Red Sox vs. Guardians
Prediction, Odds & Props
Apr 26 | MLB AI Picks

Updated: 2025-04-24T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The Boston Red Sox and Cleveland Guardians will face off in a doubleheader on April 26, 2025, at Progressive Field, after Friday’s game was postponed due to inclement weather. Both teams are looking to gain momentum in the early part of the season, with the Red Sox aiming to improve their standing in the AL East and the Guardians seeking to solidify their position in the AL Central.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Apr 26, 2025

Start Time: 1:10 PM EST​

Venue: Progressive Field​

Guardians Record: (14-10)

Red Sox Record: (14-13)

OPENING ODDS

BOS Moneyline: -111

CLE Moneyline: -109

BOS Spread: -1.5

CLE Spread: +1.5

Over/Under: 7.5

BOS
Betting Trends

  • The Red Sox have struggled against the spread (ATS) recently, going 4-9 in their last 13 games. Their performance on the road has been inconsistent, which has impacted their ATS record.

CLE
Betting Trends

  • The Guardians have been more reliable ATS, especially when favored. They have won eight out of the ten games in which they’ve been favored this season, indicating strong performance when expectations are high.

MATCHUP TRENDS

  • In head-to-head matchups, the Guardians have covered the spread in four of their last six games against the Red Sox. Additionally, games between these two teams have gone over the total runs line in five of their last seven meetings, suggesting a trend toward high-scoring affairs.

BOS vs. CLE
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: R. Devers over 0.5 Total RBIs.

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Boston vs Cleveland Prediction & Odds:
Free MLB Betting Insights for 4/26/25

The Boston Red Sox and Cleveland Guardians are set to clash in a key American League doubleheader on April 26, 2025, at Progressive Field, following a weather postponement that has only heightened the anticipation around this early-season matchup. The Red Sox enter with a 14-13 record, sitting second in the AL East, while the Guardians are close behind with a 13-12 mark, battling for position in a competitive AL Central. Both teams have played solid baseball over the last 10 games, each posting a 6-4 record, and each will look to establish momentum with two important games on Saturday. Boston’s offense has been notably more productive, scoring 124 runs so far this season compared to Cleveland’s 96, and they will lean heavily on that advantage as they aim to set the tone early in Game 1. The Red Sox are expected to start Walker Buehler in the opener, who has shown flashes of his elite form with a 4.23 ERA and a dominant seven-inning, one-run performance in his last outing, signaling he may be rounding into top shape after returning from injury. The Guardians counter with Logan Allen, who has been a steady presence in their rotation, sporting a stellar 2.11 ERA and demonstrating excellent command and poise. Game 2 will feature Boston’s Brayan Bello, back from the injured list with a sharp 1.80 ERA, against Cleveland’s Gavin Williams, who has battled some inconsistency but remains a dangerous pitcher capable of missing bats.

Key offensive players to watch include Boston’s Rafael Devers and Triston Casas, who have provided the Red Sox with crucial middle-of-the-order power, and Cleveland’s José Ramírez, who continues to be the heartbeat of the Guardians’ lineup with five home runs and five stolen bases already this season. Steven Kwan has also been a bright spot for Cleveland, hitting .337 and providing a spark at the top of the order. Defensively, both teams have been fundamentally sound, but Cleveland’s strength has been its bullpen and ability to protect leads late, while Boston’s road struggles and inconsistent bullpen performances have occasionally cost them tight games. Both matchups in this doubleheader are expected to be tightly contested, with pitching playing a major role, but Boston’s ability to generate offense more consistently could give them a slight edge if they can break through against Cleveland’s starters early. For the Guardians, the formula is clear: strong starting pitching, timely hitting, and minimizing defensive mistakes, especially against a Boston team that can score in bunches when given extra outs. With divisional standings already beginning to take shape and every win vital for building early-season confidence, both teams are likely to treat these games with postseason-level intensity. Fans can expect competitive baseball from start to finish, with plenty of intrigue around how both pitching staffs handle the doubleheader workload and whether Boston’s powerful lineup can overcome Cleveland’s impressive home-field advantage.

