Red Sox vs. Guardians
Prediction, Odds & Props
Apr 25 | MLB AI Picks

Updated: 2025-04-23T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

On April 25, 2025, the Boston Red Sox (14–11) will face the Cleveland Guardians (14–10) at Progressive Field, with first pitch scheduled for 7:10 p.m. ET. The Red Sox are slight favorites at -113 on the moneyline, while the Guardians are listed at -106, and the over/under is set at 9 runs.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Apr 25, 2025

Start Time: 7:10 PM EST​

Venue: Progressive Field​

Guardians Record: (14-10)

Red Sox Record: (14-13)

OPENING ODDS

BOS Moneyline: -113

CLE Moneyline: -106

BOS Spread: -1.5

CLE Spread: +1.5

Over/Under: 9

BOS
Betting Trends

  • The Red Sox have a 5–5 record against the spread (ATS) over their past 10 games.

CLE
Betting Trends

  • The Guardians hold an 11–10 ATS record for the season, indicating a slight edge in covering the spread.

MATCHUP TRENDS

  • The Red Sox have won 11 of the 20 games they’ve played as favorites this season, translating to a 55% success rate when favored.

BOS vs. CLE
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: K. Manzardo over 0.5 Total Bases.

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Boston vs Cleveland Prediction & Odds:
Free MLB Betting Insights for 4/25/25

The Boston Red Sox and Cleveland Guardians prepare to face off at Progressive Field on April 25, 2025, in a compelling matchup between two clubs off to promising starts in their respective divisions and each looking to make an early-season statement as playoff contenders. The Red Sox come into this game with a 14–11 record, relying heavily on their potent offense and a mix of veteran and emerging contributors to compensate for inconsistent starting pitching. Boston’s lineup, anchored by the red-hot Alex Bregman, has produced one of the most productive scoring stretches in the American League to date, with Bregman leading the way with a .320 batting average, five home runs, and 21 RBIs. Jarren Duran and Wilyer Abreu have both added spark and depth to the order, giving Boston an ability to string together rallies and apply pressure from both the top and bottom of the lineup. However, the challenge for the Red Sox remains their rotation, which has struggled to provide quality starts, most notably in the case of Tanner Houck, who enters the game with an 0–2 record and a bloated 7.66 ERA. Houck’s early-season struggles with command and his tendency to give up hard contact have left the bullpen taxed and the team needing high run totals to stay competitive. Cleveland, on the other hand, has thrived behind steady pitching and timely offense, entering this matchup at 14–10 and riding the consistency of both their bullpen and their emerging stars. Ben Lively takes the mound for the Guardians with a 1–2 record and a respectable 3.86 ERA, providing solid innings and keeping his team in games with his ability to induce weak contact and limit walks.

Offensively, the Guardians have gotten a surprising jolt from Kyle Manzardo, who leads the team with seven home runs and 18 RBIs and has been a crucial run producer in the middle of the lineup. Gabriel Arias has chipped in with a .270 average and four home runs, giving Cleveland another source of offense that balances their otherwise small-ball, station-to-station approach. The Guardians don’t often blow teams out, but they’ve been excellent at executing with runners in scoring position, moving runners with productive outs, and closing out tight games thanks to one of the more efficient bullpens in baseball. Defensively, they’ve played clean baseball and avoided the types of mistakes that have plagued less disciplined teams, particularly in the late innings. With both teams hovering near the top of their divisions, this matchup carries weight beyond just one April game—it’s a chance for either team to gain traction in what should be ultra-competitive divisional races throughout the summer. Boston will rely on their offensive firepower to overcome another shaky pitching performance if Houck can’t find a way to keep Cleveland in check, while the Guardians will look to Lively to deliver yet another quality outing and let their contact-heavy offense grind out a win against a Red Sox bullpen that has already logged heavy innings this month. The Red Sox, favored slightly in the betting lines, will need to back that up with sharp situational hitting and improved command from their starter, but if the Guardians can control the pace early and keep Bregman and company from delivering big blows, they’ll be in prime position to take the opener. With both clubs posting near-identical records and strengths that contrast as much as they complement, this game could offer an early glimpse into which roster construction holds more weight come playoff time: Cleveland’s methodical efficiency or Boston’s high-octane volatility.

