Red Sox vs. Guardians
Prediction, Odds & Props
Apr 26 | MLB AI Picks
Updated: 2025-04-24T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The Boston Red Sox and Cleveland Guardians will face off in a doubleheader on April 26, 2025, at Progressive Field, after Friday’s game was postponed due to inclement weather. Both teams are looking to gain momentum in the early part of the season, with the Red Sox aiming to improve their standing in the AL East and the Guardians seeking to solidify their position in the AL Central.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

GAME INFO
Date: Apr 26, 2025
Start Time: 1:10 PM EST
Venue: Progressive Field
Guardians Record: (14-10)
Red Sox Record: (14-13)
OPENING ODDS
BOS Moneyline: -111
CLE Moneyline: -109
BOS Spread: -1.5
CLE Spread: +1.5
Over/Under: 7.5
BOS
Betting Trends
- The Red Sox have struggled against the spread (ATS) recently, going 4-9 in their last 13 games. Their performance on the road has been inconsistent, which has impacted their ATS record.
CLE
Betting Trends
- The Guardians have been more reliable ATS, especially when favored. They have won eight out of the ten games in which they’ve been favored this season, indicating strong performance when expectations are high.
MATCHUP TRENDS
- In head-to-head matchups, the Guardians have covered the spread in four of their last six games against the Red Sox. Additionally, games between these two teams have gone over the total runs line in five of their last seven meetings, suggesting a trend toward high-scoring affairs.
BOS vs. CLE
Best Prop Bet
- Remi's searched hard and found the best prop for this matchup: R. Devers over 0.5 Total RBIs.
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Boston vs Cleveland Prediction & Odds:
Free MLB Betting Insights for 4/26/25
Key offensive players to watch include Boston’s Rafael Devers and Triston Casas, who have provided the Red Sox with crucial middle-of-the-order power, and Cleveland’s José Ramírez, who continues to be the heartbeat of the Guardians’ lineup with five home runs and five stolen bases already this season. Steven Kwan has also been a bright spot for Cleveland, hitting .337 and providing a spark at the top of the order. Defensively, both teams have been fundamentally sound, but Cleveland’s strength has been its bullpen and ability to protect leads late, while Boston’s road struggles and inconsistent bullpen performances have occasionally cost them tight games. Both matchups in this doubleheader are expected to be tightly contested, with pitching playing a major role, but Boston’s ability to generate offense more consistently could give them a slight edge if they can break through against Cleveland’s starters early. For the Guardians, the formula is clear: strong starting pitching, timely hitting, and minimizing defensive mistakes, especially against a Boston team that can score in bunches when given extra outs. With divisional standings already beginning to take shape and every win vital for building early-season confidence, both teams are likely to treat these games with postseason-level intensity. Fans can expect competitive baseball from start to finish, with plenty of intrigue around how both pitching staffs handle the doubleheader workload and whether Boston’s powerful lineup can overcome Cleveland’s impressive home-field advantage.
Friday Night Baseball starters 🏟️ pic.twitter.com/C5UyuzEJ0F
— Red Sox (@RedSox) April 25, 2025
Boston Red Sox MLB Preview
The Boston Red Sox arrive in Cleveland for Saturday’s doubleheader with a 14-13 record, a hungry roster, and the clear goal of establishing more consistency after a start to the season filled with offensive highs and bullpen frustrations. The Red Sox have been among the more productive offenses in the American League, with 124 runs scored so far, led by the power and patience of Rafael Devers and Triston Casas, who have anchored the middle of the order with clutch hitting and consistent run production. Jarren Duran and Masataka Yoshida have also sparked the lineup from the top and middle, providing Boston with much-needed versatility against both left-handed and right-handed pitching. However, inconsistency in the bullpen and occasional defensive lapses have cost the Red Sox several winnable games, something manager Alex Cora knows must be tightened up if Boston hopes to be a real playoff contender in the rugged AL East. Saturday’s doubleheader presents both a challenge and an opportunity: Walker Buehler, scheduled to pitch Game 1, has shown flashes of ace-level brilliance with a 4.23 ERA, looking sharper with each start as he continues to build back from injury, while Brayan Bello, with a stellar 1.80 ERA, offers the Red Sox a serious weapon in Game 2 as he returns from his brief IL stint.
