Phillies vs. Cubs
Prediction, Odds & Props
Apr 25 | MLB AI Picks

Updated: 2025-04-23T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The Philadelphia Phillies will face the Chicago Cubs at Wrigley Field on April 25, 2025, with first pitch scheduled for 2:20 PM EDT. The Phillies aim to break a four-game losing streak, while the Cubs look to continue their strong performance at home.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Apr 25, 2025

Start Time: 2:20 PM EST​

Venue: Wrigley Field​

Cubs Record: (16-10)

Phillies Record: (13-12)

OPENING ODDS

PHI Moneyline: +115

CHC Moneyline: -136

PHI Spread: +1.5

CHC Spread: -1.5

Over/Under: 8

PHI
Betting Trends

  • The Phillies have struggled recently, entering this game on a four-game losing streak and having dropped 10 of their last 16 games.

CHC
Betting Trends

  • The Cubs have been strong when favored, holding a 7-3 record (70% win rate) when favored by -128 or more this season.

MATCHUP TRENDS

  • The Cubs have a 56.1% implied probability to win this game based on the moneyline odds, indicating a slight edge over the Phillies.

PHI vs. CHC
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: A. Bohm over 0.5 Total Bases.

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Philadelphia vs Chicago Cubs Prediction & Odds:
Free MLB Betting Insights for 4/25/25

The Chicago Cubs and Philadelphia Phillies are set to open a pivotal weekend series on April 25, 2025, at Wrigley Field, with both teams coming in with different narratives but a shared sense of urgency. The Cubs enter the contest riding high, sitting above .500 and having recently showcased consistency both at the plate and on the mound. They’ve been particularly effective at home, where their pitching has been reliable, and their offense opportunistic—factors that give them a slight edge heading into this matchup. The Phillies, on the other hand, come in trying to halt a four-game losing streak and get back to the fundamentals that brought them early-season success. Despite boasting a top-10 offense in batting average and OPS, Philadelphia’s lineup has underperformed in clutch moments, particularly with runners in scoring position, and their bullpen has faltered in late innings, leading to frustrating finishes in winnable games. This game is an opportunity for the Cubs to continue solidifying their position as one of the National League’s more balanced clubs, while the Phillies view it as a much-needed reset to break out of a mini-slump and regain traction in the standings. Friday’s series opener will feature right-hander Taijuan Walker for the Phillies, a steady veteran arm who has been solid but hasn’t had much run support during his outings. The Cubs are expected to counter with a starter from their dependable rotation, which has been a quiet strength this season and helped them remain competitive against tough opponents. What makes this matchup particularly intriguing is the contrast in recent momentum. Chicago has quietly built a reputation for capitalizing on mistakes and executing small ball fundamentals—moving runners, turning double plays, and keeping innings alive through patient plate appearances.

Their bullpen, which struggled at times last season, has taken a step forward and now boasts a more refined late-inning formula, anchored by a closer who’s been excellent in high-leverage situations. The Cubs’ lineup, featuring a mix of power bats and on-base specialists, has proven tough for even elite pitchers to navigate when they’re working counts and stringing together base hits. Meanwhile, the Phillies’ high-powered offense has underdelivered, with key hitters like Bryce Harper and Kyle Schwarber flashing their potential but not consistently producing when the team needs it most. Philadelphia’s struggles with the bases loaded—just a .154 batting average in those situations—has been a critical factor in their inability to close out tight games, and unless they improve their situational hitting, their elite batting averages will remain a hollow stat line. From a defensive standpoint, both teams are solid but not elite, and any defensive miscues could prove costly given how closely these clubs are currently matched on paper. The implications of this series go beyond just a three-game stretch—it’s a gut check for a Phillies team hoping to assert itself as a division frontrunner and a statement opportunity for the Cubs, who are quietly becoming one of the most well-rounded teams in the National League. A win in the series opener could give the Cubs the confidence to take control of the weekend, while a victory for Philadelphia could act as a much-needed morale boost and halt the bleeding. For Chicago, the key will be continuing to execute their winning formula: timely hitting, sound pitching, and clean fielding. For the Phillies, unlocking their offensive potential at the right time—particularly in high-leverage moments—will be essential if they want to stay competitive and keep pace in a tough NL East. The crowd at Wrigley is sure to bring energy, and with both teams hungry to define the direction of their early season narrative, Game 1 promises intensity, urgency, and perhaps a little drama that only late-April baseball can deliver.

