Red Sox vs. Guardians
Prediction, Odds & Props
Apr 27 | MLB AI Picks

Updated: 2025-04-25T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The Boston Red Sox (15–14) and Cleveland Guardians (15–11) face off in the series finale on Sunday, April 27, 2025, at Progressive Field, with first pitch scheduled for 1:40 PM ET. Both teams are looking to secure a series win and gain momentum as they approach the end of April.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Apr 27, 2025

Start Time: 1:40 PM EST​

Venue: Progressive Field​

Guardians Record: (15-11)

Red Sox Record: (15-14)

OPENING ODDS

BOS Moneyline: -105

CLE Moneyline: -114

BOS Spread: -1.5

CLE Spread: +1.5

Over/Under: 7.5

BOS
Betting Trends

  • The Red Sox have a 5–5 record against the spread (ATS) over their last 10 games, with the total going over in six of those contests.

CLE
Betting Trends

  • The Guardians have won eight of the 10 games they’ve played as favorites this season, including an 8–1 record in games where they were favored by -114 or more.

MATCHUP TRENDS

  • The Guardians are slight favorites with a moneyline of -114, while the Red Sox are at -105. The over/under for the game is set at 7.5 runs.

BOS vs. CLE
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: A. Bregman over 6.5 Fantasy Score.

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Boston vs Cleveland Prediction & Odds:
Free MLB Betting Insights for 4/27/25

The Boston Red Sox and Cleveland Guardians wrap up their series on Sunday, April 27, 2025, at Progressive Field, with both teams aiming to finish the weekend on a high note and gain valuable momentum heading into May. Boston, sitting at 15–14, brings a dangerous but sometimes volatile offense into the series finale, having scored 124 runs so far this season—the second-most in the American League—while also surrendering 128 runs, an indication that while they can pile up runs quickly, preventing them remains an ongoing challenge. Cleveland, by contrast, sits at a steady 15–11, built on a more balanced approach that has seen them score 96 runs while allowing 101, leaning on strong pitching performances and timely hitting to stay competitive in a tight AL Central race. Sunday’s pitching matchup is particularly intriguing: the Red Sox send Brayan Bello to the mound, a rising star boasting a sparkling 1.80 ERA since returning from injury, while the Guardians counter with Gavin Williams, who enters with a 2–1 record and a respectable 4.15 ERA, looking to continue refining his promising arsenal. Offensively, the Guardians are led by the ever-reliable José Ramírez, who boasts an .824 OPS and five home runs on the year, and the red-hot Steven Kwan, who is batting .337 with four home runs, providing a steady presence at the top of the lineup.

Meanwhile, the Red Sox are still looking for a breakout from Triston Casas, whose .573 OPS lags behind expectations, but they have received strong contributions from other key pieces that have kept their offense dangerous on any given day. ATS trends suggest a close battle: Cleveland has excelled when favored, winning eight of 10 games as favorites of -114 or greater, while Boston has split their last 10 ATS, with the over hitting in six of those contests. With the total set at 7.5 runs, and both starting pitchers capable of controlling opposing lineups when at their best, this could turn into a tightly contested affair where small mistakes loom large. Defense, bullpen management, and situational hitting will likely decide the outcome, with the Guardians hoping to capitalize on their steadier pitching and home-field advantage, while the Red Sox look to leverage their powerful lineup to overwhelm Cleveland’s arms early. Both teams are coming off 6–4 stretches over their last 10 games, signaling that neither side will concede easily, and the energy at Progressive Field should reflect the stakes. A win for Boston would push them back above .500 and provide a boost before a key divisional stretch, while a Guardians victory would solidify their early-season positioning atop a competitive AL Central. In a series that has been competitive throughout, Sunday’s finale promises another entertaining chapter between two teams still trying to define their 2025 identities.