Boston’s game plan will revolve around getting early run support for their starters, using their power and depth to pressure Cleveland’s pitchers into mistakes, and aggressively controlling the tempo on the bases when opportunities arise. Defensively, the Red Sox will need to tighten up, as Progressive Field’s spacious outfield can be unforgiving to teams that allow extra bases through miscues or poor positioning. Another key factor will be the bullpen’s ability to lock down leads late, an area where Boston has struggled and where Cleveland’s sharp late-inning relief work could create a decisive edge. Players like Wilyer Abreu and Reese McGuire will also need to provide quality at-bats deeper in the lineup to prevent Boston from becoming overly reliant on the middle-of-the-order bats. With the AL East standings tight and every series carrying postseason implications even this early, the Red Sox know that taking at least one, if not both, games on Saturday would set a positive tone heading into May. To do that, they’ll need their pitching to match the Guardians’ excellence on the mound, their hitters to capitalize on opportunities with runners in scoring position, and a level of crispness defensively that has sometimes eluded them in the season’s opening month. Saturday’s twin bill will provide a key measuring stick for how ready this Red Sox team is to contend consistently against playoff-caliber competition.

Credit: USA TODAY/IMAGN
Cleveland Guardians MLB Preview
The Cleveland Guardians approach Saturday’s doubleheader against the Boston Red Sox with cautious optimism, looking to capitalize on their recent momentum and strengthen their standing in the tightly packed AL Central. Entering with a 13-12 record, the Guardians have shown flashes of their potential, largely driven by the steady production of cornerstone players like José Ramírez and Steven Kwan. Ramírez continues to be one of the league’s most dangerous all-around threats, combining power and speed with a veteran’s plate discipline, while Kwan has been outstanding at the top of the order, batting .337 and consistently setting the table for Cleveland’s middle-of-the-order bats. Although the Guardians’ offense has been less prolific compared to the league’s top teams, they have found ways to manufacture runs through small ball, aggressive baserunning, and timely situational hitting. Pitching has been Cleveland’s backbone, and Saturday’s projected starters Logan Allen and Gavin Williams will be critical to their chances. Allen, with his 2.11 ERA, has demonstrated excellent poise and command, often keeping hitters off balance with a mix of changeups and fastballs, while Williams, despite an ERA north of four, has shown the ability to miss bats when he’s locked in. The Guardians’ bullpen remains a major asset, anchored by reliable arms that consistently protect slim leads and close out tight games.
Manager Stephen Vogt has emphasized defense-first baseball, and the team has largely delivered, minimizing errors and playing sharp fundamental baseball that keeps games manageable even when the offense struggles. Against a Boston lineup that has been significantly more potent, Cleveland’s strategy will revolve around getting strong innings from their starters, limiting free passes, and keeping the Red Sox’s big bats from doing damage with runners on base. Offensively, they will need more contributions from players like Andrés Giménez and Josh Naylor to support Ramírez and Kwan, particularly against Boston starters Walker Buehler and Brayan Bello, who both feature sharp stuff and command. Cleveland’s home record has been respectable, and playing two games in the friendly confines of Progressive Field gives them an edge they will need to exploit. If the Guardians can win the opener behind Allen’s steady arm and get an early jump offensively, they will put themselves in position to sweep or at least split the doubleheader and continue building a strong foundation for the months ahead. In a division where every game matters, especially with the Twins and Tigers lurking nearby, Saturday’s doubleheader represents an important opportunity for Cleveland to assert themselves early in the 2025 campaign.
Bean Town Footwear.#GuardsBall pic.twitter.com/tPJALmaELf
— Cleveland Guardians (@CleGuardians) April 25, 2025
Boston vs. Cleveland Prop Picks (AI)
Boston vs. Cleveland Prediction (AI)

Remi, our AI sports wizard, has been pouring over tons of data from every angle between the Red Sox and Guardians and using recursive machine learning and kick-ass AI to boil down the data to a single cover probability.
