White Sox vs. Twins
Prediction, Odds & Props
Apr 23 | MLB AI Picks

Updated: 2025-04-21T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The Chicago White Sox and Minnesota Twins are set to face off on April 23, 2025, at Target Field. Both teams are looking to improve their standings in the American League Central division.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Apr 23, 2025

Start Time: 7:40 PM EST​

Venue: Target Field​

Twins Record: (8-15)

White Sox Record: (5-18)

OPENING ODDS

CHW Moneyline: +218

MIN Moneyline: -268

CHW Spread: +1.5

MIN Spread: -1.5

Over/Under: 8.5

CHW
Betting Trends

  • The White Sox have covered the run line in 9 of their 24 games this season, indicating challenges in meeting betting expectations.

MIN
Betting Trends

  • The Twins have an ATS record of 11-11-0, showing a balanced performance against the spread this season.

MATCHUP TRENDS

  • In their last 5 meetings, the Twins have won all 5 games, with a Handicap-Runs Win% of 60.0% and Total Runs Over% of 60.0%, suggesting a trend toward higher-scoring games favoring the Twins.

CHW vs. MIN
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: L. Robert over 0.5 Total Bases.

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Chicago White Sox vs Minnesota Prediction & Odds:
Free MLB Betting Insights for 4/23/25

The Chicago White Sox and Minnesota Twins are set to close out their divisional series at Target Field on April 23, 2025, in a game that carries significance for two struggling clubs hoping to correct course and stay competitive in a wide-open American League Central. Entering the contest, the White Sox carry a dismal 5–17 record, having covered the run line in only 9 of those 24 games, while the Twins, slightly better at 7–15, have shown a more balanced 11–11 mark against the spread, giving them a slight edge in terms of consistency, though far from a dominant advantage. Recent history between these teams heavily favors the Twins, who have won five straight head-to-head matchups, including a 60 percent win rate against the run line and a 60 percent over rate on total runs in that stretch—indicating games with offensive bursts and one-sided momentum. For the Twins, this matchup presents a valuable chance to reaffirm control over a divisional opponent and gather traction after a disappointing start to a season where injuries, underperforming bats, and rotation questions have hindered progress. Offensively, they’ve shown flashes of their 2023–24 form, with Carlos Correa and Byron Buxton anchoring the top of the lineup and younger contributors like Edouard Julien and Alex Kirilloff offering some hope for sustained pressure when they find rhythm. The key for Minnesota will be converting opportunities with runners in scoring position, an area where they’ve struggled despite getting men on base.

On the mound, their starters have generally kept them competitive into the middle innings, but the bullpen has been inconsistent—alternating between shutdown innings and blown leads that flip game momentum. The White Sox, meanwhile, are mired in a difficult stretch where both their offense and pitching have underperformed, contributing to their MLB-worst start and prompting serious concerns about whether a turnaround is realistic. Their lineup, once built around power and speed with Tim Anderson and Eloy Jiménez as cornerstones, has become one of the least productive in baseball, often struggling to string together productive at-bats and relying on sporadic home runs to generate scoring. Defensively, the White Sox have been error-prone, and their starting pitching has failed to go deep into games, putting an unsustainable load on a bullpen that lacks depth and reliability. If there’s a silver lining, it’s that divisional games often act as reset points, and if the White Sox can strike early and force Minnesota into mistakes, the door is open to at least salvage something from a rocky series. However, given their current form and the Twins’ track record against them, the odds are not in their favor, making execution in the first three innings especially vital. For both teams, this game is less about standings and more about identity—a chance to show signs of life, reverse recent narratives, and remind themselves that the long MLB season allows plenty of time for course correction if urgency and discipline are restored quickly. With run production trending up in their meetings, fans should expect a game shaped by momentum swings, middle-inning fireworks, and the fight of two teams trying to prove their worst baseball is behind them.

