Cardinals vs. Braves
Prediction, Odds & Props
Apr 22 | MLB AI Picks

Updated: 2025-04-20T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The St. Louis Cardinals (9–14) and Atlanta Braves (9–13) will face off on April 22, 2025, at Truist Park in Atlanta, Georgia. Both teams are looking to improve their standings in their respective divisions.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Apr 22, 2025

Start Time: 7:15 PM EST​

Venue: Truist Park​

Braves Record: (9-13)

Cardinals Record: (9-14)

OPENING ODDS

STL Moneyline: +116

ATL Moneyline: -136

STL Spread: +1.5

ATL Spread: -1.5

Over/Under: 8.5

STL
Betting Trends

  • The Cardinals have struggled against the spread (ATS) on the road, with a 1–10 record in away games this season.

ATL
Betting Trends

  • The Braves have performed well at home, holding a 7–2 record at Truist Park, indicating strong home-field advantage.

MATCHUP TRENDS

  • The Cardinals have lost their last five games, while the Braves are on a four-game winning streak.

STL vs. ATL
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: J. Kelenic under 1.5 Total Bases.

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St. Louis vs Atlanta Prediction & Odds:
Free MLB Betting Insights for 4/22/25

The St. Louis Cardinals and Atlanta Braves continue their early-season National League clash on April 22, 2025, at Truist Park, with both clubs in search of momentum amid mixed starts. While Atlanta is beginning to heat up with a four-game winning streak and a stellar 7–2 home record, St. Louis arrives in desperate need of a turnaround after dropping five straight and owning just a 1–10 mark on the road. This game presents a sharp contrast in form and confidence, and with both teams still trying to establish their identities in the competitive NL landscape, every inning holds weight. The pitching matchup features Cardinals left-hander Steven Matz (1–0, 2.16 ERA), who has quietly been one of their steadiest arms, against Braves right-hander Spencer Strider (0–1, 3.60 ERA), a strikeout machine who’s looking to settle into a groove after some early inconsistency. With a home crowd behind them and offensive weapons beginning to find their stride, the Braves have a clear momentum advantage heading into this matchup, but the Cardinals’ pitching and occasional offensive sparks make them capable of playing spoiler. For St. Louis, Steven Matz has been one of the lone bright spots during a rough April. With a sparkling 2.16 ERA, Matz has succeeded by working efficiently and keeping the ball in the park—something the Cardinals’ other starters have struggled with. The challenge for him will be facing a Braves lineup that’s suddenly clicking and features dangerous hitters like Austin Riley and Marcell Ozuna, who have combined for eight home runs and over 25 RBIs.

If Matz can command his sinker and keep the Braves’ powerful right-handed bats on the ground, he can provide the Cardinals with a path to stay competitive deep into the game. Offensively, Brendan Donovan has been one of the few consistent hitters for St. Louis, entering with a .380 batting average and 13 RBIs. However, the supporting cast—Paul Goldschmidt, Nolan Arenado, and Willson Contreras—has yet to find rhythm at the plate, leading to a series of low-scoring outputs and missed opportunities with runners in scoring position. For the Cardinals to snap their losing streak, they must break through early against Strider and avoid falling behind, which has been a troubling trend throughout their current skid. The Braves, meanwhile, are trending upward thanks to strong play at home and timely contributions from their core. Spencer Strider, despite an 0–1 record, remains one of the most electric arms in baseball with his strikeout prowess and fiery mound presence. His 3.60 ERA is respectable, and he’ll be looking to build deeper into games while reducing pitch count inefficiencies. With Riley anchoring the offense and Ozuna swinging the bat well, the Braves also benefit from strong complementary pieces like Ozzie Albies and Michael Harris II, giving them one of the more dynamic lineups in the National League when healthy. Their defense has been clean, and their bullpen—led by closer Raisel Iglesias—has been sharp during their recent winning streak. Given the Cardinals’ road woes and offensive struggles, Atlanta has a prime opportunity to continue their surge and assert themselves as early contenders in the NL East. If Strider dominates the zone early and the offense continues to produce runs in bunches, the Braves could be in for another convincing home win, further burying a St. Louis team that’s in urgent need of a spark.

