Rays vs. Padres
Prediction, Odds & Props
Apr 27 | MLB AI Picks

Updated: 2025-04-25T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The Tampa Bay Rays (13–14) and San Diego Padres (17–10) conclude their three-game interleague series at Petco Park on Sunday, April 27, 2025, with first pitch scheduled for 1:10 PM PDT. The Rays aim to complete a series sweep, while the Padres look to avoid a third consecutive loss at home.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Apr 27, 2025

Start Time: 4:10 PM EST​

Venue: Petco Park​

Padres Record: (17-10)

Rays Record: (13-14)

OPENING ODDS

TB Moneyline: -100

SD Moneyline: -119

TB Spread: -1.5

SD Spread: +1.5

Over/Under: 8

TB
Betting Trends

  • The Rays have covered the run line in 11 of their last 15 games, indicating a strong performance against the spread recently.

SD
Betting Trends

  • The Padres have covered the run line in 15 of their 26 games this season, showcasing a solid performance at home.

MATCHUP TRENDS

  • The Padres are 12–2 at home this season, indicating a strong home-field advantage.

TB vs. SD
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: K. Misner over 0.5 Total Bases.

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Tampa Bay vs San Diego Prediction & Odds:
Free MLB Betting Insights for 4/27/25

The Tampa Bay Rays and San Diego Padres face off Sunday afternoon at Petco Park to conclude their three-game interleague series, with Tampa Bay looking to pull off an impressive sweep on the road while the Padres aim to defend their home turf and avoid a third straight defeat. Despite entering the series with a less-than-stellar overall record, the Rays have shown resilience and opportunistic hitting throughout the series, taking advantage of San Diego’s uncharacteristic mistakes and less effective starting pitching performances. Tampa Bay will hand the ball to Zack Littell, who, despite his 0–5 record and elevated 5.28 ERA, has pitched better than his numbers suggest and will look to rebound with a sharp outing against a potent Padres lineup. Offensively, the Rays have been led by Junior Caminero, whose .248 average and .460 slugging percentage provide a dangerous middle-of-the-order presence capable of changing a game with one swing, while Isaac Paredes and Brandon Lowe have contributed key hits throughout the series. The Padres, still boasting an impressive 12–2 home record, will counter with Randy Vasquez, a young right-hander who has shown promise with a 1–2 record and a 3.97 ERA, relying on good fastball command and an effective curveball to keep hitters off balance.

Offensively, San Diego has been paced by Fernando Tatis Jr., who leads the team with a scorching .347 batting average, and veteran Xander Bogaerts, who continues to provide solid run production and stability near the top of the order. However, the Padres’ usually potent lineup has struggled with runners in scoring position during the series, leaving too many opportunities on the bases and putting additional pressure on their bullpen to keep games close late. Statistically, the Rays have been very strong against the spread recently, covering in 11 of their last 15 games, while the Padres have covered in 15 of their first 26 games this season, highlighting two teams capable of battling close no matter the setting. San Diego still holds a significant home-field advantage, and their track record at Petco Park suggests they will be highly motivated to salvage a win in front of their home fans before heading into a crucial stretch of divisional play. For the Rays, a sweep would represent a major momentum shift as they work to climb back into serious contention in the AL East, while a Padres win would not only prevent the sweep but also serve as a reminder of their capability to bounce back against adversity. Sunday’s game likely hinges on the starting pitchers—whether Littell can limit early damage and keep Tampa Bay in the game long enough for their bullpen to take over, or if Vasquez can control the strike zone, keep Tampa Bay’s hitters guessing, and hand a lead to San Diego’s late-inning specialists. With both teams hungry for a strong finish to the series, expect a competitive and closely contested matchup where execution, particularly with runners in scoring position, will ultimately decide the victor.