Boston Red Sox MLB Preview

The Boston Red Sox enter their April 25, 2025 matchup against the Cleveland Guardians with a 14–11 record and a growing reputation as one of the more offensively explosive teams in the American League, but one still searching for consistency on the mound. Their bats have carried them through the early season, led by third baseman Alex Bregman, who has emerged as the lineup’s most productive player, hitting .320 with five home runs and 21 RBIs. Bregman’s ability to drive the ball to all fields and come through in high-leverage moments has stabilized the heart of the order, while support from Wilyer Abreu (.271 AVG) and Jarren Duran (.250 AVG) has helped stretch opposing pitchers deep into counts. The Red Sox are aggressive on the bases, unafraid to take extra bags or push defensive mistakes, which has allowed them to manufacture runs beyond the long ball. However, despite the offensive depth and a bullpen that’s been largely dependable under pressure, the team continues to be held back by inconsistent starting pitching, a glaring issue highlighted by Tanner Houck’s early-season struggles. Houck, set to start this game, carries a discouraging 0–2 record and a 7.66 ERA, having failed to get out of the fifth inning in multiple starts due to command issues and hard-hit balls that quickly unravel his outings. The pressure on Houck is immense heading into this road start, not only because of his personal need to reset his trajectory but also due to the strain his short outings have placed on the bullpen, which has already logged a heavy workload through the first month of the season.

Boston’s relievers have responded admirably, keeping games close and even salvaging some wins, but continued overuse will eventually take its toll, especially in a series against a contact-heavy team like Cleveland that thrives on wearing down pitching staffs. For the Red Sox to walk away with a win in the opener, Houck needs to limit free passes and pitch to contact without falling into predictable sequencing—something that has plagued him in second and third trips through the lineup. Offensively, the Red Sox will aim to strike early against Guardians starter Ben Lively, whose 3.86 ERA suggests solid form but not invincibility, particularly against a team that can apply pressure one through nine. Bregman and Duran will be key in setting the tone, and if the bottom half of the lineup can flip the order and provide RBI opportunities for the top three hitters, Boston can control the rhythm of the game. This matchup against the Guardians provides the Red Sox with an opportunity to prove that they can win on the road without needing to score seven or more runs to mask pitching deficiencies. To do that, they’ll need to clean up defensive miscues, stay aggressive on the basepaths, and hope that Houck can rediscover some of the promise that once made him a fixture in Boston’s rotation plans. If the offense continues to produce and the bullpen isn’t forced into another five-inning shift, the Red Sox could very well open this series with a victory that not only boosts their standing but also reassures that their formula—offense-led, bullpen-reinforced—can succeed even when the starting pitching falters. But another abbreviated outing from Houck could set off a chain reaction the Guardians are well-equipped to exploit.

On April 25, 2025, the Boston Red Sox (14–11) will face the Cleveland Guardians (14–10) at Progressive Field, with first pitch scheduled for 7:10 p.m. ET. The Red Sox are slight favorites at -113 on the moneyline, while the Guardians are listed at -106, and the over/under is set at 9 runs. Boston vs Cleveland AI Prediction: Free MLB Betting Insights for Apr 25. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Cleveland Guardians MLB Preview

The Cleveland Guardians return to Progressive Field on April 25, 2025, to host the Boston Red Sox in a matchup that pits their steady, balanced approach against one of the American League’s more explosive lineups. Cleveland enters the game with a 14–10 record, built on disciplined execution, reliable pitching, and opportunistic offense that doesn’t rely on star power but instead thrives on situational success and consistency across the lineup. Ben Lively gets the nod for the series opener, coming in with a 1–2 record and a respectable 3.86 ERA—numbers that reflect his ability to limit damage and keep his team competitive even when not overpowering. His command of the zone and comfort pitching to contact make him a good matchup against Boston’s aggressive hitters, particularly if he can force early swings and work deep into the game. Behind Lively, Cleveland’s bullpen remains one of their strengths, having been tasked with preserving numerous close leads and delivering shutdown innings late in games. The Guardians don’t often blow opponents away, but they don’t beat themselves either, and that efficiency has been crucial in tight contests against both top-tier and rebuilding opponents alike. Offensively, the Guardians continue to get a major boost from breakout slugger Kyle Manzardo, who leads the team with seven home runs and 18 RBIs. Manzardo’s presence in the middle of the order has added a dimension to Cleveland’s offense that wasn’t as pronounced in recent years—a legitimate power threat who can shift momentum with one swing.