St. Louis Cardinals MLB Preview

The St. Louis Cardinals travel to Atlanta in search of answers and a much-needed spark to salvage what has been a disappointing opening stretch to the 2025 season. At 9–14, the Cardinals are firmly in the early-season danger zone, made worse by their current five-game losing streak and a staggering 1–10 record on the road. A perennial contender not long ago, St. Louis now finds itself struggling to generate momentum, plagued by inconsistent hitting, a thin bullpen, and underwhelming production from some of its veteran stars. The silver lining heading into this matchup against the Braves is left-hander Steven Matz, who takes the mound with a sharp 2.16 ERA and a 1–0 record. Matz has emerged as the rotation’s most reliable arm thus far, providing quality innings and keeping the Cardinals competitive in his outings. Against an Atlanta lineup that’s finally finding its stride, Matz will need to continue locating well and inducing ground balls to neutralize the Braves’ power. Matz’s performance, however, can only carry the Cardinals so far unless the offense finds a way to break through. Brendan Donovan has been the team’s lone offensive bright spot, posting an outstanding .380 batting average and 13 RBIs, showing maturity and balance at the plate. His contact-first approach has been a valuable asset, especially in contrast to the struggles seen from big names like Nolan Arenado and Paul Goldschmidt. Both corner infielders have yet to produce at the level expected, with a combination of slumps and timing issues plaguing the heart of the order. Willson Contreras and Jordan Walker have shown flashes, but nothing sustained enough to offset the top-of-the-order struggles.

With runners in scoring position, the Cardinals have faltered far too often, leading to missed chances that have flipped close games in the wrong direction. Their inability to cash in on early opportunities has repeatedly forced their pitching staff to hold narrow leads or chase games from behind—situations that have proven unsustainable given their current bullpen makeup. Defensively, St. Louis has been average—neither catastrophic nor particularly sharp. Defensive positioning has helped mitigate some issues, but untimely errors and mental lapses have added pressure to a pitching staff that already has little room for mistakes. The bullpen, in particular, has not held up well under strain. Ryan Helsley and Giovanny Gallegos have had little margin for error when brought in to protect leads or keep games close, and with frequent short starts, the relievers are being asked to do too much, too often. Against a surging Braves team at Truist Park, where Atlanta has posted a 7–2 record, the Cardinals will need everything to click: a deep start from Matz, timely run production from the middle of the lineup, and airtight defense. If St. Louis cannot deliver across all three phases, they risk slipping further behind in the NL Central. This game marks a pivotal point in the Cardinals’ early-season campaign—a chance to show resilience and fight, or yet another chapter in a troubling start that continues to raise questions about their direction.

The St. Louis Cardinals (9–14) and Atlanta Braves (9–13) will face off on April 22, 2025, at Truist Park in Atlanta, Georgia. Both teams are looking to improve their standings in their respective divisions. St. Louis vs Atlanta AI Prediction: Free MLB Betting Insights for Apr 22. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Atlanta Braves MLB Preview

The Atlanta Braves return to Truist Park on April 22 riding the momentum of a four-game winning streak, bolstering their 9–13 overall record with a superb 7–2 mark at home. While their overall standing remains below expectations for a team with perennial playoff ambitions, the Braves have begun to rediscover their form, and playing at home has provided the perfect spark. After a sluggish start, Atlanta’s bats are beginning to heat up, and their pitching staff—particularly their bullpen—has stabilized during this recent stretch of success. With the struggling St. Louis Cardinals in town and an opportunity to climb out of an early-season hole, the Braves are well-positioned to extend their run and reassert themselves as a top-tier National League contender. The matchup features Spencer Strider on the mound, a right-hander known for his electric fastball and high strikeout rates, who enters with a 3.60 ERA and is hungry for his first win of the season. Strider has been solid in his first few starts, and although his 0–1 record doesn’t tell the full story, his underlying metrics suggest he’s trending in the right direction. He’s managed his pitch count better, minimized damage in tough spots, and maintained his status as a strikeout threat every time he toes the rubber. His challenge against the Cardinals will be keeping Brendan Donovan off base and avoiding the types of middle-of-the-plate mistakes that have occasionally haunted him early in counts.

With Steven Matz pitching well for St. Louis, the Braves will need Strider to match him inning-for-inning and allow their offense the room to break through without feeling pressure to play from behind. Strider’s ability to get ahead in counts and put away hitters efficiently will be key, especially against a Cardinals lineup that’s been anemic on the road and prone to pressing in high-leverage moments. Offensively, the Braves are rounding into form thanks to the continued excellence of Austin Riley and the resurgence of Marcell Ozuna. Riley, with five home runs and 12 RBIs, is doing what he does best—delivering big hits in big moments—while Ozuna has been a quiet catalyst with a .288 average and renewed confidence at the plate. Michael Harris II and Ozzie Albies are finding their groove as well, giving Atlanta a dynamic mix of power, speed, and situational versatility. The lineup has improved its approach with runners in scoring position, and there’s been a noticeable uptick in quality at-bats across the board. In terms of defense, the Braves remain one of the sharper units in the league, with strong infield cohesion and athletic outfield play that has helped minimize extra-base threats and support the pitching staff. Their bullpen, anchored by Raisel Iglesias and A.J. Minter, has closed out games cleanly during the winning streak, turning late-inning leads into near certainties. With the Cardinals mired in a five-game skid and boasting one of the league’s worst road records, Atlanta has a golden opportunity to take control early and continue their climb up the NL East ladder. If the Braves can maintain their current formula of strong starting pitching, clutch offense, and airtight defense, they should be well-equipped to keep their momentum rolling in front of the home crowd.