Boston Red Sox MLB Preview

The Boston Red Sox enter Sunday’s series finale at Progressive Field looking to bounce back and leave Cleveland with a series victory that would serve as a boost to their standing in the tightly contested AL East. Despite some defensive lapses and a pitching staff that has struggled at times to contain opposing offenses, the Red Sox have remained competitive thanks to an offense that ranks among the league’s best, scoring 124 runs through the first month of the season, second only to the Yankees in the American League. Brayan Bello, who has been a revelation for the Red Sox rotation, will take the mound carrying a 1.80 ERA and seeking to build on his strong return from injury by attacking Cleveland’s lineup with a lively fastball and a devastating changeup that has induced weak contact all season. Offensively, Boston leans on the core of Rafael Devers, Masataka Yoshida, and Jarren Duran to drive run production, but they are still awaiting a breakout from young slugger Triston Casas, whose .573 OPS suggests better days ahead given his raw power potential.

Defensively, the Red Sox know they must tighten up their play, particularly in the infield where errors have occasionally extended innings and placed additional pressure on their pitching staff. Manager Alex Cora will likely look to push the pace offensively, encouraging aggressive baserunning to disrupt Cleveland’s pitching rhythm and force mistakes. The bullpen remains a bit of a question mark for Boston, with occasional command issues in late-inning situations, but when deployed effectively, the back-end duo of Kenley Jansen and Chris Martin gives the Red Sox a capable late-game advantage. Boston’s ATS trends over their last 10 games (5–5 with six overs) highlight the team’s tendency to get involved in high-scoring affairs, and with the total for Sunday set at 7.5 runs, they may need another strong offensive performance to outslug a disciplined Guardians squad. A victory would lift the Red Sox above .500 and set a positive tone heading into the next homestand, reinforcing their ability to hang with playoff-caliber teams even amid early-season adversity. With Bello on the mound and their offense always capable of exploding, the Red Sox know they have the pieces to end the series on a winning note if they can execute cleanly in the field and capitalize on scoring opportunities when they arise.

The Boston Red Sox (15–14) and Cleveland Guardians (15–11) face off in the series finale on Sunday, April 27, 2025, at Progressive Field, with first pitch scheduled for 1:40 PM ET. Both teams are looking to secure a series win and gain momentum as they approach the end of April. Boston vs Cleveland AI Prediction: Free MLB Betting Insights for Apr 27. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Cleveland Guardians MLB Preview

The Cleveland Guardians head into Sunday’s series finale against the Boston Red Sox at Progressive Field with confidence, sitting at 15–11 and aiming to maintain their steady momentum in the AL Central. Led by the consistent production of José Ramírez and Steven Kwan, the Guardians have built their success on a combination of timely hitting, strong pitching performances, and solid defensive play, elements that have been on full display throughout the early part of the season. Ramírez continues to be the heart and soul of the lineup, delivering an .824 OPS along with five home runs and providing veteran leadership that stabilizes the team during tough stretches. Steven Kwan, batting .337 with four homers, has emerged as a key catalyst at the top of the order, setting the table for Ramírez and the middle of the lineup while playing exceptional defense in left field. On the mound for Cleveland is Gavin Williams, who enters Sunday’s contest with a 2–1 record and a 4.15 ERA, looking to build off recent positive outings by pounding the zone early and keeping Boston’s powerful lineup off balance with a mix of fastballs and sharp secondary offerings. The Guardians have excelled in situations where they are favored, posting an impressive 8–1 record when the moneyline is set at -114 or greater, demonstrating an ability to perform under pressure when expectations are high.

Defensively, Cleveland remains one of the more fundamentally sound teams in the league, routinely converting balls in play into outs and minimizing extra opportunities for opponents. Manager Stephen Vogt will likely emphasize early offense to take some pressure off Williams, as Cleveland has struggled at times to play from behind, particularly against explosive offenses like Boston’s. The Guardians’ bullpen, which has been a strength, will also play a pivotal role late in the game if the score remains close, with reliable arms ready to bridge the gap to closer Emmanuel Clase. A win on Sunday would give the Guardians a critical series victory against a quality opponent and further entrench them as serious contenders in the division, while also providing momentum as they head into a tougher stretch of their schedule. With strong starting pitching, disciplined at-bats, and a home crowd ready to energize the team, Cleveland will look to execute their winning formula once again and close out the weekend on a high note.

Boston vs. Cleveland Prop Picks (AI)

Remi is pouring through loads of stats on each line. In fact, anytime the Red Sox and Guardians play there’s always several intriguing observations to key in on. Not to mention games played at Progressive Field in Apr rarely follow normal, predictable betting trends.
Remi's searched hard and found the best prop for this matchup: A. Bregman over 6.5 Fantasy Score.

