Phillies vs. Cubs
Prediction, Odds & Props
Apr 25 | MLB AI Picks
Updated: 2025-04-23T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The Philadelphia Phillies will face the Chicago Cubs at Wrigley Field on April 25, 2025, with first pitch scheduled for 2:20 PM EDT. The Phillies aim to break a four-game losing streak, while the Cubs look to continue their strong performance at home.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

GAME INFO
Date: Apr 25, 2025
Start Time: 2:20 PM EST​
Venue: Wrigley Field​
Cubs Record: (16-10)
Phillies Record: (13-12)
OPENING ODDS
PHI Moneyline: +115
CHC Moneyline: -136
PHI Spread: +1.5
CHC Spread: -1.5
Over/Under: 8
PHI
Betting Trends
- The Phillies have struggled recently, entering this game on a four-game losing streak and having dropped 10 of their last 16 games.
CHC
Betting Trends
- The Cubs have been strong when favored, holding a 7-3 record (70% win rate) when favored by -128 or more this season.
MATCHUP TRENDS
- The Cubs have a 56.1% implied probability to win this game based on the moneyline odds, indicating a slight edge over the Phillies.
PHI vs. CHC
Best Prop Bet
- Remi's searched hard and found the best prop for this matchup: A. Bohm over 0.5 Total Bases.
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Philadelphia vs Chicago Cubs Prediction & Odds:
Free MLB Betting Insights for 4/25/25
Their bullpen, which struggled at times last season, has taken a step forward and now boasts a more refined late-inning formula, anchored by a closer who’s been excellent in high-leverage situations. The Cubs’ lineup, featuring a mix of power bats and on-base specialists, has proven tough for even elite pitchers to navigate when they’re working counts and stringing together base hits. Meanwhile, the Phillies’ high-powered offense has underdelivered, with key hitters like Bryce Harper and Kyle Schwarber flashing their potential but not consistently producing when the team needs it most. Philadelphia’s struggles with the bases loaded—just a .154 batting average in those situations—has been a critical factor in their inability to close out tight games, and unless they improve their situational hitting, their elite batting averages will remain a hollow stat line. From a defensive standpoint, both teams are solid but not elite, and any defensive miscues could prove costly given how closely these clubs are currently matched on paper. The implications of this series go beyond just a three-game stretch—it’s a gut check for a Phillies team hoping to assert itself as a division frontrunner and a statement opportunity for the Cubs, who are quietly becoming one of the most well-rounded teams in the National League. A win in the series opener could give the Cubs the confidence to take control of the weekend, while a victory for Philadelphia could act as a much-needed morale boost and halt the bleeding. For Chicago, the key will be continuing to execute their winning formula: timely hitting, sound pitching, and clean fielding. For the Phillies, unlocking their offensive potential at the right time—particularly in high-leverage moments—will be essential if they want to stay competitive and keep pace in a tough NL East. The crowd at Wrigley is sure to bring energy, and with both teams hungry to define the direction of their early season narrative, Game 1 promises intensity, urgency, and perhaps a little drama that only late-April baseball can deliver.
Go right ahead, Casty! pic.twitter.com/iDM6U2nCaf
— Philadelphia Phillies (@Phillies) April 23, 2025
Philadelphia Phillies MLB Preview
The Philadelphia Phillies enter Game 1 of their series against the Chicago Cubs desperate to reverse a troubling slide that has seen them drop four straight games and 10 of their last 16, a stretch that has threatened to undo the momentum of their impressive 7-2 start to the season. The Phillies still boast a top-10 offense in both batting average and OPS, a testament to the firepower they have throughout the lineup, but the clutch hitting simply hasn’t been there—especially with the bases loaded, where they’ve posted a bleak .154 average. Stars like Bryce Harper and Kyle Schwarber continue to generate attention and occasional bursts of production, but the team has lacked consistent contributions from the supporting cast, and the situational execution has repeatedly let them down in winnable games. Philadelphia’s pitching, particularly from the bullpen, has also struggled to lock down leads in the late innings, putting undue pressure on the starters to be nearly perfect and forcing the offense to play from behind more often than they should. On the mound in this one is Taijuan Walker, a reliable veteran who’s done his job effectively this season but has received little help in the form of run support or defensive consistency when it matters most. If the Phillies want to halt their skid and reclaim their early-season identity, they’ll need to bring a sharper, more aggressive mindset to Wrigley Field. That means better plate discipline in key spots, avoiding over-swinging with runners on, and trusting the depth of their lineup to manufacture runs rather than waiting for a home run to bail them out.