St. Louis vs. Atlanta Prop Picks (AI)

AI algorithm Remi is pouring through mountains of datapoints on each line. In fact, anytime the Cardinals and Braves play there’s always several intriguing observations to key in on. Not to mention games played at Truist Park in Apr can often follow normal, predictable betting trends.
Remi's searched hard and found the best prop for this matchup: J. Kelenic under 1.5 Total Bases.

St. Louis vs. Atlanta Prediction (AI)

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Remi, our AI sports wizard, has been pouring over exorbitant amounts of data from every past game between the Cardinals and Braves and using recursive machine learning and industry leading AI to crunch the data to a single cover probability.

Interestingly enough, the data has been most fixated on the trending weight human bettors often put on Atlanta’s strength factors between a Cardinals team going up against a possibly unhealthy Braves team. Trends look to say the true game analytics appear to reflect a moderate lean against one Vegas line specifically.

Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.

Below is our current AI St. Louis vs Atlanta picks, computer picks Cardinals vs Braves, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
MLB 9/26 DET@BOS UNLOCK THIS PICK 5 EXECUTIVE Locked EXECUTIVE
MLB 9/26 BAL@NYY UNLOCK THIS PICK 4 INTEL Locked INTEL
MLB 9/26 ARI@SD UNLOCK THIS PICK 4 EXECUTIVE Locked EXECUTIVE
MLB 9/26 NYM@MIA UNLOCK THIS PICK 1 INTEL Locked INTEL
MLB 9/26 NYM@MIA GET FREE PICK NOW 1
MLB 9/26 COL@SF UNLOCK THIS PICK 0 INTEL Locked INTEL

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.

Cardinals Betting Trends

The Cardinals have struggled against the spread (ATS) on the road, with a 1–10 record in away games this season.

Braves Betting Trends

The Braves have performed well at home, holding a 7–2 record at Truist Park, indicating strong home-field advantage.

Cardinals vs. Braves Matchup Trends

The Cardinals have lost their last five games, while the Braves are on a four-game winning streak.

St. Louis vs. Atlanta Game Info

St. Louis vs Atlanta starts on April 22, 2025 at 7:15 PM EST.

Spread: Atlanta -1.5
Moneyline: St. Louis +116, Atlanta -136
Over/Under: 8.5

St. Louis: (9-14)  |  Atlanta: (9-13)

Remi's searched hard and found the best prop for this matchup: J. Kelenic under 1.5 Total Bases.. Prices move—always shop for the best number.

The Cardinals have lost their last five games, while the Braves are on a four-game winning streak.

STL trend: The Cardinals have struggled against the spread (ATS) on the road, with a 1–10 record in away games this season.

ATL trend: The Braves have performed well at home, holding a 7–2 record at Truist Park, indicating strong home-field advantage.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

St. Louis vs. Atlanta Odds

Remi is pouring through loads of data points on each team. In fact, anytime the St. Louis vs Atlanta trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme hostile environments can often follow normal, predictable patterns.

St. Louis vs Atlanta Opening Odds

STL Moneyline: +116
ATL Moneyline: -136
STL Spread: +1.5
ATL Spread: -1.5
Over/Under: 8.5

St. Louis vs Atlanta Live Odds

Games PTS ML SPR O/U
Sep 27, 2025 1:06PM EDT
Baltimore Orioles
New York Yankees
9/27/25 1:06PM
Orioles
Yankees
+190
-235
+1.5 (-110)
-1.5 (-110)
O 8.5 (-120)
U 8.5 (+100)
Sep 27, 2025 2:21PM EDT
St Louis Cardinals
Chicago Cubs
9/27/25 2:21PM
Cardinals
Cubs
 
