Red Sox vs. Guardians
Prediction, Odds & Props
Apr 25 | MLB AI Picks
Updated: 2025-04-23T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
On April 25, 2025, the Boston Red Sox (14–11) will face the Cleveland Guardians (14–10) at Progressive Field, with first pitch scheduled for 7:10 p.m. ET. The Red Sox are slight favorites at -113 on the moneyline, while the Guardians are listed at -106, and the over/under is set at 9 runs.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

GAME INFO
Date: Apr 25, 2025
Start Time: 7:10 PM EST
Venue: Progressive Field
Guardians Record: (14-10)
Red Sox Record: (14-13)
OPENING ODDS
BOS Moneyline: -113
CLE Moneyline: -106
BOS Spread: -1.5
CLE Spread: +1.5
Over/Under: 9
BOS
Betting Trends
- The Red Sox have a 5–5 record against the spread (ATS) over their past 10 games.
CLE
Betting Trends
- The Guardians hold an 11–10 ATS record for the season, indicating a slight edge in covering the spread.
MATCHUP TRENDS
- The Red Sox have won 11 of the 20 games they’ve played as favorites this season, translating to a 55% success rate when favored.
BOS vs. CLE
Best Prop Bet
- Remi's searched hard and found the best prop for this matchup: K. Manzardo over 0.5 Total Bases.
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Boston vs Cleveland Prediction & Odds:
Free MLB Betting Insights for 4/25/25
Offensively, the Guardians have gotten a surprising jolt from Kyle Manzardo, who leads the team with seven home runs and 18 RBIs and has been a crucial run producer in the middle of the lineup. Gabriel Arias has chipped in with a .270 average and four home runs, giving Cleveland another source of offense that balances their otherwise small-ball, station-to-station approach. The Guardians don’t often blow teams out, but they’ve been excellent at executing with runners in scoring position, moving runners with productive outs, and closing out tight games thanks to one of the more efficient bullpens in baseball. Defensively, they’ve played clean baseball and avoided the types of mistakes that have plagued less disciplined teams, particularly in the late innings. With both teams hovering near the top of their divisions, this matchup carries weight beyond just one April game—it’s a chance for either team to gain traction in what should be ultra-competitive divisional races throughout the summer. Boston will rely on their offensive firepower to overcome another shaky pitching performance if Houck can’t find a way to keep Cleveland in check, while the Guardians will look to Lively to deliver yet another quality outing and let their contact-heavy offense grind out a win against a Red Sox bullpen that has already logged heavy innings this month. The Red Sox, favored slightly in the betting lines, will need to back that up with sharp situational hitting and improved command from their starter, but if the Guardians can control the pace early and keep Bregman and company from delivering big blows, they’ll be in prime position to take the opener. With both clubs posting near-identical records and strengths that contrast as much as they complement, this game could offer an early glimpse into which roster construction holds more weight come playoff time: Cleveland’s methodical efficiency or Boston’s high-octane volatility.
"I get chills every day when I put pinstripes on."
— New York Yankees (@Yankees) April 24, 2025
A lifelong Yankees fan, Fernando Cruz shares his inspirational journey on the newest episode of The New York Yankees Official Podcast 🎙️👉https://t.co/OSuWNlhdkf pic.twitter.com/qHyXeQoVgm
Boston Red Sox MLB Preview
The Boston Red Sox enter their April 25, 2025 matchup against the Cleveland Guardians with a 14–11 record and a growing reputation as one of the more offensively explosive teams in the American League, but one still searching for consistency on the mound. Their bats have carried them through the early season, led by third baseman Alex Bregman, who has emerged as the lineup’s most productive player, hitting .320 with five home runs and 21 RBIs. Bregman’s ability to drive the ball to all fields and come through in high-leverage moments has stabilized the heart of the order, while support from Wilyer Abreu (.271 AVG) and Jarren Duran (.250 AVG) has helped stretch opposing pitchers deep into counts. The Red Sox are aggressive on the bases, unafraid to take extra bags or push defensive mistakes, which has allowed them to manufacture runs beyond the long ball. However, despite the offensive depth and a bullpen that’s been largely dependable under pressure, the team continues to be held back by inconsistent starting pitching, a glaring issue highlighted by Tanner Houck’s early-season struggles. Houck, set to start this game, carries a discouraging 0–2 record and a 7.66 ERA, having failed to get out of the fifth inning in multiple starts due to command issues and hard-hit balls that quickly unravel his outings. The pressure on Houck is immense heading into this road start, not only because of his personal need to reset his trajectory but also due to the strain his short outings have placed on the bullpen, which has already logged a heavy workload through the first month of the season.
