White Sox vs Athletics Prediction — AI Finds CAN'T MISS MLB Lines & Props (Apr 25)

Updated: 2025-04-23T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

On April 25, 2025, the Chicago White Sox (5–18) will face the Athletics (10–12) at Sutter Health Park in West Sacramento, California, with first pitch scheduled for 10:05 p.m. ET. The Athletics are favored at -235 on the moneyline, while the White Sox are listed at +193, and the over/under is set at 9 runs.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Apr 25, 2025

Start Time: 10:05 PM EST​

Venue: Sutter Health Park​

Athletics Record: (12-13)

White Sox Record: (6-19)

OPENING ODDS

CHW Moneyline: +192

ATH Moneyline: -234

CHW Spread: +1.5

ATH Spread: -1.5

Over/Under: 9

CHW
Betting Trends

  • The White Sox have a 1–10 record on the road this season.

ATH
Betting Trends

  • The Athletics have a 6–4 record against the spread (ATS) over their past 10 games.

MATCHUP TRENDS

  • In their last 5 head-to-head matchups, the Athletics have covered the spread in 60% of the games, while the White Sox have covered in 40%.

CHW vs. ATH
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: L. Butler over 7 Fantasy Score.

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Chicago White Sox vs Athletics Prediction & Odds:
Free MLB Betting Insights for 4/25/25

The Chicago White Sox and Athletics will open a weekend series at Sutter Health Park on April 25, 2025, in a matchup between two American League teams headed in very different directions. The White Sox come into the contest with a league-worst 5–18 record, marred by one of the most underperforming rotations and offenses in all of Major League Baseball. Chicago has struggled to build any momentum through April, particularly on the road, where they’ve posted a dismal 1–10 mark and shown little ability to protect leads or stay competitive in the late innings. They’ll hand the ball to left-hander Tyler Gilbert, who has been inserted into the rotation in hopes of bringing some control and consistency to a pitching staff that has allowed opposing hitters to slash through them with alarming ease. Meanwhile, the Athletics, while not world-beaters at 10–12, have shown noticeable improvement across the board and are quickly becoming one of the more intriguing underdog stories of the season. Luis Severino, who takes the hill for Oakland, has found new life as a staff leader, providing quality innings and keeping games within reach while the offense continues to find its rhythm. The A’s are anchored at the plate by Tyler Soderstrom, whose nine home runs and 19 RBIs are among the top marks in the AL, making him one of the early breakout bats of the 2025 season. While Oakland’s pitching hasn’t been dominant, they’ve been functional—and that’s made all the difference. Severino enters with a fresh mindset and a competitive fire that has led to improved strikeout-to-walk ratios and a better command of his off-speed arsenal, helping him neutralize left-handed hitters and maintain stamina deep into games. His presence has stabilized a rotation that last year was defined by volatility, and now he’ll face a White Sox team that ranks near the bottom of the league in batting average and slugging percentage. Behind Severino, the A’s defense has held steady, limiting errors and flashing above-average range in the infield, while the bullpen—though still a work in progress—has been serviceable in most tight-game scenarios.

At the plate, the Athletics have benefited from strong top-of-the-order presence and clutch hitting from the likes of Jacob Wilson, who enters the series hitting .354 and giving the lineup crucial contact and on-base ability. This version of Oakland isn’t overpowering, but they’re clean, opportunistic, and motivated, especially as they navigate a season filled with doubters. Against a Chicago team that’s been bleeding runs and chasing deficits, the A’s know this series opener is their chance to assert control early and potentially build toward a .500 record heading into May. For the White Sox, this game is an opportunity to start climbing out of a deep early-season hole, but the obstacles are many. The offense has been punchless in key spots despite glimmers of hope from players like Miguel Vargas and Lenyn Sosa, who have contributed with multi-hit games and occasional flashes of pop. Still, the lack of sustained rallies and an inability to extend innings has made it tough to support a pitching staff that desperately needs run insurance. Gilbert will need to pitch well beyond his track record to give Chicago a fighting chance, and even then, the bullpen will need to show marked improvement after weeks of instability and late-game letdowns. The path to success for the White Sox involves limiting mistakes, forcing Oakland into early-inning slumps, and finally stringing together quality at-bats—something they’ve failed to do in nearly every road series so far this season. If Chicago can’t capitalize on scoring opportunities or tighten up defensively, they risk allowing the Athletics to control tempo and confidence, two things the A’s have built up in recent weeks. For the White Sox, this isn’t just another road game—it’s a turning point in a season that’s already approaching critical mass. A win would do more than pad the standings—it could restore belief in a roster that badly needs to rediscover its identity.