-180
 
-1.5 (+115)
O 9.5 (-105)
U 9.5 (-115)
Sep 27, 2025 3:09PM EDT
Tampa Bay Rays
Toronto Blue Jays
9/27/25 3:09PM
Rays
Blue Jays
+130
-155
+1.5 (-155)
-1.5 (+130)
O 8.5 (-110)
U 8.5 (-110)
Sep 27, 2025 4:06PM EDT
Chicago White Sox
Washington Nationals
9/27/25 4:06PM
White Sox
Nationals
+100
-120
-1.5 (+165)
+1.5 (-200)
O 8.5 (-110)
U 8.5 (-110)
Sep 27, 2025 4:06PM EDT
Colorado Rockies
San Francisco Giants
9/27/25 4:06PM
Rockies
Giants
+185
-225
+1.5 (-110)
-1.5 (-110)
O 8 (-105)
U 8 (-115)
Sep 27, 2025 4:11PM EDT
New York Mets
Miami Marlins
9/27/25 4:11PM
Mets
Marlins
-130
+110
-1.5 (+125)
+1.5 (-150)
O 8 (-115)
U 8 (-105)
Sep 27, 2025 4:11PM EDT
Detroit Tigers
Boston Red Sox
9/27/25 4:11PM
Tigers
Red Sox
+125
-150
+1.5 (-180)
-1.5 (+150)
O 9 (+100)
U 9 (-120)
Sep 27, 2025 6:05PM EDT
Minnesota Twins
Philadelphia Phillies
9/27/25 6:05PM
Twins
Phillies
+170
-205
+1.5 (-120)
-1.5 (+100)
O 8.5 (-115)
U 8.5 (-105)
Sep 27, 2025 7:11PM EDT
Cincinnati Reds
Milwaukee Brewers
9/27/25 7:11PM
Reds
Brewers
+125
-150
+1.5 (-180)
-1.5 (+150)
O 8 (-105)
U 8 (-115)
Sep 27, 2025 7:15PM EDT
Pittsburgh Pirates
Atlanta Braves
9/27/25 7:15PM
Pirates
Braves
+145
-175
+1.5 (-155)
-1.5 (+130)
O 8 (-110)
U 8 (-110)
Sep 27, 2025 7:16PM EDT
Texas Rangers
Cleveland Guardians
9/27/25 7:16PM
Rangers
Guardians
+135
-165
+1.5 (-180)
-1.5 (+150)
O 7 (-120)
U 7 (+100)
Sep 27, 2025 8:40PM EDT
Arizona Diamondbacks
San Diego Padres
9/27/25 8:40PM
Diamondbacks
Padres
+115
-140
+1.5 (-195)
-1.5 (+160)
O 7.5 (-120)
U 7.5 (+100)
Sep 27, 2025 9:39PM EDT
Houston Astros
Los Angeles Angels
9/27/25 9:39PM
Astros
Angels
-165
+135
-1.5 (+105)
+1.5 (-125)
O 9 (+100)
U 9 (-120)
Sep 27, 2025 9:41PM EDT
Los Angeles Dodgers
Seattle Mariners
9/27/25 9:41PM
Dodgers
Mariners
+105
-125
+1.5 (-205)
-1.5 (+170)
O 7.5 (+105)
U 7.5 (-125)
Sep 27, 2025 10:05PM EDT
Kansas City Royals
Oakland Athletics
9/27/25 10:05PM
Royals
Athletics
+100
-120
-1.5 (+150)
+1.5 (-180)
O 10 (-110)
U 10 (-110)

MLB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers St. Louis Cardinals vs. Atlanta Braves on April 22, 2025 at Truist Park.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN
CHC@SF CHC -105 54.1% 4 LOSS
NYY@CHW RYAN MCMAHON OVER 0.5 BASES 54.1% 4 WIN
PHI@NYM OVER 8.5 55.6% 4 LOSS
LAA@TEX LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS 54.1% 4 LOSS
KC@CHW KC -109 54.2% 4 WIN
SD@SEA DYLAN CEASE OVER 16.5 OUTS 53.9% 3 LOSS
SD@SEA UNDER 8.5 54.4% 4 LOSS
MIN@TOR JOE RYAN UNDER 2.5 EARNED RUNS 54.1% 4 LOSS
SF@MIL MIL +100 54.0% 6 LOSS
TOR@MIA MIA +1.5 62.0% 6 WIN
CHC@LAA OVER 9.5 54.9% 4 LOSS
BOS@NYY CARLOS RODON UNDER 4.5 HITS ALLOWED 54.2% 4 WIN
KC@DET DET -115 56.1% 5 WIN
CHC@LAA LAA +1.5 57.6% 5 LOSS
CIN@ARI KEBRYAN HAYES STRIKEOUTS UNDER 0.5 56.2% 6 WIN
LAD@SD SD +110 50.9% 6 WIN