The return to health of key players and the emergence of new contributors like Bryson Stott could help provide that offensive spark, but it will ultimately come down to whether the team can string together at-bats and sustain pressure against a Cubs team that has been thriving in those very areas. Philadelphia also needs more out of its defense, which has committed untimely errors and struggled with double-play execution—mistakes that get magnified in close, low-scoring contests, particularly on the road. Walker’s ability to keep the ball on the ground and limit hard contact gives the Phillies a chance to build confidence from the mound outward, but that means everyone behind him must be sharp and clean from the first pitch onward. This road trip marks a pivotal point in the Phillies’ young season, where they’ll either rise to the challenge and reestablish themselves as a legitimate contender in the National League East or continue to spiral and fall behind in a division too competitive for extended lapses. Beating a Cubs team that’s played excellent baseball at home won’t be easy, but it’s precisely the kind of matchup where Philadelphia can test its resolve and rediscover the fundamentals that made them dangerous to begin with. If they can tighten the bullpen, make the most of their offensive opportunities, and play clean defense behind a steady Walker outing, the Phillies can turn their current narrative from one of concern to one of course correction. Otherwise, they risk letting a strong start slip away in the shadow of a rough late-April stretch, something a playoff-hopeful team can’t afford for long.

Credit: USA TODAY/IMAGN
Chicago Cubs Cubs MLB Preview
The Chicago Cubs return to Wrigley Field on April 25, 2025, to open a three-game series against the struggling Philadelphia Phillies with confidence, momentum, and a chance to further solidify their position as a quietly formidable force in the National League. Having played consistent and fundamentally sound baseball through the early part of the season, the Cubs enter this matchup with a notable edge—not just in terms of recent form, but in execution on both sides of the ball. At home, they’ve excelled by leveraging timely hitting, quality starts, and a bullpen that has increasingly proven it can be trusted to preserve leads. Their record when favored by -128 or more stands at 7-3, a reflection of their reliability when expected to win, and they’ve made a habit of capitalizing on opportunities against teams like Philadelphia who are struggling to string wins together. The Cubs have been especially sharp defensively, turning key double plays and playing clean, heads-up baseball that has consistently bailed out their pitchers in high-leverage situations, helping them navigate tight games with poise and precision. Offensively, the Cubs’ lineup has showcased balance and adaptability, with a mix of veterans and younger contributors all playing roles in what’s been a very steady attack. While they don’t always rely on explosive innings, Chicago has thrived in building pressure through quality at-bats, strong baserunning, and the ability to move runners situationally—traits that have made them a difficult team to shake once they gain momentum.
Players like Nico Hoerner and Seiya Suzuki have given them consistent production, while Dansby Swanson continues to anchor the infield defense and contribute key hits in clutch situations. The Cubs’ approach at the plate has frustrated opposing pitchers by forcing deep counts and capitalizing on mistakes, a pattern that could present major challenges for a Phillies bullpen that has struggled in late-game scenarios. On the mound, while the starting pitcher for Friday’s game hasn’t been officially confirmed, the Cubs’ rotation has been remarkably efficient in keeping games close, limiting walks, and giving their team chances to win without needing to lean too heavily on their offense. This series opener offers a prime opportunity for the Cubs to build on their recent success and potentially put further distance between themselves and middling teams like the Phillies. While the National League Central remains competitive, the Cubs’ consistency has given them an early leg up, and a win against a team currently searching for answers could serve as a springboard into a strong weekend showing. The key for Chicago will be staying true to what’s worked so far: solid starting pitching, opportunistic offense, and clean, mistake-free defense. Wrigley Field’s energy will certainly be behind them, and with the Phillies limping into town, the Cubs have an excellent chance to take control of the game early and ride their formula to another decisive win. A sharp, complete performance in Game 1 could reinforce that Chicago is not just overachieving—they’re building something sustainable.
