Twins vs. Guardians
Prediction, Odds & Props
Apr 28 | MLB AI Picks
Updated: 2025-04-26T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The Minnesota Twins (12–16) visit the Cleveland Guardians (15–12) at Progressive Field on Monday, April 28, 2025, for a pivotal AL Central matchup. The Guardians aim to capitalize on their home-field advantage, while the Twins seek to reverse their recent road struggles.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

GAME INFO
Date: Apr 28, 2025
Start Time: 6:10 PM EST
Venue: Progressive Field
Guardians Record: (15-12)
Twins Record: (12-16)
OPENING ODDS
MIN Moneyline: +109
CLE Moneyline: -128
MIN Spread: +1.5
CLE Spread: -1.5
Over/Under: 8
MIN
Betting Trends
- The Twins have struggled against the spread (ATS) on the road, covering in only 3 of their last 13 away games, reflecting a 23% success rate.
CLE
Betting Trends
- The Guardians have been solid at home, covering the run line in 8 of their 12 home games this season, yielding a 66.7% ATS success rate.
MATCHUP TRENDS
- In their last 10 head-to-head matchups, the Guardians have covered the run line in 7 games against the Twins, indicating a favorable trend for Cleveland bettors.
MIN vs. CLE
Best Prop Bet
- Remi's searched hard and found the best prop for this matchup: K. Manzardo over 0.5 Total Bases.
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Minnesota vs Cleveland Prediction & Odds:
Free MLB Betting Insights for 4/28/25
Byron Buxton has continued to be a bright spot, leading the Twins with six home runs and fifteen RBIs, but Minnesota’s offensive production has been inconsistent, often struggling to deliver timely hits in close games, and those issues have been magnified away from Target Field. Bailey Ober will be tasked with stabilizing the Twins’ starting rotation, carrying a 2–1 record but an inflated 5.04 ERA, and he will need to work more efficiently to keep Cleveland’s aggressive lineup from forcing him into high-leverage situations early. Defensively, the Twins have been average at best, and bullpen struggles — particularly in maintaining leads late — have hampered their ability to close out winnable games. From a betting perspective, the Guardians have been a reliable cover at home against the spread (ATS), while the Twins’ poor ATS record on the road mirrors their on-field struggles, making Cleveland an attractive option for bettors in this matchup. Statistically, the Guardians have also covered the run line in seven of the last ten meetings between these two clubs, further highlighting the historical edge they hold at Progressive Field. For the Twins, Monday’s game represents more than just another chance to steal a divisional road win; it’s a test of resilience, execution, and mental toughness against a disciplined Guardians squad that rarely beats itself. Expect a tightly contested battle, with pitching efficiency, defensive execution, and the ability to cash in with runners in scoring position ultimately determining who walks away with a crucial win in this important divisional clash.
No one can throw quite like Joe pic.twitter.com/DGv3y9gSGw
— Minnesota Twins (@Twins) April 27, 2025
Minnesota Twins MLB Preview
The Minnesota Twins arrive at Progressive Field on Monday facing mounting pressure to turn around what has been a frustrating start to the 2025 season, particularly on the road where they have posted a concerning 3–10 record that mirrors broader inconsistencies throughout the roster. Despite a 12–16 overall record that leaves them in the lower half of the AL Central standings, the Twins possess a core group of players capable of igniting a turnaround, led offensively by Byron Buxton, whose six home runs and fifteen RBIs remain a bright spot amid an otherwise up-and-down offensive attack. Alongside Buxton, Matt Wallner has provided some stability with a .263 batting average, but the rest of the lineup has struggled with situational hitting, leaving too many runners stranded and missing opportunities to put pressure on opposing pitchers. On the mound, Bailey Ober will be tasked with delivering a stabilizing performance for Minnesota, bringing a 2–1 record but a concerning 5.04 ERA into the matchup; Ober’s tendency to leave pitches up in the zone has made him vulnerable to extra-base hits, and against a disciplined Cleveland lineup, he will need to execute much more efficiently to avoid falling behind early.
Minnesota’s defensive execution has been a mixed bag this season, with too many unforced errors costing them critical runs, while the bullpen has failed to consistently hold leads, adding to the overall sense of urgency around tightening up all aspects of their play. Manager Rocco Baldelli knows that patience is wearing thin, and Monday’s game represents a pivotal opportunity for the Twins to start reversing the narrative by playing clean, aggressive baseball from the first pitch. The game plan will require Minnesota to manufacture runs creatively if the home-run ball isn’t available, focusing on good baserunning, advancing runners, and finding ways to win the small battles that often decide road games. Ober must give the team five to six strong innings to avoid overexposing the bullpen, while the lineup must show greater resilience against Cleveland starter Gavin Williams by forcing him into deep counts and capitalizing on any early mistakes. Securing a victory in Cleveland would not only salvage something from a difficult road trip but also serve as a potential catalyst for a team that still has the talent to climb back into the divisional race if they can string wins together and build some badly needed momentum heading into May.

