Rays vs. Diamondbacks
Prediction, Odds & Props
Apr 22 | MLB AI Picks
Updated: 2025-04-20T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The Tampa Bay Rays (9–13) visit the Arizona Diamondbacks (13–9) on April 22, 2025, at Chase Field in Phoenix. The Diamondbacks are favored in this matchup, with Brandon Pfaadt (3–1, 3.04 ERA) starting against Zack Littell (0–4, 5.48 ERA).
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

GAME INFO
Date: Apr 22, 2025
Start Time: 9:40 PM EST
Venue: Chase Field
Diamondbacks Record: (13-9)
Rays Record: (9-13)
OPENING ODDS
TB Moneyline: +135
ARI Moneyline: -159
TB Spread: +1.5
ARI Spread: -1.5
Over/Under: 9
TB
Betting Trends
- The Rays have struggled against the spread (ATS), going 1–4 in their last five games.
ARI
Betting Trends
- The Diamondbacks have been solid ATS at home, posting a 4–2 record in their last six home games.
MATCHUP TRENDS
- In their last five head-to-head matchups, the total has gone over in four games, indicating a trend toward high-scoring affairs when these teams meet.
TB vs. ARI
Best Prop Bet
- Remi's searched hard and found the best prop for this matchup: C. Carroll over 1.5 Hits+Runs+RBI.
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Tampa Bay vs Arizona Prediction & Odds:
Free MLB Betting Insights for 4/22/25
On the mound, Brandon Pfaadt has been a bright spot in the rotation. After showing flashes in 2023, Pfaadt has stepped into a larger role and delivered consistency, limiting hard contact and working deep into games. With Arizona’s bullpen continuing to develop into a reliable unit—featuring arms like Kevin Ginkel and Paul Sewald to handle late innings—the D-backs have proven they can protect leads, especially at home where they’ve covered the run line in four of their last six games. Their ability to execute defensively and force opponents to beat them with clean hits has separated them from middling teams in the early season. On the other side, the Rays are desperately searching for rhythm. Once celebrated for their deep rotation and innovative pitching strategies, Tampa Bay has suffered from both injury setbacks and underperformance. Zack Littell, a converted reliever now in a starting role, has struggled to contain opposing offenses and enters this game with an 0–4 record and a 5.48 ERA. With Littell often unable to get past the fifth inning, the burden on the bullpen has been significant—forcing manager Kevin Cash to rely too heavily on middle relievers who’ve already logged a heavy workload. Offensively, the Rays have not found consistency outside of flashes from Junior Caminero and Brandon Lowe. Wander Franco remains unavailable, and without his presence, the lineup has lacked a central threat to anchor scoring opportunities. Tampa Bay’s defense has also shown cracks, with misplays and errors contributing to run-scoring innings for opponents. If the Rays are to turn the tide in Phoenix, they’ll need a composed start from Littell, sharper at-bats with men on base, and a bullpen capable of holding down a relentless Arizona attack. Otherwise, this could be another night where the Rays fall behind early and never fully recover.
ICYMI: Take a look back at Jonathan Aranda's amazing walk-off last night, presented by @CapitalOne! pic.twitter.com/lsCnLpSJsz
— Tampa Bay Rays (@RaysBaseball) April 20, 2025
Tampa Bay Rays MLB Preview
The Tampa Bay Rays enter Tuesday’s contest against the Arizona Diamondbacks in a state of early-season disarray, holding a 9–13 record and sitting near the bottom of the American League East. While the Rays are no strangers to slow starts that eventually blossom into postseason pushes, their 2025 campaign has been marked by more structural concerns than usual. Inconsistent pitching, injuries to key players, and an underwhelming offensive output have all contributed to a disappointing first three weeks of play. Most notably, Tampa Bay’s starting rotation—which is traditionally one of its greatest strengths—has been unreliable, and Tuesday’s starter Zack Littell has embodied those struggles. Littell comes into the game with an 0–4 record and a bloated 5.48 ERA, often finding difficulty getting through lineups more than once without allowing significant damage. His move from the bullpen to a starting role last season showed early promise, but this year, command issues and an inability to shut down innings have led to short outings and overexposure of an already stressed bullpen. Offensively, the Rays have failed to find sustained momentum. While there are bright spots in the form of Junior Caminero and Brandon Lowe, the lineup as a whole has been erratic. Caminero, the highly touted young infielder, has provided pop and energy, but his youth and aggressiveness at the plate sometimes lead to inconsistent at-bats. Lowe, a veteran presence, has offered clutch hits but is also prone to cold spells that make the lineup feel top-heavy. Without Wander Franco and with Yandy Díaz off to a slower-than-expected start, the Rays lack a true anchor in the heart of their order.