Boston’s relievers have responded admirably, keeping games close and even salvaging some wins, but continued overuse will eventually take its toll, especially in a series against a contact-heavy team like Cleveland that thrives on wearing down pitching staffs. For the Red Sox to walk away with a win in the opener, Houck needs to limit free passes and pitch to contact without falling into predictable sequencing—something that has plagued him in second and third trips through the lineup. Offensively, the Red Sox will aim to strike early against Guardians starter Ben Lively, whose 3.86 ERA suggests solid form but not invincibility, particularly against a team that can apply pressure one through nine. Bregman and Duran will be key in setting the tone, and if the bottom half of the lineup can flip the order and provide RBI opportunities for the top three hitters, Boston can control the rhythm of the game. This matchup against the Guardians provides the Red Sox with an opportunity to prove that they can win on the road without needing to score seven or more runs to mask pitching deficiencies. To do that, they’ll need to clean up defensive miscues, stay aggressive on the basepaths, and hope that Houck can rediscover some of the promise that once made him a fixture in Boston’s rotation plans. If the offense continues to produce and the bullpen isn’t forced into another five-inning shift, the Red Sox could very well open this series with a victory that not only boosts their standing but also reassures that their formula—offense-led, bullpen-reinforced—can succeed even when the starting pitching falters. But another abbreviated outing from Houck could set off a chain reaction the Guardians are well-equipped to exploit.

Credit: USA TODAY/IMAGN
Cleveland Guardians MLB Preview
The Cleveland Guardians return to Progressive Field on April 25, 2025, to host the Boston Red Sox in a matchup that pits their steady, balanced approach against one of the American League’s more explosive lineups. Cleveland enters the game with a 14–10 record, built on disciplined execution, reliable pitching, and opportunistic offense that doesn’t rely on star power but instead thrives on situational success and consistency across the lineup. Ben Lively gets the nod for the series opener, coming in with a 1–2 record and a respectable 3.86 ERA—numbers that reflect his ability to limit damage and keep his team competitive even when not overpowering. His command of the zone and comfort pitching to contact make him a good matchup against Boston’s aggressive hitters, particularly if he can force early swings and work deep into the game. Behind Lively, Cleveland’s bullpen remains one of their strengths, having been tasked with preserving numerous close leads and delivering shutdown innings late in games. The Guardians don’t often blow opponents away, but they don’t beat themselves either, and that efficiency has been crucial in tight contests against both top-tier and rebuilding opponents alike. Offensively, the Guardians continue to get a major boost from breakout slugger Kyle Manzardo, who leads the team with seven home runs and 18 RBIs. Manzardo’s presence in the middle of the order has added a dimension to Cleveland’s offense that wasn’t as pronounced in recent years—a legitimate power threat who can shift momentum with one swing.
Gabriel Arias has also contributed significantly, hitting .270 with four home runs, helping to stretch the lineup and keep pressure on opposing pitchers beyond just the heart of the order. While Cleveland doesn’t boast gaudy team batting averages or home run totals, their success lies in their ability to make pitchers work, avoid prolonged slumps, and execute fundamentals—whether that’s bunting, situational hitting, or smart baserunning. Defensively, the Guardians have played clean and composed baseball, turning key double plays and making routine outs that limit damage and maintain confidence in their pitching staff. Their overall efficiency and ability to control game flow has made them tough to beat, especially at home where they’ve leveraged the dimensions of Progressive Field to their advantage with strong outfield coverage and opportunistic hitting. As they face a Red Sox team with a powerful lineup but vulnerable pitching, the Guardians have a chance to set the tone for the series by capitalizing on Tanner Houck’s struggles and forcing Boston into another early bullpen call. If Lively can provide a quality start and the Guardians’ offense continues to deliver in big moments, Cleveland could not only take the opener but gain momentum in what could be a closely contested series. The key will be staying disciplined at the plate, minimizing free passes on the mound, and trusting their defensive foundation to support what has been one of the more quietly effective teams in the early part of the 2025 season. A win in this spot wouldn’t just be a notch in the standings—it would reinforce Cleveland’s identity as a fundamentally sound, playoff-caliber team that wins not with flash, but with flawless execution.