Credit: USA TODAY/IMAGN
Cleveland Guardians MLB Preview
The Cleveland Guardians come into Monday’s matchup against the Minnesota Twins with a clear opportunity to solidify their early-season momentum and continue asserting themselves as one of the more balanced and dangerous teams in the American League Central. With a 15–12 record and an impressive 8–4 mark at Progressive Field, the Guardians have demonstrated a formula for success built on consistency, strong fundamentals, and contributions from both established stars and emerging role players. At the heart of Cleveland’s offensive success remains José Ramírez, whose ability to impact the game with both power and clutch hitting continues to make him one of the most dangerous hitters in baseball, while Steven Kwan’s .310 batting average at the top of the lineup has been critical in generating scoring opportunities, setting the table for the heavy hitters behind him. Adding to the Guardians’ effectiveness is the team’s discipline at the plate, consistently ranking among the league leaders in fewest strikeouts, allowing them to put pressure on opposing pitchers by forcing deep counts and making pitchers work for every out. Gavin Williams will take the mound for Cleveland, armed with a 2–1 record and a respectable 4.15 ERA, looking to extend a trend of strong home starts for Guardians pitchers; his ability to mix speeds effectively and attack hitters early in counts will be crucial against a Twins lineup that has struggled to produce consistently on the road.
Defensively, Cleveland has continued its reputation for playing clean, fundamentally sound baseball, minimizing errors and providing steady support to their pitchers, a factor that becomes even more valuable in tight, low-scoring games. The bullpen, anchored by reliable arms like Emmanuel Clase, has been one of the team’s greatest strengths, capable of locking down close games and maintaining late-inning leads with minimal drama. Head coach Stephen Vogt has emphasized an aggressive but smart approach to baserunning and situational hitting, strategies that have paid dividends particularly against divisional opponents where execution often trumps raw talent. Monday’s contest offers the Guardians a chance to not only widen the gap between themselves and a struggling Twins team but also to continue building a reputation as a team that can consistently handle its business at home. The path to victory will involve getting an early lead against Twins starter Bailey Ober, using disciplined at-bats to wear him down, and continuing to capitalize on scoring opportunities when they present themselves. If Cleveland can maintain its sharp defensive play, get solid innings from Williams, and let the bullpen take care of the late stages, they will be in prime position to secure another home win and keep pace with the division’s top contenders as May approaches.
Short memory.#GuardsBall pic.twitter.com/p4aWWA6UJs
— Cleveland Guardians (@CleGuardians) April 27, 2025
Minnesota vs. Cleveland Prop Picks (AI)
Minnesota vs. Cleveland Prediction (AI)

Remi, our AI sports wizard, has been pouring over millions of data from every angle between the Twins and Guardians and using recursive machine learning and industry leading AI to analyze the data to a single cover probability.
Interestingly enough, the data has been most keyed in on the trending emphasis emotional bettors regularly put on Minnesota’s strength factors between a Twins team going up against a possibly strong Guardians team. We’ve found the true game analytics appear to reflect a strong lean against one Vegas line specifically.
Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.
Below is our current AI Minnesota vs Cleveland picks, computer picks Twins vs Guardians, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
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MLB | 9/26 | DET@BOS | UNLOCK THIS PICK | 5 |
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MLB | 9/26 | BAL@NYY | UNLOCK THIS PICK | 4 |
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MLB | 9/26 | ARI@SD | UNLOCK THIS PICK | 4 |
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MLB | 9/26 | NYM@MIA | UNLOCK THIS PICK | 1 |
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MLB | 9/26 | NYM@MIA | GET FREE PICK NOW | 1 | – | |
MLB | 9/26 | COL@SF | UNLOCK THIS PICK | 0 |
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.
Twins Betting Trends
The Twins have struggled against the spread (ATS) on the road, covering in only 3 of their last 13 away games, reflecting a 23% success rate.
Guardians Betting Trends
The Guardians have been solid at home, covering the run line in 8 of their 12 home games this season, yielding a 66.7% ATS success rate.
Twins vs. Guardians Matchup Trends
In their last 10 head-to-head matchups, the Guardians have covered the run line in 7 games against the Twins, indicating a favorable trend for Cleveland bettors.
Minnesota vs. Cleveland Game Info
What time does Minnesota vs Cleveland start on April 28, 2025?
Minnesota vs Cleveland starts on April 28, 2025 at 6:10 PM EST.
Where is Minnesota vs Cleveland being played?
Venue: Progressive Field.
What are the opening odds for Minnesota vs Cleveland?