This lack of consistency has left them struggling to execute with runners in scoring position, and far too many innings have ended with stranded baserunners. While the team continues to preach patience at the plate, the inability to string together productive at-bats has kept the Rays from mounting comebacks or building early leads. Compounding matters is the team’s decline in stolen bases and aggressive base running, both of which were cornerstones of their offensive identity in recent years. Defensively, Tampa Bay has been mediocre—a departure from the crisp, fundamentally sound units of seasons past. Errors and misplays in key moments have extended innings and put additional pressure on pitchers already working from behind. In the bullpen, the usual reliability has wavered. Closer Pete Fairbanks has battled inconsistency, and the middle relief corps—typically one of the most versatile in the league—has been overtaxed due to short starts from the rotation. For the Rays to compete against a sharp Diamondbacks team that thrives on speed and pressure, they will need a clean defensive effort, a rare strong start from Littell, and at least a modest offensive breakout. The good news is that Tampa Bay has the organizational experience and coaching savvy to make adjustments, but time is of the essence. A win in Arizona could serve as a spark, giving the club a much-needed jolt of confidence and reestablishing the traits—grit, precision, and tenacity—that have defined them in recent years.

Credit: USA TODAY/IMAGN
Arizona Diamondbacks MLB Preview
The Arizona Diamondbacks enter their April 22 home matchup against the Tampa Bay Rays riding the momentum of a strong 13–9 start and a clear sense of identity built around speed, depth, and high-energy execution. The D-backs have continued their post–2023 World Series evolution into one of the National League’s most dynamic and well-rounded teams. Their success early in 2025 stems from the same formula that carried them deep into October: relentless baserunning, versatile offensive threats, and reliable pitching. Manager Torey Lovullo has leaned on a well-balanced lineup and a deep bullpen, and the team has responded with consistent play at Chase Field, where they have posted a 4–2 record against the spread over their last six home games. On Tuesday night, they turn to emerging right-hander Brandon Pfaadt, who brings a 3–1 record and a 3.04 ERA into the contest. Pfaadt has made notable strides in command and pitch sequencing this season, evolving from a mid-rotation question mark to a reliable starter capable of setting the tone in big games. Pfaadt’s growth has been particularly important given the overall balance in the Diamondbacks’ pitching staff. He has shown an ability to keep the ball in the park and avoid big innings, a trait that has served Arizona well against free-swinging lineups. With the Rays struggling to find consistent offense, this is a favorable matchup for Pfaadt to continue his strong form. Should he pitch deep into the game, the Diamondbacks can lean on a rested bullpen that includes steady arms like Kevin Ginkel, Joe Mantiply, and closer Paul Sewald—each of whom has demonstrated command in tight, high-leverage situations.
Offensively, Arizona is driven by its dynamic leadoff hitter Corbin Carroll, whose combination of speed, contact ability, and aggression on the basepaths consistently disrupts opposing pitchers. Carroll has reached base at a high clip this season and quickly turns singles into scoring threats with his elite baserunning instincts. Supporting Carroll are Ketel Marte, Lourdes Gurriel Jr., and Christian Walker—all of whom have provided timely power and extra-base hits throughout the early portion of the season. The Diamondbacks don’t rely solely on the long ball but rather thrive on creating chaos through hit-and-run tactics, bunts for base hits, and first-to-third baserunning—hallmarks of Lovullo’s aggressive offensive philosophy. Defensively, the team has played with poise and efficiency, with Perdomo and Marte solid up the middle and Carroll covering vast ground in center field. Their defensive acumen has helped Arizona rank among the NL leaders in fewest errors and runs prevented. Against a Rays team prone to defensive lapses and lacking offensive rhythm, Arizona has a prime opportunity to assert dominance early and apply scoreboard pressure. If Pfaadt can navigate the top of Tampa Bay’s lineup cleanly and Carroll gets on base in the first inning, the Diamondbacks will be in prime position to dictate the pace. With strong home-field support and superior team balance, Arizona has every reason to approach this contest with confidence, aiming to add another win to a growing résumé of early-season success.