Welcome to The Show, Will!#GuardsBall pic.twitter.com/bQrgAN732c
— Cleveland Guardians (@CleGuardians) April 23, 2025
Boston vs. Cleveland Prop Picks (AI)
Boston vs. Cleveland Prediction (AI)

Remi, our AI sports genius, has been pouring over tons of data from every angle between the Red Sox and Guardians and using recursive machine learning and kick-ass AI to boil down the data to a single cover probability.
Remi has been most keyed in on the growing factor human bettors regularly put on coaching factors between a Red Sox team going up against a possibly improved Guardians team. Trends look to say the true game analytics might reflect a slight lean against one Vegas line specifically.
Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.
Below is our current AI Boston vs Cleveland picks, computer picks Red Sox vs Guardians, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
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MLB | 9/26 | DET@BOS | UNLOCK THIS PICK | 5 |
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MLB | 9/26 | BAL@NYY | UNLOCK THIS PICK | 4 |
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MLB | 9/26 | ARI@SD | UNLOCK THIS PICK | 4 |
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MLB | 9/26 | NYM@MIA | UNLOCK THIS PICK | 1 |
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MLB | 9/26 | NYM@MIA | GET FREE PICK NOW | 1 | – | |
MLB | 9/26 | COL@SF | UNLOCK THIS PICK | 0 |
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.
Red Sox Betting Trends
The Red Sox have a 5–5 record against the spread (ATS) over their past 10 games.
Guardians Betting Trends
The Guardians hold an 11–10 ATS record for the season, indicating a slight edge in covering the spread.
Red Sox vs. Guardians Matchup Trends
The Red Sox have won 11 of the 20 games they’ve played as favorites this season, translating to a 55% success rate when favored.
Boston vs. Cleveland Game Info
What time does Boston vs Cleveland start on April 25, 2025?
Boston vs Cleveland starts on April 25, 2025 at 7:10 PM EST.
Where is Boston vs Cleveland being played?
Venue: Progressive Field.
What are the opening odds for Boston vs Cleveland?
Spread: Cleveland +1.5
Moneyline: Boston -113, Cleveland -106
Over/Under: 9
What are the records for Boston vs Cleveland?
Boston: (14-13) | Cleveland: (14-10)
What is the AI best bet for Boston vs Cleveland?
Remi's searched hard and found the best prop for this matchup: K. Manzardo over 0.5 Total Bases.. Prices move—always shop for the best number.
What are Boston vs Cleveland trending bets?
The Red Sox have won 11 of the 20 games they’ve played as favorites this season, translating to a 55% success rate when favored.
What are Boston trending bets?
BOS trend: The Red Sox have a 5–5 record against the spread (ATS) over their past 10 games.
What are Cleveland trending bets?
CLE trend: The Guardians hold an 11–10 ATS record for the season, indicating a slight edge in covering the spread.
Where can I find AI Picks for Boston vs Cleveland?
See our latest MLB picks and odds pages for 2025 to compare prices before you bet.
Boston vs. Cleveland Odds
Remi is pouring through loads of data on each player. In fact, anytime the Boston vs Cleveland trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme temps seemingly never follow normal, predictable patterns.
Boston vs Cleveland Opening Odds
BOS Moneyline:
-113 CLE Moneyline: -106
BOS Spread: -1.5
CLE Spread: +1.5
Over/Under: 9
Boston vs Cleveland Live Odds
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U 8 (+100)
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O 9 (+100)
U 9 (-120)
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Sep 27, 2025 6:05PM EDT
Minnesota Twins
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Sep 27, 2025 7:11PM EDT
Cincinnati Reds
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+115
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O 7.5 (-120)
U 7.5 (+100)
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+118
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O 7.5 (-115)
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MLB Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers Boston Red Sox vs. Cleveland Guardians on April 25, 2025 at Progressive Field.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.