Gabriel Arias has also contributed significantly, hitting .270 with four home runs, helping to stretch the lineup and keep pressure on opposing pitchers beyond just the heart of the order. While Cleveland doesn’t boast gaudy team batting averages or home run totals, their success lies in their ability to make pitchers work, avoid prolonged slumps, and execute fundamentals—whether that’s bunting, situational hitting, or smart baserunning. Defensively, the Guardians have played clean and composed baseball, turning key double plays and making routine outs that limit damage and maintain confidence in their pitching staff. Their overall efficiency and ability to control game flow has made them tough to beat, especially at home where they’ve leveraged the dimensions of Progressive Field to their advantage with strong outfield coverage and opportunistic hitting. As they face a Red Sox team with a powerful lineup but vulnerable pitching, the Guardians have a chance to set the tone for the series by capitalizing on Tanner Houck’s struggles and forcing Boston into another early bullpen call. If Lively can provide a quality start and the Guardians’ offense continues to deliver in big moments, Cleveland could not only take the opener but gain momentum in what could be a closely contested series. The key will be staying disciplined at the plate, minimizing free passes on the mound, and trusting their defensive foundation to support what has been one of the more quietly effective teams in the early part of the 2025 season. A win in this spot wouldn’t just be a notch in the standings—it would reinforce Cleveland’s identity as a fundamentally sound, playoff-caliber team that wins not with flash, but with flawless execution.

Boston vs. Cleveland Prop Picks (AI)

AI algorithm Remi is pouring through tons of datapoints on each player. In fact, anytime the Red Sox and Guardians play there’s always several intriguing trends to key in on. Not to mention games played at Progressive Field in Apr almost always follow normal, predictable patterns.
Remi's searched hard and found the best prop for this matchup: K. Manzardo over 0.5 Total Bases.

Boston vs. Cleveland Prediction (AI)

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Remi, our AI sports genius, has been pouring over tons of data from every angle between the Red Sox and Guardians and using recursive machine learning and kick-ass AI to boil down the data to a single cover probability.

Remi has been most keyed in on the growing factor human bettors regularly put on coaching factors between a Red Sox team going up against a possibly improved Guardians team. Trends look to say the true game analytics might reflect a slight lean against one Vegas line specifically.

Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.

Below is our current AI Boston vs Cleveland picks, computer picks Red Sox vs Guardians, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
MLB 9/26 DET@BOS UNLOCK THIS PICK 5 EXECUTIVE Locked EXECUTIVE
MLB 9/26 BAL@NYY UNLOCK THIS PICK 4 INTEL Locked INTEL
MLB 9/26 ARI@SD UNLOCK THIS PICK 4 EXECUTIVE Locked EXECUTIVE
MLB 9/26 NYM@MIA UNLOCK THIS PICK 1 INTEL Locked INTEL
MLB 9/26 NYM@MIA GET FREE PICK NOW 1
MLB 9/26 COL@SF UNLOCK THIS PICK 0 INTEL Locked INTEL

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.

Red Sox Betting Trends

The Red Sox have a 5–5 record against the spread (ATS) over their past 10 games.

Guardians Betting Trends

The Guardians hold an 11–10 ATS record for the season, indicating a slight edge in covering the spread.

Red Sox vs. Guardians Matchup Trends

The Red Sox have won 11 of the 20 games they’ve played as favorites this season, translating to a 55% success rate when favored.

Boston vs. Cleveland Game Info

Boston vs Cleveland starts on April 25, 2025 at 7:10 PM EST.

Venue: Progressive Field.

Spread: Cleveland +1.5
Moneyline: Boston -113, Cleveland -106
Over/Under: 9

Boston: (14-13)  |  Cleveland: (14-10)

Remi's searched hard and found the best prop for this matchup: K. Manzardo over 0.5 Total Bases.. Prices move—always shop for the best number.

The Red Sox have won 11 of the 20 games they’ve played as favorites this season, translating to a 55% success rate when favored.

BOS trend: The Red Sox have a 5–5 record against the spread (ATS) over their past 10 games.

CLE trend: The Guardians hold an 11–10 ATS record for the season, indicating a slight edge in covering the spread.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

Boston vs. Cleveland Odds

Remi is pouring through loads of data on each player. In fact, anytime the Boston vs Cleveland trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme temps seemingly never follow normal, predictable patterns.

Boston vs Cleveland Opening Odds

BOS Moneyline: -113
CLE Moneyline: -106
BOS Spread: -1.5
CLE Spread: +1.5
Over/Under: 9

Boston vs Cleveland Live Odds

Games PTS ML SPR O/U
Sep 27, 2025 1:06PM EDT
Baltimore Orioles
New York Yankees
9/27/25 1:06PM
Orioles
Yankees
+192
-235
+1.5 (-110)
-1.5 (-110)
O 9 (+100)
U 9 (-120)
Sep 27, 2025 2:21PM EDT
St Louis Cardinals
Chicago Cubs
9/27/25 2:21PM
Cardinals
Cubs
 
