenging start to the season. New York Yankees vs Baltimore AI Prediction: Free MLB Betting Insights for Apr 28. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Baltimore Orioles MLB Preview

The Baltimore Orioles return to Oriole Park at Camden Yards on Monday night looking to turn the page on a difficult start to their 2025 season, entering the series against the New York Yankees with a 10–16 record and in urgent need of a reset to regain their footing in the American League East. Despite flashes of potential, particularly from young stars like Gunnar Henderson, whose six home runs and eighteen RBIs have been a bright spot in an otherwise inconsistent offense, the Orioles have struggled mightily with both run production and pitching efficiency through the season’s first month. Manager Brandon Hyde has continued to shuffle the lineup in search of a spark, but a team batting average of .226 and an OPS below league average indicate a group that has not yet found its rhythm at the plate, often failing to capitalize on scoring opportunities or sustain rallies over multiple innings. On the pitching side, the rotation has battled inconsistency, with starters frequently exiting early and placing additional strain on a bullpen that has struggled to contain opponents in high-leverage situations. The lack of effective starting pitching has been a particular Achilles’ heel, leading to a bloated team ERA and putting Baltimore behind early far too often, a dangerous trend against a Yankees team known for jumping on mistakes quickly and punishing teams who fall behind.

Defensively, the Orioles have also had lapses that have contributed to their woes, with untimely errors extending innings and costing crucial runs that have swung games out of their favor. Hyde has emphasized the need for sharper focus and execution, particularly in fundamentals like baserunning, defensive positioning, and two-strike hitting, all of which have been inconsistent during the early stages of the year. Facing a Yankees team that has covered the run line in seven of the last ten head-to-head matchups, the Orioles know they must start strong, limit free passes, and make the most of any scoring opportunities they generate if they hope to protect their home field and begin climbing out of the division cellar. Key players like Adley Rutschman and Ryan Mountcastle will be counted on to provide more offensive support behind Henderson, while the pitching staff must find a way to neutralize the Yankees’ deep and potent lineup. Monday’s game offers Baltimore not just a chance to steal a win against a division rival, but also to set a new tone for a crucial stretch ahead; playing with more energy, urgency, and discipline will be vital if the Orioles want to stop the slide and begin reshaping the narrative around a season that is dangerously close to slipping away before May even arrives.

New York Yankees vs. Baltimore Prop Picks (AI)

Remi is pouring through mountains of stats on each line. In fact, anytime the Yankees and Orioles play there’s always several intriguing observations to key in on. Not to mention games played at Oriole Park at Camden Yards in Apr rarely follow normal, predictable betting trends.
Remi's searched hard and found the best prop for this matchup: C. Mullins over 0.5 Total Bases.

New York Yankees vs. Baltimore Prediction (AI)

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Remi, our AI sports algorithm, has been pouring over exorbitant amounts of data from every simulation between the Yankees and Orioles and using recursive machine learning and industry leading AI to analyze the data to a single cover probability.

Oddly enough, we’ve seen the AI has been most keyed in on the linear correlation of weight knucklehead sportsbettors regularly put on coaching factors between a Yankees team going up against a possibly tired Orioles team. In reality, the true game analytics might reflect a slight lean against one Vegas line specifically.

Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.

Below is our current AI New York Yankees vs Baltimore picks, computer picks Yankees vs Orioles, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
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Yankees Betting Trends

The Yankees have covered the run line in 8 of their last 12 games, reflecting a 66.7% success rate against the spread (ATS).

Orioles Betting Trends

The Orioles have struggled against the spread at home, covering in only 2 of their last 10 home games, yielding a 20% ATS success rate.

Yankees vs. Orioles Matchup Trends

In their last 10 head-to-head matchups, the Yankees have covered the run line in 7 games against the Orioles, indicating a favorable trend for New York bettors.

New York Yankees vs. Baltimore Game Info

New York Yankees vs Baltimore starts on April 28, 2025 at 6:35 PM EST.

Venue: Oriole Park at Camden Yards.

Spread: Baltimore +1.5
Moneyline: New York Yankees -120, Baltimore +100
Over/Under: 9.5

New York Yankees: (17-11)  |  Baltimore: (10-17)

Remi's searched hard and found the best prop for this matchup: C. Mullins over 0.5 Total Bases.. Prices move—always shop for the best number.

In their last 10 head-to-head matchups, the Yankees have covered the run line in 7 games against the Orioles, indicating a favorable trend for New York bettors.

NYY trend: The Yankees have covered the run line in 8 of their last 12 games, reflecting a 66.7% success rate against the spread (ATS).

BAL trend: The Orioles have struggled against the spread at home, covering in only 2 of their last 10 home games, yielding a 20% ATS success rate.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

New York Yankees vs. Baltimore Odds

Remi is pouring through loads of stats on each line. In fact, anytime the New York Yankees vs Baltimore trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme travel distance almost always follow normal, predictable betting trends.

New York Yankees vs Baltimore Opening Odds

NYY Moneyline: -120
BAL Moneyline: +100
NYY Spread: -1.5
BAL Spread: +1.5
Over/Under: 9.5

New York Yankees vs Baltimore Live Odds

Games PTS ML SPR O/U
Oct 19, 2025 8:04PM EDT
Seattle Mariners
Toronto Blue Jays
10/19/25 8:04PM
Mariners
Blue Jays
+110
-121
+1.5 (-195)
-1.5 (+168)
O 7.5 (-120)
U 7.5 (+100)

MLB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers New York Yankees Yankees vs. Baltimore Orioles on April 28, 2025 at Oriole Park at Camden Yards.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
TOR@SEA OVER 7 54.9% 3 WIN
LAD@MIL UNDER 7.5 56.6% 6 WIN
TOR@NYY OVER 8 54.9% 4 WIN
TOR@NYY CARLOS RODON OVER 1.5 TOTAL WALKS ALLOWED 53.3% 3 WIN
NYY@TOR OVER 7.5 54.8% 2 WIN
LAD@PHI OVER 7 53.8% 3 WIN
SD@CHC CHC -109 53.8% 3 WIN
SD@CHC OVER 7.5 54.5% 4 LOSS
SD@CHC CHC -111 54.8% 4 LOSS
CIN@LAD SHOHEI OHTANI OVER 1.5 BASES 53.5% 3 WIN
BOS@NYY OVER 7 53.8% 3 LOSS
CIN@LAD ELLY DE LA CRUZ OVER 0.5 BASES 54.4% 4 LOSS
ARI@SD SD -131 57.3% 4 WIN
DET@BOS BOS -115 56.4% 5 WIN
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN
CHC@SF CHC -105 54.1% 4 LOSS
NYY@CHW RYAN MCMAHON OVER 0.5 BASES 54.1% 4 WIN