Chicago White Sox White Sox MLB Preview

The Chicago White Sox enter their April 25, 2025 matchup against the Athletics with the worst record in baseball at 5–18, and they are a team clearly in freefall searching for any form of momentum or identity as the first month of the season draws to a close. Their road woes have been especially pronounced, with just one win in 11 tries away from home, and that poor showing is directly tied to the team’s inability to pitch effectively in the early innings or generate enough offense to stay within striking distance. Southpaw Tyler Gilbert will take the mound in hopes of providing a spark for a rotation that’s cycled through arms with minimal success; Gilbert has shown flashes of control but hasn’t yet proven he can consistently navigate opposing lineups with the kind of presence required to give the White Sox six competitive innings. With Chicago’s bullpen already stretched thin from short outings and late-game collapses, the pressure on Gilbert is immense—not only to prevent runs, but to spare the relievers from more high-leverage damage. It’s a tall order against an Athletics lineup featuring red-hot bats like Tyler Soderstrom, and given the White Sox’s ongoing defensive lapses, Gilbert will need pinpoint command and solid ground-ball execution to have any chance of avoiding early trouble. On offense, the White Sox have struggled to deliver when it matters most, failing to capitalize with runners in scoring position and lacking the kind of lineup depth needed to mount consistent rallies. Miguel Vargas and Lenyn Sosa have provided some much-needed sparks in recent games, showing gap-to-gap ability and contributing extra-base hits, but their efforts haven’t been enough to cover for the broader inefficiency of the team’s at-bats.

Chicago is batting near the bottom of the league in runs scored, and the lack of plate discipline and contact quality has translated into quick innings and little sustained pressure on opposing pitchers. Against Luis Severino, a veteran right-hander with the ability to exploit overaggressive hitters with sharp breaking stuff, the White Sox will need to stay patient, work deep counts, and manufacture opportunities with smart baserunning and aggressive situational play. If they revert to the form that’s led to so many early exits and scoreless stretches, they’ll find themselves chasing yet another deficit and asking a bullpen that’s consistently faltered to clean up the mess. This game represents a crucial opportunity for the White Sox to show they’re still capable of fighting out of adversity, even if the odds are firmly stacked against them. It’s not about turning the season around in one night—it’s about breaking habits that have defined the first three weeks: sloppy defense, quiet bats, and ineffective starting pitching. If Gilbert can keep the ball in the park and Vargas and Sosa can continue to create at the plate, Chicago may have the pieces to at least remain competitive in this series opener. But without sharp execution and better in-game management, the White Sox will likely continue to drift in a season that’s slipping away fast, especially as stronger opponents begin to pile up on the calendar. A win in Oakland wouldn’t erase the losses, but it would offer something the White Sox haven’t had in weeks—hope.

On April 25, 2025, the Chicago White Sox (5–18) will face the Athletics (10–12) at Sutter Health Park in West Sacramento, California, with first pitch scheduled for 10:05 p.m. ET. The Athletics are favored at -235 on the moneyline, while the White Sox are listed at +193, and the over/under is set at 9 runs. Chicago White Sox vs Athletics AI Prediction: Free MLB Betting Insights for Apr 25. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Athletics Athletics MLB Preview

The Athletics return to Sutter Health Park on April 25, 2025, to host the struggling Chicago White Sox in a matchup that presents a clear opportunity to capitalize on recent momentum and inch closer to the .500 mark. At 10–12, the A’s have outperformed modest preseason expectations, and with solid home-field play and an improving rotation, they appear to be trending upward. Veteran right-hander Luis Severino will start the opener and look to build upon his recent consistency, bringing an edge and experience that’s helped anchor a staff still finding its identity. Severino’s effectiveness has stemmed from a sharpened command of his fastball-slider combination and a more composed approach on the mound, allowing him to neutralize middle-of-the-order bats and pitch deep enough to minimize bullpen strain. Facing a White Sox lineup that has been among the league’s worst in runs scored and batting average, Severino will likely challenge hitters early in the count and pitch to contact against a team that’s struggled to extend innings. With a defense that’s limited mistakes and a bullpen that’s held its own in recent weeks, the Athletics are well-positioned to control tempo if Severino delivers even an average-quality start. Offensively, the Athletics have found a groove, led by breakout slugger Tyler Soderstrom, whose nine home runs and 19 RBIs have made him one of the most dangerous hitters in the American League this month. Soderstrom’s ability to launch the ball to all fields and work counts has turned him into a nightly threat, while the supporting cast—including contact machine Jacob Wilson, batting .354—has helped stretch the lineup and create frequent scoring opportunities.