Philadelphia Phillies MLB Preview

The Philadelphia Phillies enter Game 1 of their series against the Chicago Cubs desperate to reverse a troubling slide that has seen them drop four straight games and 10 of their last 16, a stretch that has threatened to undo the momentum of their impressive 7-2 start to the season. The Phillies still boast a top-10 offense in both batting average and OPS, a testament to the firepower they have throughout the lineup, but the clutch hitting simply hasn’t been there—especially with the bases loaded, where they’ve posted a bleak .154 average. Stars like Bryce Harper and Kyle Schwarber continue to generate attention and occasional bursts of production, but the team has lacked consistent contributions from the supporting cast, and the situational execution has repeatedly let them down in winnable games. Philadelphia’s pitching, particularly from the bullpen, has also struggled to lock down leads in the late innings, putting undue pressure on the starters to be nearly perfect and forcing the offense to play from behind more often than they should. On the mound in this one is Taijuan Walker, a reliable veteran who’s done his job effectively this season but has received little help in the form of run support or defensive consistency when it matters most. If the Phillies want to halt their skid and reclaim their early-season identity, they’ll need to bring a sharper, more aggressive mindset to Wrigley Field. That means better plate discipline in key spots, avoiding over-swinging with runners on, and trusting the depth of their lineup to manufacture runs rather than waiting for a home run to bail them out.

The return to health of key players and the emergence of new contributors like Bryson Stott could help provide that offensive spark, but it will ultimately come down to whether the team can string together at-bats and sustain pressure against a Cubs team that has been thriving in those very areas. Philadelphia also needs more out of its defense, which has committed untimely errors and struggled with double-play execution—mistakes that get magnified in close, low-scoring contests, particularly on the road. Walker’s ability to keep the ball on the ground and limit hard contact gives the Phillies a chance to build confidence from the mound outward, but that means everyone behind him must be sharp and clean from the first pitch onward. This road trip marks a pivotal point in the Phillies’ young season, where they’ll either rise to the challenge and reestablish themselves as a legitimate contender in the National League East or continue to spiral and fall behind in a division too competitive for extended lapses. Beating a Cubs team that’s played excellent baseball at home won’t be easy, but it’s precisely the kind of matchup where Philadelphia can test its resolve and rediscover the fundamentals that made them dangerous to begin with. If they can tighten the bullpen, make the most of their offensive opportunities, and play clean defense behind a steady Walker outing, the Phillies can turn their current narrative from one of concern to one of course correction. Otherwise, they risk letting a strong start slip away in the shadow of a rough late-April stretch, something a playoff-hopeful team can’t afford for long.

The Philadelphia Phillies will face the Chicago Cubs at Wrigley Field on April 25, 2025, with first pitch scheduled for 2:20 PM EDT. The Phillies aim to break a four-game losing streak, while the Cubs look to continue their strong performance at home. Philadelphia vs Chicago Cubs AI Prediction: Free MLB Betting Insights for Apr 25. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Chicago Cubs Cubs MLB Preview

The Chicago Cubs return to Wrigley Field on April 25, 2025, to open a three-game series against the struggling Philadelphia Phillies with confidence, momentum, and a chance to further solidify their position as a quietly formidable force in the National League. Having played consistent and fundamentally sound baseball through the early part of the season, the Cubs enter this matchup with a notable edge—not just in terms of recent form, but in execution on both sides of the ball. At home, they’ve excelled by leveraging timely hitting, quality starts, and a bullpen that has increasingly proven it can be trusted to preserve leads. Their record when favored by -128 or more stands at 7-3, a reflection of their reliability when expected to win, and they’ve made a habit of capitalizing on opportunities against teams like Philadelphia who are struggling to string wins together. The Cubs have been especially sharp defensively, turning key double plays and playing clean, heads-up baseball that has consistently bailed out their pitchers in high-leverage situations, helping them navigate tight games with poise and precision. Offensively, the Cubs’ lineup has showcased balance and adaptability, with a mix of veterans and younger contributors all playing roles in what’s been a very steady attack. While they don’t always rely on explosive innings, Chicago has thrived in building pressure through quality at-bats, strong baserunning, and the ability to move runners situationally—traits that have made them a difficult team to shake once they gain momentum.