Interestingly enough, the data has been most keyed in on the linear correlation of emphasis emotional bettors regularly put on Cleveland’s strength factors between a Red Sox team going up against a possibly deflated Guardians team. In reality, the true game analytics appear to reflect a moderate lean against one Vegas line specifically.
Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.
Below is our current AI Boston vs Cleveland picks, computer picks Red Sox vs Guardians, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
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MLB | 9/26 | DET@BOS | UNLOCK THIS PICK | 5 |
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MLB | 9/26 | BAL@NYY | UNLOCK THIS PICK | 4 |
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MLB | 9/26 | ARI@SD | UNLOCK THIS PICK | 4 |
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MLB | 9/26 | NYM@MIA | UNLOCK THIS PICK | 1 |
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MLB | 9/26 | NYM@MIA | GET FREE PICK NOW | 1 | – | |
MLB | 9/26 | COL@SF | UNLOCK THIS PICK | 0 |
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.
Red Sox Betting Trends
The Red Sox have struggled against the spread (ATS) recently, going 4-9 in their last 13 games. Their performance on the road has been inconsistent, which has impacted their ATS record.
Guardians Betting Trends
The Guardians have been more reliable ATS, especially when favored. They have won eight out of the ten games in which they’ve been favored this season, indicating strong performance when expectations are high.
Red Sox vs. Guardians Matchup Trends
In head-to-head matchups, the Guardians have covered the spread in four of their last six games against the Red Sox. Additionally, games between these two teams have gone over the total runs line in five of their last seven meetings, suggesting a trend toward high-scoring affairs.
Boston vs. Cleveland Game Info
What time does Boston vs Cleveland start on April 26, 2025?
Boston vs Cleveland starts on April 26, 2025 at 1:10 PM EST.
Where is Boston vs Cleveland being played?
Venue: Progressive Field.
What are the opening odds for Boston vs Cleveland?
Spread: Cleveland +1.5
Moneyline: Boston -111, Cleveland -109
Over/Under: 7.5
What are the records for Boston vs Cleveland?
Boston: (14-13) | Cleveland: (14-10)
What is the AI best bet for Boston vs Cleveland?
Remi's searched hard and found the best prop for this matchup: R. Devers over 0.5 Total RBIs.. Prices move—always shop for the best number.
What are Boston vs Cleveland trending bets?
In head-to-head matchups, the Guardians have covered the spread in four of their last six games against the Red Sox. Additionally, games between these two teams have gone over the total runs line in five of their last seven meetings, suggesting a trend toward high-scoring affairs.
What are Boston trending bets?
BOS trend: The Red Sox have struggled against the spread (ATS) recently, going 4-9 in their last 13 games. Their performance on the road has been inconsistent, which has impacted their ATS record.
What are Cleveland trending bets?
CLE trend: The Guardians have been more reliable ATS, especially when favored. They have won eight out of the ten games in which they’ve been favored this season, indicating strong performance when expectations are high.
Where can I find AI Picks for Boston vs Cleveland?
See our latest MLB picks and odds pages for 2025 to compare prices before you bet.
Boston vs. Cleveland Odds
Remi is pouring through mountains of stats on each line. In fact, anytime the Boston vs Cleveland trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme altitude almost always follow normal, predictable betting trends.
Boston vs Cleveland Opening Odds
BOS Moneyline:
-111 CLE Moneyline: -109
BOS Spread: -1.5
CLE Spread: +1.5
Over/Under: 7.5
Boston vs Cleveland Live Odds
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MLB Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers Boston Red Sox vs. Cleveland Guardians on April 26, 2025 at Progressive Field.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.