Boston Red Sox MLB Preview

The Boston Red Sox arrive in Cleveland for Saturday’s doubleheader with a 14-13 record, a hungry roster, and the clear goal of establishing more consistency after a start to the season filled with offensive highs and bullpen frustrations. The Red Sox have been among the more productive offenses in the American League, with 124 runs scored so far, led by the power and patience of Rafael Devers and Triston Casas, who have anchored the middle of the order with clutch hitting and consistent run production. Jarren Duran and Masataka Yoshida have also sparked the lineup from the top and middle, providing Boston with much-needed versatility against both left-handed and right-handed pitching. However, inconsistency in the bullpen and occasional defensive lapses have cost the Red Sox several winnable games, something manager Alex Cora knows must be tightened up if Boston hopes to be a real playoff contender in the rugged AL East. Saturday’s doubleheader presents both a challenge and an opportunity: Walker Buehler, scheduled to pitch Game 1, has shown flashes of ace-level brilliance with a 4.23 ERA, looking sharper with each start as he continues to build back from injury, while Brayan Bello, with a stellar 1.80 ERA, offers the Red Sox a serious weapon in Game 2 as he returns from his brief IL stint.

Boston’s game plan will revolve around getting early run support for their starters, using their power and depth to pressure Cleveland’s pitchers into mistakes, and aggressively controlling the tempo on the bases when opportunities arise. Defensively, the Red Sox will need to tighten up, as Progressive Field’s spacious outfield can be unforgiving to teams that allow extra bases through miscues or poor positioning. Another key factor will be the bullpen’s ability to lock down leads late, an area where Boston has struggled and where Cleveland’s sharp late-inning relief work could create a decisive edge. Players like Wilyer Abreu and Reese McGuire will also need to provide quality at-bats deeper in the lineup to prevent Boston from becoming overly reliant on the middle-of-the-order bats. With the AL East standings tight and every series carrying postseason implications even this early, the Red Sox know that taking at least one, if not both, games on Saturday would set a positive tone heading into May. To do that, they’ll need their pitching to match the Guardians’ excellence on the mound, their hitters to capitalize on opportunities with runners in scoring position, and a level of crispness defensively that has sometimes eluded them in the season’s opening month. Saturday’s twin bill will provide a key measuring stick for how ready this Red Sox team is to contend consistently against playoff-caliber competition.

The Boston Red Sox and Cleveland Guardians will face off in a doubleheader on April 26, 2025, at Progressive Field, after Friday’s game was postponed due to inclement weather. Both teams are looking to gain momentum in the early part of the season, with the Red Sox aiming to improve their standing in the AL East and the Guardians seeking to solidify their position in the AL Central. Boston vs Cleveland AI Prediction: Free MLB Betting Insights for Apr 26. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Cleveland Guardians MLB Preview

The Cleveland Guardians approach Saturday’s doubleheader against the Boston Red Sox with cautious optimism, looking to capitalize on their recent momentum and strengthen their standing in the tightly packed AL Central. Entering with a 13-12 record, the Guardians have shown flashes of their potential, largely driven by the steady production of cornerstone players like José Ramírez and Steven Kwan. Ramírez continues to be one of the league’s most dangerous all-around threats, combining power and speed with a veteran’s plate discipline, while Kwan has been outstanding at the top of the order, batting .337 and consistently setting the table for Cleveland’s middle-of-the-order bats. Although the Guardians’ offense has been less prolific compared to the league’s top teams, they have found ways to manufacture runs through small ball, aggressive baserunning, and timely situational hitting. Pitching has been Cleveland’s backbone, and Saturday’s projected starters Logan Allen and Gavin Williams will be critical to their chances. Allen, with his 2.11 ERA, has demonstrated excellent poise and command, often keeping hitters off balance with a mix of changeups and fastballs, while Williams, despite an ERA north of four, has shown the ability to miss bats when he’s locked in. The Guardians’ bullpen remains a major asset, anchored by reliable arms that consistently protect slim leads and close out tight games.

Manager Stephen Vogt has emphasized defense-first baseball, and the team has largely delivered, minimizing errors and playing sharp fundamental baseball that keeps games manageable even when the offense struggles. Against a Boston lineup that has been significantly more potent, Cleveland’s strategy will revolve around getting strong innings from their starters, limiting free passes, and keeping the Red Sox’s big bats from doing damage with runners on base. Offensively, they will need more contributions from players like Andrés Giménez and Josh Naylor to support Ramírez and Kwan, particularly against Boston starters Walker Buehler and Brayan Bello, who both feature sharp stuff and command. Cleveland’s home record has been respectable, and playing two games in the friendly confines of Progressive Field gives them an edge they will need to exploit. If the Guardians can win the opener behind Allen’s steady arm and get an early jump offensively, they will put themselves in position to sweep or at least split the doubleheader and continue building a strong foundation for the months ahead. In a division where every game matters, especially with the Twins and Tigers lurking nearby, Saturday’s doubleheader represents an important opportunity for Cleveland to assert themselves early in the 2025 campaign.

