Rays vs. Padres
Prediction, Odds & Props
Apr 27 | MLB AI Picks
Updated: 2025-04-25T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The Tampa Bay Rays (13–14) and San Diego Padres (17–10) conclude their three-game interleague series at Petco Park on Sunday, April 27, 2025, with first pitch scheduled for 1:10 PM PDT. The Rays aim to complete a series sweep, while the Padres look to avoid a third consecutive loss at home.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

GAME INFO
Date: Apr 27, 2025
Start Time: 4:10 PM EST
Venue: Petco Park
Padres Record: (17-10)
Rays Record: (13-14)
OPENING ODDS
TB Moneyline: -100
SD Moneyline: -119
TB Spread: -1.5
SD Spread: +1.5
Over/Under: 8
TB
Betting Trends
- The Rays have covered the run line in 11 of their last 15 games, indicating a strong performance against the spread recently.
SD
Betting Trends
- The Padres have covered the run line in 15 of their 26 games this season, showcasing a solid performance at home.
MATCHUP TRENDS
- The Padres are 12–2 at home this season, indicating a strong home-field advantage.
TB vs. SD
Best Prop Bet
- Remi's searched hard and found the best prop for this matchup: K. Misner over 0.5 Total Bases.
LIVE MLB ODDS
MLB ODDS COMPARISON
WANT MORE AI PICKS?
VS. SPREAD
308-221
NET UNITS
(INCL VIG)
+418
NET PROFIT
(INCL VIG)
$100/UNIT
$41,803
VS. SPREAD
1551-1329
NET UNITS
(INCL VIG)
+365.7
NET PROFIT
(INCL VIG)
$100/UNIT
$36,569
AI SPORTS PICK PRODUCTS
Create a Free Account

Remi Finds New Picks

Remi Works 24/7
Remi uses this probability to assign units to each pick.
Get Remi's AI Picks
Get Remi’s Top AI Sports Picks sent direct to your inbox.
Hedge Meaning in Betting | 4 Obvious Times to Hedge
Learn about hedge betting to manage risk and secure profits. Understand...
What is a Push in Betting? | 3 Ways To Use To Your Advantage
Understand what a push in betting means, how it happens in...
What Does the + and – Mean in Sports Betting? | 5 Easy Tips
Learn the basics of sports betting odds, what the plus (+)...
Tampa Bay vs San Diego Prediction & Odds:
Free MLB Betting Insights for 4/27/25
Offensively, San Diego has been paced by Fernando Tatis Jr., who leads the team with a scorching .347 batting average, and veteran Xander Bogaerts, who continues to provide solid run production and stability near the top of the order. However, the Padres’ usually potent lineup has struggled with runners in scoring position during the series, leaving too many opportunities on the bases and putting additional pressure on their bullpen to keep games close late. Statistically, the Rays have been very strong against the spread recently, covering in 11 of their last 15 games, while the Padres have covered in 15 of their first 26 games this season, highlighting two teams capable of battling close no matter the setting. San Diego still holds a significant home-field advantage, and their track record at Petco Park suggests they will be highly motivated to salvage a win in front of their home fans before heading into a crucial stretch of divisional play. For the Rays, a sweep would represent a major momentum shift as they work to climb back into serious contention in the AL East, while a Padres win would not only prevent the sweep but also serve as a reminder of their capability to bounce back against adversity. Sunday’s game likely hinges on the starting pitchers—whether Littell can limit early damage and keep Tampa Bay in the game long enough for their bullpen to take over, or if Vasquez can control the strike zone, keep Tampa Bay’s hitters guessing, and hand a lead to San Diego’s late-inning specialists. With both teams hungry for a strong finish to the series, expect a competitive and closely contested matchup where execution, particularly with runners in scoring position, will ultimately decide the victor.