Players like Nico Hoerner and Seiya Suzuki have given them consistent production, while Dansby Swanson continues to anchor the infield defense and contribute key hits in clutch situations. The Cubs’ approach at the plate has frustrated opposing pitchers by forcing deep counts and capitalizing on mistakes, a pattern that could present major challenges for a Phillies bullpen that has struggled in late-game scenarios. On the mound, while the starting pitcher for Friday’s game hasn’t been officially confirmed, the Cubs’ rotation has been remarkably efficient in keeping games close, limiting walks, and giving their team chances to win without needing to lean too heavily on their offense. This series opener offers a prime opportunity for the Cubs to build on their recent success and potentially put further distance between themselves and middling teams like the Phillies. While the National League Central remains competitive, the Cubs’ consistency has given them an early leg up, and a win against a team currently searching for answers could serve as a springboard into a strong weekend showing. The key for Chicago will be staying true to what’s worked so far: solid starting pitching, opportunistic offense, and clean, mistake-free defense. Wrigley Field’s energy will certainly be behind them, and with the Phillies limping into town, the Cubs have an excellent chance to take control of the game early and ride their formula to another decisive win. A sharp, complete performance in Game 1 could reinforce that Chicago is not just overachieving—they’re building something sustainable.

Philadelphia vs. Chicago Cubs Prop Picks (AI)

Remi is pouring through loads of data on each team. In fact, anytime the Phillies and Cubs play there’s always several intriguing angles to key in on. Not to mention games played at Wrigley Field in Apr can often follow normal, predictable betting trends.
Remi's searched hard and found the best prop for this matchup: A. Bohm over 0.5 Total Bases.

Philadelphia vs. Chicago Cubs Prediction (AI)

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Remi, our AI sports algorithm, has been pouring over exorbitant amounts of data from every simulation between the Phillies and Cubs and using recursive machine learning and kick-ass AI to examine the data to a single cover probability.

The Algorithm has been most keyed in on the unproportionally assigned emphasis human bettors tend to put on Philadelphia’s strength factors between a Phillies team going up against a possibly rested Cubs team. Trends look to say the true game analytics appear to reflect a slight lean against one Vegas line in particular.

Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.

Below is our current AI Philadelphia vs Chicago Cubs picks, computer picks Phillies vs Cubs, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.

Phillies Betting Trends

The Phillies have struggled recently, entering this game on a four-game losing streak and having dropped 10 of their last 16 games.

Cubs Betting Trends

The Cubs have been strong when favored, holding a 7-3 record (70% win rate) when favored by -128 or more this season.

Phillies vs. Cubs Matchup Trends

The Cubs have a 56.1% implied probability to win this game based on the moneyline odds, indicating a slight edge over the Phillies.

Philadelphia vs. Chicago Cubs Game Info

Philadelphia vs Chicago Cubs starts on April 25, 2025 at 2:20 PM EST.

Spread: Chicago Cubs -1.5
Moneyline: Philadelphia +115, Chicago Cubs -136
Over/Under: 8

Philadelphia: (13-12)  |  Chicago Cubs: (16-10)

Remi's searched hard and found the best prop for this matchup: A. Bohm over 0.5 Total Bases.. Prices move—always shop for the best number.

The Cubs have a 56.1% implied probability to win this game based on the moneyline odds, indicating a slight edge over the Phillies.

PHI trend: The Phillies have struggled recently, entering this game on a four-game losing streak and having dropped 10 of their last 16 games.

CHC trend: The Cubs have been strong when favored, holding a 7-3 record (70% win rate) when favored by -128 or more this season.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

Philadelphia vs. Chicago Cubs Odds

AI algorithm Remi is pouring through mountains of data on each line. In fact, anytime the Philadelphia vs Chicago Cubs trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme altitude rarely follow normal, predictable patterns.

Philadelphia vs Chicago Cubs Opening Odds

PHI Moneyline: +115
CHC Moneyline: -136
PHI Spread: +1.5
CHC Spread: -1.5
Over/Under: 8