FIRE US UP, BOYS. pic.twitter.com/xsCLyZ27qB
— Chicago Cubs (@Cubs) April 24, 2025
Philadelphia vs. Chicago Cubs Prop Picks (AI)
Philadelphia vs. Chicago Cubs Prediction (AI)

Remi, our AI sports algorithm, has been pouring over exorbitant amounts of data from every simulation between the Phillies and Cubs and using recursive machine learning and kick-ass AI to examine the data to a single cover probability.
The Algorithm has been most keyed in on the unproportionally assigned emphasis human bettors tend to put on Philadelphia’s strength factors between a Phillies team going up against a possibly rested Cubs team. Trends look to say the true game analytics appear to reflect a slight lean against one Vegas line in particular.
Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.
Below is our current AI Philadelphia vs Chicago Cubs picks, computer picks Phillies vs Cubs, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
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Phillies Betting Trends
The Phillies have struggled recently, entering this game on a four-game losing streak and having dropped 10 of their last 16 games.
Cubs Betting Trends
The Cubs have been strong when favored, holding a 7-3 record (70% win rate) when favored by -128 or more this season.
Phillies vs. Cubs Matchup Trends
The Cubs have a 56.1% implied probability to win this game based on the moneyline odds, indicating a slight edge over the Phillies.
Philadelphia vs. Chicago Cubs Game Info
What time does Philadelphia vs Chicago Cubs start on April 25, 2025?
Philadelphia vs Chicago Cubs starts on April 25, 2025 at 2:20 PM EST.
Where is Philadelphia vs Chicago Cubs being played?
Venue: Wrigley Field.
What are the opening odds for Philadelphia vs Chicago Cubs?
Spread: Chicago Cubs -1.5
Moneyline: Philadelphia +115, Chicago Cubs -136
Over/Under: 8
What are the records for Philadelphia vs Chicago Cubs?
Philadelphia: (13-12) Â |Â Chicago Cubs: (16-10)
What is the AI best bet for Philadelphia vs Chicago Cubs?
Remi's searched hard and found the best prop for this matchup: A. Bohm over 0.5 Total Bases.. Prices move—always shop for the best number.
What are Philadelphia vs Chicago Cubs trending bets?
The Cubs have a 56.1% implied probability to win this game based on the moneyline odds, indicating a slight edge over the Phillies.
What are Philadelphia trending bets?
PHI trend: The Phillies have struggled recently, entering this game on a four-game losing streak and having dropped 10 of their last 16 games.
What are Chicago Cubs trending bets?
CHC trend: The Cubs have been strong when favored, holding a 7-3 record (70% win rate) when favored by -128 or more this season.
Where can I find AI Picks for Philadelphia vs Chicago Cubs?
See our latest MLB picks and odds pages for 2025 to compare prices before you bet.
Philadelphia vs. Chicago Cubs Odds
AI algorithm Remi is pouring through mountains of data on each line. In fact, anytime the Philadelphia vs Chicago Cubs trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme altitude rarely follow normal, predictable patterns.