Spread: Cleveland -1.5
Moneyline: Minnesota +109, Cleveland -128
Over/Under: 8
What are the records for Minnesota vs Cleveland?
Minnesota: (12-16) | Cleveland: (15-12)
What is the AI best bet for Minnesota vs Cleveland?
Remi's searched hard and found the best prop for this matchup: K. Manzardo over 0.5 Total Bases.. Prices move—always shop for the best number.
What are Minnesota vs Cleveland trending bets?
In their last 10 head-to-head matchups, the Guardians have covered the run line in 7 games against the Twins, indicating a favorable trend for Cleveland bettors.
What are Minnesota trending bets?
MIN trend: The Twins have struggled against the spread (ATS) on the road, covering in only 3 of their last 13 away games, reflecting a 23% success rate.
What are Cleveland trending bets?
CLE trend: The Guardians have been solid at home, covering the run line in 8 of their 12 home games this season, yielding a 66.7% ATS success rate.
Where can I find AI Picks for Minnesota vs Cleveland?
See our latest MLB picks and odds pages for 2025 to compare prices before you bet.
Minnesota vs. Cleveland Odds
Remi is pouring through tons of data on each team. In fact, anytime the Minnesota vs Cleveland trends are analyzed, there’s always several intriguing trends to key in on. Not to mention games played at extreme altitude almost always follow normal, predictable patterns.
Minnesota vs Cleveland Opening Odds
MIN Moneyline:
+109 CLE Moneyline: -128
MIN Spread: +1.5
CLE Spread: -1.5
Over/Under: 8
Minnesota vs Cleveland Live Odds
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Sep 27, 2025 1:06PM EDT
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New York Yankees
9/27/25 1:06PM
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–
–
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+192
-235
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+1.5 (-110)
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O 9 (+100)
U 9 (-120)
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-178
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-1.5 (+115)
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O 9.5 (+100)
U 9.5 (-120)
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+135
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+1.5 (-160)
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O 8.5 (-110)
U 8.5 (-110)
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–
–
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+100
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+1.5 (-205)
-1.5 (+170)
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O 8.5 (-110)
U 8.5 (-110)
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Sep 27, 2025 4:06PM EDT
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Rockies
Giants
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–
–
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+192
-235
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+1.5 (-110)
-1.5 (-110)
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O 8 (-105)
U 8 (-115)
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Sep 27, 2025 4:11PM EDT
New York Mets
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Mets
Marlins
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–
–
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-130
+110
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-1.5 (+130)
+1.5 (-155)
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O 8 (-120)
U 8 (+100)
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Sep 27, 2025 4:11PM EDT
Detroit Tigers
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Tigers
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–
–
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+110
-130
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+1.5 (-190)
-1.5 (+158)
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O 9 (+100)
U 9 (-120)
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Sep 27, 2025 6:05PM EDT
Minnesota Twins
Philadelphia Phillies
9/27/25 6:05PM
Twins
Phillies
|
–
–
|
+175
-210
|
+1.5 (-120)
-1.5 (+100)
|
O 8.5 (-115)
U 8.5 (-105)
|
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Sep 27, 2025 7:11PM EDT
Cincinnati Reds
Milwaukee Brewers
9/27/25 7:11PM
Reds
Brewers
|
–
–
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+115
-135
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+1.5 (-190)
-1.5 (+158)
|
O 7.5 (-120)
U 7.5 (+100)
|
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Sep 27, 2025 7:15PM EDT
Pittsburgh Pirates
Atlanta Braves
9/27/25 7:15PM
Pirates
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–
–
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+150
-178
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+1.5 (-145)
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O 8 (-110)
U 8 (-110)
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Sep 27, 2025 7:16PM EDT
Texas Rangers
Cleveland Guardians
9/27/25 7:16PM
Rangers
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–
–
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+122
-145
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+1.5 (-190)
-1.5 (+158)
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O 7 (-120)
U 7 (+100)
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Sep 27, 2025 8:40PM EDT
Arizona Diamondbacks
San Diego Padres
9/27/25 8:40PM
Diamondbacks
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–
–
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+118
-140
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+1.5 (-190)
-1.5 (+158)
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O 7.5 (-115)
U 7.5 (-105)
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Sep 27, 2025 9:39PM EDT
Houston Astros
Los Angeles Angels
9/27/25 9:39PM
Astros
Angels
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–
–
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-145
+122
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-1.5 (+115)
+1.5 (-135)
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O 9 (-110)
U 9 (-110)
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Sep 27, 2025 9:41PM EDT
Los Angeles Dodgers
Seattle Mariners
9/27/25 9:41PM
Dodgers
Mariners
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–
–
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+110
-130
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+1.5 (-205)
-1.5 (+170)
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O 7 (-120)
U 7 (+100)
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Sep 27, 2025 10:05PM EDT
Kansas City Royals
Oakland Athletics
9/27/25 10:05PM
Royals
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–
–
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+100
-120
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+1.5 (-195)
-1.5 (+162)
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O 10 (-110)
U 10 (-110)
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MLB Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers Minnesota Twins vs. Cleveland Guardians on April 28, 2025 at Progressive Field.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.