Happy flight home ✈️ pic.twitter.com/HE8RnUb97I
— Arizona Diamondbacks (@Dbacks) April 20, 2025
Tampa Bay vs. Arizona Prop Picks (AI)
Tampa Bay vs. Arizona Prediction (AI)

Remi, our AI sports algorithm, has been pouring over exorbitant amounts of data from every past game between the Rays and Diamondbacks and using recursive machine learning and kick-ass AI to analyze the data to a single cover probability.
Remi has been most fixated on the unproportionally assigned weight emotional bettors tend to put on Arizona’s strength factors between a Rays team going up against a possibly strong Diamondbacks team. Trends look to say the true game analytics might reflect a moderate lean against one Vegas line in particular.
Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.
Below is our current AI Tampa Bay vs Arizona picks, computer picks Rays vs Diamondbacks, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
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MLB | 9/26 | DET@BOS | UNLOCK THIS PICK | 5 |
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MLB | 9/26 | BAL@NYY | UNLOCK THIS PICK | 4 |
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MLB | 9/26 | ARI@SD | UNLOCK THIS PICK | 4 |
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MLB | 9/26 | NYM@MIA | UNLOCK THIS PICK | 1 |
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MLB | 9/26 | NYM@MIA | GET FREE PICK NOW | 1 | – | |
MLB | 9/26 | COL@SF | UNLOCK THIS PICK | 0 |
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.
Rays Betting Trends
The Rays have struggled against the spread (ATS), going 1–4 in their last five games.
Diamondbacks Betting Trends
The Diamondbacks have been solid ATS at home, posting a 4–2 record in their last six home games.
Rays vs. Diamondbacks Matchup Trends
In their last five head-to-head matchups, the total has gone over in four games, indicating a trend toward high-scoring affairs when these teams meet.
Tampa Bay vs. Arizona Game Info
What time does Tampa Bay vs Arizona start on April 22, 2025?
Tampa Bay vs Arizona starts on April 22, 2025 at 9:40 PM EST.
Where is Tampa Bay vs Arizona being played?
Venue: Chase Field.
What are the opening odds for Tampa Bay vs Arizona?
Spread: Arizona -1.5
Moneyline: Tampa Bay +135, Arizona -159
Over/Under: 9
What are the records for Tampa Bay vs Arizona?
Tampa Bay: (9-13) | Arizona: (13-9)
What is the AI best bet for Tampa Bay vs Arizona?
Remi's searched hard and found the best prop for this matchup: C. Carroll over 1.5 Hits+Runs+RBI.. Prices move—always shop for the best number.
What are Tampa Bay vs Arizona trending bets?
In their last five head-to-head matchups, the total has gone over in four games, indicating a trend toward high-scoring affairs when these teams meet.
What are Tampa Bay trending bets?
TB trend: The Rays have struggled against the spread (ATS), going 1–4 in their last five games.
What are Arizona trending bets?
ARI trend: The Diamondbacks have been solid ATS at home, posting a 4–2 record in their last six home games.
Where can I find AI Picks for Tampa Bay vs Arizona?
See our latest MLB picks and odds pages for 2025 to compare prices before you bet.
Tampa Bay vs. Arizona Odds
Remi is pouring through tons of stats on each line. In fact, anytime the Tampa Bay vs Arizona trends are analyzed, there’s always several intriguing trends to key in on. Not to mention games played at extreme hostile environments rarely follow normal, predictable patterns.