Boston vs. Cleveland Prop Picks (AI)

Remi is pouring through loads of datapoints on each line. In fact, anytime the Red Sox and Guardians play there’s always several intriguing angles to key in on. Not to mention games played at Progressive Field in Apr rarely follow normal, predictable betting trends.
Remi's searched hard and found the best prop for this matchup: R. Devers over 0.5 Total RBIs.

Boston vs. Cleveland Prediction (AI)

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Remi, our AI sports wizard, has been pouring over tons of data from every angle between the Red Sox and Guardians and using recursive machine learning and kick-ass AI to boil down the data to a single cover probability.

Interestingly enough, the data has been most keyed in on the linear correlation of emphasis emotional bettors regularly put on Cleveland’s strength factors between a Red Sox team going up against a possibly deflated Guardians team. In reality, the true game analytics appear to reflect a moderate lean against one Vegas line specifically.

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Below is our current AI Boston vs Cleveland picks, computer picks Red Sox vs Guardians, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
MLB 9/26 DET@BOS UNLOCK THIS PICK 5 EXECUTIVE Locked EXECUTIVE
MLB 9/26 BAL@NYY UNLOCK THIS PICK 4 INTEL Locked INTEL
MLB 9/26 ARI@SD UNLOCK THIS PICK 4 EXECUTIVE Locked EXECUTIVE
MLB 9/26 NYM@MIA UNLOCK THIS PICK 1 INTEL Locked INTEL
MLB 9/26 NYM@MIA GET FREE PICK NOW 1
MLB 9/26 COL@SF UNLOCK THIS PICK 0 INTEL Locked INTEL

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.

Red Sox Betting Trends

The Red Sox have struggled against the spread (ATS) recently, going 4-9 in their last 13 games. Their performance on the road has been inconsistent, which has impacted their ATS record.

Guardians Betting Trends

The Guardians have been more reliable ATS, especially when favored. They have won eight out of the ten games in which they’ve been favored this season, indicating strong performance when expectations are high.

Red Sox vs. Guardians Matchup Trends

In head-to-head matchups, the Guardians have covered the spread in four of their last six games against the Red Sox. Additionally, games between these two teams have gone over the total runs line in five of their last seven meetings, suggesting a trend toward high-scoring affairs.

Boston vs. Cleveland Game Info

Boston vs Cleveland starts on April 26, 2025 at 1:10 PM EST.

Venue: Progressive Field.

Spread: Cleveland +1.5
Moneyline: Boston -111, Cleveland -109
Over/Under: 7.5

Boston: (14-13)  |  Cleveland: (14-10)

Remi's searched hard and found the best prop for this matchup: R. Devers over 0.5 Total RBIs.. Prices move—always shop for the best number.

In head-to-head matchups, the Guardians have covered the spread in four of their last six games against the Red Sox. Additionally, games between these two teams have gone over the total runs line in five of their last seven meetings, suggesting a trend toward high-scoring affairs.

BOS trend: The Red Sox have struggled against the spread (ATS) recently, going 4-9 in their last 13 games. Their performance on the road has been inconsistent, which has impacted their ATS record.

CLE trend: The Guardians have been more reliable ATS, especially when favored. They have won eight out of the ten games in which they’ve been favored this season, indicating strong performance when expectations are high.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

Boston vs. Cleveland Odds

Remi is pouring through mountains of stats on each line. In fact, anytime the Boston vs Cleveland trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme altitude almost always follow normal, predictable betting trends.

Boston vs Cleveland Opening Odds

BOS Moneyline: -111
CLE Moneyline: -109
BOS Spread: -1.5
CLE Spread: +1.5
Over/Under: 7.5

Boston vs Cleveland Live Odds

Games PTS ML SPR O/U
Sep 27, 2025 1:06PM EDT
Baltimore Orioles
New York Yankees
9/27/25 1:06PM
Orioles
Yankees
+190
-235
+1.5 (-110)
-1.5 (-110)
O 8.5 (-120)
U 8.5 (+100)
Sep 27, 2025 2:21PM EDT
St Louis Cardinals
Chicago Cubs
9/27/25 2:21PM
Cardinals
Cubs
 