Boston vs. Cleveland Prediction (AI)

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Remi, our AI sports wizard, has been pouring over tons of data from every simulation between the Red Sox and Guardians and using recursive machine learning and industry leading AI to boil down the data to a single cover probability.

Remi has been most watching on the growing weight human bettors often put on Cleveland’s strength factors between a Red Sox team going up against a possibly rested Guardians team. We’ve found the true game analytics appear to reflect a strong lean against one Vegas line in particular.

Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.

Below is our current AI Boston vs Cleveland picks, computer picks Red Sox vs Guardians, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
MLB 9/26 DET@BOS UNLOCK THIS PICK 5 EXECUTIVE Locked EXECUTIVE
MLB 9/26 BAL@NYY UNLOCK THIS PICK 4 INTEL Locked INTEL
MLB 9/26 ARI@SD UNLOCK THIS PICK 4 EXECUTIVE Locked EXECUTIVE
MLB 9/26 NYM@MIA UNLOCK THIS PICK 1 INTEL Locked INTEL
MLB 9/26 NYM@MIA GET FREE PICK NOW 1
MLB 9/26 COL@SF UNLOCK THIS PICK 0 INTEL Locked INTEL

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.

Red Sox Betting Trends

The Red Sox have a 5–5 record against the spread (ATS) over their last 10 games, with the total going over in six of those contests.

Guardians Betting Trends

The Guardians have won eight of the 10 games they’ve played as favorites this season, including an 8–1 record in games where they were favored by -114 or more.

Red Sox vs. Guardians Matchup Trends

The Guardians are slight favorites with a moneyline of -114, while the Red Sox are at -105. The over/under for the game is set at 7.5 runs.

Boston vs. Cleveland Game Info

Boston vs Cleveland starts on April 27, 2025 at 1:40 PM EST.

Venue: Progressive Field.

Spread: Cleveland +1.5
Moneyline: Boston -105, Cleveland -114
Over/Under: 7.5

Boston: (15-14)  |  Cleveland: (15-11)

Remi's searched hard and found the best prop for this matchup: A. Bregman over 6.5 Fantasy Score.. Prices move—always shop for the best number.

The Guardians are slight favorites with a moneyline of -114, while the Red Sox are at -105. The over/under for the game is set at 7.5 runs.

BOS trend: The Red Sox have a 5–5 record against the spread (ATS) over their last 10 games, with the total going over in six of those contests.

CLE trend: The Guardians have won eight of the 10 games they’ve played as favorites this season, including an 8–1 record in games where they were favored by -114 or more.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

Boston vs. Cleveland Odds

Remi is pouring through loads of data points on each team. In fact, anytime the Boston vs Cleveland trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme hostile environments can often follow normal, predictable patterns.

Boston vs Cleveland Opening Odds

BOS Moneyline: -105
CLE Moneyline: -114
BOS Spread: -1.5
CLE Spread: +1.5
Over/Under: 7.5

Boston vs Cleveland Live Odds

Games PTS ML SPR O/U
Sep 27, 2025 1:06PM EDT
Baltimore Orioles
New York Yankees
9/27/25 1:06PM
Orioles
Yankees
+190
-235
+1.5 (-110)
-1.5 (-110)
O 8.5 (-120)
U 8.5 (+100)
Sep 27, 2025 2:21PM EDT
St Louis Cardinals
Chicago Cubs
9/27/25 2:21PM
Cardinals
Cubs
 