Tampa Bay vs Arizona Opening Odds
TB Moneyline:
+135 ARI Moneyline: -159
TB Spread: +1.5
ARI Spread: -1.5
Over/Under: 9
Tampa Bay vs Arizona Live Odds
Games | PTS | ML | SPR | O/U | |
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Sep 27, 2025 1:06PM EDT
Baltimore Orioles
New York Yankees
9/27/25 1:06PM
Orioles
Yankees
|
–
–
|
+190
-235
|
+1.5 (-110)
-1.5 (-110)
|
O 8.5 (-120)
U 8.5 (+100)
|
|
Sep 27, 2025 2:21PM EDT
St Louis Cardinals
Chicago Cubs
9/27/25 2:21PM
Cardinals
Cubs
|
–
–
|
-175
|
-1.5 (+115)
|
O 9.5 (-105)
U 9.5 (-115)
|
|
Sep 27, 2025 3:09PM EDT
Tampa Bay Rays
Toronto Blue Jays
9/27/25 3:09PM
Rays
Blue Jays
|
–
–
|
+130
-155
|
+1.5 (-155)
-1.5 (+130)
|
O 8.5 (-110)
U 8.5 (-110)
|
|
Sep 27, 2025 4:06PM EDT
Chicago White Sox
Washington Nationals
9/27/25 4:06PM
White Sox
Nationals
|
–
–
|
+100
-120
|
-1.5 (+165)
+1.5 (-200)
|
O 8.5 (-110)
U 8.5 (-110)
|
|
Sep 27, 2025 4:06PM EDT
Colorado Rockies
San Francisco Giants
9/27/25 4:06PM
Rockies
Giants
|
–
–
|
+185
-225
|
+1.5 (-110)
-1.5 (-110)
|
O 8 (-105)
U 8 (-115)
|
|
Sep 27, 2025 4:11PM EDT
New York Mets
Miami Marlins
9/27/25 4:11PM
Mets
Marlins
|
–
–
|
-130
+110
|
-1.5 (+125)
+1.5 (-150)
|
O 8.5 (-105)
U 8.5 (-115)
|
|
Sep 27, 2025 6:05PM EDT
Minnesota Twins
Philadelphia Phillies
9/27/25 6:05PM
Twins
Phillies
|
–
–
|
+170
-205
|
+1.5 (-120)
-1.5 (+100)
|
O 8.5 (-115)
U 8.5 (-105)
|
|
Sep 27, 2025 7:11PM EDT
Cincinnati Reds
Milwaukee Brewers
9/27/25 7:11PM
Reds
Brewers
|
–
–
|
+125
-150
|
+1.5 (-180)
-1.5 (+150)
|
O 8 (-105)
U 8 (-115)
|
|
Sep 27, 2025 7:15PM EDT
Pittsburgh Pirates
Atlanta Braves
9/27/25 7:15PM
Pirates
Braves
|
–
–
|
+140
-170
|
+1.5 (-155)
-1.5 (+130)
|
O 8 (-110)
U 8 (-110)
|
|
Sep 27, 2025 7:16PM EDT
Texas Rangers
Cleveland Guardians
9/27/25 7:16PM
Rangers
Guardians
|
–
–
|
+135
-165
|
+1.5 (-180)
-1.5 (+150)
|
O 7 (-120)
U 7 (+100)
|
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Sep 27, 2025 8:40PM EDT
Arizona Diamondbacks
San Diego Padres
9/27/25 8:40PM
Diamondbacks
Padres
|
–
–
|
+115
-140
|
+1.5 (-190)
-1.5 (+155)
|
O 7.5 (-120)
U 7.5 (+100)
|
|
Sep 27, 2025 9:39PM EDT
Houston Astros
Los Angeles Angels
9/27/25 9:39PM
Astros
Angels
|
–
–
|
-165
+135
|
-1.5 (+105)
+1.5 (-125)
|
O 9 (+100)
U 9 (-120)
|
|
Sep 27, 2025 9:41PM EDT
Los Angeles Dodgers
Seattle Mariners
9/27/25 9:41PM
Dodgers
Mariners
|
–
–
|
+100
-120
|
-1.5 (+170)
+1.5 (-205)
|
O 7.5 (-110)
U 7.5 (-110)
|
|
Sep 27, 2025 10:05PM EDT
Kansas City Royals
Oakland Athletics
9/27/25 10:05PM
Royals
Athletics
|
–
–
|
+100
-120
|
-1.5 (+150)
+1.5 (-180)
|
O 10 (-110)
U 10 (-110)
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MLB Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers Tampa Bay Rays vs. Arizona Diamondbacks on April 22, 2025 at Chase Field.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.