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LEAN | %WIN | UNITS | RESULT |
---|---|---|---|---|
NYM@CHC | NYM -110 | 54.1% | 3 | WIN |
HOU@ATH | ATH +118 | 50.8% | 4 | WIN |
NYM@CHC | OVER 7 | 54.5% | 3 | WIN |
STL@SF | OVER 7.5 | 55.9% | 5 | LOSS |
KC@LAA | TYLER TOLBERT UNDER 1.5 BASES | 54.4% | 4 | WIN |
MIL@SD | UNDER 9 | 54.7% | 4 | WIN |
MIA@PHI | KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS | 53.3% | 3 | WIN |
WAS@NYM | OVER 8.5 | 56.1% | 6 | LOSS |
LAA@COL | COL +108 | 50.5% | 3 | WIN |
TOR@KC | UNDER 9 | 54.7% | 4 | LOSS |
SEA@KC | KC +1.5 | 62.3% | 5 | LOSS |
NYY@MIN | OVER 9 | 55.1% | 4 | WIN |
MIA@COL | OVER 10.5 | 55.0% | 4 | WIN |
MIA@COL | AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS | 54.3% | 4 | WIN |
SEA@KC | BOBBY WITT UNDER 0.5 SINGLES | 54.4% | 4 | LOSS |
PHI@LAD | LAD -113 | 54.7% | 4 | LOSS |
NYY@BOS | OVER 7.5 | 54.3% | 3 | WIN |
KC@PHI | PHI -130 | 58.3% | 4 | WIN |
LAD@SF | OVER 7.5 | 54.7% | 4 | LOSS |
NYM@PHI | PHI -122 | 55.6% | 4 | WIN |
KC@CLE | KC -104 | 52.0% | 3 | WIN |
CIN@SD | JAKE CRONEWORTH OVER 0.5 HITS | 53.1% | 3 | WIN |
WAS@MIA | MIA -123 | 55.2% | 4 | LOSS |
LAA@KC | UNDER 9.5 | 54.9% | 3 | WIN |
TEX@ARI | UNDER 9 | 54.2% | 4 | WIN |
SF@COL | UNDER 11.5 | 56.4% | 6 | LOSS |
SF@COL | RAFAEL DEVERS OVER 1.5 BASES | 56.1% | 6 | WIN |
MIA@WAS | WAS -110 | 54.4% | 4 | WIN |
NYM@DET | OVER 8.5 | 54.5% | 4 | WIN |
TEX@ARI | UNDER 9.5 | 56.4% | 6 | WIN |
TEX@ARI | ALEJANDRO OSUNA UNDER 1.5 BASES | 54.1% | 4 | LOSS |
ATL@CHC | CHC -116 | 55.1% | 3 | WIN |
PHI@MIL | OVER 8.5 | 55.0% | 3 | WIN |
ARI@LAD | SHOHEI OHTANI OVER 2.5 BASES | 54.2% | 4 | WIN |
SEA@CLE | CLE +1.5 | 57.2% | 3 | WIN |
CHC@SF | CHC -105 | 54.1% | 4 | LOSS |
NYY@CHW | RYAN MCMAHON OVER 0.5 BASES | 54.1% | 4 | WIN |
PHI@NYM | OVER 8.5 | 55.6% | 4 | LOSS |
LAA@TEX | LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS | 54.1% | 4 | LOSS |
KC@CHW | KC -109 | 54.2% | 4 | WIN |
SD@SEA | DYLAN CEASE OVER 16.5 OUTS | 53.9% | 3 | LOSS |
SD@SEA | UNDER 8.5 | 54.4% | 4 | LOSS |
MIN@TOR | JOE RYAN UNDER 2.5 EARNED RUNS | 54.1% | 4 | LOSS |
SF@MIL | MIL +100 | 54.0% | 6 | LOSS |
TOR@MIA | MIA +1.5 | 62.0% | 6 | WIN |
CHC@LAA | OVER 9.5 | 54.9% | 4 | LOSS |
BOS@NYY | CARLOS RODON UNDER 4.5 HITS ALLOWED | 54.2% | 4 | WIN |
KC@DET | DET -115 | 56.1% | 5 | WIN |
CHC@LAA | LAA +1.5 | 57.6% | 5 | LOSS |
CIN@ARI | KEBRYAN HAYES STRIKEOUTS UNDER 0.5 | 56.2% | 6 | WIN |
LAD@SD | SD +110 | 50.9% | 6 | WIN |