Night Mode 😎@BudweiserUSA | #RaysUp
— Tampa Bay Rays (@RaysBaseball) April 27, 2025
Tampa Bay Rays MLB Preview
The Tampa Bay Rays enter Sunday’s matchup at Petco Park with momentum and belief, eyeing a potential sweep that could serve as a much-needed boost for a team striving to find consistency in a competitive American League landscape. With a 13–14 record, the Rays have battled through injuries, lineup shuffling, and pitching inconsistency, but they have shown resilience on this West Coast trip, highlighted by their ability to capitalize on mistakes and execute in high-leverage moments. Tampa Bay will send Zack Littell to the mound, a starter still looking for his first win of the season despite flashes of effectiveness; carrying an 0–5 record and a 5.28 ERA, Littell’s success will depend heavily on his ability to limit long counts and keep the Padres’ power hitters from finding their rhythm early. Offensively, the Rays have leaned on the emerging talents of Junior Caminero, who brings a .248 average and a .460 slugging percentage into Sunday’s game, and Brandon Lowe, who provides much-needed left-handed power capable of changing games with a single swing.
Tampa Bay’s lineup, while not among the most explosive, has shown an ability to manufacture runs through aggressive baserunning and situational hitting, taking advantage of opportunities when they arise. Defensively, the Rays have been steady, if unspectacular, minimizing mistakes and giving their pitchers solid support, a key factor when facing an offense as potent as San Diego’s. Manager Kevin Cash has continued to emphasize flexibility, using platoon advantages and smart bullpen management to maximize every edge available in tightly contested games. Tampa Bay’s recent success against the spread—covering the run line in 11 of their last 15 games—reflects a team that consistently stays competitive regardless of opponent, and their ability to frustrate and pressure opponents even when trailing has been on full display during this series. If Littell can keep the game close and the bullpen can maintain its strong form, the Rays are well-positioned to complete a sweep that would send a strong message about their resilience and their intentions to reassert themselves as contenders in the AL East as the season heads into May.

Credit: USA TODAY/IMAGN
San Diego Padres MLB Preview
The San Diego Padres approach Sunday’s series finale against the Tampa Bay Rays with a sense of urgency, eager to avoid an unexpected home sweep that would slightly dampen what has otherwise been a strong start to the 2025 season. With a 17–10 overall record and an impressive 12–2 mark at Petco Park, the Padres have typically made their home field a fortress, blending dynamic offense, solid starting pitching, and airtight late-inning bullpen work to overpower opponents. However, recent struggles with situational hitting have left them vulnerable, and they will turn to Randy Vasquez on Sunday to help steady the ship. Vasquez, posting a 1–2 record with a 3.97 ERA, has demonstrated good command and the ability to induce soft contact, but will need to be sharp early to prevent Tampa Bay’s opportunistic lineup from gaining confidence. Offensively, the Padres continue to be led by Fernando Tatis Jr., who boasts a sizzling .347 batting average, setting the tone with both his bat and speed, while Xander Bogaerts provides power and consistency, offering protection in the heart of the order.
Ha-Seong Kim and Manny Machado add additional depth to a lineup that can be lethal when clicking, but missed opportunities with runners in scoring position have been a recurring issue that manager Mike Shildt has emphasized correcting. Defensively, San Diego remains solid, minimizing errors and backing their pitchers effectively, while their bullpen remains one of the more reliable units in baseball, capable of locking down leads if given even a slim margin. With the series finale looming large, the Padres know that reasserting control early and capitalizing on any cracks in Tampa Bay’s pitching will be critical, especially considering the Rays’ knack for staying in games and finding ways to win late. A victory on Sunday would not only help the Padres maintain their strong position in the NL West but would also reinforce the resilience and depth that has defined much of their early-season success.
Final. pic.twitter.com/izBXkcGcrh
— San Diego Padres (@Padres) April 27, 2025
Tampa Bay vs. San Diego Prop Picks (AI)
Tampa Bay vs. San Diego Prediction (AI)

Remi, our AI sports wizard, has been pouring over exorbitant amounts of data from every past game between the Rays and Padres and using recursive machine learning and impressive AI to examine the data to a single cover probability.
Remi has been most focused on the unproportionally assigned factor human bettors tend to put on Tampa Bay’s strength factors between a Rays team going up against a possibly rested Padres team. We’ve found the true game analytics appear to reflect a slight lean against one Vegas line in particular.
Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.
Below is our current AI Tampa Bay vs San Diego picks, computer picks Rays vs Padres, best bets, model edges, confidence ratings.
![]() |
DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
---|---|---|---|---|---|---|
MLB | 9/26 | DET@BOS | UNLOCK THIS PICK | 5 |
![]() |
|
MLB | 9/26 | BAL@NYY | UNLOCK THIS PICK | 4 |
![]() |
|
MLB | 9/26 | ARI@SD | UNLOCK THIS PICK | 4 |
![]() |
|
MLB | 9/26 | NYM@MIA | UNLOCK THIS PICK | 1 |
![]() |
|
MLB | 9/26 | NYM@MIA | GET FREE PICK NOW | 1 | – | |
MLB | 9/26 | COL@SF | UNLOCK THIS PICK | 0 |
![]() |
These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.
Rays Betting Trends
The Rays have covered the run line in 11 of their last 15 games, indicating a strong performance against the spread recently.
Padres Betting Trends
The Padres have covered the run line in 15 of their 26 games this season, showcasing a solid performance at home.
Rays vs. Padres Matchup Trends
The Padres are 12–2 at home this season, indicating a strong home-field advantage.
Tampa Bay vs. San Diego Game Info
What time does Tampa Bay vs San Diego start on April 27, 2025?
Tampa Bay vs San Diego starts on April 27, 2025 at 4:10 PM EST.
Where is Tampa Bay vs San Diego being played?
Venue: Petco Park.
What are the opening odds for Tampa Bay vs San Diego?
Spread: San Diego +1.5
Moneyline: Tampa Bay -100, San Diego -119
Over/Under: 8
What are the records for Tampa Bay vs San Diego?
Tampa Bay: (13-14) | San Diego: (17-10)
What is the AI best bet for Tampa Bay vs San Diego?
Remi's searched hard and found the best prop for this matchup: K. Misner over 0.5 Total Bases.. Prices move—always shop for the best number.
What are Tampa Bay vs San Diego trending bets?
The Padres are 12–2 at home this season, indicating a strong home-field advantage.
What are Tampa Bay trending bets?
TB trend: The Rays have covered the run line in 11 of their last 15 games, indicating a strong performance against the spread recently.
What are San Diego trending bets?
SD trend: The Padres have covered the run line in 15 of their 26 games this season, showcasing a solid performance at home.
Where can I find AI Picks for Tampa Bay vs San Diego?
See our latest MLB picks and odds pages for 2025 to compare prices before you bet.
Tampa Bay vs. San Diego Odds
Remi is pouring through mountains of stats on each team. In fact, anytime the Tampa Bay vs San Diego trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme travel distance seemingly never follow normal, predictable betting trends.
Tampa Bay vs San Diego Opening Odds
TB Moneyline:
-100 SD Moneyline: -119
TB Spread: -1.5
SD Spread: +1.5
Over/Under: 8