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LEAN | %WIN | UNITS | RESULT |
---|---|---|---|---|
NYM@CHC | NYM -110 | 54.1% | 3 | WIN |
HOU@ATH | ATH +118 | 50.8% | 4 | WIN |
NYM@CHC | OVER 7 | 54.5% | 3 | WIN |
STL@SF | OVER 7.5 | 55.9% | 5 | LOSS |
KC@LAA | TYLER TOLBERT UNDER 1.5 BASES | 54.4% | 4 | WIN |
MIL@SD | UNDER 9 | 54.7% | 4 | WIN |
MIA@PHI | KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS | 53.3% | 3 | WIN |
WAS@NYM | OVER 8.5 | 56.1% | 6 | LOSS |
LAA@COL | COL +108 | 50.5% | 3 | WIN |
TOR@KC | UNDER 9 | 54.7% | 4 | LOSS |
SEA@KC | KC +1.5 | 62.3% | 5 | LOSS |
NYY@MIN | OVER 9 | 55.1% | 4 | WIN |
MIA@COL | OVER 10.5 | 55.0% | 4 | WIN |
MIA@COL | AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS | 54.3% | 4 | WIN |
SEA@KC | BOBBY WITT UNDER 0.5 SINGLES | 54.4% | 4 | LOSS |
PHI@LAD | LAD -113 | 54.7% | 4 | LOSS |
NYY@BOS | OVER 7.5 | 54.3% | 3 | WIN |
KC@PHI | PHI -130 | 58.3% | 4 | WIN |
LAD@SF | OVER 7.5 | 54.7% | 4 | LOSS |
NYM@PHI | PHI -122 | 55.6% | 4 | WIN |
KC@CLE | KC -104 | 52.0% | 3 | WIN |
CIN@SD | JAKE CRONEWORTH OVER 0.5 HITS | 53.1% | 3 | WIN |
WAS@MIA | MIA -123 | 55.2% | 4 | LOSS |
LAA@KC | UNDER 9.5 | 54.9% | 3 | WIN |
TEX@ARI | UNDER 9 | 54.2% | 4 | WIN |
SF@COL | UNDER 11.5 | 56.4% | 6 | LOSS |
SF@COL | RAFAEL DEVERS OVER 1.5 BASES | 56.1% | 6 | WIN |
MIA@WAS | WAS -110 | 54.4% | 4 | WIN |
NYM@DET | OVER 8.5 | 54.5% | 4 | WIN |
TEX@ARI | UNDER 9.5 | 56.4% | 6 | WIN |
TEX@ARI | ALEJANDRO OSUNA UNDER 1.5 BASES | 54.1% | 4 | LOSS |
ATL@CHC | CHC -116 | 55.1% | 3 | WIN |
PHI@MIL | OVER 8.5 | 55.0% | 3 | WIN |
ARI@LAD | SHOHEI OHTANI OVER 2.5 BASES | 54.2% | 4 | WIN |
SEA@CLE | CLE +1.5 | 57.2% | 3 | WIN |
CHC@SF | CHC -105 | 54.1% | 4 | LOSS |
NYY@CHW | RYAN MCMAHON OVER 0.5 BASES | 54.1% | 4 | WIN |
PHI@NYM | OVER 8.5 | 55.6% | 4 | LOSS |
LAA@TEX | LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS | 54.1% | 4 | LOSS |
KC@CHW | KC -109 | 54.2% | 4 | WIN |
SD@SEA | DYLAN CEASE OVER 16.5 OUTS | 53.9% | 3 | LOSS |
SD@SEA | UNDER 8.5 | 54.4% | 4 | LOSS |
MIN@TOR | JOE RYAN UNDER 2.5 EARNED RUNS | 54.1% | 4 | LOSS |
SF@MIL | MIL +100 | 54.0% | 6 | LOSS |
TOR@MIA | MIA +1.5 | 62.0% | 6 | WIN |
CHC@LAA | OVER 9.5 | 54.9% | 4 | LOSS |
BOS@NYY | CARLOS RODON UNDER 4.5 HITS ALLOWED | 54.2% | 4 | WIN |
KC@DET | DET -115 | 56.1% | 5 | WIN |
CHC@LAA | LAA +1.5 | 57.6% | 5 | LOSS |
CIN@ARI | KEBRYAN HAYES STRIKEOUTS UNDER 0.5 | 56.2% | 6 | WIN |
LAD@SD | SD +110 | 50.9% | 6 | WIN |