Philadelphia vs Chicago Cubs Live Odds

Games PTS ML SPR O/U
In Progress
Cincinnati Reds
Milwaukee Brewers
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Reds
Brewers
7
4
-50000
+3500
-2.5 (-800)
+2.5 (+450)
O 13.5 (-105)
U 13.5 (-125)
In Progress
Arizona Diamondbacks
San Diego Padres
In Progress
Diamondbacks
Padres
1
5
+1700
-10000
+4.5 (-178)
-4.5 (+132)
O 8.5 (+124)
U 8.5 (-166)
In Progress
Houston Astros
Los Angeles Angels
In Progress
Astros
Angels
2
0
-350
+255
-2.5 (-102)
+2.5 (-130)
O 8.5 (-114)
U 8.5 (-114)
In Progress
Los Angeles Dodgers
Seattle Mariners
In Progress
Dodgers
Mariners
0
0
+118
-150
+1.5 (-240)
-1.5 (+174)
O 4.5 (-146)
U 4.5 (+110)
In Progress
Kansas City Royals
Oakland Athletics
In Progress
Royals
Athletics
1
0
-115
-111
-1.5 (+134)
+1.5 (-180)
O 10.5 (-114)
U 10.5 (-114)
Sep 28, 2025 3:06PM EDT
Baltimore Orioles
New York Yankees
9/28/25 3:06PM
Orioles
Yankees
+160
-190
+1.5 (-130)
-1.5 (+108)
O 8.5 (-122)
U 8.5 (+100)
Sep 28, 2025 3:06PM EDT
Colorado Rockies
San Francisco Giants
9/28/25 3:06PM
Rockies
Giants
+240
-295
+1.5 (+126)
-1.5 (-152)
O 7.5 (-110)
U 7.5 (-110)
Sep 28, 2025 3:06PM EDT
Minnesota Twins
Philadelphia Phillies
9/28/25 3:06PM
Twins
Phillies
+180
-215
+1.5 (-125)
-1.5 (+104)
O 8 (-122)
U 8 (+100)
Sep 28, 2025 3:06PM EDT
Chicago White Sox
Washington Nationals
9/28/25 3:06PM
White Sox
Nationals
-102
-116
-1.5 (+164)
+1.5 (-200)
O 8.5 (-115)
U 8.5 (-105)
Sep 28, 2025 3:08PM EDT
Tampa Bay Rays
Toronto Blue Jays
9/28/25 3:08PM
Rays
Blue Jays
+166
-198
+1.5 (-134)
-1.5 (+112)
O 7.5 (-122)
U 7.5 (+100)
Sep 28, 2025 3:10PM EDT
Los Angeles Dodgers
Seattle Mariners
9/28/25 3:10PM
Dodgers
Mariners
-108
-108
-1.5 (+146)
+1.5 (-178)
O 8 (-115)
U 8 (-105)
Sep 28, 2025 3:11PM EDT
Cincinnati Reds
Milwaukee Brewers
9/28/25 3:11PM
Reds
Brewers
+110
-130
+1.5 (-200)
-1.5 (+164)
O 7.5 (-115)
U 7.5 (-105)
Sep 28, 2025 3:16PM EDT
Pittsburgh Pirates
Atlanta Braves
9/28/25 3:16PM
Pirates
Braves
+184
-220
+1.5 (-115)
-1.5 (-104)
O 7.5 (-105)
U 7.5 (-115)
Sep 28, 2025 3:20PM EDT
St Louis Cardinals
Chicago Cubs
9/28/25 3:20PM
Cardinals
Cubs
 
-165
pk
pk
Sep 30, 2025 2:30PM EDT
San Diego Padres
Chicago Cubs
9/30/25 2:30PM
Padres
Cubs
+101
-123
pk
pk

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We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Philadelphia Phillies vs. Chicago Cubs Cubs on April 25, 2025 at Wrigley Field.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
ARI@SD SD -131 57.3% 4 WIN
DET@BOS BOS -115 56.4% 5 WIN
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN
CHC@SF CHC -105 54.1% 4 LOSS
NYY@CHW RYAN MCMAHON OVER 0.5 BASES 54.1% 4 WIN
PHI@NYM OVER 8.5 55.6% 4 LOSS
LAA@TEX LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS 54.1% 4 LOSS
KC@CHW KC -109 54.2% 4 WIN
SD@SEA DYLAN CEASE OVER 16.5 OUTS 53.9% 3 LOSS
SD@SEA UNDER 8.5 54.4% 4 LOSS
MIN@TOR JOE RYAN UNDER 2.5 EARNED RUNS 54.1% 4 LOSS
SF@MIL MIL +100 54.0% 6 LOSS
TOR@MIA MIA +1.5 62.0% 6 WIN
CHC@LAA OVER 9.5 54.9% 4 LOSS
BOS@NYY CARLOS RODON UNDER 4.5 HITS ALLOWED 54.2% 4 WIN
KC@DET DET -115 56.1% 5 WIN
CHC@LAA LAA +1.5 57.6% 5 LOSS