-180
 
-1.5 (+115)
O 9.5 (-105)
U 9.5 (-115)
Sep 27, 2025 3:09PM EDT
Tampa Bay Rays
Toronto Blue Jays
9/27/25 3:09PM
Rays
Blue Jays
+130
-155
+1.5 (-155)
-1.5 (+130)
O 8.5 (-110)
U 8.5 (-110)
Sep 27, 2025 4:06PM EDT
Chicago White Sox
Washington Nationals
9/27/25 4:06PM
White Sox
Nationals
+100
-120
-1.5 (+165)
+1.5 (-200)
O 8.5 (-110)
U 8.5 (-110)
Sep 27, 2025 4:06PM EDT
Colorado Rockies
San Francisco Giants
9/27/25 4:06PM
Rockies
Giants
+185
-225
+1.5 (-110)
-1.5 (-110)
O 8 (-105)
U 8 (-115)
Sep 27, 2025 4:11PM EDT
New York Mets
Miami Marlins
9/27/25 4:11PM
Mets
Marlins
-130
+110
-1.5 (+125)
+1.5 (-150)
O 8 (-115)
U 8 (-105)
Sep 27, 2025 4:11PM EDT
Detroit Tigers
Boston Red Sox
9/27/25 4:11PM
Tigers
Red Sox
+125
-150
+1.5 (-180)
-1.5 (+150)
O 9 (+100)
U 9 (-120)
Sep 27, 2025 6:05PM EDT
Minnesota Twins
Philadelphia Phillies
9/27/25 6:05PM
Twins
Phillies
+170
-205
+1.5 (-120)
-1.5 (+100)
O 8.5 (-115)
U 8.5 (-105)
Sep 27, 2025 7:11PM EDT
Cincinnati Reds
Milwaukee Brewers
9/27/25 7:11PM
Reds
Brewers
+125
-150
+1.5 (-180)
-1.5 (+150)
O 8 (-105)
U 8 (-115)
Sep 27, 2025 7:15PM EDT
Pittsburgh Pirates
Atlanta Braves
9/27/25 7:15PM
Pirates
Braves
+145
-175
+1.5 (-155)
-1.5 (+130)
O 8 (-110)
U 8 (-110)
Sep 27, 2025 7:16PM EDT
Texas Rangers
Cleveland Guardians
9/27/25 7:16PM
Rangers
Guardians
+135
-165
+1.5 (-180)
-1.5 (+150)
O 7 (-120)
U 7 (+100)
Sep 27, 2025 8:40PM EDT
Arizona Diamondbacks
San Diego Padres
9/27/25 8:40PM
Diamondbacks
Padres
+115
-140
+1.5 (-195)
-1.5 (+160)
O 7.5 (-120)
U 7.5 (+100)
Sep 27, 2025 9:39PM EDT
Houston Astros
Los Angeles Angels
9/27/25 9:39PM
Astros
Angels
-165
+135
-1.5 (+105)
+1.5 (-125)
O 9 (+100)
U 9 (-120)
Sep 27, 2025 9:41PM EDT
Los Angeles Dodgers
Seattle Mariners
9/27/25 9:41PM
Dodgers
Mariners
+105
-125
+1.5 (-205)
-1.5 (+170)
O 7.5 (+105)
U 7.5 (-125)
Sep 27, 2025 10:05PM EDT
Kansas City Royals
Oakland Athletics
9/27/25 10:05PM
Royals
Athletics
+100
-120
-1.5 (+150)
+1.5 (-180)
O 10 (-110)
U 10 (-110)

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We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Boston Red Sox vs. Cleveland Guardians on April 26, 2025 at Progressive Field.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN
CHC@SF CHC -105 54.1% 4 LOSS
NYY@CHW RYAN MCMAHON OVER 0.5 BASES 54.1% 4 WIN
PHI@NYM OVER 8.5 55.6% 4 LOSS
LAA@TEX LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS 54.1% 4 LOSS
KC@CHW KC -109 54.2% 4 WIN
SD@SEA DYLAN CEASE OVER 16.5 OUTS 53.9% 3 LOSS
SD@SEA UNDER 8.5 54.4% 4 LOSS
MIN@TOR JOE RYAN UNDER 2.5 EARNED RUNS 54.1% 4 LOSS
SF@MIL MIL +100 54.0% 6 LOSS
TOR@MIA MIA +1.5 62.0% 6 WIN
CHC@LAA OVER 9.5 54.9% 4 LOSS
BOS@NYY CARLOS RODON UNDER 4.5 HITS ALLOWED 54.2% 4 WIN
KC@DET DET -115 56.1% 5 WIN
CHC@LAA LAA +1.5 57.6% 5 LOSS
CIN@ARI KEBRYAN HAYES STRIKEOUTS UNDER 0.5 56.2% 6 WIN
LAD@SD SD +110 50.9% 6 WIN