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LEAN | %WIN | UNITS | RESULT |
---|---|---|---|---|
NYM@CHC | NYM -110 | 54.1% | 3 | WIN |
HOU@ATH | ATH +118 | 50.8% | 4 | WIN |
NYM@CHC | OVER 7 | 54.5% | 3 | WIN |
STL@SF | OVER 7.5 | 55.9% | 5 | LOSS |
KC@LAA | TYLER TOLBERT UNDER 1.5 BASES | 54.4% | 4 | WIN |
MIL@SD | UNDER 9 | 54.7% | 4 | WIN |
MIA@PHI | KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS | 53.3% | 3 | WIN |
WAS@NYM | OVER 8.5 | 56.1% | 6 | LOSS |
LAA@COL | COL +108 | 50.5% | 3 | WIN |
TOR@KC | UNDER 9 | 54.7% | 4 | LOSS |
SEA@KC | KC +1.5 | 62.3% | 5 | LOSS |
NYY@MIN | OVER 9 | 55.1% | 4 | WIN |
MIA@COL | OVER 10.5 | 55.0% | 4 | WIN |
MIA@COL | AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS | 54.3% | 4 | WIN |
SEA@KC | BOBBY WITT UNDER 0.5 SINGLES | 54.4% | 4 | LOSS |
PHI@LAD | LAD -113 | 54.7% | 4 | LOSS |
NYY@BOS | OVER 7.5 | 54.3% | 3 | WIN |
KC@PHI | PHI -130 | 58.3% | 4 | WIN |
LAD@SF | OVER 7.5 | 54.7% | 4 | LOSS |
NYM@PHI | PHI -122 | 55.6% | 4 | WIN |
KC@CLE | KC -104 | 52.0% | 3 | WIN |
CIN@SD | JAKE CRONEWORTH OVER 0.5 HITS | 53.1% | 3 | WIN |
WAS@MIA | MIA -123 | 55.2% | 4 | LOSS |
LAA@KC | UNDER 9.5 | 54.9% | 3 | WIN |
TEX@ARI | UNDER 9 | 54.2% | 4 | WIN |
SF@COL | UNDER 11.5 | 56.4% | 6 | LOSS |
SF@COL | RAFAEL DEVERS OVER 1.5 BASES | 56.1% | 6 | WIN |
MIA@WAS | WAS -110 | 54.4% | 4 | WIN |
NYM@DET | OVER 8.5 | 54.5% | 4 | WIN |
TEX@ARI | UNDER 9.5 | 56.4% | 6 | WIN |
TEX@ARI | ALEJANDRO OSUNA UNDER 1.5 BASES | 54.1% | 4 | LOSS |
ATL@CHC | CHC -116 | 55.1% | 3 | WIN |
PHI@MIL | OVER 8.5 | 55.0% | 3 | WIN |
ARI@LAD | SHOHEI OHTANI OVER 2.5 BASES | 54.2% | 4 | WIN |
SEA@CLE | CLE +1.5 | 57.2% | 3 | WIN |
CHC@SF | CHC -105 | 54.1% | 4 | LOSS |
NYY@CHW | RYAN MCMAHON OVER 0.5 BASES | 54.1% | 4 | WIN |
PHI@NYM | OVER 8.5 | 55.6% | 4 | LOSS |
LAA@TEX | LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS | 54.1% | 4 | LOSS |
KC@CHW | KC -109 | 54.2% | 4 | WIN |
SD@SEA | DYLAN CEASE OVER 16.5 OUTS | 53.9% | 3 | LOSS |
SD@SEA | UNDER 8.5 | 54.4% | 4 | LOSS |
MIN@TOR | JOE RYAN UNDER 2.5 EARNED RUNS | 54.1% | 4 | LOSS |
SF@MIL | MIL +100 | 54.0% | 6 | LOSS |
TOR@MIA | MIA +1.5 | 62.0% | 6 | WIN |
CHC@LAA | OVER 9.5 | 54.9% | 4 | LOSS |
BOS@NYY | CARLOS RODON UNDER 4.5 HITS ALLOWED | 54.2% | 4 | WIN |
KC@DET | DET -115 | 56.1% | 5 | WIN |
CHC@LAA | LAA +1.5 | 57.6% | 5 | LOSS |
CIN@ARI | KEBRYAN HAYES STRIKEOUTS UNDER 0.5 | 56.2% | 6 | WIN |
LAD@SD | SD +110 | 50.9% | 6 | WIN |