Chicago White Sox White Sox MLB Preview

The Chicago White Sox enter the series finale against the Minnesota Twins desperately searching for a spark to break free from what has become one of the most difficult starts to any MLB season in recent memory, carrying a 5–17 record that reflects deep issues across every facet of their game. The White Sox have covered the run line in only 9 of those 24 contests, and the broader numbers paint a troubling picture of a team lacking consistency, confidence, and cohesion. On the offensive side, Chicago has struggled mightily to produce sustained rallies, relying too often on isolated home runs rather than building innings through contact and patience, which has left them near the bottom of the league in key categories like batting average with runners in scoring position and on-base percentage. While players like Eloy Jiménez and Andrew Vaughn have had brief flashes of power, the lack of table-setting from the top of the order and the absence of timely hitting have made it nearly impossible to compete in games where they fall behind early. Compounding those issues is the team’s poor defensive execution, with errors and mental lapses routinely extending innings and further taxing a pitching staff already operating under thin margins. On the mound, the rotation has been inconsistent and often short-lived, with few starters able to provide length or dominate lineups, which has forced the bullpen into action earlier than ideal and revealed a lack of depth and durability in relief.

The bullpen itself has not fared well, with blown saves, high walk rates, and a general inability to shut the door in close games serving as repeated setbacks in what few winnable games the White Sox have found themselves in. Against the Twins, the White Sox have been especially overmatched, losing five straight in the season series and only covering the spread in one of those contests, further illustrating the team’s struggles against familiar divisional foes. If Chicago has any hope of salvaging this game and snapping the Twins’ win streak over them, it starts with improved plate discipline, early offensive pressure, and a clean defensive effort—three elements that have rarely aligned so far this season. The team desperately needs a statement performance from its starting pitcher to set the tone and give the offense a chance to settle in without the pressure of chasing a deficit, and the bullpen must hold any lead or tight scoreline with a level of execution and poise that has been sorely lacking. While the odds and trends are firmly stacked against them, the White Sox have reached a point where pride, urgency, and internal accountability must take hold if they hope to avoid letting this season spiral completely out of reach. A strong showing in this divisional matchup wouldn’t fix everything, but it could provide a much-needed emotional lift and a foundation to build on as they prepare for the next stretch of their schedule with the hope of salvaging some respectability from a disappointing April.

The Chicago White Sox and Minnesota Twins are set to face off on April 23, 2025, at Target Field. Both teams are looking to improve their standings in the American League Central division. Chicago White Sox vs Minnesota AI Prediction: Free MLB Betting Insights for Apr 23. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Minnesota Twins MLB Preview

The Minnesota Twins take the field for the final game of their series against the Chicago White Sox with a clear opportunity to close out a divisional sweep and gather momentum after a frustrating start to the 2025 season that has seen them enter with a 7–15 record but showing signs of stabilization in recent outings. While they’ve been far from dominant overall, the Twins have been remarkably effective against the White Sox specifically, winning five straight head-to-head matchups and covering the run line in three of those contests, signaling a pattern of situational dominance and an ability to capitalize on Chicago’s mistakes. The Twins have balanced veteran leadership and developing youth with Carlos Correa anchoring the infield and batting order, while Byron Buxton remains a game-changer with his athleticism both at the plate and in center field when healthy. Recent games have also seen encouraging strides from younger players like Edouard Julien and Alex Kirilloff, who have begun to find their rhythm at the plate, extending innings and offering consistent threats throughout the bottom half of the lineup. The offense still struggles at times with consistency and tends to leave runners stranded, but when the top of the order sets the tone, Minnesota has demonstrated it can post crooked numbers quickly, especially against weaker pitching.

On the mound, their starting rotation has begun to stabilize, with arms like Joe Ryan and Bailey Ober showing the ability to navigate five to six innings efficiently, while the bullpen—although stretched at times—has been competitive when asked to hold narrow leads or close out middle-inning chaos. Jhoan Duran remains one of the most electrifying closers in the game with his elite velocity and sharp offspeed offerings, and he gives the Twins a psychological edge when entering the late innings with a lead. Defensively, Minnesota has played relatively clean baseball, relying on strong up-the-middle presence from Correa and Buxton and minimizing extra-base mistakes that can shift momentum in tightly contested games. At Target Field, the Twins have not yet fully reestablished home dominance but are beginning to show the swagger that comes from getting back in sync, and against a floundering White Sox team, they’ll be motivated to impose control from the first pitch. If they can get early contact off Chicago’s starter, avoid chasing pitches, and maintain pressure through the middle innings, Minnesota is well-positioned to continue their streak in the season series and use this win as a launchpad into the more competitive stretch of their schedule. Manager Rocco Baldelli will likely look to play aggressive, stretching leads with steals, hit-and-runs, and trusting his bullpen if the game tightens, knowing that every divisional win carries weight in a tightly bunched Central. While their overall record doesn’t reflect their potential, the Twins have an opportunity here to make a definitive statement at home and remind the league—and perhaps themselves—that their talent, when firing in rhythm, is more than enough to contend.

Chicago White Sox vs. Minnesota Prop Picks (AI)

AI algorithm Remi is pouring through loads of datapoints on each line. In fact, anytime the White Sox and Twins play there’s always several intriguing angles to key in on. Not to mention games played at Target Field in Apr rarely follow normal, predictable betting trends.
Remi's searched hard and found the best prop for this matchup: L. Robert over 0.5 Total Bases.

Chicago White Sox vs. Minnesota Prediction (AI)

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Remi, our AI sports genius, has been pouring over tons of data from every simulation between the White Sox and Twins and using recursive machine learning and cutting-edge AI to examine the data to a single cover probability.

Remi has been most fixated on the linear correlation of weight emotional bettors often put on coaching factors between a White Sox team going up against a possibly rested Twins team. In reality, the true game analytics might reflect a strong lean against one Vegas line specifically.

Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.

Below is our current AI Chicago White Sox vs Minnesota picks, computer picks White Sox vs Twins, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
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White Sox Betting Trends

The White Sox have covered the run line in 9 of their 24 games this season, indicating challenges in meeting betting expectations.

Twins Betting Trends

The Twins have an ATS record of 11-11-0, showing a balanced performance against the spread this season.

White Sox vs. Twins Matchup Trends

In their last 5 meetings, the Twins have won all 5 games, with a Handicap-Runs Win% of 60.0% and Total Runs Over% of 60.0%, suggesting a trend toward higher-scoring games favoring the Twins.

Chicago White Sox vs. Minnesota Game Info

Chicago White Sox vs Minnesota starts on April 23, 2025 at 7:40 PM EST.

Spread: Minnesota -1.5
Moneyline: Chicago White Sox +218, Minnesota -268
Over/Under: 8.5

Chicago White Sox: (5-18)  |  Minnesota: (8-15)

Remi's searched hard and found the best prop for this matchup: L. Robert over 0.5 Total Bases.. Prices move—always shop for the best number.

In their last 5 meetings, the Twins have won all 5 games, with a Handicap-Runs Win% of 60.0% and Total Runs Over% of 60.0%, suggesting a trend toward higher-scoring games favoring the Twins.

CHW trend: The White Sox have covered the run line in 9 of their 24 games this season, indicating challenges in meeting betting expectations.

MIN trend: The Twins have an ATS record of 11-11-0, showing a balanced performance against the spread this season.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

Chicago White Sox vs. Minnesota Odds

AI algorithm Remi is pouring through mountains of data on each team. In fact, anytime the Chicago White Sox vs Minnesota trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme temps seemingly never follow normal, predictable patterns.

Chicago White Sox vs Minnesota Opening Odds

CHW Moneyline: +218
MIN Moneyline: -268
CHW Spread: +1.5
MIN Spread: -1.5
Over/Under: 8.5

Chicago White Sox vs Minnesota Live Odds

Games PTS ML SPR O/U
Sep 27, 2025 1:06PM EDT
Baltimore Orioles
New York Yankees
9/27/25 1:06PM
Orioles
Yankees
+196
-240
+1.5 (-105)
-1.5 (-115)
O 9 (-105)
U 9 (-115)
Sep 27, 2025 2:21PM EDT
St Louis Cardinals
Chicago Cubs
9/27/25 2:21PM
Cardinals
Cubs
 
-178
 
-1.5 (+115)
O 9.5 (+100)
U 9.5 (-120)
Sep 27, 2025 3:09PM EDT
Tampa Bay Rays
Toronto Blue Jays
9/27/25 3:09PM
Rays
Blue Jays
+135
-160
+1.5 (-155)
-1.5 (+130)
O 8.5 (-105)
U 8.5 (-115)
Sep 27, 2025 4:05PM EDT
Chicago White Sox
Washington Nationals
9/27/25 4:05PM
White Sox
Nationals
+100
-120
+1.5 (-205)
-1.5 (+170)
O 8.5 (-115)
U 8.5 (-105)
Sep 27, 2025 4:06PM EDT
Colorado Rockies
San Francisco Giants
9/27/25 4:06PM
Rockies
Giants
+196
-240
+1.5 (-110)
-1.5 (-110)
O 8 (-105)
U 8 (-115)
Sep 27, 2025 4:11PM EDT
New York Mets
Miami Marlins
9/27/25 4:11PM
Mets
Marlins
-130
+110
-1.5 (+130)
+1.5 (-155)
O 8 (-115)
U 8 (-105)
Sep 27, 2025 4:11PM EDT
Detroit Tigers
Boston Red Sox
9/27/25 4:11PM
Tigers
Red Sox
+110
-130
+1.5 (-190)
-1.5 (+158)
O 9 (+100)
U 9 (-120)
Sep 27, 2025 6:05PM EDT
Minnesota Twins
Philadelphia Phillies
9/27/25 6:05PM
Twins
Phillies
+175
-210
+1.5 (-120)
-1.5 (+100)
O 8.5 (-115)
U 8.5 (-105)
Sep 27, 2025 7:11PM EDT
Cincinnati Reds
Milwaukee Brewers
9/27/25 7:11PM
Reds
Brewers
+115
-135
+1.5 (-190)
-1.5 (+158)
O 7.5 (-120)
U 7.5 (+100)
Sep 27, 2025 7:15PM EDT
Pittsburgh Pirates
Atlanta Braves
9/27/25 7:15PM
Pirates
Braves
+150
-178
+1.5 (-145)
-1.5 (+122)
O 8 (-110)
U 8 (-110)
Sep 27, 2025 7:16PM EDT
Texas Rangers
Cleveland Guardians
9/27/25 7:16PM
Rangers
Guardians
+122
-145
+1.5 (-190)
-1.5 (+158)
O 7 (-120)
U 7 (+100)
Sep 27, 2025 8:40PM EDT
Arizona Diamondbacks
San Diego Padres
9/27/25 8:40PM
Diamondbacks
Padres
+118
-140
+1.5 (-190)
-1.5 (+158)
O 7.5 (-115)
U 7.5 (-105)
Sep 27, 2025 9:39PM EDT
Houston Astros
Los Angeles Angels
9/27/25 9:39PM
Astros
Angels
-140
+118
-1.5 (+115)
+1.5 (-135)
O 9 (-110)
U 9 (-110)
Sep 27, 2025 9:41PM EDT
Los Angeles Dodgers
Seattle Mariners
9/27/25 9:41PM
Dodgers
Mariners
+100
-120
+1.5 (-220)
-1.5 (+180)
O 7 (-120)
U 7 (+100)
Sep 27, 2025 10:05PM EDT
Kansas City Royals
Oakland Athletics
9/27/25 10:05PM
Royals
Athletics
+100
-120
+1.5 (-195)
-1.5 (+162)
O 10 (-115)
U 10 (-105)

MLB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Chicago White Sox White Sox vs. Minnesota Twins on April 23, 2025 at Target Field.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
ARI@SD SD -131 57.3% 4 WIN
DET@BOS BOS -115 56.4% 5 WIN
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN
CHC@SF CHC -105 54.1% 4 LOSS
NYY@CHW RYAN MCMAHON OVER 0.5 BASES 54.1% 4 WIN
PHI@NYM OVER 8.5 55.6% 4 LOSS
LAA@TEX LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS 54.1% 4 LOSS
KC@CHW KC -109 54.2% 4 WIN
SD@SEA DYLAN CEASE OVER 16.5 OUTS 53.9% 3 LOSS
SD@SEA UNDER 8.5 54.4% 4 LOSS
MIN@TOR JOE RYAN UNDER 2.5 EARNED RUNS 54.1% 4 LOSS
SF@MIL MIL +100 54.0% 6 LOSS
TOR@MIA MIA +1.5 62.0% 6 WIN
CHC@LAA OVER 9.5 54.9% 4 LOSS
BOS@NYY CARLOS RODON UNDER 4.5 HITS ALLOWED 54.2% 4 WIN
KC@DET DET -115 56.1% 5 WIN
CHC@LAA LAA +1.5 57.6% 5 LOSS