Philadelphia vs Chicago Cubs Opening Odds
PHI Moneyline:
+115 CHC Moneyline: -136
PHI Spread: +1.5
CHC Spread: -1.5
Over/Under: 8
Philadelphia vs Chicago Cubs Live Odds
Games | PTS | ML | SPR | O/U | |
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Cincinnati Reds
Milwaukee Brewers
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Reds
Brewers
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O 13.5 (-105)
U 13.5 (-125)
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Arizona Diamondbacks
San Diego Padres
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Diamondbacks
Padres
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1
5
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+1700
-10000
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-4.5 (+132)
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O 8.5 (+124)
U 8.5 (-166)
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Houston Astros
Los Angeles Angels
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Angels
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2
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-350
+255
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+2.5 (-130)
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O 8.5 (-114)
U 8.5 (-114)
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Los Angeles Dodgers
Seattle Mariners
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Dodgers
Mariners
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0
0
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+118
-150
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+1.5 (-240)
-1.5 (+174)
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O 4.5 (-146)
U 4.5 (+110)
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Kansas City Royals
Oakland Athletics
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Royals
Athletics
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1
0
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-115
-111
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-1.5 (+134)
+1.5 (-180)
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O 10.5 (-114)
U 10.5 (-114)
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Sep 28, 2025 3:06PM EDT
Baltimore Orioles
New York Yankees
9/28/25 3:06PM
Orioles
Yankees
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–
–
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+160
-190
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+1.5 (-130)
-1.5 (+108)
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O 8.5 (-122)
U 8.5 (+100)
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Sep 28, 2025 3:06PM EDT
Colorado Rockies
San Francisco Giants
9/28/25 3:06PM
Rockies
Giants
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–
–
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+240
-295
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+1.5 (+126)
-1.5 (-152)
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O 7.5 (-110)
U 7.5 (-110)
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Sep 28, 2025 3:06PM EDT
Minnesota Twins
Philadelphia Phillies
9/28/25 3:06PM
Twins
Phillies
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–
–
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+180
-215
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+1.5 (-125)
-1.5 (+104)
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O 8 (-122)
U 8 (+100)
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Sep 28, 2025 3:06PM EDT
Chicago White Sox
Washington Nationals
9/28/25 3:06PM
White Sox
Nationals
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–
–
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-102
-116
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-1.5 (+164)
+1.5 (-200)
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O 8.5 (-115)
U 8.5 (-105)
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Sep 28, 2025 3:08PM EDT
Tampa Bay Rays
Toronto Blue Jays
9/28/25 3:08PM
Rays
Blue Jays
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–
–
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+166
-198
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+1.5 (-134)
-1.5 (+112)
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O 7.5 (-122)
U 7.5 (+100)
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Sep 28, 2025 3:10PM EDT
Los Angeles Dodgers
Seattle Mariners
9/28/25 3:10PM
Dodgers
Mariners
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–
–
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-108
-108
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-1.5 (+146)
+1.5 (-178)
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O 8 (-115)
U 8 (-105)
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Sep 28, 2025 3:11PM EDT
Cincinnati Reds
Milwaukee Brewers
9/28/25 3:11PM
Reds
Brewers
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–
–
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+110
-130
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+1.5 (-200)
-1.5 (+164)
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O 7.5 (-115)
U 7.5 (-105)
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Sep 28, 2025 3:16PM EDT
Pittsburgh Pirates
Atlanta Braves
9/28/25 3:16PM
Pirates
Braves
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–
–
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+184
-220
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+1.5 (-115)
-1.5 (-104)
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O 7.5 (-105)
U 7.5 (-115)
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Sep 28, 2025 3:20PM EDT
St Louis Cardinals
Chicago Cubs
9/28/25 3:20PM
Cardinals
Cubs
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–
–
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-165
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pk
pk
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Sep 30, 2025 2:30PM EDT
San Diego Padres
Chicago Cubs
9/30/25 2:30PM
Padres
Cubs
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–
–
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+101
-123
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MLB Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers Philadelphia Phillies vs. Chicago Cubs Cubs on April 25, 2025 at Wrigley Field.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.