What sets Oakland apart right now isn’t overwhelming power up and down the order, but a balanced approach that emphasizes patient at-bats, line-drive contact, and speed on the bases. Against White Sox left-hander Tyler Gilbert, the A’s will likely lean on aggressive early swings from right-handed hitters and a willingness to exploit Gilbert’s tendency to fall behind in counts. Given Chicago’s defensive inefficiencies and bullpen volatility, the Athletics should look to press early and force the White Sox into reactive, high-stress pitching situations—something Oakland has done well during recent series wins. This game represents more than just a chance for the Athletics to stack another win; it’s an opportunity to show they can consistently beat the teams they’re expected to beat—something essential for any club hoping to remain relevant through the summer. With Severino’s veteran presence on the mound, Soderstrom’s middle-of-the-order power, and an increasingly confident clubhouse, Oakland has all the ingredients to not only win this series opener but to control it from the first pitch. Discipline, execution, and clean defense will be the key—three elements the Athletics have increasingly delivered throughout April. If they continue on that path, this game could mark the start of a crucial stretch where Oakland redefines its ceiling for 2025 and plants itself more firmly in the conversation within the AL West. Against a White Sox team clearly searching for answers, the Athletics don’t just have the edge—they have the momentum.

Chicago White Sox vs. Athletics Prop Picks (AI)

AI algorithm Remi is pouring through mountains of data on each team. In fact, anytime the White Sox and Athletics play there’s always several intriguing observations to key in on. Not to mention games played at Sutter Health Park in Apr almost always follow normal, predictable betting trends.
Remi's searched hard and found the best prop for this matchup: L. Butler over 7 Fantasy Score.

Chicago White Sox vs. Athletics Prediction (AI)

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Remi, our AI sports algorithm, has been pouring over millions of data from every facet between the White Sox and Athletics and using recursive machine learning and industry leading AI to analyze the data to a single cover probability.

The Algorithm has been most fixated on the linear correlation of factor human bettors tend to put on coaching factors between a White Sox team going up against a possibly healthy Athletics team. We’ve found the true game analytics might reflect a slight lean against one Vegas line specifically.

Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.

Below is our current AI Chicago White Sox vs Athletics picks, computer picks White Sox vs Athletics, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.

White Sox Betting Trends

The White Sox have a 1–10 record on the road this season.

Athletics Betting Trends

The Athletics have a 6–4 record against the spread (ATS) over their past 10 games.

White Sox vs. Athletics Matchup Trends

In their last 5 head-to-head matchups, the Athletics have covered the spread in 60% of the games, while the White Sox have covered in 40%.

Chicago White Sox vs. Athletics Game Info

Chicago White Sox vs Athletics starts on April 25, 2025 at 10:05 PM EST.

Spread: Athletics -1.5
Moneyline: Chicago White Sox +192, Athletics -234
Over/Under: 9

Chicago White Sox: (6-19)  |  Athletics: (12-13)

Remi's searched hard and found the best prop for this matchup: L. Butler over 7 Fantasy Score.. Prices move—always shop for the best number.

In their last 5 head-to-head matchups, the Athletics have covered the spread in 60% of the games, while the White Sox have covered in 40%.

CHW trend: The White Sox have a 1–10 record on the road this season.

ATH trend: The Athletics have a 6–4 record against the spread (ATS) over their past 10 games.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

Chicago White Sox vs. Athletics Odds

AI algorithm Remi is pouring through tons of data points on each line. In fact, anytime the Chicago White Sox vs Athletics trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme travel distance can often follow normal, predictable betting trends.

Chicago White Sox vs Athletics Opening Odds

CHW Moneyline: +192
ATH Moneyline: -234
CHW Spread: +1.5
ATH Spread: -1.5
Over/Under: 9

Chicago White Sox vs Athletics Live Odds

Games PTS ML SPR O/U

MLB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Chicago White Sox White Sox vs. Athletics Athletics on April 25, 2025 at Sutter Health Park.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
LAD@TOR TOR +1.5 56.7% 2 WIN
TOR@LAD TOR +1.5 55.3% 4 WIN
TOR@SEA OVER 7 54.9% 3 WIN
LAD@MIL UNDER 7.5 56.6% 6 WIN
TOR@NYY OVER 8 54.9% 4 WIN
TOR@NYY CARLOS RODON OVER 1.5 TOTAL WALKS ALLOWED 53.3% 3 WIN
NYY@TOR OVER 7.5 54.8% 2 WIN
LAD@PHI OVER 7 53.8% 3 WIN
SD@CHC CHC -109 53.8% 3 WIN
SD@CHC OVER 7.5 54.5% 4 LOSS
SD@CHC CHC -111 54.8% 4 LOSS
CIN@LAD SHOHEI OHTANI OVER 1.5 BASES 53.5% 3 WIN
BOS@NYY OVER 7 53.8% 3 LOSS
CIN@LAD ELLY DE LA CRUZ OVER 0.5 BASES 54.4% 4 LOSS
ARI@SD SD -131 57.3% 4 WIN
DET@BOS BOS -115 56.4% 5 WIN
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN