Orioles vs. Nationals
Prediction, Odds & Props
Apr 23 | MLB AI Picks

Updated: 2025-04-21T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The Baltimore Orioles and Washington Nationals face off on April 23, 2025, at Nationals Park, concluding their interleague series. Both teams are looking to secure a series win and gain momentum in their respective divisions.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Apr 23, 2025

Start Time: 6:45 PM EST​

Venue: Nationals Park​

Nationals Record: (10-13)

Orioles Record: (9-13)

OPENING ODDS

BAL Moneyline: -134

WAS Moneyline: +113

BAL Spread: -1.5

WAS Spread: +1.5

Over/Under: 9.5

BAL
Betting Trends

  • The Orioles have covered the run line in 6 of their last 10 games, showcasing a strong performance against the spread recently.

WAS
Betting Trends

  • The Nationals have covered the run line in 4 of their last 10 home games, indicating inconsistent performance against the spread at Nationals Park.

MATCHUP TRENDS

  • In the last 6 meetings between the Orioles and Nationals, the total has gone OVER 4 times, suggesting a trend toward high-scoring games in this matchup.

BAL vs. WAS
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: R. O'Hearn over 1.5 Hits+Runs+RBI.

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Baltimore vs Washington Prediction & Odds:
Free MLB Betting Insights for 4/23/25

The interleague finale between the Baltimore Orioles and Washington Nationals on April 23, 2025, at Nationals Park promises a compelling close to a series that has showcased offensive fireworks and strategic chess matches between two teams navigating very different arcs in the 2025 season. The Orioles come into this game with clear momentum, having covered the run line in six of their last ten and continuing to prove they are among the American League’s most dangerous lineups when their bats are clicking. Their offensive production has been steady and explosive, and they’ve been especially effective against teams with inconsistent pitching—a profile the Nationals unfortunately match at this stage in their development. Baltimore has thrived by capitalizing on early counts, forcing opposing starters into high-stress innings, and using its bullpen efficiently to protect leads late. In contrast, Washington enters this game still looking for consistency, particularly at home where they’ve covered the run line just four times in their last ten and have struggled to hold late-inning leads. Their offense, while productive at times, has leaned heavily on a few key contributors to carry the load, leaving them vulnerable when opponents neutralize those bats.

The total has gone over in four of the last six meetings between these clubs, a trend fueled by both teams’ ability to generate runs and their susceptibility to lapses on the mound. This sets up a potentially high-scoring finale unless one of the starting pitchers can establish early dominance and avoid giving up free passes, which have haunted both staffs in this series. The Orioles’ approach at the plate—aggressive but selective—has proven especially effective in these interleague games, and they’ll look to maintain that pressure from the first pitch, likely pushing the Nationals’ bullpen into action by the middle innings. For Washington, the game plan likely revolves around manufacturing runs early and hoping for a shutdown performance from their starter to keep Baltimore’s power bats at bay. Defensively, the Nationals must clean up the mental mistakes that have extended innings and allowed Baltimore to put up big numbers. The Orioles, by contrast, have been more composed and precise, especially when protecting narrow leads in late innings. With both teams hungry for a series win—Baltimore to extend its lead in a tough AL East, and Washington to prove its youth movement can hang with postseason-caliber squads—this game has the potential to swing on one big inning, one bullpen decision, or one defensive miscue. Fans can expect a high-energy matchup defined by contrasting identities: a polished, playoff-minded Orioles club looking to close strong and a gritty Nationals team eager to prove they’re building something real. The result may ultimately come down to which side executes better under pressure, and which lineup delivers when the game’s biggest moments arrive.

Baltimore Orioles MLB Preview

The Baltimore Orioles head into the final game of their interleague series against the Washington Nationals with growing momentum and the kind of balanced, high-octane identity that has defined their early-season success in 2025. At 14–8 and consistently performing well against the spread—covering in six of their last ten—they’ve emerged as one of the most formidable road teams in the American League, blending explosive offense with sound fundamentals and a bullpen that has proven itself capable of holding leads against a wide range of opponents. Central to Baltimore’s current surge is the bat of Gunnar Henderson, who has quickly become the spark plug at the top of the order with a mature plate approach, gap-to-gap power, and an ability to set the tone in the first inning. Behind him, Adley Rutschman continues to anchor the lineup, not just with his bat but with his presence behind the plate, guiding a young but effective pitching staff and calling games with the poise of a seasoned veteran. The middle of the order—featuring sluggers like Anthony Santander, Ryan Mountcastle, and Jordan Westburg—has given the Orioles a feared run-producing engine that can punish mistakes and work counts deep, often forcing opposing starters out early and setting up favorable matchups late. Speed and baserunning IQ further diversify their attack, with Cedric Mullins leading the way on the basepaths and generating pressure on defenses from the nine-hole or top of the order depending on the day.

On the mound, the Orioles have leaned on solid, if unspectacular, starting pitching to get through the early innings and bridge the game to a bullpen that ranks among the league’s best in strikeout rate and ERA. Yennier Cano has been electric in the late innings, pairing with lefty Danny Coulombe and a cast of matchup-specific arms that have thrived in Hyde’s aggressive bullpen deployment. Though their starters may not lead the league in velocity or strikeouts, their ability to limit walks, manage pitch counts, and avoid big innings has kept Baltimore in almost every game they’ve played, which is why they’ve consistently covered the spread even in tough environments. Defensively, Baltimore has shown marked improvement over last season, with Henderson and Jorge Mateo forming a reliable infield tandem and outfielders like Mullins and Austin Hays providing range and sure hands in the gaps. The Orioles’ current road trip has reinforced their identity as a team that not only travels well but thrives in interleague matchups thanks to their depth, lineup flexibility, and a fundamentally sound approach that emphasizes run prevention as much as run production. Against a Nationals team still finding its rhythm, the Orioles are positioned well to exploit inconsistencies in Washington’s rotation and bullpen, especially if they can get on the board early and dictate the pace of the game. A win would not only secure the series but also serve as another benchmark in a season where Baltimore’s ceiling appears to be rising with every passing week, signaling to the rest of the American League that this is not just a playoff-caliber squad—it’s a club with championship ambitions, executing daily with purpose, poise, and a clear plan to stay atop the standings.

The Baltimore Orioles and Washington Nationals face off on April 23, 2025, at Nationals Park, concluding their interleague series. Both teams are looking to secure a series win and gain momentum in their respective divisions. Baltimore vs Washington AI Prediction: Free MLB Betting Insights for Apr 23. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Washington Nationals MLB Preview

The Washington Nationals enter the final game of their interleague series against the Baltimore Orioles at Nationals Park with the hope of salvaging a win and regaining some consistency as they continue to define their identity in the early stretch of the 2025 season. While sitting near the .500 mark with an 11–12 record, the Nationals have shown moments of competitiveness, especially with their offense, but have struggled to maintain momentum at home, covering the run line in only four of their last ten games at Nationals Park. Their performance against Baltimore has also been uneven, and the total has gone over in four of the last six meetings between these two teams—highlighting both the potential for offense and the challenges Washington has faced in run prevention. Leading the offensive charge for the Nationals is CJ Abrams, whose speed, athleticism, and emerging bat-to-ball skills have given Washington a consistent presence at the top of the order. Alongside Abrams, Joey Meneses has offered middle-of-the-order power, though the Nationals have yet to see sustained production from the full lineup. Players like Keibert Ruiz and Lane Thomas have had their moments, but timely hitting remains a problem, especially with runners in scoring position where missed opportunities have defined several losses this season. The Nationals are not built around the long ball, and instead rely on situational execution, contact hitting, and small ball tactics—an approach that can work well when they play clean and efficient baseball, but one that is vulnerable against power-heavy lineups like Baltimore’s if they fall behind early. On the mound, Washington’s starting pitching has been one of their most unpredictable components.

The rotation has shown flashes of potential, particularly from young arms like MacKenzie Gore and Josiah Gray, but inconsistency in command and difficulty navigating lineups the second and third time through has put pressure on a bullpen that has already logged a heavy workload. The relief corps, featuring Hunter Harvey and Kyle Finnegan in late innings, has had some bright moments, but overall lacks the depth or shutdown capability needed to consistently protect one- or two-run leads, especially when overexposed. Defensively, the Nationals have played a fairly clean brand of baseball, with Abrams continuing to develop into a reliable shortstop and outfielders like Victor Robles and Lane Thomas providing above-average coverage and arms. Still, the margin for error is thin for this team, and unforced mistakes—whether it’s a missed cutoff, an errant throw, or a failed bunt attempt—have often been the difference between competitive games and late-inning losses. Manager Dave Martinez has done his best to manage a roster still in transition, balancing development with competitiveness, but against a team like Baltimore that applies constant pressure, Washington must be perfect in execution, opportunistic with runners on base, and stingy with free passes. If the Nationals can get a solid outing from their starter, avoid multi-run innings early, and find just enough timely offense, they have a shot to level the series and take a much-needed confidence boost into their next homestand. But anything short of sharp execution across all phases will likely result in another frustrating close loss, emblematic of a team still learning how to close the gap between flashes of promise and sustained success.

Baltimore vs. Washington Prop Picks (AI)

Remi is pouring through loads of datapoints on each line. In fact, anytime the Orioles and Nationals play there’s always several intriguing angles to key in on. Not to mention games played at Nationals Park in Apr seemingly never follow normal, predictable betting trends.
Remi's searched hard and found the best prop for this matchup: R. O'Hearn over 1.5 Hits+Runs+RBI.

Baltimore vs. Washington Prediction (AI)

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Remi, our AI sports algorithm, has been pouring over tons of data from every facet between the Orioles and Nationals and using recursive machine learning and industry leading AI to analyze the data to a single cover probability.

The Algorithm has been most watching on the growing weight emotional bettors tend to put on Baltimore’s strength factors between a Orioles team going up against a possibly healthy Nationals team. It appears the true game analytics appear to reflect a slight lean against one Vegas line specifically.

Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.

Below is our current AI Baltimore vs Washington picks, computer picks Orioles vs Nationals, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
MLB 9/26 DET@BOS UNLOCK THIS PICK 5 EXECUTIVE Locked EXECUTIVE
MLB 9/26 BAL@NYY UNLOCK THIS PICK 4 INTEL Locked INTEL
MLB 9/26 ARI@SD UNLOCK THIS PICK 4 EXECUTIVE Locked EXECUTIVE
MLB 9/26 NYM@MIA UNLOCK THIS PICK 1 INTEL Locked INTEL
MLB 9/26 NYM@MIA GET FREE PICK NOW 1
MLB 9/26 COL@SF UNLOCK THIS PICK 0 INTEL Locked INTEL

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.

Orioles Betting Trends

The Orioles have covered the run line in 6 of their last 10 games, showcasing a strong performance against the spread recently.

Nationals Betting Trends

The Nationals have covered the run line in 4 of their last 10 home games, indicating inconsistent performance against the spread at Nationals Park.

Orioles vs. Nationals Matchup Trends

In the last 6 meetings between the Orioles and Nationals, the total has gone OVER 4 times, suggesting a trend toward high-scoring games in this matchup.

Baltimore vs. Washington Game Info

Baltimore vs Washington starts on April 23, 2025 at 6:45 PM EST.

Spread: Washington +1.5
Moneyline: Baltimore -134, Washington +113
Over/Under: 9.5

Baltimore: (9-13)  |  Washington: (10-13)

Remi's searched hard and found the best prop for this matchup: R. O'Hearn over 1.5 Hits+Runs+RBI.. Prices move—always shop for the best number.

In the last 6 meetings between the Orioles and Nationals, the total has gone OVER 4 times, suggesting a trend toward high-scoring games in this matchup.

BAL trend: The Orioles have covered the run line in 6 of their last 10 games, showcasing a strong performance against the spread recently.

WAS trend: The Nationals have covered the run line in 4 of their last 10 home games, indicating inconsistent performance against the spread at Nationals Park.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

Baltimore vs. Washington Odds

Remi is pouring through loads of data on each player. In fact, anytime the Baltimore vs Washington trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme travel distance rarely follow normal, predictable patterns.

Baltimore vs Washington Opening Odds

BAL Moneyline: -134
WAS Moneyline: +113
BAL Spread: -1.5
WAS Spread: +1.5
Over/Under: 9.5

Baltimore vs Washington Live Odds

Games PTS ML SPR O/U
Sep 27, 2025 1:06PM EDT
Baltimore Orioles
New York Yankees
9/27/25 1:06PM
Orioles
Yankees
+190
-235
+1.5 (-110)
-1.5 (-110)
O 8.5 (-120)
U 8.5 (+100)
Sep 27, 2025 2:21PM EDT
St Louis Cardinals
Chicago Cubs
9/27/25 2:21PM
Cardinals
Cubs
 
-180
 
-1.5 (+115)
O 9.5 (-105)
U 9.5 (-115)
Sep 27, 2025 3:09PM EDT
Tampa Bay Rays
Toronto Blue Jays
9/27/25 3:09PM
Rays
Blue Jays
+130
-155
+1.5 (-155)
-1.5 (+130)
O 8.5 (-110)
U 8.5 (-110)
Sep 27, 2025 4:06PM EDT
Chicago White Sox
Washington Nationals
9/27/25 4:06PM
White Sox
Nationals
+100
-120
-1.5 (+165)
+1.5 (-200)
O 8.5 (-110)
U 8.5 (-110)
Sep 27, 2025 4:06PM EDT
Colorado Rockies
San Francisco Giants
9/27/25 4:06PM
Rockies
Giants
+185
-225
+1.5 (-110)
-1.5 (-110)
O 8 (-105)
U 8 (-115)
Sep 27, 2025 4:11PM EDT
New York Mets
Miami Marlins
9/27/25 4:11PM
Mets
Marlins
-130
+110
-1.5 (+125)
+1.5 (-150)
O 8 (-115)
U 8 (-105)
Sep 27, 2025 4:11PM EDT
Detroit Tigers
Boston Red Sox
9/27/25 4:11PM
Tigers
Red Sox
+125
-150
+1.5 (-180)
-1.5 (+150)
O 9 (+100)
U 9 (-120)
Sep 27, 2025 6:05PM EDT
Minnesota Twins
Philadelphia Phillies
9/27/25 6:05PM
Twins
Phillies
+170
-205
+1.5 (-120)
-1.5 (+100)
O 8.5 (-115)
U 8.5 (-105)
Sep 27, 2025 7:11PM EDT
Cincinnati Reds
Milwaukee Brewers
9/27/25 7:11PM
Reds
Brewers
+125
-150
+1.5 (-180)
-1.5 (+150)
O 8 (-105)
U 8 (-115)
Sep 27, 2025 7:15PM EDT
Pittsburgh Pirates
Atlanta Braves
9/27/25 7:15PM
Pirates
Braves
+145
-175
+1.5 (-155)
-1.5 (+130)
O 8 (-110)
U 8 (-110)
Sep 27, 2025 7:16PM EDT
Texas Rangers
Cleveland Guardians
9/27/25 7:16PM
Rangers
Guardians
+135
-165
+1.5 (-180)
-1.5 (+150)
O 7 (-120)
U 7 (+100)
Sep 27, 2025 8:40PM EDT
Arizona Diamondbacks
San Diego Padres
9/27/25 8:40PM
Diamondbacks
Padres
+115
-140
+1.5 (-195)
-1.5 (+160)
O 7.5 (-120)
U 7.5 (+100)
Sep 27, 2025 9:39PM EDT
Houston Astros
Los Angeles Angels
9/27/25 9:39PM
Astros
Angels
-165
+135
-1.5 (+105)
+1.5 (-125)
O 9 (+100)
U 9 (-120)
Sep 27, 2025 9:41PM EDT
Los Angeles Dodgers
Seattle Mariners
9/27/25 9:41PM
Dodgers
Mariners
+105
-125
+1.5 (-205)
-1.5 (+170)
O 7.5 (+105)
U 7.5 (-125)
Sep 27, 2025 10:05PM EDT
Kansas City Royals
Oakland Athletics
9/27/25 10:05PM
Royals
Athletics
+100
-120
-1.5 (+150)
+1.5 (-180)
O 10 (-110)
U 10 (-110)

MLB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Baltimore Orioles vs. Washington Nationals on April 23, 2025 at Nationals Park.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN
CHC@SF CHC -105 54.1% 4 LOSS
NYY@CHW RYAN MCMAHON OVER 0.5 BASES 54.1% 4 WIN
PHI@NYM OVER 8.5 55.6% 4 LOSS
LAA@TEX LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS 54.1% 4 LOSS
KC@CHW KC -109 54.2% 4 WIN
SD@SEA DYLAN CEASE OVER 16.5 OUTS 53.9% 3 LOSS
SD@SEA UNDER 8.5 54.4% 4 LOSS
MIN@TOR JOE RYAN UNDER 2.5 EARNED RUNS 54.1% 4 LOSS
SF@MIL MIL +100 54.0% 6 LOSS
TOR@MIA MIA +1.5 62.0% 6 WIN
CHC@LAA OVER 9.5 54.9% 4 LOSS
BOS@NYY CARLOS RODON UNDER 4.5 HITS ALLOWED 54.2% 4 WIN
KC@DET DET -115 56.1% 5 WIN
CHC@LAA LAA +1.5 57.6% 5 LOSS
CIN@ARI KEBRYAN HAYES STRIKEOUTS UNDER 0.5 56.2% 6 WIN
LAD@SD SD +110 50.9% 6 WIN