Tampa Bay Rays MLB Preview

The Tampa Bay Rays enter Sunday’s matchup at Petco Park with momentum and belief, eyeing a potential sweep that could serve as a much-needed boost for a team striving to find consistency in a competitive American League landscape. With a 13–14 record, the Rays have battled through injuries, lineup shuffling, and pitching inconsistency, but they have shown resilience on this West Coast trip, highlighted by their ability to capitalize on mistakes and execute in high-leverage moments. Tampa Bay will send Zack Littell to the mound, a starter still looking for his first win of the season despite flashes of effectiveness; carrying an 0–5 record and a 5.28 ERA, Littell’s success will depend heavily on his ability to limit long counts and keep the Padres’ power hitters from finding their rhythm early. Offensively, the Rays have leaned on the emerging talents of Junior Caminero, who brings a .248 average and a .460 slugging percentage into Sunday’s game, and Brandon Lowe, who provides much-needed left-handed power capable of changing games with a single swing.

Tampa Bay’s lineup, while not among the most explosive, has shown an ability to manufacture runs through aggressive baserunning and situational hitting, taking advantage of opportunities when they arise. Defensively, the Rays have been steady, if unspectacular, minimizing mistakes and giving their pitchers solid support, a key factor when facing an offense as potent as San Diego’s. Manager Kevin Cash has continued to emphasize flexibility, using platoon advantages and smart bullpen management to maximize every edge available in tightly contested games. Tampa Bay’s recent success against the spread—covering the run line in 11 of their last 15 games—reflects a team that consistently stays competitive regardless of opponent, and their ability to frustrate and pressure opponents even when trailing has been on full display during this series. If Littell can keep the game close and the bullpen can maintain its strong form, the Rays are well-positioned to complete a sweep that would send a strong message about their resilience and their intentions to reassert themselves as contenders in the AL East as the season heads into May.

The Tampa Bay Rays (13–14) and San Diego Padres (17–10) conclude their three-game interleague series at Petco Park on Sunday, April 27, 2025, with first pitch scheduled for 1:10 PM PDT. The Rays aim to complete a series sweep, while the Padres look to avoid a third consecutive loss at home. Tampa Bay vs San Diego AI Prediction: Free MLB Betting Insights for Apr 27. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

San Diego Padres MLB Preview

The San Diego Padres approach Sunday’s series finale against the Tampa Bay Rays with a sense of urgency, eager to avoid an unexpected home sweep that would slightly dampen what has otherwise been a strong start to the 2025 season. With a 17–10 overall record and an impressive 12–2 mark at Petco Park, the Padres have typically made their home field a fortress, blending dynamic offense, solid starting pitching, and airtight late-inning bullpen work to overpower opponents. However, recent struggles with situational hitting have left them vulnerable, and they will turn to Randy Vasquez on Sunday to help steady the ship. Vasquez, posting a 1–2 record with a 3.97 ERA, has demonstrated good command and the ability to induce soft contact, but will need to be sharp early to prevent Tampa Bay’s opportunistic lineup from gaining confidence. Offensively, the Padres continue to be led by Fernando Tatis Jr., who boasts a sizzling .347 batting average, setting the tone with both his bat and speed, while Xander Bogaerts provides power and consistency, offering protection in the heart of the order.

Ha-Seong Kim and Manny Machado add additional depth to a lineup that can be lethal when clicking, but missed opportunities with runners in scoring position have been a recurring issue that manager Mike Shildt has emphasized correcting. Defensively, San Diego remains solid, minimizing errors and backing their pitchers effectively, while their bullpen remains one of the more reliable units in baseball, capable of locking down leads if given even a slim margin. With the series finale looming large, the Padres know that reasserting control early and capitalizing on any cracks in Tampa Bay’s pitching will be critical, especially considering the Rays’ knack for staying in games and finding ways to win late. A victory on Sunday would not only help the Padres maintain their strong position in the NL West but would also reinforce the resilience and depth that has defined much of their early-season success.

Tampa Bay vs. San Diego Prop Picks (AI)

AI algorithm Remi is pouring through tons of stats on each team. In fact, anytime the Rays and Padres play there’s always several intriguing angles to key in on. Not to mention games played at Petco Park in Apr almost always follow normal, predictable patterns.
Remi's searched hard and found the best prop for this matchup: K. Misner over 0.5 Total Bases.

Tampa Bay vs. San Diego Prediction (AI)

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Remi, our AI sports wizard, has been pouring over exorbitant amounts of data from every past game between the Rays and Padres and using recursive machine learning and impressive AI to examine the data to a single cover probability.

Remi has been most focused on the unproportionally assigned factor human bettors tend to put on Tampa Bay’s strength factors between a Rays team going up against a possibly rested Padres team. We’ve found the true game analytics appear to reflect a slight lean against one Vegas line in particular.

Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.

Below is our current AI Tampa Bay vs San Diego picks, computer picks Rays vs Padres, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
MLB 9/26 DET@BOS UNLOCK THIS PICK 5 EXECUTIVE Locked EXECUTIVE
MLB 9/26 BAL@NYY UNLOCK THIS PICK 4 INTEL Locked INTEL
MLB 9/26 ARI@SD UNLOCK THIS PICK 4 EXECUTIVE Locked EXECUTIVE
MLB 9/26 NYM@MIA UNLOCK THIS PICK 1 INTEL Locked INTEL
MLB 9/26 NYM@MIA GET FREE PICK NOW 1
MLB 9/26 COL@SF UNLOCK THIS PICK 0 INTEL Locked INTEL

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.

Rays Betting Trends

The Rays have covered the run line in 11 of their last 15 games, indicating a strong performance against the spread recently.

Padres Betting Trends

The Padres have covered the run line in 15 of their 26 games this season, showcasing a solid performance at home.

Rays vs. Padres Matchup Trends

The Padres are 12–2 at home this season, indicating a strong home-field advantage.

Tampa Bay vs. San Diego Game Info

Tampa Bay vs San Diego starts on April 27, 2025 at 4:10 PM EST.

Spread: San Diego +1.5
Moneyline: Tampa Bay -100, San Diego -119
Over/Under: 8

Tampa Bay: (13-14)  |  San Diego: (17-10)

Remi's searched hard and found the best prop for this matchup: K. Misner over 0.5 Total Bases.. Prices move—always shop for the best number.

The Padres are 12–2 at home this season, indicating a strong home-field advantage.

TB trend: The Rays have covered the run line in 11 of their last 15 games, indicating a strong performance against the spread recently.

SD trend: The Padres have covered the run line in 15 of their 26 games this season, showcasing a solid performance at home.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

Tampa Bay vs. San Diego Odds

Remi is pouring through mountains of stats on each team. In fact, anytime the Tampa Bay vs San Diego trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme travel distance seemingly never follow normal, predictable betting trends.

Tampa Bay vs San Diego Opening Odds

TB Moneyline: -100
SD Moneyline: -119
TB Spread: -1.5
SD Spread: +1.5
Over/Under: 8

Tampa Bay vs San Diego Live Odds

Games PTS ML SPR O/U
Sep 27, 2025 1:06PM EDT
Baltimore Orioles
New York Yankees
9/27/25 1:06PM
Orioles
Yankees
+192
-235
+1.5 (-110)
-1.5 (-110)
O 9 (+100)
U 9 (-120)
Sep 27, 2025 2:21PM EDT
St Louis Cardinals
Chicago Cubs
9/27/25 2:21PM
Cardinals
Cubs
 