-178
 
-1.5 (+115)
O 9.5 (+100)
U 9.5 (-120)
Sep 27, 2025 3:09PM EDT
Tampa Bay Rays
Toronto Blue Jays
9/27/25 3:09PM
Rays
Blue Jays
+135
-160
+1.5 (-160)
-1.5 (+135)
O 8.5 (-110)
U 8.5 (-110)
Sep 27, 2025 4:06PM EDT
Chicago White Sox
Washington Nationals
9/27/25 4:06PM
White Sox
Nationals
+100
-120
+1.5 (-205)
-1.5 (+170)
O 8.5 (-110)
U 8.5 (-110)
Sep 27, 2025 4:06PM EDT
Colorado Rockies
San Francisco Giants
9/27/25 4:06PM
Rockies
Giants
+192
-235
+1.5 (-110)
-1.5 (-110)
O 8 (-105)
U 8 (-115)
Sep 27, 2025 4:11PM EDT
New York Mets
Miami Marlins
9/27/25 4:11PM
Mets
Marlins
-130
+110
-1.5 (+130)
+1.5 (-155)
O 8 (-120)
U 8 (+100)
Sep 27, 2025 4:11PM EDT
Detroit Tigers
Boston Red Sox
9/27/25 4:11PM
Tigers
Red Sox
+110
-130
+1.5 (-190)
-1.5 (+158)
O 9 (+100)
U 9 (-120)
Sep 27, 2025 6:05PM EDT
Minnesota Twins
Philadelphia Phillies
9/27/25 6:05PM
Twins
Phillies
+175
-210
+1.5 (-120)
-1.5 (+100)
O 8.5 (-115)
U 8.5 (-105)
Sep 27, 2025 7:11PM EDT
Cincinnati Reds
Milwaukee Brewers
9/27/25 7:11PM
Reds
Brewers
+115
-135
+1.5 (-190)
-1.5 (+158)
O 7.5 (-120)
U 7.5 (+100)
Sep 27, 2025 7:15PM EDT
Pittsburgh Pirates
Atlanta Braves
9/27/25 7:15PM
Pirates
Braves
+150
-178
+1.5 (-145)
-1.5 (+122)
O 8 (-110)
U 8 (-110)
Sep 27, 2025 7:16PM EDT
Texas Rangers
Cleveland Guardians
9/27/25 7:16PM
Rangers
Guardians
+122
-145
+1.5 (-190)
-1.5 (+158)
O 7 (-120)
U 7 (+100)
Sep 27, 2025 8:40PM EDT
Arizona Diamondbacks
San Diego Padres
9/27/25 8:40PM
Diamondbacks
Padres
+118
-140
+1.5 (-190)
-1.5 (+158)
O 7.5 (-115)
U 7.5 (-105)
Sep 27, 2025 9:39PM EDT
Houston Astros
Los Angeles Angels
9/27/25 9:39PM
Astros
Angels
-145
+122
-1.5 (+115)
+1.5 (-135)
O 9 (-110)
U 9 (-110)
Sep 27, 2025 9:41PM EDT
Los Angeles Dodgers
Seattle Mariners
9/27/25 9:41PM
Dodgers
Mariners
+110
-130
+1.5 (-205)
-1.5 (+170)
O 7 (-120)
U 7 (+100)
Sep 27, 2025 10:05PM EDT
Kansas City Royals
Oakland Athletics
9/27/25 10:05PM
Royals
Athletics
+100
-120
+1.5 (-195)
-1.5 (+162)
O 10 (-110)
U 10 (-110)

MLB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Boston Red Sox vs. Cleveland Guardians on April 25, 2025 at Progressive Field.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN
CHC@SF CHC -105 54.1% 4 LOSS
NYY@CHW RYAN MCMAHON OVER 0.5 BASES 54.1% 4 WIN
PHI@NYM OVER 8.5 55.6% 4 LOSS
LAA@TEX LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS 54.1% 4 LOSS
KC@CHW KC -109 54.2% 4 WIN
SD@SEA DYLAN CEASE OVER 16.5 OUTS 53.9% 3 LOSS
SD@SEA UNDER 8.5 54.4% 4 LOSS
MIN@TOR JOE RYAN UNDER 2.5 EARNED RUNS 54.1% 4 LOSS
SF@MIL MIL +100 54.0% 6 LOSS
TOR@MIA MIA +1.5 62.0% 6 WIN
CHC@LAA OVER 9.5 54.9% 4 LOSS
BOS@NYY CARLOS RODON UNDER 4.5 HITS ALLOWED 54.2% 4 WIN
KC@DET DET -115 56.1% 5 WIN
CHC@LAA LAA +1.5 57.6% 5 LOSS
CIN@ARI KEBRYAN HAYES STRIKEOUTS UNDER 0.5 56.2% 6 WIN
LAD@SD SD +110 50.9% 6 WIN