Tampa Bay vs San Diego Live Odds
Games | PTS | ML | SPR | O/U | |
---|---|---|---|---|---|
Sep 27, 2025 1:06PM EDT
Baltimore Orioles
New York Yankees
9/27/25 1:06PM
Orioles
Yankees
|
–
–
|
+192
-235
|
+1.5 (-110)
-1.5 (-110)
|
O 9 (+100)
U 9 (-120)
|
|
Sep 27, 2025 2:21PM EDT
St Louis Cardinals
Chicago Cubs
9/27/25 2:21PM
Cardinals
Cubs
|
–
–
|
-178
|
-1.5 (+115)
|
O 9.5 (+100)
U 9.5 (-120)
|
|
Sep 27, 2025 3:09PM EDT
Tampa Bay Rays
Toronto Blue Jays
9/27/25 3:09PM
Rays
Blue Jays
|
–
–
|
+135
-160
|
+1.5 (-160)
-1.5 (+135)
|
O 8.5 (-110)
U 8.5 (-110)
|
|
Sep 27, 2025 4:06PM EDT
Chicago White Sox
Washington Nationals
9/27/25 4:06PM
White Sox
Nationals
|
–
–
|
+100
-120
|
+1.5 (-205)
-1.5 (+170)
|
O 8.5 (-110)
U 8.5 (-110)
|
|
Sep 27, 2025 4:06PM EDT
Colorado Rockies
San Francisco Giants
9/27/25 4:06PM
Rockies
Giants
|
–
–
|
+192
-235
|
+1.5 (-110)
-1.5 (-110)
|
O 8 (-105)
U 8 (-115)
|
|
Sep 27, 2025 4:11PM EDT
New York Mets
Miami Marlins
9/27/25 4:11PM
Mets
Marlins
|
–
–
|
-130
+110
|
-1.5 (+130)
+1.5 (-155)
|
O 8 (-120)
U 8 (+100)
|
|
Sep 27, 2025 4:11PM EDT
Detroit Tigers
Boston Red Sox
9/27/25 4:11PM
Tigers
Red Sox
|
–
–
|
+110
-130
|
+1.5 (-190)
-1.5 (+158)
|
O 9 (+100)
U 9 (-120)
|
|
Sep 27, 2025 6:05PM EDT
Minnesota Twins
Philadelphia Phillies
9/27/25 6:05PM
Twins
Phillies
|
–
–
|
+175
-210
|
+1.5 (-120)
-1.5 (+100)
|
O 8.5 (-115)
U 8.5 (-105)
|
|
Sep 27, 2025 7:11PM EDT
Cincinnati Reds
Milwaukee Brewers
9/27/25 7:11PM
Reds
Brewers
|
–
–
|
+115
-135
|
+1.5 (-190)
-1.5 (+158)
|
O 7.5 (-120)
U 7.5 (+100)
|
|
Sep 27, 2025 7:15PM EDT
Pittsburgh Pirates
Atlanta Braves
9/27/25 7:15PM
Pirates
Braves
|
–
–
|
+150
-178
|
+1.5 (-145)
-1.5 (+122)
|
O 8 (-110)
U 8 (-110)
|
|
Sep 27, 2025 7:16PM EDT
Texas Rangers
Cleveland Guardians
9/27/25 7:16PM
Rangers
Guardians
|
–
–
|
+122
-145
|
+1.5 (-190)
-1.5 (+158)
|
O 7 (-120)
U 7 (+100)
|
|
Sep 27, 2025 8:40PM EDT
Arizona Diamondbacks
San Diego Padres
9/27/25 8:40PM
Diamondbacks
Padres
|
–
–
|
+118
-140
|
+1.5 (-190)
-1.5 (+158)
|
O 7.5 (-115)
U 7.5 (-105)
|
|
Sep 27, 2025 9:39PM EDT
Houston Astros
Los Angeles Angels
9/27/25 9:39PM
Astros
Angels
|
–
–
|
-145
+122
|
-1.5 (+115)
+1.5 (-135)
|
O 9 (-110)
U 9 (-110)
|
|
Sep 27, 2025 9:41PM EDT
Los Angeles Dodgers
Seattle Mariners
9/27/25 9:41PM
Dodgers
Mariners
|
–
–
|
+110
-130
|
+1.5 (-205)
-1.5 (+170)
|
O 7 (-120)
U 7 (+100)
|
|
Sep 27, 2025 10:05PM EDT
Kansas City Royals
Oakland Athletics
9/27/25 10:05PM
Royals
Athletics
|
–
–
|
+100
-120
|
+1.5 (-195)
-1.5 (+162)
|
O 10 (-110)
U 10 (-110)
|
MLB Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers Tampa Bay Rays vs. San Diego Padres on April 27, 2025 at Petco Park.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.
![]() |
LEAN | %WIN | UNITS | RESULT |
---|---|---|---|---|
NYM@CHC | NYM -110 | 54.1% | 3 | WIN |
HOU@ATH | ATH +118 | 50.8% | 4 | WIN |
NYM@CHC | OVER 7 | 54.5% | 3 | WIN |
STL@SF | OVER 7.5 | 55.9% | 5 | LOSS |
KC@LAA | TYLER TOLBERT UNDER 1.5 BASES | 54.4% | 4 | WIN |
MIL@SD | UNDER 9 | 54.7% | 4 | WIN |
MIA@PHI | KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS | 53.3% | 3 | WIN |
WAS@NYM | OVER 8.5 | 56.1% | 6 | LOSS |
LAA@COL | COL +108 | 50.5% | 3 | WIN |
TOR@KC | UNDER 9 | 54.7% | 4 | LOSS |
SEA@KC | KC +1.5 | 62.3% | 5 | LOSS |
NYY@MIN | OVER 9 | 55.1% | 4 | WIN |
MIA@COL | OVER 10.5 | 55.0% | 4 | WIN |
MIA@COL | AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS | 54.3% | 4 | WIN |
SEA@KC | BOBBY WITT UNDER 0.5 SINGLES | 54.4% | 4 | LOSS |
PHI@LAD | LAD -113 | 54.7% | 4 | LOSS |
NYY@BOS | OVER 7.5 | 54.3% | 3 | WIN |
KC@PHI | PHI -130 | 58.3% | 4 | WIN |
LAD@SF | OVER 7.5 | 54.7% | 4 | LOSS |
NYM@PHI | PHI -122 | 55.6% | 4 | WIN |
KC@CLE | KC -104 | 52.0% | 3 | WIN |
CIN@SD | JAKE CRONEWORTH OVER 0.5 HITS | 53.1% | 3 | WIN |
WAS@MIA | MIA -123 | 55.2% | 4 | LOSS |
LAA@KC | UNDER 9.5 | 54.9% | 3 | WIN |
TEX@ARI | UNDER 9 | 54.2% | 4 | WIN |
SF@COL | UNDER 11.5 | 56.4% | 6 | LOSS |
SF@COL | RAFAEL DEVERS OVER 1.5 BASES | 56.1% | 6 | WIN |
MIA@WAS | WAS -110 | 54.4% | 4 | WIN |
NYM@DET | OVER 8.5 | 54.5% | 4 | WIN |
TEX@ARI | UNDER 9.5 | 56.4% | 6 | WIN |
TEX@ARI | ALEJANDRO OSUNA UNDER 1.5 BASES | 54.1% | 4 | LOSS |
ATL@CHC | CHC -116 | 55.1% | 3 | WIN |
PHI@MIL | OVER 8.5 | 55.0% | 3 | WIN |
ARI@LAD | SHOHEI OHTANI OVER 2.5 BASES | 54.2% | 4 | WIN |
SEA@CLE | CLE +1.5 | 57.2% | 3 | WIN |
CHC@SF | CHC -105 | 54.1% | 4 | LOSS |
NYY@CHW | RYAN MCMAHON OVER 0.5 BASES | 54.1% | 4 | WIN |
PHI@NYM | OVER 8.5 | 55.6% | 4 | LOSS |
LAA@TEX | LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS | 54.1% | 4 | LOSS |
KC@CHW | KC -109 | 54.2% | 4 | WIN |
SD@SEA | DYLAN CEASE OVER 16.5 OUTS | 53.9% | 3 | LOSS |
SD@SEA | UNDER 8.5 | 54.4% | 4 | LOSS |
MIN@TOR | JOE RYAN UNDER 2.5 EARNED RUNS | 54.1% | 4 | LOSS |
SF@MIL | MIL +100 | 54.0% | 6 | LOSS |
TOR@MIA | MIA +1.5 | 62.0% | 6 | WIN |
CHC@LAA | OVER 9.5 | 54.9% | 4 | LOSS |
BOS@NYY | CARLOS RODON UNDER 4.5 HITS ALLOWED | 54.2% | 4 | WIN |
KC@DET | DET -115 | 56.1% | 5 | WIN |
CHC@LAA | LAA +1.5 | 57.6% | 5 | LOSS |
CIN@ARI | KEBRYAN HAYES STRIKEOUTS UNDER 0.5 | 56.2% | 6 | WIN |
LAD@SD | SD +110 | 50.9% | 6 | WIN |