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   LEAN |    %WIN |    UNITS | RESULT |
---|---|---|---|---|
ARI@SD | SD -131 | 57.3% | 4 | WIN |
DET@BOS | BOS -115 | 56.4% | 5 | WIN |
NYM@CHC | NYM -110 | 54.1% | 3 | WIN |
HOU@ATH | ATH +118 | 50.8% | 4 | WIN |
NYM@CHC | OVER 7 | 54.5% | 3 | WIN |
STL@SF | OVER 7.5 | 55.9% | 5 | LOSS |
KC@LAA | TYLER TOLBERT UNDER 1.5 BASES | 54.4% | 4 | WIN |
MIL@SD | UNDER 9 | 54.7% | 4 | WIN |
MIA@PHI | KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS | 53.3% | 3 | WIN |
WAS@NYM | OVER 8.5 | 56.1% | 6 | LOSS |
LAA@COL | COL +108 | 50.5% | 3 | WIN |
TOR@KC | UNDER 9 | 54.7% | 4 | LOSS |
SEA@KC | KC +1.5 | 62.3% | 5 | LOSS |
NYY@MIN | OVER 9 | 55.1% | 4 | WIN |
MIA@COL | OVER 10.5 | 55.0% | 4 | WIN |
MIA@COL | AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS | 54.3% | 4 | WIN |
SEA@KC | BOBBY WITT UNDER 0.5 SINGLES | 54.4% | 4 | LOSS |
PHI@LAD | LAD -113 | 54.7% | 4 | LOSS |
NYY@BOS | OVER 7.5 | 54.3% | 3 | WIN |
KC@PHI | PHI -130 | 58.3% | 4 | WIN |
LAD@SF | OVER 7.5 | 54.7% | 4 | LOSS |
NYM@PHI | PHI -122 | 55.6% | 4 | WIN |
KC@CLE | KC -104 | 52.0% | 3 | WIN |
CIN@SD | JAKE CRONEWORTH OVER 0.5 HITS | 53.1% | 3 | WIN |
WAS@MIA | MIA -123 | 55.2% | 4 | LOSS |
LAA@KC | UNDER 9.5 | 54.9% | 3 | WIN |
TEX@ARI | UNDER 9 | 54.2% | 4 | WIN |
SF@COL | UNDER 11.5 | 56.4% | 6 | LOSS |
SF@COL | RAFAEL DEVERS OVER 1.5 BASES | 56.1% | 6 | WIN |
MIA@WAS | WAS -110 | 54.4% | 4 | WIN |
NYM@DET | OVER 8.5 | 54.5% | 4 | WIN |
TEX@ARI | UNDER 9.5 | 56.4% | 6 | WIN |
TEX@ARI | ALEJANDRO OSUNA UNDER 1.5 BASES | 54.1% | 4 | LOSS |
ATL@CHC | CHC -116 | 55.1% | 3 | WIN |
PHI@MIL | OVER 8.5 | 55.0% | 3 | WIN |
ARI@LAD | SHOHEI OHTANI OVER 2.5 BASES | 54.2% | 4 | WIN |
SEA@CLE | CLE +1.5 | 57.2% | 3 | WIN |
CHC@SF | CHC -105 | 54.1% | 4 | LOSS |
NYY@CHW | RYAN MCMAHON OVER 0.5 BASES | 54.1% | 4 | WIN |
PHI@NYM | OVER 8.5 | 55.6% | 4 | LOSS |
LAA@TEX | LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS | 54.1% | 4 | LOSS |
KC@CHW | KC -109 | 54.2% | 4 | WIN |
SD@SEA | DYLAN CEASE OVER 16.5 OUTS | 53.9% | 3 | LOSS |
SD@SEA | UNDER 8.5 | 54.4% | 4 | LOSS |
MIN@TOR | JOE RYAN UNDER 2.5 EARNED RUNS | 54.1% | 4 | LOSS |
SF@MIL | MIL +100 | 54.0% | 6 | LOSS |
TOR@MIA | MIA +1.5 | 62.0% | 6 | WIN |
CHC@LAA | OVER 9.5 | 54.9% | 4 | LOSS |
BOS@NYY | CARLOS RODON UNDER 4.5 HITS ALLOWED | 54.2% | 4 | WIN |
KC@DET | DET -115 | 56.1% | 5 | WIN |
CHC@LAA | LAA +1.5 | 57.6% | 5 | LOSS |