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LEAN | %WIN | UNITS | RESULT |
---|---|---|---|---|
NYM@CHC | NYM -110 | 54.1% | 3 | WIN |
HOU@ATH | ATH +118 | 50.8% | 4 | WIN |
NYM@CHC | OVER 7 | 54.5% | 3 | WIN |
STL@SF | OVER 7.5 | 55.9% | 5 | LOSS |
KC@LAA | TYLER TOLBERT UNDER 1.5 BASES | 54.4% | 4 | WIN |
MIL@SD | UNDER 9 | 54.7% | 4 | WIN |
MIA@PHI | KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS | 53.3% | 3 | WIN |
WAS@NYM | OVER 8.5 | 56.1% | 6 | LOSS |
LAA@COL | COL +108 | 50.5% | 3 | WIN |
TOR@KC | UNDER 9 | 54.7% | 4 | LOSS |
SEA@KC | KC +1.5 | 62.3% | 5 | LOSS |
NYY@MIN | OVER 9 | 55.1% | 4 | WIN |
MIA@COL | OVER 10.5 | 55.0% | 4 | WIN |
MIA@COL | AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS | 54.3% | 4 | WIN |
SEA@KC | BOBBY WITT UNDER 0.5 SINGLES | 54.4% | 4 | LOSS |
PHI@LAD | LAD -113 | 54.7% | 4 | LOSS |
NYY@BOS | OVER 7.5 | 54.3% | 3 | WIN |
KC@PHI | PHI -130 | 58.3% | 4 | WIN |
LAD@SF | OVER 7.5 | 54.7% | 4 | LOSS |
NYM@PHI | PHI -122 | 55.6% | 4 | WIN |
KC@CLE | KC -104 | 52.0% | 3 | WIN |
CIN@SD | JAKE CRONEWORTH OVER 0.5 HITS | 53.1% | 3 | WIN |
WAS@MIA | MIA -123 | 55.2% | 4 | LOSS |
LAA@KC | UNDER 9.5 | 54.9% | 3 | WIN |
TEX@ARI | UNDER 9 | 54.2% | 4 | WIN |
SF@COL | UNDER 11.5 | 56.4% | 6 | LOSS |
SF@COL | RAFAEL DEVERS OVER 1.5 BASES | 56.1% | 6 | WIN |
MIA@WAS | WAS -110 | 54.4% | 4 | WIN |
NYM@DET | OVER 8.5 | 54.5% | 4 | WIN |
TEX@ARI | UNDER 9.5 | 56.4% | 6 | WIN |
TEX@ARI | ALEJANDRO OSUNA UNDER 1.5 BASES | 54.1% | 4 | LOSS |
ATL@CHC | CHC -116 | 55.1% | 3 | WIN |
PHI@MIL | OVER 8.5 | 55.0% | 3 | WIN |
ARI@LAD | SHOHEI OHTANI OVER 2.5 BASES | 54.2% | 4 | WIN |
SEA@CLE | CLE +1.5 | 57.2% | 3 | WIN |
CHC@SF | CHC -105 | 54.1% | 4 | LOSS |
NYY@CHW | RYAN MCMAHON OVER 0.5 BASES | 54.1% | 4 | WIN |
PHI@NYM | OVER 8.5 | 55.6% | 4 | LOSS |
LAA@TEX | LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS | 54.1% | 4 | LOSS |
KC@CHW | KC -109 | 54.2% | 4 | WIN |
SD@SEA | DYLAN CEASE OVER 16.5 OUTS | 53.9% | 3 | LOSS |
SD@SEA | UNDER 8.5 | 54.4% | 4 | LOSS |
MIN@TOR | JOE RYAN UNDER 2.5 EARNED RUNS | 54.1% | 4 | LOSS |
SF@MIL | MIL +100 | 54.0% | 6 | LOSS |
TOR@MIA | MIA +1.5 | 62.0% | 6 | WIN |
CHC@LAA | OVER 9.5 | 54.9% | 4 | LOSS |
BOS@NYY | CARLOS RODON UNDER 4.5 HITS ALLOWED | 54.2% | 4 | WIN |
KC@DET | DET -115 | 56.1% | 5 | WIN |
CHC@LAA | LAA +1.5 | 57.6% | 5 | LOSS |
CIN@ARI | KEBRYAN HAYES STRIKEOUTS UNDER 0.5 | 56.2% | 6 | WIN |
LAD@SD | SD +110 | 50.9% | 6 | WIN |