-175
 
-1.5 (+115)
O 9.5 (-105)
U 9.5 (-115)
Sep 27, 2025 3:09PM EDT
Tampa Bay Rays
Toronto Blue Jays
9/27/25 3:09PM
Rays
Blue Jays
+130
-155
+1.5 (-155)
-1.5 (+130)
O 8.5 (-110)
U 8.5 (-110)
Sep 27, 2025 4:06PM EDT
Chicago White Sox
Washington Nationals
9/27/25 4:06PM
White Sox
Nationals
+100
-120
-1.5 (+165)
+1.5 (-200)
O 8.5 (-110)
U 8.5 (-110)
Sep 27, 2025 4:06PM EDT
Colorado Rockies
San Francisco Giants
9/27/25 4:06PM
Rockies
Giants
+185
-225
+1.5 (-110)
-1.5 (-110)
O 8 (-105)
U 8 (-115)
Sep 27, 2025 4:11PM EDT
New York Mets
Miami Marlins
9/27/25 4:11PM
Mets
Marlins
-130
+110
-1.5 (+125)
+1.5 (-150)
O 8.5 (-105)
U 8.5 (-115)
Sep 27, 2025 4:11PM EDT
Detroit Tigers
Boston Red Sox
9/27/25 4:11PM
Tigers
Red Sox
 
 
pk
pk
Sep 27, 2025 6:05PM EDT
Minnesota Twins
Philadelphia Phillies
9/27/25 6:05PM
Twins
Phillies
+170
-205
+1.5 (-120)
-1.5 (+100)
O 8.5 (-115)
U 8.5 (-105)
Sep 27, 2025 7:11PM EDT
Cincinnati Reds
Milwaukee Brewers
9/27/25 7:11PM
Reds
Brewers
+125
-150
+1.5 (-180)
-1.5 (+150)
O 8 (-105)
U 8 (-115)
Sep 27, 2025 7:15PM EDT
Pittsburgh Pirates
Atlanta Braves
9/27/25 7:15PM
Pirates
Braves
+140
-170
+1.5 (-155)
-1.5 (+130)
O 8 (-110)
U 8 (-110)
Sep 27, 2025 7:16PM EDT
Texas Rangers
Cleveland Guardians
9/27/25 7:16PM
Rangers
Guardians
+135
-165
+1.5 (-180)
-1.5 (+150)
O 7 (-120)
U 7 (+100)
Sep 27, 2025 8:40PM EDT
Arizona Diamondbacks
San Diego Padres
9/27/25 8:40PM
Diamondbacks
Padres
+115
-140
+1.5 (-190)
-1.5 (+155)
O 7.5 (-120)
U 7.5 (+100)
Sep 27, 2025 9:39PM EDT
Houston Astros
Los Angeles Angels
9/27/25 9:39PM
Astros
Angels
-165
+135
-1.5 (+105)
+1.5 (-125)
O 9 (+100)
U 9 (-120)
Sep 27, 2025 9:41PM EDT
Los Angeles Dodgers
Seattle Mariners
9/27/25 9:41PM
Dodgers
Mariners
+100
-120
-1.5 (+170)
+1.5 (-205)
O 7.5 (-110)
U 7.5 (-110)
Sep 27, 2025 10:05PM EDT
Kansas City Royals
Oakland Athletics
9/27/25 10:05PM
Royals
Athletics
+100
-120
-1.5 (+150)
+1.5 (-180)
O 10 (-110)
U 10 (-110)

MLB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Boston Red Sox vs. Cleveland Guardians on April 27, 2025 at Progressive Field.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN
CHC@SF CHC -105 54.1% 4 LOSS
NYY@CHW RYAN MCMAHON OVER 0.5 BASES 54.1% 4 WIN
PHI@NYM OVER 8.5 55.6% 4 LOSS
LAA@TEX LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS 54.1% 4 LOSS
KC@CHW KC -109 54.2% 4 WIN
SD@SEA DYLAN CEASE OVER 16.5 OUTS 53.9% 3 LOSS
SD@SEA UNDER 8.5 54.4% 4 LOSS
MIN@TOR JOE RYAN UNDER 2.5 EARNED RUNS 54.1% 4 LOSS
SF@MIL MIL +100 54.0% 6 LOSS
TOR@MIA MIA +1.5 62.0% 6 WIN
CHC@LAA OVER 9.5 54.9% 4 LOSS
BOS@NYY CARLOS RODON UNDER 4.5 HITS ALLOWED 54.2% 4 WIN
KC@DET DET -115 56.1% 5 WIN
CHC@LAA LAA +1.5 57.6% 5 LOSS
CIN@ARI KEBRYAN HAYES STRIKEOUTS UNDER 0.5 56.2% 6 WIN
LAD@SD SD +110 50.9% 6 WIN