-178
 
-1.5 (+115)
O 9.5 (+100)
U 9.5 (-120)
Sep 27, 2025 3:09PM EDT
Tampa Bay Rays
Toronto Blue Jays
9/27/25 3:09PM
Rays
Blue Jays
+135
-160
+1.5 (-160)
-1.5 (+135)
O 8.5 (-110)
U 8.5 (-110)
Sep 27, 2025 4:06PM EDT
Chicago White Sox
Washington Nationals
9/27/25 4:06PM
White Sox
Nationals
+100
-120
+1.5 (-205)
-1.5 (+170)
O 8.5 (-110)
U 8.5 (-110)
Sep 27, 2025 4:06PM EDT
Colorado Rockies
San Francisco Giants
9/27/25 4:06PM
Rockies
Giants
+192
-235
+1.5 (-110)
-1.5 (-110)
O 8 (-105)
U 8 (-115)
Sep 27, 2025 4:11PM EDT
New York Mets
Miami Marlins
9/27/25 4:11PM
Mets
Marlins
-130
+110
-1.5 (+130)
+1.5 (-155)
O 8 (-120)
U 8 (+100)
Sep 27, 2025 4:11PM EDT
Detroit Tigers
Boston Red Sox
9/27/25 4:11PM
Tigers
Red Sox
+110
-130
+1.5 (-190)
-1.5 (+158)
O 9 (+100)
U 9 (-120)
Sep 27, 2025 6:05PM EDT
Minnesota Twins
Philadelphia Phillies
9/27/25 6:05PM
Twins
Phillies
+175
-210
+1.5 (-120)
-1.5 (+100)
O 8.5 (-115)
U 8.5 (-105)
Sep 27, 2025 7:11PM EDT
Cincinnati Reds
Milwaukee Brewers
9/27/25 7:11PM
Reds
Brewers
+115
-135
+1.5 (-190)
-1.5 (+158)
O 7.5 (-120)
U 7.5 (+100)
Sep 27, 2025 7:15PM EDT
Pittsburgh Pirates
Atlanta Braves
9/27/25 7:15PM
Pirates
Braves
+150
-178
+1.5 (-145)
-1.5 (+122)
O 8 (-110)
U 8 (-110)
Sep 27, 2025 7:16PM EDT
Texas Rangers
Cleveland Guardians
9/27/25 7:16PM
Rangers
Guardians
+122
-145
+1.5 (-190)
-1.5 (+158)
O 7 (-120)
U 7 (+100)
Sep 27, 2025 8:40PM EDT
Arizona Diamondbacks
San Diego Padres
9/27/25 8:40PM
Diamondbacks
Padres
+118
-140
+1.5 (-190)
-1.5 (+158)
O 7.5 (-115)
U 7.5 (-105)
Sep 27, 2025 9:39PM EDT
Houston Astros
Los Angeles Angels
9/27/25 9:39PM
Astros
Angels
-145
+122
-1.5 (+115)
+1.5 (-135)
O 9 (-110)
U 9 (-110)
Sep 27, 2025 9:41PM EDT
Los Angeles Dodgers
Seattle Mariners
9/27/25 9:41PM
Dodgers
Mariners
+110
-130
+1.5 (-205)
-1.5 (+170)
O 7 (-120)
U 7 (+100)
Sep 27, 2025 10:05PM EDT
Kansas City Royals
Oakland Athletics
9/27/25 10:05PM
Royals
Athletics
+100
-120
+1.5 (-195)
-1.5 (+162)
O 10 (-110)
U 10 (-110)

MLB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Tampa Bay Rays vs. San Diego Padres on April 27, 2025 at Petco Park.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN
CHC@SF CHC -105 54.1% 4 LOSS
NYY@CHW RYAN MCMAHON OVER 0.5 BASES 54.1% 4 WIN
PHI@NYM OVER 8.5 55.6% 4 LOSS
LAA@TEX LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS 54.1% 4 LOSS
KC@CHW KC -109 54.2% 4 WIN
SD@SEA DYLAN CEASE OVER 16.5 OUTS 53.9% 3 LOSS
SD@SEA UNDER 8.5 54.4% 4 LOSS
MIN@TOR JOE RYAN UNDER 2.5 EARNED RUNS 54.1% 4 LOSS
SF@MIL MIL +100 54.0% 6 LOSS
TOR@MIA MIA +1.5 62.0% 6 WIN
CHC@LAA OVER 9.5 54.9% 4 LOSS
BOS@NYY CARLOS RODON UNDER 4.5 HITS ALLOWED 54.2% 4 WIN
KC@DET DET -115 56.1% 5 WIN
CHC@LAA LAA +1.5 57.6% 5 LOSS
CIN@ARI KEBRYAN HAYES STRIKEOUTS UNDER 0.5 56.2% 6 WIN
LAD@SD SD +110 50.9% 6 WIN